CA2673085C - Transferrin fusion protein libraries - Google Patents

Transferrin fusion protein libraries Download PDF

Info

Publication number
CA2673085C
CA2673085C CA2673085A CA2673085A CA2673085C CA 2673085 C CA2673085 C CA 2673085C CA 2673085 A CA2673085 A CA 2673085A CA 2673085 A CA2673085 A CA 2673085A CA 2673085 C CA2673085 C CA 2673085C
Authority
CA
Canada
Prior art keywords
leu
ala
ser
thr
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2673085A
Other languages
English (en)
French (fr)
Other versions
CA2673085A1 (en
Inventor
Andrew John Turner
Baiyang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorexis Pharmaceutical Corp
Original Assignee
Biorexis Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorexis Pharmaceutical Corp filed Critical Biorexis Pharmaceutical Corp
Publication of CA2673085A1 publication Critical patent/CA2673085A1/en
Application granted granted Critical
Publication of CA2673085C publication Critical patent/CA2673085C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2673085A 2006-12-12 2007-12-07 Transferrin fusion protein libraries Expired - Fee Related CA2673085C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93495106P 2006-12-12 2006-12-12
US60/934,951 2006-12-12
PCT/IB2007/003908 WO2008072075A2 (en) 2006-12-12 2007-12-07 Transferrin fusion protein libraries

Publications (2)

Publication Number Publication Date
CA2673085A1 CA2673085A1 (en) 2008-06-19
CA2673085C true CA2673085C (en) 2013-10-15

Family

ID=39362844

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2673085A Expired - Fee Related CA2673085C (en) 2006-12-12 2007-12-07 Transferrin fusion protein libraries

Country Status (13)

Country Link
US (1) US8822639B2 (enExample)
EP (2) EP2114999A2 (enExample)
JP (1) JP5492563B2 (enExample)
KR (1) KR20090098880A (enExample)
CN (1) CN101622274A (enExample)
AU (1) AU2007331195A1 (enExample)
CA (1) CA2673085C (enExample)
ES (1) ES2535358T3 (enExample)
IL (1) IL198815A0 (enExample)
MX (1) MX2009006398A (enExample)
NO (1) NO20092591L (enExample)
WO (1) WO2008072075A2 (enExample)
ZA (1) ZA200904757B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8401798B2 (en) * 2008-06-06 2013-03-19 Dna Twopointo, Inc. Systems and methods for constructing frequency lookup tables for expression systems
AU2010306940A1 (en) 2009-10-12 2012-06-07 Smith, Larry Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
CN102258767B (zh) * 2010-05-24 2013-05-15 黄敏铨 促进伤口愈合的组合物
US20130251740A1 (en) * 2010-10-26 2013-09-26 Rockefeller University (The) Immunogenic agents
CA2825641C (en) * 2011-02-02 2016-10-11 Medipost Co., Ltd. Use of icam-1 for prevention or treatment of neurological diseases
US9623117B2 (en) * 2011-04-04 2017-04-18 Wisconsin Alumni Research Foundation Method for selective targeting and entry of bacterial toxins to cells
SI3401402T1 (sl) * 2012-06-08 2021-03-31 Alkermes Pharma Ireland Limited Ligandi modificirani s krožno permutacijo kot agonisti in antagonisti
EP2929351B1 (en) * 2012-12-10 2019-10-09 The University of Queensland Cell-free biofragment compositions and related systems, devices, and methods
CN107075507B (zh) * 2014-11-10 2021-08-24 小利兰斯坦福大学理事会 用于在细胞表面上表达多肽的组合物和方法
EP3438254A4 (en) * 2016-03-30 2019-10-16 Kaneka Corporation POLYPEPTIDE WITH ENDONUCLEASE ACTIVITY AND MANUFACTURING METHOD THEREFOR
BR112019003622A2 (pt) * 2016-08-25 2019-05-21 Jcr Pharmaceuticals Co., Ltd. método para produção de uma proteína de fusão.
JP7627910B2 (ja) * 2018-12-21 2025-02-07 フエー・イー・ベー・フエー・ゼツト・ウエー サイトカイン及び足場タンパク質を含む融合タンパク質
CN113045670B (zh) * 2019-12-27 2022-11-01 华南农业大学 一种可溶性鸡α干扰素融合蛋白及其生产方法与应用
EP4314073A4 (en) 2021-03-24 2025-02-19 Alkermes, Inc. Upar antibodies and fusion proteins with the same
US20250041398A1 (en) * 2021-12-16 2025-02-06 Thomas Jefferson University A therapeutic against crimean-congo hemorrhagic fever virus

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4782137A (en) 1984-01-24 1988-11-01 Immunex Corporation Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5026651A (en) 1985-04-25 1991-06-25 Board Of Regents, The University Of Texas System Methods and compositions for the production of human transferrin
US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US4851341A (en) 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US5346989A (en) 1990-08-22 1994-09-13 Syntello Vaccine Development Kb Peptides for use in induction of T cell activation against HIV-1
US5347849A (en) 1990-08-30 1994-09-20 Tanknology Corporation International Water sensor that detects tank or vessel leakage
US5986067A (en) 1991-02-08 1999-11-16 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
EP0611306B1 (en) 1991-11-08 1998-07-08 Somatogen, Inc. Hemoglobins as drug delivery agents
WO1994002505A1 (en) 1992-07-20 1994-02-03 Duke University Compounds which inhibit hiv replication
US5547871A (en) 1993-01-25 1996-08-20 American Cyanamid Company Heterologous signal sequences for secretion of insect controlling proteins
AU6235294A (en) * 1993-02-02 1994-08-29 Scripps Research Institute, The Methods for producing polypeptide binding sites
EP0682710B1 (en) 1993-02-10 2003-10-29 Unilever Plc Isolation process using immobilized proteins with specific binding capacities
WO1994017810A1 (en) 1993-02-12 1994-08-18 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
WO1994023744A1 (en) 1993-04-16 1994-10-27 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
US6017536A (en) 1993-06-07 2000-01-25 Trimeris, Inc. Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US5603933A (en) 1993-08-31 1997-02-18 Board Of Regents, The University Of Texas CD4 peptides for binding to viral envelope proteins
US5981478A (en) * 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5843882A (en) 1995-04-27 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Antiviral proteins and peptides
US5817789A (en) 1995-06-06 1998-10-06 Transkaryotic Therapies, Inc. Chimeric proteins for use in transport of a selected substance into cells
EP0831873A4 (en) 1995-06-07 2002-07-17 Trimeris Inc COMBINATORY THERAPY FOR THE TREATMENT OF HIV AND OTHER VIRAL INFECTIONS
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6699658B1 (en) 1996-05-31 2004-03-02 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6300065B1 (en) 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
US6258782B1 (en) 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6699677B1 (en) 1999-12-20 2004-03-02 Chemocentryx, Inc. Tethered ligands and methods of use
US6623741B1 (en) 2000-02-29 2003-09-23 Trimeris, Inc. Methods and compositions for inhibition of membrane fusion-associated events including RSV transmission
AU2001264563A1 (en) 2000-04-12 2001-10-30 Human Genome Sciences, Inc. Albumin fusion proteins
US20030226155A1 (en) 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
ATE490969T1 (de) 2001-08-30 2010-12-15 Biorexis Pharmaceutical Corp Modifizierte transferrin-fusionsproteine
US20070031440A1 (en) 2001-08-30 2007-02-08 Prior Christopher P Modified transferin-antibody fusion proteins
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
WO2004019872A2 (en) 2002-08-30 2004-03-11 Biorexis Pharmaceutical Corporation Oral delivery of modified transferrin fusion proteins
US20060105387A1 (en) 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
CN1713920A (zh) 2002-08-30 2005-12-28 比奥雷克西斯药物公司 被修饰的转铁蛋白融合蛋白
ES2337245T3 (es) * 2002-08-30 2010-04-22 Biorexis Pharmaceutical Corporation Bibliotecas de proteinas de fucion de la transferrina.
EP1626981A4 (en) 2003-03-04 2006-11-22 Biorexis Pharmaceutical Corp PROTEINS PROTECTED AGAINST DIPEPTIDYLPEPTIDASE
US20070060512A1 (en) 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
US20060205037A1 (en) 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins
EP1663278A4 (en) 2003-08-28 2009-07-29 Biorexis Pharmaceutical Corp EPO MIMETIC PEPTIDES AND FUSION PROTEINS
WO2006049983A2 (en) 2004-10-27 2006-05-11 Biorexis Pharmaceutical Corporation Peptide yy modified transferrin fusion proteins
EP1858546A4 (en) 2005-03-04 2009-03-04 Biorexis Pharmaceutical Corp MODIFIED TRANSFERRINFUSION PROTEINS
JP2008546392A (ja) * 2005-06-17 2008-12-25 バイオレクシス ファーマシューティカル コーポレーション 固定されたトランスフェリン融合タンパク質ライブラリー
CN101511868B (zh) 2006-07-24 2013-03-06 比奥雷克西斯制药公司 毒蜥外泌肽融合蛋白

Also Published As

Publication number Publication date
KR20090098880A (ko) 2009-09-17
EP2114999A2 (en) 2009-11-11
US20110086768A1 (en) 2011-04-14
MX2009006398A (es) 2009-06-23
CA2673085A1 (en) 2008-06-19
JP5492563B2 (ja) 2014-05-14
EP2479189B1 (en) 2015-02-25
CN101622274A (zh) 2010-01-06
US8822639B2 (en) 2014-09-02
ES2535358T3 (es) 2015-05-08
AU2007331195A1 (en) 2008-06-19
IL198815A0 (en) 2011-08-01
WO2008072075A3 (en) 2008-11-06
EP2479189A1 (en) 2012-07-25
WO2008072075A2 (en) 2008-06-19
NO20092591L (no) 2009-09-11
JP2010512160A (ja) 2010-04-22
ZA200904757B (en) 2010-04-28

Similar Documents

Publication Publication Date Title
CA2673085C (en) Transferrin fusion protein libraries
EP1427750B1 (en) Modified transferrin fusion proteins
Rich et al. Survey of the year 2001 commercial optical biosensor literature
EP1545595B1 (en) Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains
WO2017165245A2 (en) Methods and compositions for transducing lymphocytes and regulated expansion thereof
CA2430528A1 (en) Hybrid antibodies
US20100297701A1 (en) Trimerizing polypeptides
US20060105387A1 (en) Transferrin fusion proteins libraries
US20090275481A1 (en) Anchored Transferrin Fusion Protein Libraries
EP1539221B1 (en) Transferrin fusion protein libraries
HK1135992A (en) Transferrin fusion protein libraries
WO2024013402A1 (en) Novel soluble gamma t-cell (or soluble delta t-cell) receptor chains (or soluble gammadelta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
WO1985004673A1 (fr) Nouvel adn et son utilisation
HK1131625A (en) Modified transferrin fusion proteins
JPS61501607A (ja) T−細胞レセプタ−−抗原特異的ポリペプチド及びポリヌクレオチド

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20171207