CN101616667A - 可用作激酶抑制剂的杂环酰胺化合物 - Google Patents

可用作激酶抑制剂的杂环酰胺化合物 Download PDF

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CN101616667A
CN101616667A CN200780048839A CN200780048839A CN101616667A CN 101616667 A CN101616667 A CN 101616667A CN 200780048839 A CN200780048839 A CN 200780048839A CN 200780048839 A CN200780048839 A CN 200780048839A CN 101616667 A CN101616667 A CN 101616667A
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斯蒂芬·T·罗布尔斯基
杰加班杜·达斯
T·G·穆拉利·达尔
阿拉里克·J·戴克曼
约翰·海因斯
凯特琳娜·莱夫塞里斯
林子正
蔺恕群
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Bristol Myers Squibb Co
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  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104086528A (zh) * 2010-07-15 2014-10-08 拜耳知识产权有限责任公司 作为杀虫剂的新杂环化合物
CN109153651A (zh) * 2015-05-05 2019-01-04 拜耳制药股份公司 酰胺基-取代的环己烷衍生物
CN109641911A (zh) * 2016-08-19 2019-04-16 百时美施贵宝公司 seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
CN111233734A (zh) * 2019-12-06 2020-06-05 济宁医学院 一种芳氧基马来酰亚胺化合物及其制备方法
CN114656414A (zh) * 2022-05-24 2022-06-24 常熟华虞环境科技有限公司 三氮唑改性二氧化钛光催化剂及其制备方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2083816A2 (en) * 2006-10-27 2009-08-05 Brystol-Myers Squibb Company Heterocyclic amide compounds useful as kinase inhibitors
WO2009124259A1 (en) * 2008-04-04 2009-10-08 Cv Therapeutics, Inc. Pyrrolotriazinone derivatives for use as stearoyl coa desaturase inhibitors
AU2009244664A1 (en) 2008-04-04 2009-11-12 Gilead Sciences, Inc. Triazolopyridinone derivatives for use as stearoyl CoA desaturase inhibitors
CA2735770A1 (en) * 2008-09-02 2010-03-11 Boehringer Ingelheim International Gmbh 7-(piperazine-1-ymethyl)-1h-indole-2-carboxylic acid (phenyl)-amide derivatives and allied compounds as p38 map kinase inhibitors for the treatment of respiratory diseases
JP5634997B2 (ja) 2008-09-02 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なベンズアミド、その製造、及び医薬としてのその使用
JP2012505232A (ja) * 2008-10-08 2012-03-01 ブリストル−マイヤーズ スクイブ カンパニー アゾロトリアジノンメラニン凝集ホルモン受容体−１アンタゴニスト
US8969350B2 (en) 2008-12-18 2015-03-03 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
TW201035100A (en) 2008-12-19 2010-10-01 Cephalon Inc Pyrrolotriazines as ALK and JAK2 inhibitors
UA106740C2 (uk) * 2009-01-30 2014-10-10 Глаксосмітклайн Ллс Кристалічний гідрохлорид n-{(1s)-2-аміно-1-[(3-фторфеніл)метил]етил}-5-хлор-4-(4-хлор-1-метил-1h-піразол-5-іл)-2-тіофенкарбоксаміду
WO2010101246A1 (ja) 2009-03-05 2010-09-10 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
WO2011075377A1 (en) * 2009-12-14 2011-06-23 Novartis Ag Methods for making silicone hydrogel lenses from water-based lens formulations
WO2011163198A2 (en) * 2010-06-21 2011-12-29 Board Of Regents, The University Of Texas System Tg2 inhibitors and uses thereof
CN103221395A (zh) * 2010-11-23 2013-07-24 先正达参股股份有限公司 杀虫化合物
WO2013161871A1 (ja) * 2012-04-25 2013-10-31 興和株式会社 Ｔｌｒ阻害作用を有するチオフェン誘導体

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200750A (en) * 1977-01-07 1980-04-29 Westwood Pharmaceuticals Inc. 4-Substituted imidazo [1,2-a]quinoxalines
GB9816837D0 (en) * 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
IL118544A (en) * 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
TR199801361T2 (xx) * 1996-01-11 1998-10-21 Smithkline Beecham Corporation Yeni ikameli imidazol bile�imleri.
US5945418A (en) * 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6147080A (en) 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6087496A (en) * 1998-05-22 2000-07-11 G. D. Searle & Co. Substituted pyrazoles suitable as p38 kinase inhibitors
CA2288741A1 (en) 1997-05-22 1998-11-26 G.D. Searle And Co. 4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
CA2295762A1 (en) 1997-07-02 1999-01-14 Ravi Shanker Garigipati Novel cycloalkyl substituted imidazoles
US6130235A (en) 1998-05-22 2000-10-10 Scios Inc. Compounds and methods to treat cardiac failure and other disorders
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
JP2002523448A (ja) 1998-08-28 2002-07-30 サイオス インコーポレイテッド ｐ３８−αキナーゼのインヒビター
CN100352804C (zh) 1999-03-17 2007-12-05 阿斯特拉曾尼卡有限公司 酰胺衍生物
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
US6610697B1 (en) 1999-11-10 2003-08-26 Ortho-Mcneil Pharmaceutical, Inc. Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a]pyrimidines, and related pharmaceutical compositions and methods
US6924296B2 (en) 2000-08-17 2005-08-02 Eli Lilly And Company Antithrombotic agents
GB0124928D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
DE602004028907D1 (de) 2003-02-06 2010-10-14 Bristol Myers Squibb Co Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis
GB0308511D0 (en) * 2003-04-14 2003-05-21 Astex Technology Ltd Pharmaceutical compounds
WO2004099156A1 (en) * 2003-05-01 2004-11-18 Bristol-Myers Squibb Company Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
US7419978B2 (en) * 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
GB0329572D0 (en) * 2003-12-20 2004-01-28 Astrazeneca Ab Amide derivatives
NZ548793A (en) * 2004-01-28 2009-12-24 Mitsui Chemicals Inc Amide derivatives, process for preparation thereof and use thereof as insecticide
US7652146B2 (en) * 2004-02-06 2010-01-26 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
EP1756082A1 (en) * 2004-04-13 2007-02-28 Astex Therapeutics Limited 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators
US20090105218A1 (en) 2004-05-29 2009-04-23 7Tm Pharma A/S CRTH2 Receptor Ligands For Therapeutic Use
EP1831198B1 (en) * 2004-12-22 2009-04-08 AstraZeneca AB Pyridine carboxamide derivatives for use as anticancer agents
AR053992A1 (es) 2004-12-22 2007-05-30 Astrazeneca Ab Compuestos quimicos con actividad anticancerosa, un procedimiento para su preparacion, su uso en la preparacion de medicamentos y composicion farmaceutica.
CA2599989A1 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N-phenyl benzamide derivatives as sirtuin modulators
CA2612976C (en) * 2005-06-21 2012-04-10 Mitsui Chemicals, Inc. Amide derivative and insecticide containing the same
EP2083816A2 (en) * 2006-10-27 2009-08-05 Brystol-Myers Squibb Company Heterocyclic amide compounds useful as kinase inhibitors
US7943658B2 (en) * 2007-07-23 2011-05-17 Bristol-Myers Squibb Company Indole indane amide compounds useful as CB2 agonists and method

Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN104086528A (zh) * 2010-07-15 2014-10-08 拜耳知识产权有限责任公司 作为杀虫剂的新杂环化合物
CN109153651A (zh) * 2015-05-05 2019-01-04 拜耳制药股份公司 酰胺基-取代的环己烷衍生物
CN109641911A (zh) * 2016-08-19 2019-04-16 百时美施贵宝公司 seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
CN109641911B (zh) * 2016-08-19 2023-02-21 百时美施贵宝公司 seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
CN111233734A (zh) * 2019-12-06 2020-06-05 济宁医学院 一种芳氧基马来酰亚胺化合物及其制备方法
CN111233734B (zh) * 2019-12-06 2023-09-19 济宁医学院 一种芳氧基马来酰亚胺化合物及其制备方法
CN114656414A (zh) * 2022-05-24 2022-06-24 常熟华虞环境科技有限公司 三氮唑改性二氧化钛光催化剂及其制备方法

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WO2008057775A2 (en) 2008-05-15
EP2468717B1 (en) 2013-11-20
US7935696B2 (en) 2011-05-03
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