CN101600426B - 用于治疗肠道疾病的异山梨醇单硝酸酯衍生物 - Google Patents

用于治疗肠道疾病的异山梨醇单硝酸酯衍生物 Download PDF

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Publication number
CN101600426B
CN101600426B CN2007800443012A CN200780044301A CN101600426B CN 101600426 B CN101600426 B CN 101600426B CN 2007800443012 A CN2007800443012 A CN 2007800443012A CN 200780044301 A CN200780044301 A CN 200780044301A CN 101600426 B CN101600426 B CN 101600426B
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China
Prior art keywords
compounds
intestinal
alkyl
general formula
mononitrate
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Expired - Fee Related
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CN2007800443012A
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English (en)
Chinese (zh)
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CN101600426A (zh
Inventor
何塞·瑞波利斯莫利纳
弗朗西斯科·普比尔科伊
玛丽萨贝尔·莫瑞尔曼奇尼
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Lacer SA
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Lacer SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2007800443012A 2006-12-28 2007-12-27 用于治疗肠道疾病的异山梨醇单硝酸酯衍生物 Expired - Fee Related CN101600426B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06380338A EP1941876A1 (en) 2006-12-28 2006-12-28 Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
EP06380338.1 2006-12-28
PCT/EP2007/064591 WO2008080955A1 (en) 2006-12-28 2007-12-27 Isosorbide mononitrate derivatives for the treatment of intestinal disorders

Publications (2)

Publication Number Publication Date
CN101600426A CN101600426A (zh) 2009-12-09
CN101600426B true CN101600426B (zh) 2012-07-25

Family

ID=38043051

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2007800443012A Expired - Fee Related CN101600426B (zh) 2006-12-28 2007-12-27 用于治疗肠道疾病的异山梨醇单硝酸酯衍生物
CNA2007800441623A Pending CN101600425A (zh) 2006-12-28 2007-12-27 用于治疗高眼压的单硝酸异山梨酯衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2007800441623A Pending CN101600425A (zh) 2006-12-28 2007-12-27 用于治疗高眼压的单硝酸异山梨酯衍生物

Country Status (21)

Country Link
US (1) US20080161389A1 (enExample)
EP (3) EP1941876A1 (enExample)
JP (2) JP2010514733A (enExample)
KR (2) KR20090112673A (enExample)
CN (2) CN101600426B (enExample)
AR (1) AR064543A1 (enExample)
AT (2) ATE484279T1 (enExample)
AU (2) AU2007341289B2 (enExample)
BR (2) BRPI0720663A2 (enExample)
CA (2) CA2674550A1 (enExample)
CL (2) CL2007003836A1 (enExample)
DE (2) DE602007009877D1 (enExample)
ES (3) ES2324130B1 (enExample)
IL (2) IL198912A0 (enExample)
MX (2) MX2009007040A (enExample)
NO (2) NO20092763L (enExample)
PL (2) PL2114398T3 (enExample)
RU (2) RU2009128970A (enExample)
UY (1) UY30847A1 (enExample)
WO (2) WO2008080939A1 (enExample)
ZA (2) ZA200903566B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2149577B1 (en) * 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2149576A1 (en) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2177216A1 (en) * 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) * 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
CA2822747A1 (en) * 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
RU2015139514A (ru) * 2013-03-05 2017-04-07 Арчер Дэниелс Мидлэнд Компани Монотрифлаты изогексида и способ их синтеза
WO2018224419A1 (en) 2017-06-06 2018-12-13 Nicox S.A. Nitric oxide donating isomannide derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1863905A (zh) * 2003-09-08 2006-11-15 得克萨斯系统大学董事会 通过用前列腺素或前列腺素类似物补充培养基加强体外胚发育的方法以及组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2739689C2 (de) * 1977-09-02 1986-10-16 Euratom Thermische Wärmepumpe
JPS60149521A (ja) * 1984-01-18 1985-08-07 Eisai Co Ltd 高眼圧・緑内障治療・予防用点眼剤
US5573758A (en) * 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5925342A (en) * 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
GB9720797D0 (en) * 1997-09-30 1997-12-03 Rhodes John Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome
ES2142773B1 (es) * 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
JP2004517940A (ja) * 2001-01-31 2004-06-17 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ピラゾロ［４，３−ｄ］ピリミジンおよびニトレートまたはチエノピリミジンおよびニトレートを含む医薬製剤
US20060264353A1 (en) * 2002-03-21 2006-11-23 Maxey Kirk M Prostaglandin f2alpha analogs and their use in combination with antimicrobial proteins for the treatment of glaucoma and intraocular hypertension
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1863905A (zh) * 2003-09-08 2006-11-15 得克萨斯系统大学董事会 通过用前列腺素或前列腺素类似物补充培养基加强体外胚发育的方法以及组合物

Also Published As

Publication number Publication date
EP2114398A1 (en) 2009-11-11
EP2124930A1 (en) 2009-12-02
ZA200903566B (en) 2010-08-25
NO20092764L (no) 2009-07-27
RU2009128968A (ru) 2011-02-10
BRPI0720663A2 (pt) 2014-01-14
EP2114398B1 (en) 2010-06-30
ES2354317T3 (es) 2011-03-14
JP2010514733A (ja) 2010-05-06
AU2007341218B2 (en) 2010-09-09
MX2009007038A (es) 2009-08-25
ZA200903567B (en) 2010-08-25
IL198941A0 (en) 2010-02-17
ES2348314T3 (es) 2010-12-02
ES2324130B1 (es) 2010-03-22
CN101600425A (zh) 2009-12-09
ATE472324T1 (de) 2010-07-15
DE602007007523D1 (de) 2010-08-12
AU2007341289B2 (en) 2010-08-26
UY30847A1 (es) 2008-05-31
KR20090112673A (ko) 2009-10-28
PL2114398T3 (pl) 2010-11-30
WO2008080955A1 (en) 2008-07-10
BRPI0720664A2 (pt) 2014-01-14
RU2009128970A (ru) 2011-02-10
JP2010514734A (ja) 2010-05-06
WO2008080939A1 (en) 2008-07-10
NO20092763L (no) 2009-07-27
IL198912A0 (en) 2010-02-17
EP2124930B1 (en) 2010-10-13
CN101600426A (zh) 2009-12-09
CL2007003836A1 (es) 2008-07-11
PL2124930T3 (pl) 2011-04-29
KR20100100584A (ko) 2010-09-15
CA2674144A1 (en) 2008-07-10
AR064543A1 (es) 2009-04-08
ATE484279T1 (de) 2010-10-15
EP1941876A1 (en) 2008-07-09
ES2324130A1 (es) 2009-07-30
DE602007009877D1 (de) 2010-11-25
AU2007341218A1 (en) 2008-07-10
CL2007003837A1 (es) 2008-07-11
MX2009007040A (es) 2009-08-25
AU2007341289A1 (en) 2008-07-10
CA2674550A1 (en) 2008-07-10
US20080161389A1 (en) 2008-07-03

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Granted publication date: 20120725

Termination date: 20121227