CN101596177B - 辅酶q10自乳化组合物及其制备方法与应用 - Google Patents
辅酶q10自乳化组合物及其制备方法与应用 Download PDFInfo
- Publication number
- CN101596177B CN101596177B CN2009100900019A CN200910090001A CN101596177B CN 101596177 B CN101596177 B CN 101596177B CN 2009100900019 A CN2009100900019 A CN 2009100900019A CN 200910090001 A CN200910090001 A CN 200910090001A CN 101596177 B CN101596177 B CN 101596177B
- Authority
- CN
- China
- Prior art keywords
- coenzyme
- self
- emulsifying composition
- parts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 118
- 239000000203 mixture Substances 0.000 title claims abstract description 75
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims abstract description 67
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims abstract description 67
- 229940110767 coenzyme Q10 Drugs 0.000 title claims abstract description 62
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 14
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 239000003814 drug Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 15
- 229940093633 tricaprin Drugs 0.000 claims description 15
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 12
- 235000010445 lecithin Nutrition 0.000 claims description 12
- 239000000787 lecithin Substances 0.000 claims description 12
- 229940067606 lecithin Drugs 0.000 claims description 12
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000006184 cosolvent Substances 0.000 claims description 9
- 101000656751 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 30S ribosomal protein S24e Proteins 0.000 claims description 7
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000005457 triglyceride group Chemical group 0.000 claims description 2
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 abstract description 8
- 239000007908 nanoemulsion Substances 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 239000000490 cosmetic additive Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 150000004667 medium chain fatty acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 14
- 230000009182 swimming Effects 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000001804 emulsifying effect Effects 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- -1 Polyethylene Polymers 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000004945 emulsification Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000005515 coenzyme Substances 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229940035936 ubiquinone Drugs 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 230000003064 anti-oxidating effect Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000010579 first pass effect Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 238000010630 lipid peroxidation (MDA) assay Methods 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 208000006770 Ascorbic Acid Deficiency Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 208000010354 Coenzyme Q10 deficiency Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000010632 SOD assay Methods 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011987 exercise tolerance test Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 238000002356 laser light scattering Methods 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 150000002711 medium chain fatty acid esters Chemical class 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000008811 mitochondrial respiratory chain Effects 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- 125000004151 quinonyl group Chemical group 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 150000003505 terpenes Chemical group 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100900019A CN101596177B (zh) | 2009-07-24 | 2009-07-24 | 辅酶q10自乳化组合物及其制备方法与应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100900019A CN101596177B (zh) | 2009-07-24 | 2009-07-24 | 辅酶q10自乳化组合物及其制备方法与应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101596177A CN101596177A (zh) | 2009-12-09 |
CN101596177B true CN101596177B (zh) | 2011-02-02 |
Family
ID=41417897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009100900019A Withdrawn - After Issue CN101596177B (zh) | 2009-07-24 | 2009-07-24 | 辅酶q10自乳化组合物及其制备方法与应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101596177B (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102293753B (zh) * | 2010-06-25 | 2014-03-12 | 沈阳药科大学 | 辅酶q10纳米混悬剂冻干组合物及其制备方法和应用 |
CN102379829B (zh) * | 2011-10-27 | 2013-05-08 | 北京天辰空间生物医药研发有限公司 | 加入皮肤护理用品的辅酶q10澄清制剂及其制备方法 |
CN105167105B (zh) * | 2014-06-04 | 2017-12-12 | 百岳特生物科技(上海)有限公司 | 一种具有辅酶q10的组成物及其制备方法 |
CN106137787B (zh) * | 2015-04-10 | 2019-07-26 | 伊比西(北京)植物药物技术有限公司 | 还原型辅酶q10的乳化组合物及其制备方法 |
CN105434331B (zh) * | 2015-11-18 | 2018-11-09 | 厦门金达威生物科技有限公司 | 一种自乳化辅酶q10油剂及其制备方法和应用 |
CN105748313A (zh) * | 2016-03-10 | 2016-07-13 | 江苏隆力奇生物科技股份有限公司 | 一种辅酶q10用于预防皮肤光老化的方法 |
CN106619588B (zh) * | 2016-12-29 | 2019-08-16 | 厦门金达威生物科技有限公司 | 一种含辅酶q10的自微乳型营养组合物、制备方法及用途 |
CN106635380A (zh) * | 2017-02-15 | 2017-05-10 | 安徽天祥粮油食品有限公司 | 一种液态猪油制作方法 |
CN117180245B (zh) * | 2023-10-26 | 2024-04-26 | 广东润和生物科技有限公司 | 辅酶q10组合物及其制备工艺和在保护心脏中的应用 |
CN117582422B (zh) * | 2023-10-31 | 2024-07-09 | 广东润和生物科技有限公司 | 一种含葵花籽油的辅酶q10组合物及其制备工艺 |
CN117502646A (zh) * | 2023-11-29 | 2024-02-06 | 航天神舟生物科技集团有限公司 | 一种高含量、可水溶的辅酶q10组合物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030147927A1 (en) * | 2001-11-14 | 2003-08-07 | Khan Mansoor A. | Eutectic-based self-nanoemulsified drug delivery system |
US20060275358A1 (en) * | 2005-06-01 | 2006-12-07 | Cardinal Health Australia 401 Pty. Ltd. | Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10 |
-
2009
- 2009-07-24 CN CN2009100900019A patent/CN101596177B/zh not_active Withdrawn - After Issue
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030147927A1 (en) * | 2001-11-14 | 2003-08-07 | Khan Mansoor A. | Eutectic-based self-nanoemulsified drug delivery system |
US20060275358A1 (en) * | 2005-06-01 | 2006-12-07 | Cardinal Health Australia 401 Pty. Ltd. | Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10 |
Also Published As
Publication number | Publication date |
---|---|
CN101596177A (zh) | 2009-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101596177B (zh) | 辅酶q10自乳化组合物及其制备方法与应用 | |
ES2249797T3 (es) | Composiciones de lipidos solidos de componentes lipofilicos para mejorar la biodisponibilidad oral. | |
EP0447318B1 (fr) | Composition pour le traitement cosmétique et/ou pharmaceutique des couches supérieures de l'épiderme par application topique sur la peau et procédé de préparation correspondant | |
EP2205219B1 (en) | Methods and formulations for converting intravenous and injectable drugs into oral dosage forms | |
CN101366697A (zh) | 一种新的包含紫杉醇类物质的注射用纳米脂质载体及其制备方法 | |
WO2009012718A1 (fr) | Émulsifiant composite, émulsion préparée à partir de celui-ci et procédé de préparation de celle-ci | |
JP6282645B2 (ja) | ラセカドトリル脂質組成物 | |
BRPI0704205A2 (pt) | métodos e formulações para o realce da absorção e diminuição da variabilidade da absorção das drogas, vitaminas e nutrientes oralmente administrados | |
WO2017045034A1 (en) | Ubiquinone and ubiquinol compositions, and methods relating thereto | |
JP2016512828A (ja) | ラセカドトリル脂質組成物 | |
CN112399847B (zh) | 维生素k2微胶囊及其制备方法和在制备防治心脑血管疾病的药物中的应用 | |
CN106256345A (zh) | 维生素c传递系统及其脂质体组合物 | |
CN114796111A (zh) | 一种含有难溶性药物的浓缩液以及由其制备的乳剂 | |
Shailendrakumar et al. | Improved oral pharmacokinetics of pentoxifylline with palm oil and capmul® mcm containing self-nano-emulsifying drug delivery system | |
CN101810576B (zh) | 一种基于混合油的葛根素自微乳组合物及其制备方法 | |
CN105963254B (zh) | 一种辅酶q10药物组合物及其制备工艺 | |
CN105919949B (zh) | 一种稳定的氟比洛芬酯冻干乳及其制备方法 | |
US20110250239A1 (en) | Pharmaceutical and/or cosmetic composition for treating the skin | |
CN101288682B (zh) | 一种含有鸦胆子油的微乳及其制备方法 | |
CN1813733A (zh) | 维生素e烟酸酯脂质微球注射液及其制备方法 | |
CN103859395B (zh) | 一种高吸收率的辅酶q10的自乳化释药体系及其制备方法及应用 | |
CN100362993C (zh) | 一种丹参酮乳剂及其制备方法 | |
CN105832744A (zh) | 一种供注射用的前列地尔冻干乳剂组合物 | |
CN101700224A (zh) | 一种硫酸软骨素口服纳米乳的制备方法 | |
KR100524700B1 (ko) | 자가미세유화형 약물전달시스템을 이용한 고지혈증치료용약제 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SUZHOU GUONA BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: TSINGHUA UNIVERSITY Effective date: 20130902 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100084 HAIDIAN, BEIJING TO: 215200 SUZHOU, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130902 Address after: 215200 Jiangsu Province, Suzhou Wujiang economic and Technological Development Zone, Road No. 208 leaf Patentee after: Suzhou state Biotechnology Co., Ltd. Address before: 100084 Haidian District Tsinghua Yuan Beijing No. 1 Patentee before: Tsinghua University |
|
AV01 | Patent right actively abandoned | ||
AV01 | Patent right actively abandoned |
Granted publication date: 20110202 Effective date of abandoning: 20171101 |