CN101588789B - 用于治疗牛和其它动物炎症的药物组合物和方法 - Google Patents

用于治疗牛和其它动物炎症的药物组合物和方法 Download PDF

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Publication number
CN101588789B
CN101588789B CN2007800470359A CN200780047035A CN101588789B CN 101588789 B CN101588789 B CN 101588789B CN 2007800470359 A CN2007800470359 A CN 2007800470359A CN 200780047035 A CN200780047035 A CN 200780047035A CN 101588789 B CN101588789 B CN 101588789B
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agent body
body preparation
permeable agent
cutaneous permeable
flunixin
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CN101588789A (zh
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C·梅多斯
K·A·弗里豪夫
R·D·西蒙斯
A·J·韦因加滕
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Intervet International BV
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先灵-普劳有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2007800470359A 2006-12-20 2007-12-18 用于治疗牛和其它动物炎症的药物组合物和方法 Active CN101588789B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310549264.8A CN103690471B (zh) 2006-12-20 2007-12-18 用于治疗牛和其它动物炎症的药物组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87090706P 2006-12-20 2006-12-20
US60/870,907 2006-12-20
PCT/US2007/025808 WO2008082507A2 (en) 2006-12-20 2007-12-18 Pharmaceutical compositions and method for treating inflammation in cattle and other animals

Related Child Applications (1)

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CN201310549264.8A Division CN103690471B (zh) 2006-12-20 2007-12-18 用于治疗牛和其它动物炎症的药物组合物和方法

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CN101588789A CN101588789A (zh) 2009-11-25
CN101588789B true CN101588789B (zh) 2013-12-11

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CN2007800470359A Active CN101588789B (zh) 2006-12-20 2007-12-18 用于治疗牛和其它动物炎症的药物组合物和方法
CN201310549264.8A Active CN103690471B (zh) 2006-12-20 2007-12-18 用于治疗牛和其它动物炎症的药物组合物和方法

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Country Link
US (1) US9006272B2 (enExample)
EP (1) EP2120860B1 (enExample)
JP (1) JP5377326B2 (enExample)
KR (1) KR20090091328A (enExample)
CN (2) CN101588789B (enExample)
AR (1) AR064425A1 (enExample)
AU (1) AU2007339312B2 (enExample)
BR (1) BRPI0720500B1 (enExample)
CA (1) CA2672964C (enExample)
CL (1) CL2007003711A1 (enExample)
CO (1) CO6190598A2 (enExample)
ES (1) ES2714550T3 (enExample)
MX (1) MX2009006893A (enExample)
NZ (1) NZ598554A (enExample)
PE (1) PE20081406A1 (enExample)
RU (1) RU2466715C2 (enExample)
TW (1) TWI350182B (enExample)
WO (1) WO2008082507A2 (enExample)
ZA (1) ZA200904329B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2738970A1 (en) * 2008-10-31 2010-05-06 Moberg Derma Ab Topical composition comprising a combination of at least two penetration enhancing agents
EP2544662B1 (en) 2010-03-10 2020-05-20 Nuvo Pharmaceuticals Inc. Foamable formulation
WO2012022837A1 (en) * 2010-08-16 2012-02-23 Helsingin Yliopisto Transdermal compositions
JP5827954B2 (ja) * 2010-09-30 2015-12-02 富山化学工業株式会社 経皮吸収製剤
CA3186350A1 (en) * 2013-02-27 2014-09-04 Argenta Innovation Limited Transdermal formulations
CN105769827B (zh) * 2016-03-09 2018-07-17 金陵科技学院 用于动物清热镇痛氟尼辛葡甲胺涂膜剂及其制备方法
KR20200065711A (ko) 2018-11-30 2020-06-09 한원경 동물 피부질환 개선용 조성물
BR112022000767A2 (pt) 2019-07-16 2022-03-15 Donaghys Ltd Sistema de solvente transdérmico e métodos de uso
US11419876B2 (en) 2019-09-06 2022-08-23 Iowa State University Research Foundation, Inc. Mirtazapine as a pre-shipping inhibitor of bovine respiratory disease
EP4251205A1 (en) * 2020-11-25 2023-10-04 Intervet International B.V. Method of treatment of pain through buccal administration of flunixin
WO2022238965A1 (en) * 2021-05-12 2022-11-17 Argenta Innovation Limited Veterinary transdermal formulation
CN114404360B (zh) * 2021-12-16 2023-03-28 江西益昕葆生物科技有限公司 一种氟尼辛葡甲胺注射液的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001035883A1 (en) * 1999-11-19 2001-05-25 Xel Herbaceuticals Transdermal delivery system for alkaloids of aconitum species
WO2005009510A3 (en) * 2003-07-23 2005-04-07 Univ California Penetration enhancer combinations for transdermal delivery

Family Cites Families (10)

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JPS63225316A (ja) * 1986-10-21 1988-09-20 Nitto Electric Ind Co Ltd 外皮投与用組成物
JPH11222443A (ja) * 1997-11-11 1999-08-17 Saitama Daiichi Seiyaku Kk 経皮吸収促進組成物および経皮吸収製剤
JP4865958B2 (ja) * 2001-05-23 2012-02-01 株式会社トクホン 鎮痛抗炎症局所作用型の貼付剤
US6790867B2 (en) * 2002-05-20 2004-09-14 Schering-Plough Animal Health Corporation Compositions and method for treating infection in cattle and swine
KR100780983B1 (ko) * 2003-07-31 2007-11-30 파마시아 앤드 업존 캄파니 엘엘씨 소염제의 분산성 제제
DE10358525A1 (de) * 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
US7618651B2 (en) * 2004-06-24 2009-11-17 Idexx Laboratories Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
RU2006147288A (ru) * 2004-07-19 2008-08-27 Уорнер-Ламберт Компани Эл-Эл-Си (US) Препарат для стимуляции роста волос
MX2007002961A (es) * 2004-09-16 2008-03-13 Bayer Healthcare Ag Fromulaciones aplicables dermicamente para el tratamiento de enfermedades cutaneas en animales.
EP1954275A2 (en) 2005-11-21 2008-08-13 Schering-Plough Ltd. Pharmaceutical compositions comprising buprenorphine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001035883A1 (en) * 1999-11-19 2001-05-25 Xel Herbaceuticals Transdermal delivery system for alkaloids of aconitum species
CN1450883A (zh) * 1999-11-19 2003-10-22 美国爱科赛尔制药有限公司 乌头属生物碱经皮给药系统
WO2005009510A3 (en) * 2003-07-23 2005-04-07 Univ California Penetration enhancer combinations for transdermal delivery

Also Published As

Publication number Publication date
PE20081406A1 (es) 2008-10-17
BRPI0720500A2 (pt) 2014-02-04
CA2672964A1 (en) 2008-07-10
JP5377326B2 (ja) 2013-12-25
EP2120860A2 (en) 2009-11-25
US20080153885A1 (en) 2008-06-26
WO2008082507A2 (en) 2008-07-10
CL2007003711A1 (es) 2008-07-25
TW200833367A (en) 2008-08-16
CN103690471A (zh) 2014-04-02
AU2007339312B2 (en) 2013-06-06
RU2466715C2 (ru) 2012-11-20
ES2714550T3 (es) 2019-05-29
CN103690471B (zh) 2015-11-18
CA2672964C (en) 2018-04-03
BRPI0720500A8 (pt) 2015-12-29
RU2009127500A (ru) 2011-01-27
KR20090091328A (ko) 2009-08-27
TWI350182B (en) 2011-10-11
WO2008082507A3 (en) 2009-03-19
AR064425A1 (es) 2009-04-01
NZ598554A (en) 2013-08-30
ZA200904329B (en) 2010-05-26
EP2120860B1 (en) 2019-01-23
CN101588789A (zh) 2009-11-25
JP2010513500A (ja) 2010-04-30
US9006272B2 (en) 2015-04-14
MX2009006893A (es) 2009-07-03
AU2007339312A1 (en) 2008-07-10
CO6190598A2 (es) 2010-08-19
BRPI0720500B1 (pt) 2019-01-02

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