Summary of the invention:
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of ruminant fore-stomach stony indigestion, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Folium Isatidis 30-70 Cortex Magnoliae Officinalis 30-70 Fructus Aurantii Immaturus 30-70
Matrii Sulfas Exsiccatus 30-70 Pericarpium Citri Reticulatae 30-70 Fructus Crataegi 30-70
Fructus Hordei Germinatus 30-70.
Preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Folium Isatidis 40-60 Cortex Magnoliae Officinalis 40-60 Fructus Aurantii Immaturus 40-60
Matrii Sulfas Exsiccatus 40-60 Pericarpium Citri Reticulatae 40-60 Fructus Crataegi 40-60
Fructus Hordei Germinatus 40-60.
Most preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Folium Isatidis 50 Cortex Magnoliae Officinalis 50 Fructus Aurantii Immaturuss 50 Matrii Sulfas Exsiccatus 50
Pericarpium Citri Reticulatae 50 Fructus Crataegis 50 Fructus Hordei Germinatus 50.
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes oral powder, and is preferred but be not limited to oral powder.In order to prepare these preparations, the pharmaceutically acceptable auxiliaries that can in compositions of the present invention, add conventional animal taste as required, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing oral powder, in the present composition, can add sweeting agent, flavoring agent and antiseptic.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention provides a kind of preparation method of the present composition, it is characterized in that: may further comprise the steps:
With described Folium Isatidis, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Matrii Sulfas Exsiccatus, Pericarpium Citri Reticulatae, Fructus Crataegi, the dried medicine raw material of Fructus Hordei Germinatus seven flavor natural Chinese medicines cleans, weigh by weight, place heated-air circulation oven oven dry 1 hour---2 hours, be ground into powder with the hammer slice type feed grinder after going out baking oven, add flavoring agent and/or antiseptic as required, cross 80 mesh sieves, sieving powder places mixer to mix 10 minutes---and 30 minutes, then, the check uniformity, 50 grams or 100 grams or 250 grams or unit of 350 grams promptly get oral powder of the present invention with paper bag or mould bag and pack by weight.
Described heated-air circulation oven is the DMH--3 heated-air circulation oven of being made by Nanjing, Jiangsu Province wind group drying equipment factory.
Described hammer slice type feed grinder is the SFY set hammer chip feed grinder that meets clever machine-building company limited to make by Shanghai.
Described mixer is the Wtypeofblender of being made by Shandong Province's absolute sincerity machine-building company limited.
Described sieve is the vortex oscillation sieve of being made by the great pharmaceutical machine company limited of Jiangsu Province's Changzhou gold.
Above-mentioned raw material and equipment are all commercially available to be arrived.
Need to prove that method of the present invention is a kind of preferable preparation technique but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, particularly the oral medication ruminant fore-stomach stony indigestion obtains better curative effect, does not see any toxic and side effects.
The inventor has researched and developed " urging to ruminate the fast raw edge that helps digestion takes medicine " cure rate at this disease of ruminant fore-stomach stony indigestion and has reached more than 98%, this medicine is that the pure natural Chinese herbal medicine is made, to suffer from poultry take the back noresidue, nontoxic, make the continuous stimulating appetite of ruminant after having no side effect, curing, strengthen animal body constitution, improve milk yield and fresh milk quality.The Chinese medicine of this prescription promptly has and exists together mutually and place inequality arranged, and by the proportion of every flavor medicine, but activity is incomplete same again, and its secondary structure and tertiary structure are all inequality, can produce the bigger efficacy of a drug, the volatilization property of medicine separately, and curative effect is more outstanding.
The functional component of the Chinese medicine composition of treatment ruminant fore-stomach stony indigestion of the present invention is Folium Isatidis, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Matrii Sulfas Exsiccatus, Pericarpium Citri Reticulatae, Fructus Crataegi, Fructus Hordei Germinatus.
In the prescription of the Chinese medicine composition of treatment ruminant fore-stomach stony indigestion of the present invention: put down in writing according to the Chinese medicine voluminous dictionary:
Folium Isatidis---[function cures mainly]: heat clearing away, detoxifcation, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Cortex Magnoliae Officinalis---[function cures mainly]: warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant.Control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, the cold-damp dysentery.
Fructus Aurantii Immaturus---[function cures mainly]: dispelling the stagnated QI, the painful abdominal mass of loosing is rushed down expectorant, removing food stagnancy.Control distension and fullness of the chest and abdomen, the thoracic obstruction, the painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse,, proctoptosis.
Matrii Sulfas Exsiccatus---[function cures mainly]: purge heat, moisturize, softening the hard mass.It is stagnant to control excess-heat, constipation, conjunctival congestion and swelling pain, pharyngeal swelling aphtha, swollen ulcer drug.
Fructus Crataegi---[function cures mainly]: it is long-pending to help digestion, dissipating blood stasis blood, expelling tenia.It is long-pending to control meat, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's's breast food is stagnated.
Fructus Hordei Germinatus---[function cures mainly]: help digestion and in, the therapeutic method to keep the adverse QI flowing downwards.Control food stagnation and do not disappear, distension and fullness in the abdomen,, inappetence, vomiting is had loose bowels, mammary swelling does not disappear.
In the prescription of the Chinese medicine composition of treatment ruminant fore-stomach stony indigestion of the present invention: Pericarpium Citri Reticulatae Pericarpium Citri Reticulatae Pericarpium Citri Reticulatae (English) Tangerine Peel calls red Fructus Citri tangerinae, Radix Campylotropis Hirtella (Herba Myrsines Africanae), river Fructus Citri tangerinae.The source is the peel of rutaceae orange Citrus reticulata Bianco.[different name] Pericarpium Citri tangerinae Shennong's Herbal, Fructus Citri tangerinae skin " chicken peak Prescriptions for Universal Relief ", Folium Styracis Suberifoliae Materia Medica of Decoction, orange peel " the southern regions of the Yunnan Province book on Chinese herbal medicine ", wide Pericarpium Citri tangerinae " proper book on Chinese herbal medicine ".
Pericarpium Citri Reticulatae---[function cures mainly]: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.The peel of the variety of [note] Fructus Citri tangerinae also is used as medicine as Pericarpium Citri Reticulatae; The outer peel of its immature fruit also is used as medicine, and medical material is called Pericarpium Citri Reticulatae Viride, and the soothing the liver dispelling the stagnated QI of energy, removing food stagnancyization stagnate.
Above-mentioned various medical materials are combined by weight proportion, are had following characteristics: 1. the pure environmental type veterinary drug of this medicine, reasonable recipe, novelty, nontoxic, have no side effect.2. medication is convenient easy-to-use, and only needing to reconcile into the medicated porridge shape with warm water can gavage.3. consumption evident in efficacy is little, gavage once a day, serve on that three days fore-stomach stonies recover normal, swelling disappearance, amount of drinking water is big, two of animals have god, gentleness flexibly and light, two ears are constantly swung, reflection is responsive, hollow billet is shinny, asoscope is moistening, globule uniform distribution, and the gastrointestinal peristalsis number of times is ruminated reach more than 10 times every day, ruminate every day is time more than 7 hours, it is strong to walk, the tail flexible swinging, and amplitude is bigger.Anosis ruminant is taken this medicine and plays health-care effect, and appetite strengthening can be eaten, and can drink, plump and sturdy.
Adopt a kind of medicine trade name for the treatment of the Chinese medicine composition preparation of ruminant fore-stomach stony indigestion provided by the invention to be: " urging to ruminate fast the loosing that help digestion ", adopted name is: " holding gas greatly looses ", be through Chinese herbal medicine screening 7 kinds of above raw materials to be ground into Powderedly, the Chinese powder medicine of making is used for specially controlling the ruminant fore-stomach stony indigestion disease.Take " urging to ruminate fast the loosing that help digestion " through more than 500 ten thousand cow heads over 5 years, milk yield and fresh milk quality have been improved, this medicine is subjected to dairy farmer's welcome deeply, experimental results show that: Chinese medicine composition of the present invention is to fore-stomach stony, intractable fore-stomach stony due to milch cow, the sheep a variety of causes, cureless digestive function obstacle, ruminate stop, appetite reduces or diseases such as lienteric disease, obstruction of omasum such as useless exhausted, defecation stench have specially good effect.Cure mainly: to fore-stomach stony, the ruminal tympany due to foods such as surfeit frost grass, dish leaf such as cattle, sheep, a large amount of surfeit corn, the beans, grainsick, excited gastrointestinal peristalsis is arranged, impel the remarkable efficacy that refuse is discharged fast in the gastrointestinal tract, digestibility diarrhoea is also had better curative effect.
Beneficial effect of the present invention owing to adopt the medical material in the above-mentioned prescription to fit over together by weight complex group, has following effect:
1, pure Chinese medicinal preparation is pure green medicine, and is pollution-free to milk, and noresidue has no side effect.
2, dosage form is many, and what veterinary's technology arranged can medication, and the people of no veterinary's technology also can medication, and is easy to use.
3, curative effect is outstanding, and effect is remarkable, dosage is little, the medication number of times is few, and cost is low, short treating period, and instant effect, cure rate are absolutely.
4, ill curing the disease, anosis medication can prevent the generation of fore-stomach stony indigestion disease.
For this reason, another object of the present invention provides the application of a kind of present composition in preparation ruminant fore-stomach stony indigestion medicine.
The specific embodiment
Embodiment 1
Oral powder (trade name: urge to ruminate fast the loosing that help digestion; Adopted name: hold gas greatly and loose)
Raw material of Chinese medicine and consumption:
Folium Isatidis 50g, Cortex Magnoliae Officinalis 50g, Fructus Aurantii Immaturus 50g, Matrii Sulfas Exsiccatus 50g, Pericarpium Citri Reticulatae 50g, Fructus Crataegi 50g, Fructus Hordei Germinatus 50g.
Method for making: the dried medicine of above seven flavor Chinese medicines places heated-air circulation oven oven dry 1 hour, going out baking oven is placed on the hammer slice type feed grinder and is ground into powder, cross 80 mesh sieves, sieving powder places mixer to mix 10 minutes, then, the check uniformity, 100 grams bag are packed with moulding by weight, promptly get oral powder of the present invention.
Character: this product is a chocolate brown powder, and feeble QI is hot fragrant, salty in the mouth, little hardship, puckery.
Usage and consumption: oral: cattle is obeyed 250 grams at every turn, and sheep is obeyed 50 grams at every turn---70 grams, every day 1 time.The heavier trouble poultry of the state of an illness: cattle is obeyed 350 grams at every turn, and sheep is obeyed 100 grams at every turn.
[operative norm]: two ones of Chinese veterinary drug allusion quotation versions in 2005.
Embodiment 2
Oral powder (trade name: urge to ruminate fast the loosing that help digestion; Adopted name: hold gas greatly and loose)
Raw material of Chinese medicine and consumption:
Folium Isatidis 70g, Cortex Magnoliae Officinalis 30g, Fructus Aurantii Immaturus 50g, Matrii Sulfas Exsiccatus 50g, Pericarpium Citri Reticulatae 50g, Fructus Crataegi 50g, Fructus Hordei Germinatus 50g.
Method for making: the dried medicine of above seven flavor Chinese medicines places heated-air circulation oven oven dry 1.5 hours, going out baking oven is placed on the hammer slice type feed grinder and is ground into powder, cross 80 mesh sieves, sieving powder places mixer to mix 20 minutes, then, the check uniformity, 350 grams bag are packed with moulding by weight, promptly get oral powder of the present invention.
Character: this product is a chocolate brown powder, and feeble QI is hot fragrant, salty in the mouth, little hardship, puckery.
Usage and consumption: oral: cattle is obeyed 250 grams at every turn, and sheep is obeyed 50 grams at every turn---70 grams, every day 1 time.The heavier trouble poultry of the state of an illness: cattle is obeyed 350 grams at every turn, and sheep is obeyed 100 grams at every turn.
[operative norm]: two ones of Chinese veterinary drug allusion quotation versions in 2005.
Embodiment 3
Oral powder (trade name: urge to ruminate fast the loosing that help digestion; Adopted name: hold gas greatly and loose)
Raw material of Chinese medicine and consumption:
Folium Isatidis 30g, Cortex Magnoliae Officinalis 70g, Fructus Aurantii Immaturus 50g, Matrii Sulfas Exsiccatus 50g, Pericarpium Citri Reticulatae 50g, Fructus Crataegi 50g, Fructus Hordei Germinatus 50g.
Method for making: the dried medicine of above seven flavor Chinese medicines places heated-air circulation oven oven dry 2 hours, going out baking oven is placed on the hammer slice type feed grinder and is ground into powder, cross 80 mesh sieves, sieving powder places mixer to mix 30 minutes, then, the check uniformity, 50 grams bag are packed with moulding by weight, promptly get oral powder of the present invention.
Character: this product is a chocolate brown powder, and feeble QI is hot fragrant, salty in the mouth, little hardship, puckery.
Usage and consumption: oral: cattle is obeyed 250 grams at every turn, and sheep is obeyed 50 grams at every turn---70 grams, every day 1 time.The heavier trouble poultry of the state of an illness: cattle is obeyed 350 grams at every turn, and sheep is obeyed 100 grams at every turn.
[operative norm]: two ones of Chinese veterinary drug allusion quotation versions in 2005.
Embodiment 4
Clinical trial
The oral powder oral powder of the application of the invention embodiment 1 (trade name: urge to ruminate fast the loosing that help digestion; Adopted name: hold gas greatly and loose) treatment 100 routine cattle fore-stomach stony indigestions, 100 routine sheep fore-stomach stony indigestions prove the curative effect of Chinese medicine composition of the present invention.
The material method:
The usage and the consumption of " oral powders of treatment milch cow, milk sheep and milk pig mastitis "
Experimental result shows the using method dosage form, and consumption has substantial connection, and consumption is better by heavy dose of medication effect, and during consumption is pressed, low dose of medication, effect is a little low, and the course of treatment is longer.From this medicinal medicine optimum efficiency dosage of above description of test: be by the middle dosage medication better effects if the positive usual amounts.
Best usage and dosage is: each consumption 300 grams of the adult cattle of oral powder, and each consumption 120 grams of sheep, medication every day 1 time is until recovery from illness.
The oral liquid medication is convenient, does not have veterinary's disposal technology, all can use, and usage is easy, and everybody can both medication, and oral liquid is popular drug formulation.
More than example of the present invention is had been described in detail, but described content only is a preferred embodiments of the present invention, can not be considered to be used to limit practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should belong to patent covering scope of the present invention.