CN105902741A - Pharmaceutical composition for treating damp-heat diarrhea type calf diarrhea and preparation method thereof - Google Patents

Pharmaceutical composition for treating damp-heat diarrhea type calf diarrhea and preparation method thereof Download PDF

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CN105902741A
CN105902741A CN201610307022.1A CN201610307022A CN105902741A CN 105902741 A CN105902741 A CN 105902741A CN 201610307022 A CN201610307022 A CN 201610307022A CN 105902741 A CN105902741 A CN 105902741A
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weight portion
diarrhea
fructus
radix
pharmaceutical composition
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衣文娟
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
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Abstract

The invention discloses a pharmaceutical composition for treating damp-heat diarrhea type calf diarrhea and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw medicine materials: cortex magnoliae officinalis, fructus evodiae, radix aucklandiae, rhizoma pinelliae, rhizoma atractylodis, dracocephalum rupestra, marsdenia tenacissima, herb of Wilson passionflower, fructus mume, field opium poppy, trachycarpus root, quercus variabilis, castanopsis sclerophylla, root of R.punjabensis, asiatic bilberry, fructus rosae laevigatae, calabash, semen cuscutae, tender catchweed bedstraw herb, malachite, argentina anserina, metaplexis japonica, rhizoma dioscoreae cirrhosae, herba melastomatis dodecandri, root and bark of seguin argyreia, radix morindae officinalis, twig and leaf of tibet lyonia, orobanche coerulescens and viburnum sargenti. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition is used for treating the damp-heat diarrhea type calf diarrhea and has the effects of warming middle warmer, eliminating dampness, relieving diarrhea with astringents, replenishing qi, enriching the blood, strengthening the tendons and dredging collaterals; through scientific regulation on a basal body, the effect is good, the curative effect is quickly obtained, relapse is unlikely to cause, no toxic and side effects exist, and a great promotion action on growth of calves is obtained.

Description

A kind of pharmaceutical composition treating diarrhea due to damp-heat type calf diarrhea and preparation method thereof
Technical field
The present invention relates to herbal medicine pharmaceutical technology field, particularly to a kind of pharmaceutical composition treating diarrhea due to damp-heat type calf diarrhea and preparation method thereof.
Background technology
Calf diarrhea is had loose bowels also known as calf, the most all can occur, and is a kind of gastrointestinal disease of often sending out of calf.Calf often 2～3d starts morbidity the most after birth, to the growth of calf, grows, survives etc. and to have a significant impact.When jumpbogroup is raised, calf diarrhea incidence rate often reaches 90%～100%, and mortality rate reaches as high as 50 more than %, and the development to milk industry threatens the biggest.
The generation of calf diarrhea, the impact with the condition of fetal development phase and external environment is relevant.Because of the difference in area and season etc., the situation that calf suffers from diarrhoea is the most different.It is summed up, mainly has the reason of following several respects to cause.
The cause of disease: 1. antibacterial causes product enterotoxin angstrom Xi Shi escherichia coli (ETEC), Campylobacter, Salmonella, bacillus aerogenes capsulatus etc. all can cause calf diarrhea.And ETEC is the main bacteria causing the calf diarrhea in 1 week old, it invades and discharges one or both enterotoxins after in calf body and cause calf diarrhea.Clostridium perfringens bacterium is the pathogen that calf suffers from enterotoxemia.2. virus causes rotavirus, coronavirus, star virus, viral, the micro-virus of small cup shape etc. all can cause calf diarrhea, and rotavirus and coronavirus play important nosetiology effect.3. feeding and management is improper causes (1) if daily ration is uneven during cow miscarriage 1. cow gestation, not full price, lack motion, the nutritional metabolic process then making cow gets muddled, result makes fetus normal development in parent be affected, cause new-born calve dysplasia, have bad physiques, lower for the resistance, postnatal initial several days, nearly all it is susceptible to suffer from diarrhoea.2. breast and the nipple of cow be not clean, or feeds calf with the milk suffering from mastitis cow, it is also possible to causes the another kind of approach of calf diarrhea.The most underfed biestings is of poor quality, secretion is few, and immunoglobulin content is low, and new-born calve failed to have colostrum within several hours of puerperal, easily caused lienteric diarrhea.4. just tire Niu Yinqi diarrhea disease percentage is high.Owing to first tire mother's beestings is few, milk is poor, and contained immunoglobulin concentrations is low;Just tire cow takes care of the ability of calf, and calf Chang Buneng has enough colostrums;Difficult labour rate is high, big to the stress of calf, the most mostly needs midwifery during childbirth, and artificial pollution chance is many.(2) calf raising, manage and nurse that bad 1. calf house is excessively moist or body catches cold: the thermoregulation of nascent calf is unsound, to moist and cold adaptation ability is the most weak, lienteric diarrhea the most easily occurs.2. sanitary condition is bad, has important impact.The milk feeding calf is unclean, and feed trough, to raise tool contaminated, cowshed unclean (cattle pen, cattle bed do not clean, and do not sterilize, and pad grass is changed without causing fecaluria accumulation and dirty etc. for a long time), thus adds morbidity chance.3. artificial suckling variable interval, non-quantitative, the temperature of indefinite Lac Bovis seu Bubali, can interfere with the normal activity of digestive function and cause a disease.4. feeding method is different.According to investigations, during as breast-feeded with the nursing-bottle of band nipple or well-bucket, because of diarrhoea, the calf of death to reach 95 or 9.4%, and using instead when suckling bucket is breast-feeded is then 6.9%.5. the feed supplement of calf age of sucking is improper.When being fed transition by breast milk changed course feedstuff, wean too urgent, or supply feedstuff or is modulated inappropriate in quality, the most easily makes the gastrointestinal tract irriate of calf that lienteric diarrhea occurs.6. animal house improper ventilation, sultry crowded, lacks sunlight darkness moist etc., all can promote the generation of disease.7. time of nursing is too late, and calf licks dirt because of hungry, causes the blunt system of active receiving grandson of lactic acid bacteria in intestinal, and lactic acid lacks, enteral corruption mattress amount reproduction, thus destroys the normal stool effect to milk.(3) raising scale is the biggest, and the calf mortality rate that diarrhoea causes is the highest.The research report of Cornell Univ USA confirms this point.Such as raising scale mortality rate average out to 6.8% of diarrhoea within 44 cows of 50,3 monthly ages;And at 15 cows of 150, average out to 11.0%;21.3 % then it are up to when 200～350.(4) during calf group feeding, prevalence and mortality rate are all fed high than individually, and when its reason is group feeding, calf suffers from fecal pollution, suffers from anthelmintic, and the sickness rate of calf diarrhea may be up to 60%, and change into when individually feeding only 9%;Calf, as, when group feeding is main in house, often to eat by hair because mutually sucking umbilicus or ear, to be formed ball top by hair in cud, causes dyspepsia and causes diarrhoea.4. stress cause owing to the Alimentary 26S Proteasome Structure and Function of new-born calve is grown the most perfect, so at some undesirable elements, as often resulted in the disorder of calf digestive system under the effect of hot and cold, noise etc., there is malnutrition in the bad adaptability of environment to external world.Such as, when bottle-feeding, spirit and environment aspect also can cause stress to calf and affect its absorption to colostrum B-IgG, thus reduces the premunition of calf, causes diarrhoea.And for example, when calf is by harsh weather and when taking the photograph the various stresses such as people's full milk in a large number, and digestive function weakens, and in intestinal, generation drastically changes, in intestinal poison type escherichia coli or Clostridium perfringens bacterium the most easily invade human body and breed in a large number, thus cause the generation of dysentery or enterotoxemia.5. Cryptosporidium causes Cryptosporidium to be a kind of protozoacide (coccidiosis), may result in new-born calve and breaks out diarrhoea.Cryptosporidium often colonizes in calf jejunum and ileum and adsorbs on enterocyte microvillus, only infects the calf within 4 ages in days, and the calf with 6～17 ages in days is multiple, and by digestive tract infection, mortality rate is up to 30%.
Chinese medical discrimination is divided into, and cold-damp is had loose bowels type: disease sees that feces is thin such as water, and stomachache, borborygmus, mouth color is light white or bluish white；Diarrhea due to damp-heat type: disease sees that calf spirit is depressed, appetite is useless absolutely, languishment, enophthalmos,enophthalmus, mouth red complexion is red, yellowish fur, morbidity is very fast, suffers from diarrhoea lasting, violent, and feces is thin such as water, yellow skin, sometimes band blood, borborygmus are suffered from abdominal pain, slack anus, faecal incontinence, heart sound is muddy, palpitating speed, extremity tip is ice-cold sometimes, goes into a coma drowsiness；Dyspepsia due to improper feeding is had loose bowels type: disease sees that calf spirit is depressed, is reluctant to walk about, and mouth, nose are sent out cool, and the rotten acid of prolixity is smelly, and anorexia, slight distension gas, the dilute thickness of excrement, color are yellowish, have unpleasant foul odour；Diarrhea due to hypofunction of the spleen type: disease sees that diarrhoea does not heals, and feces is thin, is mixed with bubble, or accompanies indigested feedstuff or milk block, sucks the breast seldom, gradually becomes thin, spiritlessness and weakness is reluctant to stand, and mouth color is light white, deep-slow pulse；Suffering from a deficiency of the kidney the type of having loose bowels: disease sees that chronic diarrhea is not healed, excrement is dilute such as water, rushes down weight night, and borborygmus are i.e. rushed down, and after rushing down, pain subtracts, coldness of the body with chills, tetraparesis, and waist hip is unable, anal incontinence, and under abdomen and hind leg edema, mouth color is light, deep,thready and forceless pulse；Incoordination between the liver and spleen type: disease sees that borborygmus are suffered from abdominal pain, loose stool and diarrhea, rushes down and must suffer from abdominal pain, thin white fur of tongue, and arteries and veins revolves and delays.
Western medical treatment is the most only cured the symptoms, not the disease, and milk cattle itself is caused certain injury by Western medicine, is unfavorable for the growth of cattle, and therefore, Chinese medicine has certain advantage.
Summary of the invention
In order to solve the problems referred to above, the invention provides a kind of pharmaceutical composition treating diarrhea due to damp-heat type calf diarrhea and preparation method thereof.
nullIn order to realize foregoing invention purpose，The invention provides a kind of pharmaceutical composition treating diarrhea due to damp-heat type calf diarrhea，Wherein，Prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 10-20 weight portion、Fructus Evodiae 2-4 weight portion、Rhizoma Atractylodis 15-20 weight portion、Herba Dracocephali Rupestris's 8-15 weight portion、Caulis et Radix Tetrastigmatis Planicaulis 12-20 weight portion、Herba Passiflorae Wilsonii 8-13 weight portion、Fructus Mume 8-15 weight portion、Radix trachycarpi 10-15 weight portion、Fructus Querci variabilis 12-17 weight portion、Semen castanopsis sclerophyllae 8-15 weight portion、Radix Rhois Sinicae root 10-20 weight portion、Fructus Vaccinii Bracteati 8-15 weight portion、Fructus Rosae Laevigatae 6-13 weight portion、Calabash 10-15 weight portion、Semen Cuscutae 8-15 weight portion、Herba Galii Teneri 8-15 weight portion、Malachitum 2-4 weight portion、Radix potentillae anserinae 12-18 weight portion、Trailing plants 10-14 weight portion、Ground 8-13 weight portion、Cortex Argyreiae Seguinii Radicis 8-12 weight portion、Radix Morindae Officinalis 8-15 weight portion、Wood 10-20 weight portion、Herba Orobanches 8-12 weight portion and Folium et Cacumen Viburni Sargentii 8-13 weight portion.
Wherein, prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 15 weight portion, Fructus Evodiae 3 weight portion, Rhizoma Atractylodis 17 weight portion, Herba Dracocephali Rupestris 12 weight portion, Caulis et Radix Tetrastigmatis Planicaulis 17 weight portion, Herba Passiflorae Wilsonii 10 weight portion, Fructus Mume 12 weight portion, Radix trachycarpi 12 weight portion, Fructus Querci variabilis 15 weight portion, Semen castanopsis sclerophyllae 12 weight portion, Radix Rhois Sinicae root 15 weight portion, Fructus Vaccinii Bracteati 10 weight portion, Fructus Rosae Laevigatae 9 weight portion, calabash 12 weight portion, Semen Cuscutae 12 weight portion, Herba Galii Teneri 10 weight portion, Malachitum 3 weight portion, Radix potentillae anserinae 15 weight portion, trailing plants 12 weight portion, ground 9 weight portions, Cortex Argyreiae Seguinii Radicis 10 weight portion, Radix Morindae Officinalis 12 weight portion, wood 16 weight portions, Herba Orobanches 10 weight portion and Folium et Cacumen Viburni Sargentii 10 weight portion.
In order to achieve the above object, present invention also offers the preparation method of the pharmaceutical composition of described treatment diarrhea due to damp-heat type calf diarrhea, comprise the following steps:
The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the ethanol that determining alcohol is 80～90% of 4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 350 mesh～the micropowders of 400 mesh；
3rd step, adds relative to its quality 2～the starch of 4 times, mixing, it is thus achieved that powder in the micropowders obtained by second step.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention, treatment diarrhea due to damp-heat type calf diarrhea, there is warming middle-JIAO dampness, relieving diarrhea with astringents, vigorate qi and replenish the blood and effect of strong muscle dredging collateral, by the science of matrix is nursed one's health, effective, curative effect is fast, is difficult to recurrence, and having no side effect, the growth to calf has the biggest facilitation.
Detailed description of the invention
The present invention provides a kind of pharmaceutical composition treating diarrhea due to damp-heat type calf diarrhea, wherein, including following raw medicinal material: Cortex Magnoliae Officinalis, Fructus Evodiae, Rhizoma Atractylodis, Herba Dracocephali Rupestris, Caulis et Radix Tetrastigmatis Planicaulis, Herba Passiflorae Wilsonii, Fructus Mume, Radix trachycarpi, Fructus Querci variabilis, Semen castanopsis sclerophyllae, Radix Rhois Sinicae root, Fructus Vaccinii Bracteati, Fructus Rosae Laevigatae, calabash, Semen Cuscutae, Herba Galii Teneri, Malachitum, Radix potentillae anserinae, trailing plants, Cortex Argyreiae Seguinii Radicis, Radix Morindae Officinalis, wood, Herba Orobanches and Folium et Cacumen Viburni Sargentii.Ingredients scientific matching, reaches to treat the purpose of diarrhea due to damp-heat type calf diarrhea, has preferable effect.
The pharmacology of various raw medicinal materials is as follows:
Cortex Magnoliae Officinalis: [nature and flavor] toil, temperature.1. " herbal classic ": " bitter in the mouth, temperature." 2. " not Lu ": " temperature greatly, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is pungent, the hottest." [return through] enters spleen, stomach, large intestine channel.1. " Thunder God concocts property of medicine solution ": " enter spleen, stomach two warp.It is lunar that " 2. " Bencao Jingshu ": " enters foot, brothers' Yangming Channel." 3. " book on Chinese herbal medicine is through solving ": " enters liver channel of foot-Jueyin, heart channel of Hand-Shaoyin." [function cures mainly] warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant.
Fructus Evodiae: nature and flavor are worked hard, temperature, poisonous.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " be the hottest, slightly poisonous." 3. " property of medicine opinion ": " bitter in the mouth is pungent, the hottest, poisonous." [return through] enters liver, stomach warp.1. Materia Medica of Decoction: " enter foot cloudy, JUE YIN meridian lunar, few." 2. " Thunder God concocts property of medicine solution ": " enters liver, spleen, stomach, large intestine, kidney channel." [function cures mainly] warming middle-JIAO, pain relieving, regulate the flow of vital energy, dampness.
Rhizoma Atractylodis: [nature and flavor] are pungent, bitter, temperature.[return through] returns spleen, stomach, Liver Channel.[function cures mainly] is drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, tinea pedis flaccidity, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Herba Dracocephali Rupestris: [nature and flavor] are pungent, cool.[function cures mainly] antipyretic antiinflammatory.Cure mainly headache due to pathogenic wind-dampness, laryngalgia cough, thoracic cavity distension.
Caulis et Radix Tetrastigmatis Planicaulis: [nature and flavor] 1. Guangzhou army " conventional Chinese herbal medicine handbook ": " Xin Wei is puckery, temperature." 2. " Guangxi Chinese herbal medicine ": " is sour and astringent, flat." [function cures mainly] Guangzhou army " conventional Chinese herbal medicine handbook ": " dispeiling pathogenic wind and removing dampness.Treating rheumatic lumbago and skelalgia, hemiplegia, rheumatism of muscles pain."
Herba Passiflorae Wilsonii: [nature and flavor] micro-hardship, temperature.1. " choosing of Yunnan Chinese herbal medicine ": " micro-hardship, temperature." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " is lightly seasoned, warm in nature." [function cures mainly] relaxing muscles and tendons to promote blood circulation, removing dampness and killing parasites.Treating rheumatic arthritis, injury and bone fracture, hepatitis.Malaria, ascariasis.
Fructus Mume: [nature and flavor] are sour, puckery is flat.[return through] returns liver, spleen, lung, large intestine channel.[function cures mainly] astringes the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat quenches one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
Radix trachycarpi: [nature and flavor] " Traditional Chinese Medicine in Sichuan will ": " property is put down, and bitter and puckery flavor is nontoxic." [function cures mainly] stops blooding, damp eliminating, subduing swelling and detoxicating.Control haematemesis, have blood in stool, stranguria with blood, metrorrhagia, leukorrhagia, dysentery, arthralgia, edema, scrofula, multiple abscess, traumatic injury.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's chuonic metrorrhagia, control again large intestine hematochezia, man's five types of stranguria turbid urine." 2. " conventional glossary of Herbs and Drugs among the people ": " stimulates the menstrual flow, damp eliminating." 3. " Traditional Chinese Medicine in Sichuan will ": " convergence of nourishing blood, relieving dysentery with astringents.Control haematemesis, discharging fresh blood stool, collapse, carry, traumatic injury and lumbago."
Fructus Querci variabilis: [nature and flavor] " Guizhou medical herbs ": " shell: pained is flat." [function cures mainly] 1. " register planted by Guangxi medicine ": " fruit: stomach invigorating, convergence, dysentery of stopping blooding.Control hemorrhoid, malignant boil, carbuncle." 2. " Guizhou medical herbs ": " shell: cough-relieving, astringing intestine to stop diarrhea.Control cough, watery diarrhea, tinea capitis."
Semen castanopsis sclerophyllae: [nature and flavor] 1. supplement to the Herbal: " bitter and puckery flavor." 2. " Yin Shan Zhengyao, Principles of Correct Diet circle ": " sour in the mouth is sweet, flat, nontoxic, cold nature." [function cures mainly] 1. supplement to the Herbal: " stopping leak dysentery, food the most hungry, order hikes, and can remove stagnant blood, quench the thirst." 2. " occupying diet spectrum with breath ": " suffers from wine diaphragm person, chews carefully frequency food."
Radix Rhois Sinicae root: nature and flavor acid；Puckery；Flat.[function cures mainly] relieving diarrhea with astringents.Main dysentery；Have loose bowels.
Fructus Vaccinii Bracteati: [nature and flavor] " detailed outline ": " acid is sweet, flat, nontoxic." [return through] " book on Chinese herbal medicine is newly organized ": " enters kidney, liver two warp." [function cures mainly] supplementing the kidney to control the nocturnal, strong muscle improving eyesight.Control chronic diarrhea nocturnal emission, chronic dysentery chronic diarrhea, leucorrhea with red and white discharge.1. " detailed outline ": " controlling nocturnal emission with astringent drugs is preserved youthful looks for bone and muscle strengthening, physical strength profiting." 2. " pharmacognosy ": " strong lean kidney.Control chronic diarrhea nocturnal emission, body void gas is weak, leucorrhea with red and white discharge."
Fructus Rosae Laevigatae: [nature and flavor] are sour, sweet, puckery, flat.[return through] returns kidney, bladder, large intestine channel.[function cures mainly] controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.For emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery.
Calabash: [nature and flavor] are sweet, flat.[function cures mainly] diuresis, detumescence, eliminating stagnation.For edema, ascites, lymphoid tuberculosis.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma.
Herba Galii Teneri: [nature and flavor] toil, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " acrid in the mouth is bitter, cold nature." 2. " Guangxi Chinese medicinal herbal: " puckery, property is put down." 3. " Hunan medicine will ": " is sweet puckery, is slightly cold." [return through] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters few cloudy, Taiyin channels." [function cures mainly] clearing away damp-heat, dissipating blood stasis, detumescence, removing toxic substances.Control stranguria with turbid discharge, hematuria, traumatic injury, acute appendicitis, furuncle and phyma, otitis media.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control damp and hot, all through exopathogenic heat, chronic consumptive disease, virgin consumptive disease, bones and muscles pain, pyretic stranguria, red white turbid urine, beautiful pain in the penis.Move back blood system dysphoria with smothery sensation, only hematuria.' 2. " Guizhou side among the people medicine collection ": " control scabies." 3. " Guangxi Chinese medicinal herbal ": " controls married woman's dysmenorrhea.Mash again extracting juice and rush sticky rice syrup, control and fly upward skin ulcer." 4. Jiangxi " medical herbs handbook ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Controlling carbuncle, appendicitis, closely for for cancer." 5. " Kunming conventional medical herbs among the people ": " heat clearing and inflammation relieving, wind-damp dispelling, dissipating blood stasis blood, control phlegm-fire heat symptom-complex, acute conjunctivitis mist gum is many, rheumatic bone-setting pain, the subcutaneous congestive edema of wound." 6. " Yunnan Chinese herbal medicine ": " clearing away heat and cooling blood, diuresis.Control stranguria with blood, urinary tract infection."
Malachitum: [nature and flavor] acid, cold.1. " not Lu ": " sour in the mouth, cold, nontoxic." [return through] " beautiful Chinese catalpa medicine solution ": " enters liver channel of foot-Jueyin." [function cures mainly] controls expectorant fan's infantile convulsion, chancre.1. " not Lu ": " main QI invigorating treats allergic rhinitis, stopping leak profit." 2. " Bencao Tujing): " tell wind-phlegm." 3. " beautiful Chinese catalpa medicine solution ": " refrigerant heavy pendant.Control wind-phlegm heap soil or fertilizer over and around the roots to close, anxious frightened stupor."
Radix potentillae anserinae: [nature and flavor] " Chinese herbal medicine is commonly used in Tibet ": " sweet, flat." [function cures mainly] " Chinese herbal medicine is commonly used in Tibet ": " invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst, vigorate qi and replenish the blood, control insufficiency of the spleen diarrhoea, after being ill anemia, malnutrition."
Trailing plants: [nature and flavor] Gan Xin, flat.1. " product remittance essence is wanted ": " sweet in the mouth is pungent, warm in nature, nontoxic." 2. " detailed outline ": " is sweet, micro-pungent." 3. " Sichuan rushes medicine will ": " property is put down, lightly seasoned, nontoxic." [function cures mainly] nourishing the essence and strengthening QI, lactogenesis, removing toxic substances.Control deficient impairment caused by overstrain, sexual impotence, leukorrhagia, galactostasis, red carbuncle toxin.
Ground: [nature and flavor] are sweet, puckery is flat.[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, tonifying blood and arresting bleeding.For preventing the lonely inflammation of epidemic cerebrospinal, enteritis, dysentery, lung abscess, pelvic inflammatory disease, metrorrhagia, anemia, leucorrhea, lumbago and skelalgia, rheumatic ostalgia, traumatic hemorrhage, venom.
Cortex Argyreiae Seguinii Radicis: [nature and flavor] " Yunnan Chinese herbal medicine ": " micro-puckery, temperature." [function cures mainly] 1. " register planted by Guangxi medicine ": " Herb: refute bone, hemostasis, granulation promoting, convergence, clear away heart-fire, lung moistening, cough-relieving.Control internal injury." 2. " Yunnan Chinese herbal medicine ": " rich in nutrition."
Radix Morindae Officinalis: [nature and flavor] are sweet, pungent, tepor.[return through] returns kidney, Liver Channel.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Wood: [nature and flavor] are sweet, sour is flat.[function cures mainly] invigorating the spleen to arrest diarrhea, invigorates blood circulation, strong muscle.
Herba Orobanches: [nature and flavor] are sweet, temperature.[function cures mainly] reinforcing the kidney and supporting YANG, bone and muscle strengthening.For sexual neurasthenie, lassitude loin and legs；Infantile diarrhea, enteritis, dysentery are controlled in external.
Folium et Cacumen Viburni Sargentii: [nature and flavor] " Chinese herbal medicine handbook is commonly used in northeast ": " sweetness and bitterness, flat." [function cures mainly] dispelling wind and removing obstruction in the collateral, promoting blood circulation and detumescence.Controlling waist joint aches, traumatic injury sprain and contusion are hindered, furuncle, scabies.
Currently preferred only above raw medicinal material prepares.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1
Proportioning: Cortex Magnoliae Officinalis 10g, Fructus Evodiae 2g, Rhizoma Atractylodis 15g, Herba Dracocephali Rupestris 8g, Caulis et Radix Tetrastigmatis Planicaulis 12g, Herba Passiflorae Wilsonii 8g, Fructus Mume 8g, Radix trachycarpi 10g, Fructus Querci variabilis 12g, Semen castanopsis sclerophyllae 8g, Radix Rhois Sinicae root 10g, Fructus Vaccinii Bracteati 8g, Fructus Rosae Laevigatae 6g, calabash 10g, Semen Cuscutae 8g, Herba Galii Teneri 8g, Malachitum 2g, Radix potentillae anserinae 12g, trailing plants 10g, 8g, Cortex Argyreiae Seguinii Radicis 8g, Radix Morindae Officinalis 8g, wood 10g, Herba Orobanches 8g and Folium et Cacumen Viburni Sargentii 8g.
Its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 90% relative to 5 times of mixture, it is heated to boiling reflux 4 hours, filters, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.08Mpa is the mastic of 1.05, is spray-dried, the inlet temperature of spray dryer 165 DEG C, leaving air temp 80 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the cane sugar powder relative to dried cream powder quality 0.3 times and the dextrin of 0.2 times in the dried cream powder obtained, make granule, is dried in 45 DEG C, it is thus achieved that granule.
Embodiment 2
Proportioning: Cortex Magnoliae Officinalis 20g, Fructus Evodiae 4g, Rhizoma Atractylodis 20g, Herba Dracocephali Rupestris 15g, Caulis et Radix Tetrastigmatis Planicaulis 20g, Herba Passiflorae Wilsonii 13g, Fructus Mume 15g, Radix trachycarpi 15g, Fructus Querci variabilis 17g, Semen castanopsis sclerophyllae 15g, Radix Rhois Sinicae root 20g, Fructus Vaccinii Bracteati 15g, Fructus Rosae Laevigatae 13g, calabash 15g, Semen Cuscutae 15g, Herba Galii Teneri 15g, Malachitum 4g, Radix potentillae anserinae 18g, trailing plants 14g, 13g, Cortex Argyreiae Seguinii Radicis 12g, Radix Morindae Officinalis 15g, wood 20g, Herba Orobanches 12g and Folium et Cacumen Viburni Sargentii 13g.
Its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 2 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that the micropowders of 350 mesh；
3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
Embodiment 3
Proportioning: Cortex Magnoliae Officinalis 15g, Fructus Evodiae 3g, Rhizoma Atractylodis 17g, Herba Dracocephali Rupestris 12g, Caulis et Radix Tetrastigmatis Planicaulis 17g, Herba Passiflorae Wilsonii 10g, Fructus Mume 12g, Radix trachycarpi 12g, Fructus Querci variabilis 15g, Semen castanopsis sclerophyllae 12g, Radix Rhois Sinicae root 15g, Fructus Vaccinii Bracteati 10g, Fructus Rosae Laevigatae 9g, calabash 12g, Semen Cuscutae 12g, Herba Galii Teneri 10g, Malachitum 3g, Radix potentillae anserinae 15g, trailing plants 12g, 9g, Cortex Argyreiae Seguinii Radicis 10g, Radix Morindae Officinalis 12g, wood 16g, Herba Orobanches 10g and Folium et Cacumen Viburni Sargentii 10g.
Its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 3 times, is heated to reflux 3 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that the micropowders of 400 mesh；
3rd step, adds the starch relative to its quality 2 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
The toxicity test of medicine
1. acute toxicity test: with the pharmaceutical composition of the embodiment of the present invention 1 as object, 150 times of clinical consumption per day are offerd medicine to the big enteral of white mouse, are observed 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not has toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: mice is pressed 15,30 and 45g crude drugs/kg continuous use 16 weeks (1.0ml/100g body weight by the pharmaceutical composition of the embodiment of the present invention 2, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Contrast test
Vaccary, Shandong cultivation cattle about 1000, has 200 calves the symptom of diarrhea due to damp-heat type calf diarrhea occur: disease sees that calf spirit is depressed, and appetite is useless absolutely, languishment, enophthalmos,enophthalmus, mouth red complexion is red, yellowish fur, morbidity is very fast, suffers from diarrhoea lasting, violent, and feces is thin such as water, yellow skin, sometimes band blood, borborygmus are suffered from abdominal pain, slack anus, faecal incontinence, heart sound is muddy, palpitating speed, extremity tip is ice-cold sometimes, goes into a coma drowsiness.
Select 200 ill calves, isolation cultivation, and be randomly divided into four groups, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often group 50.
Embodiment 1 group uses the medicament composition granule agent of the embodiment of the present invention 1 to treat, and is mixed in conventional feed according to the ratio of 4:100 by granule, normally feeds, carries out 2.
Embodiment 2 groups uses the medicinal composition powders of the embodiment of the present invention 2 to treat, and is mixed in conventional feed according to the ratio of 4:100 by powder, normally feeds, carries out 2.
Embodiment 3 groups uses the medicinal composition powders of the embodiment of the present invention 3 to treat, and is mixed in conventional feed according to the ratio of 4:100 by powder, normally feeds, carries out 2.
Matched group: use the every kg body weight of sulfamethoxyplridazine 0.1～0.3g, take orally once a day.Conventional feed normally feeds, and carries out 2.
The treatment situation of record experimentation.See table 1.
The average weight of the calf before and after record experiment, calculates average weight growth pattern.See table 2.
Table 1 is treatment situation contrast (often organizing 50 altogether) of each group
Group Cure number Invalid number Cure rate Inefficiency
Embodiment 1 group 50 0 100% 0%
Embodiment 2 groups 50 0 100% 0%
Embodiment 3 groups 50 0 100% 0%
Matched group 40 10 80% 20%
See table 1 can be seen that, healing number and the cure rate of the treatment calf of embodiment 1 group, embodiment 2 groups and embodiment 3 groups will be higher than the healing number of the calf of matched group and cure rates, it is appreciated that, the pharmaceutical composition of the present invention, on treatment diarrhea due to damp-heat type calf diarrhea, therapeutic effect is good, determined curative effect, instant effect, well improves the state of an illness.
Table 2 is the balanced growth body weight contrast of the calf of each group
Group Sum Average weight before experiment Average weight after test Average daily gain
Embodiment group 1 50 45.3kg 47.2kg 0.95kg/d
Embodiment group 2 50 45.4kg 47.32kg 0.96kg/d
Embodiment group 2 50 45.3kg 47.24kg 0.97kg/d
Matched group 50 45.4kg 46.82kg 0.72kg/d
See table 2 it can be seen that while the treatment diarrhea due to damp-heat type calf diarrhea of embodiment 1 group, embodiment 2 groups and embodiment 3 groups, growth rate will be faster than matched group, maintains the normal growth of calf.
In sum, pharmaceutical composition of the present invention, on treatment diarrhea due to damp-heat type calf diarrhea, therapeutic effect is good, determined curative effect, instant effect, and ensure that the normal growth of calf.
Citing: vaccary, Dezhou cowboying 1000, in March, 2015, diarrhea due to damp-heat type calf diarrhea symptom occur in 200 calves: disease sees that calf spirit is depressed, appetite is useless absolutely, languishment, enophthalmos,enophthalmus, mouth red complexion is red, yellowish fur, morbidity is very fast, suffers from diarrhoea lasting, violent, and feces is thin such as water, yellow skin, sometimes band blood, borborygmus are suffered from abdominal pain, slack anus, faecal incontinence, heart sound is muddy, palpitating speed, extremity tip is ice-cold sometimes, goes into a coma drowsiness.200 ill calves are treated, uses the medicinal composition powders of the embodiment of the present invention 2 to treat, powder is mixed in conventional feed according to the ratio of 4:100, normally feeds, carry out 2.Cure for 200, cure rate 100%.Body weight increases 1.93kg during treating.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (4)

  1. null1. the pharmaceutical composition treating diarrhea due to damp-heat type calf diarrhea，It is characterized in that，Prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 10-20 weight portion、Fructus Evodiae 2-4 weight portion、Rhizoma Atractylodis 15-20 weight portion、Herba Dracocephali Rupestris's 8-15 weight portion、Caulis et Radix Tetrastigmatis Planicaulis 12-20 weight portion、Herba Passiflorae Wilsonii 8-13 weight portion、Fructus Mume 8-15 weight portion、Radix trachycarpi 10-15 weight portion、Fructus Querci variabilis 12-17 weight portion、Semen castanopsis sclerophyllae 8-15 weight portion、Radix Rhois Sinicae root 10-20 weight portion、Fructus Vaccinii Bracteati 8-15 weight portion、Fructus Rosae Laevigatae 6-13 weight portion、Calabash 10-15 weight portion、Semen Cuscutae 8-15 weight portion、Herba Galii Teneri 8-15 weight portion、Malachitum 2-4 weight portion、Radix potentillae anserinae 12-18 weight portion、Trailing plants 10-14 weight portion、Ground 8-13 weight portion、Cortex Argyreiae Seguinii Radicis 8-12 weight portion、Radix Morindae Officinalis 8-15 weight portion、Wood 10-20 weight portion、Herba Orobanches 8-12 weight portion and Folium et Cacumen Viburni Sargentii 8-13 weight portion.
  2. nullThe pharmaceutical composition for the treatment of diarrhea due to damp-heat type calf diarrhea the most according to claim 1，It is characterized in that，Prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 15 weight portion、Fructus Evodiae 3 weight portion、Rhizoma Atractylodis 17 weight portion、Herba Dracocephali Rupestris 12 weight portion、Caulis et Radix Tetrastigmatis Planicaulis 17 weight portion、Herba Passiflorae Wilsonii 10 weight portion、Fructus Mume 12 weight portion、Radix trachycarpi 12 weight portion、Fructus Querci variabilis 15 weight portion、Semen castanopsis sclerophyllae 12 weight portion、Radix Rhois Sinicae root 15 weight portion、Fructus Vaccinii Bracteati 10 weight portion、Fructus Rosae Laevigatae 9 weight portion、Calabash 12 weight portion、Semen Cuscutae 12 weight portion、Herba Galii Teneri 10 weight portion、Malachitum 3 weight portion、Radix potentillae anserinae 15 weight portion、Trailing plants 12 weight portion、Ground 9 weight portions、Cortex Argyreiae Seguinii Radicis 10 weight portion、Radix Morindae Officinalis 12 weight portion、Wood 16 weight portions、Herba Orobanches 10 weight portion and Folium et Cacumen Viburni Sargentii 10 weight portion.
  3. The pharmaceutical composition for the treatment of diarrhea due to damp-heat type calf diarrhea the most according to claim 1 and 2, it is characterised in that its preparation method comprises the following steps:
    The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the ethanol that determining alcohol is 80～90% of 4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
    Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 350 mesh～the micropowders of 400 mesh；
    3rd step, adds relative to its quality 2～the starch of 4 times, mixing, it is thus achieved that powder in the micropowders obtained by second step.
  4. 4. the preparation method of the pharmaceutical composition of the treatment diarrhea due to damp-heat type calf diarrhea described in an any one of claims 1 to 3, it is characterised in that comprise the following steps:
    The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the ethanol that determining alcohol is 80～90% of 4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
    Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 350 mesh～the micropowders of 400 mesh；
    3rd step, adds relative to its quality 2～the starch of 4 times, mixing, it is thus achieved that powder in the micropowders obtained by second step.
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