CN105727124A - Pharmaceutical composition for treating kidney-deficiency diarrhea type calf diarrhea - Google Patents

Pharmaceutical composition for treating kidney-deficiency diarrhea type calf diarrhea Download PDF

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CN105727124A
CN105727124A CN201610307023.6A CN201610307023A CN105727124A CN 105727124 A CN105727124 A CN 105727124A CN 201610307023 A CN201610307023 A CN 201610307023A CN 105727124 A CN105727124 A CN 105727124A
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weight portion
diarrhea
herba
radix
pharmaceutical composition
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傅建功
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Abstract

The invention discloses a pharmaceutical composition for treating kidney-deficiency diarrhea type calf diarrhea. The pharmaceutical composition is prepared from the following medicinal raw materials: betel pepper, mangnolia officinalis, pepper, semen canavaliae, trigonotis peduncularis, rhodiola dumulosa, cynomorium songaricum, cortex lycii radicis, nutgall, persimmons, melastoma dodecandrum lour, fructus alpiniae oxyphyllae, castanopsis sclerophylla, smilacina japonica, pericarpium arecae, radix rubiae, aster auriculatus franch, osmanthus fragrans lour, tupistra pachynema, shii-take mushrooms, lucid ganoderma and stellaria media. The pharmaceutical composition for treating kidney-deficiency diarrhea type calf diarrhea has the beneficial effects of warming middle-warmer, tonifying kidneys, relieving diarrhea with astringents, tonifying qi, expelling cold, consolidating body resistance and benefiting intestines, has the advantages of good effect, quick response, relapse prevention and no toxic or side effect by means of scientific regulating for bodies, and has an obvious promoting effect for calf growth.

Description

A kind for the treatment of is suffered from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels
Technical field
The present invention relates to herbal medicine pharmaceutical technology field, the pharmaceutical composition of type calf diarrhea of having loose bowels of suffering from a deficiency of the kidney particularly to a kind for the treatment of.
Background technology
Calf diarrhea is had loose bowels also known as calf, all can occur throughout the year, is a kind of gastrointestinal disease of often sending out of calf.Calf often after birth 2～3d start morbidity, to the growth of calf, grow, survive etc. and to have a significant impact.When jumpbogroup is raised, calf diarrhea incidence rate often reaches 90%～100%, and mortality rate reaches as high as more than 50%, threatens very big to the development of milk industry.
The generation of calf diarrhea, the impact with the condition of fetal development phase and external environment is relevant.Because of the difference in area and season etc., the situation that calf suffers from diarrhoea is also different.It is summed up, mainly has the reason of following several respects to cause.
The cause of disease: 1. antibacterial causes product enterotoxin angstrom Xi Shi escherichia coli (ETEC), Campylobacter, Salmonella, bacillus aerogenes capsulatus etc. all can cause calf diarrhea.And ETEC is the main bacteria causing the calf diarrhea in 1 week old, it invades and discharges one or both enterotoxins after in calf body and cause calf diarrhea.Clostridium perfringens bacterium is the pathogen that calf suffers from enterotoxemia.2. virus causes rotavirus, coronavirus, star virus, viral, the micro-virus of small cup shape etc. all can cause calf diarrhea, and rotavirus and coronavirus play important nosetiology effect.3. feeding and management is improper causes (1) if daily ration is uneven during cow miscarriage 1. cow gestation, not full price, lack motion, the nutritional metabolic process then making cow gets muddled, result makes fetus normal development in parent be affected, cause new-born calve dysplasia, have bad physiques, lower for the resistance, postnatal initial several days, nearly all it is susceptible to suffer from diarrhoea.2. the breast of cow and nipple are clean, or with suffering from milk hello the calf of mastitis cow, it is also possible to cause the another kind of approach of calf diarrhea.3. underfed biestings is of poor quality, secretion is few, and immunoglobulin content is low, and new-born calve failed to have colostrum within several hours puerperal, very easily caused lienteric diarrhea.4. just tire Niu Yinqi diarrhea disease percentage is high.Owing to first tire mother's beestings is few, milk is poor, and contained immunoglobulin concentrations is low;First tire cow takes care of the ability of calf, and calf Chang Buneng has enough colostrums;Difficult labour rate is high, and the stress of calf is big, mostly needs again midwifery during childbirth, and artificial pollution chance is many.(2), to moist and cold adaptation ability is very weak, the most easily there is lienteric diarrhea in the raising of calf, management and nurse that bad 1. calf house is excessively moist or body catches cold: the thermoregulation of nascent calf is unsound.2. sanitary condition is bad, has important impact.The milk feeding calf is unclean, and feed trough, to raise tool contaminated, and cowshed unclean (cattle pen, cattle bed do not clean for a long time, do not sterilize, and pad grass is changed without causing fecaluria for a long time and gathers and dirty etc.), thus adding morbidity chance.3. artificial suckling variable interval, non-quantitative, indefinite Lac Bovis seu Bubali temperature, can interfere with the normal activity of digestive function and cause a disease.4. feeding method is different.According to investigations, during as breast-feeded with the nursing-bottle with nipple or well-bucket, because of diarrhoea, the calf of death to reach 95 or 9.4%, and using instead when suckling bucket is breast-feeded is then 6.9%.5. the feed supplement of calf age of sucking is improper.When being fed transition by breast milk changed course feedstuff, wean too urgent, or supply feedstuff or is modulated inappropriate in quality, then easily make the gastrointestinal tract irriate of calf that lienteric diarrhea occurs.6. animal house improper ventilation, sultry crowded, lacks sunlight darkness moist etc., all can promote the generation of disease.7. time of nursing is too late, and calf licks dirt because of hungry, causes the blunt system of active receiving grandson of lactic acid bacteria in intestinal, and lactic acid lacks, enteral corruption mattress amount reproduction, thus destroying the normal stool effect to milk.(3) raising scale is more big, and the calf mortality rate that diarrhoea causes is more high.The research report of Cornell Univ USA confirms this point.Such as raising scale mortality rate average out to 6.8% of diarrhoea in 44 cows of 50,3 monthly ages;And at 15 cows of 150, average out to 11.0%;When 200～350 then up to 21.3%.(4) during calf group feeding, prevalence and mortality rate are all fed high than individually, and when its reason is group feeding, calf suffers from fecal pollution, suffers from anthelmintic, and the sickness rate of calf diarrhea may be up to 60%, and change into when individually feeding only 9%;Calf is as to give up interior group feeding for, time main, often eating by hair because mutually sucking umbilicus or ear, formed ball top by hair in cud, caused dyspepsia and cause diarrhoea.4. stress cause owing to the Alimentary 26S Proteasome Structure and Function of new-born calve is grown perfect not, the bad adaptability of environment to external world, thus at some undesirable elements, as disorderly in often resulted in calf digestive system under the effect of hot and cold, noise etc., there is malnutrition.Such as, when bottle-feeding, spirit and environment aspect also can cause stress to calf and affect its absorption to first calf immunoglobulin, thus reducing the premunition of calf, causes diarrhoea.And for example, when calf is subject to harsh weather and takes the photograph the various stresses such as people's full milk in a large number, digestive function weakens, and in intestinal, generation sharply changes, intestinal poison type escherichia coli or Clostridium perfringens bacterium are then easily invaded in human body and breed in a large number, thus causing the generation of dysentery or enterotoxemia.5. Cryptosporidium causes Cryptosporidium to be a kind of protozoacide (coccidiosis), may result in new-born calve and breaks out diarrhoea.Cryptosporidium often colonizes in calf jejunum and ileum and is adsorbed on enterocyte microvillus, only infects the calf within 4 ages in days, and multiple with the calf of 6～17 ages in days, by digestive tract infection, mortality rate is up to 30%.
Chinese medical discrimination is divided into, and cold-damp is had loose bowels type: disease sees that feces is thin in water, and stomachache, borborygmus, mouth color is light white or bluish white；Diarrhea due to damp-heat type: disease sees that calf spirit is depressed, appetite is useless absolutely, languishment, enophthalmos,enophthalmus, mouth red complexion is red, yellowish fur, morbidity is very fast, suffers from diarrhoea lasting, violent, and feces is thin in water, yellow skin, sometimes band blood, borborygmus are suffered from abdominal pain, slack anus, faecal incontinence, heart sound is muddy, palpitating speed, extremity tip is ice-cold sometimes, goes into a coma drowsiness；Dyspepsia due to improper feeding is had loose bowels type: disease sees that calf spirit is depressed, is reluctant to walk about, and mouth, nose are sent out cool, and the rotten acid of prolixity is smelly, and anorexia, slight distension gas, the rare thickness of excrement, color are yellowish, have unpleasant foul odour；Diarrhea due to hypofunction of the spleen type: disease sees that with the passing of time diarrhoea do not heal, and feces is thin, is mixed with bubble, or accompanies indigested feedstuff or milk block, sucks the breast seldom, becomes thin gradually, spiritlessness and weakness is reluctant to stand, and mouth color is light white, deep-slow pulse；Suffering from a deficiency of the kidney the type of having loose bowels: disease sees that chronic diarrhea is not healed, excrement is rare such as water, rushes down weight night, and namely borborygmus rush down, and after rushing down, pain subtracts, coldness of the body with chills, tetraparesis, and waist hip is unable, anal incontinence, and under abdomen and hind leg edema, mouth color is light, deep,thready and forceless pulse；Incoordination between the liver and spleen type: disease sees that borborygmus are suffered from abdominal pain, loose stool and diarrhea, rushes down and must suffer from abdominal pain, thin white fur of tongue, and arteries and veins revolves and delays.
Western medical treatment is generally only cured the symptoms, not the disease, and calf itself is caused certain injury by Western medicine, is unfavorable for the growth of cattle, and therefore, Chinese medicine has certain advantage.
Summary of the invention
In order to solve the problems referred to above, the invention provides a kind for the treatment of and suffer from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels.
In order to realize foregoing invention purpose, the invention provides a kind for the treatment of to suffer from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels, wherein, including following raw medicinal material: beans, Cortex Magnoliae Officinalis, Pericarpium Zanthoxyli, Semen Canavaliae, Herba Trigonotidis peduncularis, Radix Rhodiolae Dumulosae, Herba Cynomorii, Cortex Lycii, Galla Turcica (Galla Helepensis), Fructus Kaki, DIGEN, Fructus Alpiniae Oxyphyllae, Semen castanopsis sclerophyllae, Radix et rhizoma smilacinae japonicae, Pericarpium Arecae, Radix Rubiae, Aster auriculatus Franch., Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Tupistrae pachynemae, Lentinus Edodes, Ganoderma and Herba malachii aquatici.
Wherein, prepared by the raw medicinal material of following mass fraction: beans 4-9 weight portion, Cortex Magnoliae Officinalis 10-15 weight portion, Pericarpium Zanthoxyli 3-5 weight portion, Semen Canavaliae 10-15 weight portion, Herba Trigonotidis peduncularis 6-13 weight portion, Radix Rhodiolae Dumulosae 10-20 weight portion, Herba Cynomorii 3-5 weight portion, Cortex Lycii 10-15 weight portion, Galla Turcica (Galla Helepensis) 7-12 weight portion, Fructus Kaki 8-15 weight portion, DIGEN 10-15 weight portion, Fructus Alpiniae Oxyphyllae 10-20 weight portion, Semen castanopsis sclerophyllae 8-13 weight portion, Radix et rhizoma smilacinae japonicae 7-13 weight portion, Pericarpium Arecae 10-20 weight portion, Radix Rubiae 15-20 weight portion, Aster auriculatus Franch. 10-15 weight portion, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 12-20 weight portion, Rhizoma Tupistrae pachynemae 2-3 weight portion, Lentinus Edodes 6-12 weight portion, Ganoderma 5-9 weight portion and Herba malachii aquatici 10-15 weight portion.
Wherein, prepared by the raw medicinal material of following mass fraction: beans 6 weight portion, Cortex Magnoliae Officinalis 12 weight portion, Pericarpium Zanthoxyli 4 weight portion, Semen Canavaliae 12 weight portion, Herba Trigonotidis peduncularis 12 weight portion, Radix Rhodiolae Dumulosae 15 weight portion, Herba Cynomorii 4 weight portion, Cortex Lycii 12 weight portion, Galla Turcica (Galla Helepensis) 9 weight portion, Fructus Kaki 12 weight portion, DIGEN 12 weight portion, Fructus Alpiniae Oxyphyllae 15 weight portion, Semen castanopsis sclerophyllae 12 weight portion, Radix et rhizoma smilacinae japonicae 9 weight portion, Pericarpium Arecae 16 weight portion, Radix Rubiae 18 weight portion, Aster auriculatus Franch. 12 weight portion, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 17 weight portion, Rhizoma Tupistrae pachynemae 2 weight portion, Lentinus Edodes 8 weight portion, Ganoderma 7 weight portion and Herba malachii aquatici 12 weight portion.
In order to achieve the above object, present invention also offers described treatment and suffer from a deficiency of the kidney the preparation method of pharmaceutical composition of type calf diarrhea of having loose bowels, comprise the following steps:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 80～90% relative to mixture quality 2～5 times, is heated to reflux 2～3 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 2～3 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；
3rd step, adds the starch relative to its quality 1～3 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
Or, comprise the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 98%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 98%；
3rd step, takes mixed powder 1～3g that second step obtains, and adds sodium chloride 50～80g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.22～0.24 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention, treat type calf diarrhea of having loose bowels of suffering from a deficiency of the kidney, there is effect of warming middle-JIAO the kidney invigorating, relieving diarrhea with astringents, QI invigorating cold expelling and Gubeng Yichang, by the science of matrix is nursed one's health, effective, curative effect is fast, not easily recurs, and have no side effect, the growth of calf is had very big facilitation.
Detailed description of the invention
The present invention provides a kind for the treatment of to suffer from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels, wherein, including following raw medicinal material: beans, Cortex Magnoliae Officinalis, Pericarpium Zanthoxyli, Semen Canavaliae, Herba Trigonotidis peduncularis, Radix Rhodiolae Dumulosae, Herba Cynomorii, Cortex Lycii, Galla Turcica (Galla Helepensis), Fructus Kaki, DIGEN, Fructus Alpiniae Oxyphyllae, Semen castanopsis sclerophyllae, Radix et rhizoma smilacinae japonicae, Pericarpium Arecae, Radix Rubiae, Aster auriculatus Franch., Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Tupistrae pachynemae, Lentinus Edodes, Ganoderma and Herba malachii aquatici.Ingredients scientific matching, reaches that treating suffers from a deficiency of the kidney and has loose bowels the purpose of type calf diarrhea, have good effect.
The pharmacology of various raw medicinal materials is as follows:
Beans: [nature and flavor] 1. Tang Materia Medica: " acrid in the mouth, temperature, nontoxic." 2. " detailed outline ": " gas heat, acrid in the mouth." [function cures mainly] warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, eliminating stagnation, expectorant.Control trusted subordinate's cold type of pain, vomit and diarrhoea, worm pain, cough with dyspnea.1. Tang Materia Medica: " main therapeutic method to keep the adverse QI flowing downwards warming middle-JIAO, broken accumulation of phlegm." 2. " Treatise on Dietetic Therapy ": " eliminating stagnation gas, controls cold air in trusted subordinate." 3. " Haiyao Bencao, Oversea Materia Medica ": " main cough with dyspnea, trusted subordinate worm pain, the weak diarrhea of deficiency type of stomach, cholera is told inverse, and relieve the effect of alcohol food flavor."
Cortex Magnoliae Officinalis: [nature and flavor] are bitter, pungent, temperature.[return through] returns spleen, stomach, lung, large intestine channel.[function cures mainly] dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Pericarpium Zanthoxyli: [nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, kidney channel.[function cures mainly] warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis；External treatment eczema pruritus.
Semen Canavaliae: [nature and flavor] are sweet, temperature.[return through] returns stomach, kidney channel.[function cures mainly] warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, only oh.For deficiency and coldness singultus, vomiting.
Herba Trigonotidis peduncularis: [source] is Boraginaceae Herba Trigonotidis peduncularis platymiscium Herba Trigonotidis peduncularis, with all herbal medicine.Xia Qiu gathers, Herb of choosing, and removes impurity, dries standby.[nature and flavor] sweet, acrid, warm.[function cures mainly] warming middle-JIAO stomach invigorating, reducing swelling and alleviating pain, hemostasis.For having a stomachache, acid regurgitation, spit blood；Traumatic injury is controlled in external, fracture.
Radix Rhodiolae Dumulosae: [source] Crassulaceae Rhodida plant Rhodiola dumulosa, with all herbal medicine.The whole year can adopt, and cleans and dries.[nature and flavor] hardship sweet, micro-, puckery, temperature.[function cures mainly] tonifying blood and regulating menstruation, yin nourishing.For menoxenia, deficiency of YIN hectic fever, have a dizzy spell, women's asthenia.
Herba Cynomorii: [nature and flavor] are sweet, temperature.[return through] returns spleen, kidney, large intestine channel.[function cures mainly] kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Soft for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation.
Cortex Lycii: [nature and flavor] are sweet, cold.[return through] returns lung, liver, kidney channel.[function cures mainly] removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.
Galla Turcica (Galla Helepensis): [nature and flavor] are bitter, temperature.1. Tang materia medica ": " bitter in the mouth, temperature, nontoxic." 2. " Haiyao Bencao, Oversea Materia Medica ": " Wen Ping is nontoxic." [return through] enters lung, spleen, kidney channel.1. " beautiful Chinese catalpa medicine solution ": " enter kidney meridian, liver channel of foot-Jueyin." 2. " book on Chinese herbal medicine is looked for the truth ": " enters kidney, double enter spleen, stomach." 3. " can about cure mirror ": " enters lung, kidney two warp." [function cures mainly] solid and gas, arresting seminal emission, astringe the lung, hemostasis.Controlling asthenia of the large intestine sliding, dysentery is more than, has blood in stool, seminal emission, polyhidrosis around the external genitals, cough, and spitting of blood, toothache, wound hemorrhage, skin infection does not close up for a long time.
Fructus Kaki: [nature and flavor] are sweet；Puckery；Cool in nature.[return through] heart；Lung；Large intestine channel.[function cures mainly] heat clearing away；Lung moistening；Promote the production of body fluid；Removing toxic substances.Main cough；Spit blood；Heat is thirsty；Aphtha；Hematodiarrhoea；Have blood in stool.
DIGEN: [nature and flavor] " east, Fujian book on Chinese herbal medicine ": " property is put down, the micro-sweet acid of taste." [return through] " east, Fujian book on Chinese herbal medicine ": " enters liver, kidney, spleen, lung four warp." [function cures mainly] invigorates blood circulation, hemostasis, dampness removing, removing toxic substances.Control dysmenorrhea, puerperal abdonimal pain, metrorrhagia, leucorrhea, dysentery, scrofula, toothache.
Fructus Alpiniae Oxyphyllae: [nature and flavor] are pungent, temperature.1. " south vegetation shape ": " acrid in the mouth." 2. TAO Hong-Jing: " heat." 3. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 4. " book on Chinese herbal medicine is just read ": " acrid in the mouth is bitter, hot in nature." [return through] enters spleen, kidney channel.1. Materia Medica of Decoction: " hands, meridian of Foot-TAI YIN, meridian of Foot-SHAO YIN." 2. " Thunder God concocts property of medicine solution ": " enters spleen, stomach, kidney three warp." 3. " book on Chinese herbal medicine is through solving ": " enters liver channel of foot-Jueyin, lung meridian." [function cures mainly] warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.
Semen castanopsis sclerophyllae: [nature and flavor] 1. supplement to the Herbal: " bitter and puckery flavor." 2. " Yin Shan Zhengyao, Principles of Correct Diet circle ": " sour in the mouth is sweet, flat, nontoxic, cold nature." [function cures mainly] 1. supplement to the Herbal: " stopping leak dysentery, food not hungry, order hikes, and can remove stagnant blood, quench the thirst." 2. " occupying diet spectrum with breath ": " suffers from wine diaphragm person, chews carefully frequency food."
Radix et rhizoma smilacinae japonicae: [nature and flavor] sweetness and bitterness, temperature.1. " Kaibao Bencao ": " sweet, temperature, nontoxic." 2. " Shaanxi Chinese herbal medicine ": " Gan Weixin, temperature." [function cures mainly] QI invigorating kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation.Control consumptive disease wound, sexual impotence, inclined, aching all over the head, rheumatalgia, traumatic injury, acute mastitis, menoxenia.
Pericarpium Arecae: [nature and flavor] are pungent, tepor.1. " Kaibao Bencao ": " tepor, nontoxic." 2. " detailed outline ": " is pungent, and tepor is nontoxic." [return through] enters spleen, stomach, intestine and small intestine warp.1. " Thunder God concocts property of medicine solution ": " enter lung；Spleen two warp." 2. " medicineization justice ": " enters spleen, lung, stomach, the intestine and small intestine Five Classics." [function cures mainly] therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, row water.Control gastral cavity abdomen painful abdominal mass swollen, beriberi, edema.
Radix Rubiae: nature and flavor are bitter, cold.[return through] returns Liver Channel.[function cures mainly] removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.
Aster auriculatus Franch.: [nature and flavor] acrid in the mouth；Warm in nature.[function cures mainly] dispersing wind-cold；Relieving cough and asthma.Main anemofrigid cold；Cough；Asthma.
Fructus osmanthi fragrantis (Osmanthus fragrans Lour.): [nature and flavor] " Jiangsu medical material will ": " sweet, acrid, warm." [function cures mainly] 1. Lengthy Compilation of Plants with Illustrations: " is controlled pained." 2. " Jiangsu medical material will ": " warming the stomach, suppressing the hyperactive liver, kidney tonifying, cold expelling, the only sound of vomiting.Among the people as analgesic, treating the liver peratodynia."
Rhizoma Tupistrae pachynemae: [nature and flavor] are pungent, bitter, temperature.[function cures mainly] warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain.For having a stomachache, treating swelling and pain by traumatic injury.
Lentinus Edodes: [source] Mycophyta Basidiomycetes Agaricales Agaricaceae Lentinus Edodes, is used as medicine with sporophore.[habitats distribution] is distributed in Anhui, Zhejiang, Fujian, Guangxi, Sichuan, Guizhou, Yunnan.[nature and flavor] are sweet, flat.[function cures mainly] QI invigorating is not hungry, control wind removing blood stasis, phlegm-eliminiating and qi-regulating, benefit taste helps food, the rickets often suffered from after the obstacle of the edible serium inorganic phosphorus that human body for want of vitamin D can be prevented to cause and blood calcium metabolism, the inflammation of the prevention various mucosa of human body and skin, prevention health is weak, capillary rupture, dental bed and abdominal cavity hemorrhage etc..
Ganoderma: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, liver, kidney channel.[function cures mainly] invigorating QI and tranquilization, relieving cough and asthma.For dizziness sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Herba malachii aquatici: [nature and flavor] acid is flat.[function cures mainly] clearing away heat and cooling blood, reducing swelling and alleviating pain, removing food stagnancy lactogenesis.For infantile malnutrition, toothache, dysentery, hemorrhoid toxic swelling, mastitis, galactostasis；Furuncle is controlled in external.
Currently preferred only above raw medicinal material prepares.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1
Proportioning: beans 4g, Cortex Magnoliae Officinalis 10g, Pericarpium Zanthoxyli 3g, Semen Canavaliae 10g, Herba Trigonotidis peduncularis 6g, Radix Rhodiolae Dumulosae 10g, Herba Cynomorii 3g, Cortex Lycii 10g, Galla Turcica (Galla Helepensis) 7g, Fructus Kaki 8g, DIGEN 10g, Fructus Alpiniae Oxyphyllae 10g, Semen castanopsis sclerophyllae 8g, Radix et rhizoma smilacinae japonicae 7g, Pericarpium Arecae 10g, Radix Rubiae 15g, Aster auriculatus Franch. 10g, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 12g, Rhizoma Tupistrae pachynemae 2g, Lentinus Edodes 6g, Ganoderma 5g and Herba malachii aquatici 10g.
Its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 350 orders；
3rd step, adds the starch relative to its quality 2 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
Embodiment 2
Proportioning: beans 9g, Cortex Magnoliae Officinalis 15g, Pericarpium Zanthoxyli 5g, Semen Canavaliae 15g, Herba Trigonotidis peduncularis 13g, Radix Rhodiolae Dumulosae 20g, Herba Cynomorii 5g, Cortex Lycii 15g, Galla Turcica (Galla Helepensis) 12g, Fructus Kaki 15g, DIGEN 15g, Fructus Alpiniae Oxyphyllae 20g, Semen castanopsis sclerophyllae 13g, Radix et rhizoma smilacinae japonicae 13g, Pericarpium Arecae 20g, Radix Rubiae 20g, Aster auriculatus Franch. 15g, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 20g, Rhizoma Tupistrae pachynemae 3g, Lentinus Edodes 12g, Ganoderma 9g and Herba malachii aquatici 15g.
Its preparation method is:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 1 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 98%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24 hours when 10 DEG C, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, concentrate and dry, and pulverizing 50 minutes in super micron mill are put at this, the mixed powder that the micron particles of 1 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 98%；
3rd step, takes the mixed powder 2g that second step obtains, and adds sodium chloride 60g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.23 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
Embodiment 3
Proportioning: beans 6g, Cortex Magnoliae Officinalis 12g, Pericarpium Zanthoxyli 4g, Semen Canavaliae 12g, Herba Trigonotidis peduncularis 12g, Radix Rhodiolae Dumulosae 15g, Herba Cynomorii 4g, Cortex Lycii 12g, Galla Turcica (Galla Helepensis) 9g, Fructus Kaki 12g, DIGEN 12g, Fructus Alpiniae Oxyphyllae 15g, Semen castanopsis sclerophyllae 12g, Radix et rhizoma smilacinae japonicae 9g, Pericarpium Arecae 16g, Radix Rubiae 18g, Aster auriculatus Franch. 12g, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 17g, Rhizoma Tupistrae pachynemae 2g, Lentinus Edodes 8g, Ganoderma 7g and Herba malachii aquatici 12g.
Its preparation method is:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 1 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is 99%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24 hours when 8 DEG C, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, concentrate and dry, and pulverizing 50 minutes in super micron mill are put at this, the mixed powder that the micron particles of 1 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is 99%；
3rd step, takes the mixed powder 2g that second step obtains, and adds sodium chloride 60g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.23 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
The toxicity test of medicine
1. acute toxicity test: with the pharmaceutical composition of the embodiment of the present invention 1 for object, 150 times of clinical consumption per day give white mouse big enteral dispensing, observe 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not have toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: mice is pressed 15,30 and 45g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight by the pharmaceutical composition of the embodiment of the present invention 2, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Contrast test
Vaccary, Shandong cultivation cattle about 2000, has 200 cattle to occur suffering from a deficiency of the kidney the symptom of type calf diarrhea of having loose bowels: disease sees that chronic diarrhea is not healed, and excrement is rare such as water, rush down weight night, namely borborygmus rush down, and after rushing down, pain subtracts, coldness of the body with chills, tetraparesis, waist hip is unable, anal incontinence, with hind leg edema under abdomen, mouth color is light, deep,thready and forceless pulse.
Select 200 ill cattle, isolation cultivation, and be randomly divided into four groups, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often group 50.
Embodiment 1 group adopts the medicinal composition powders of the embodiment of the present invention 1 to treat, and is mixed in conventional feed by powder according to the ratio of 4:100, normally feeds, carries out 2.
Embodiment 2 groups adopts the medicine composition injection agent of the embodiment of the present invention 3 to treat, and intramuscular injection every day 5ml normally feeds conventional feed, carries out 2.
Embodiment 3 groups adopts the medicine composition injection agent of the embodiment of the present invention 3 to treat, and intramuscular injection every day 5ml normally feeds conventional feed, carries out 2.
Matched group: adopt the every kg body weight 0.1～0.3g of sulfamethoxyplridazine, take orally once a day.Conventional feed normally feeds, and carries out 2.
The treatment situation of record experimentation.Referring to table 1.
The average weight of the cattle before and after record experiment, calculates average weight growth pattern.Referring to table 2.
Table 1 is treatment situation contrast (often organizing 50 altogether) of each group
Group Cure number Invalid number Cure rate Inefficiency
Embodiment 1 group 50 0 100% 0%
Embodiment 2 groups 50 0 100% 0%
Embodiment 3 groups 50 0 100% 0%
Matched group 28 22 56% 44%
Can be seen that referring to table 1, the healing number of the treatment cattle of embodiment 1 group, embodiment 2 groups and embodiment 3 groups and cure rate will be higher than healing number and the cure rate of the cattle of matched group, it is appreciated that, the pharmaceutical composition of the present invention, treatment is suffered from a deficiency of the kidney and is had loose bowels on type calf diarrhea, therapeutic effect is good, determined curative effect, well improves the state of an illness.
Table 2 is the balanced growth body weight contrast of the cattle of each group
Group Sum Average weight before experiment Average weight after test Average daily gain
Embodiment group 1 50 522.0kg 523.94kg 0.97kg/d
Embodiment group 2 50 521.2kg 523.16kg 0.98kg/d
Embodiment group 2 50 520.1kg 522.08kg 0.99kg/d
Matched group 50 520.1kg 521.58kg 0.74kg/d
Referring to table 2 it can be seen that the treatment of embodiment 1 group, embodiment 2 groups and embodiment 3 groups is suffered from a deficiency of the kidney has loose bowels while type calf diarrhea, growth rate faster than matched group, will maintain the normal growth of cattle.
In sum, pharmaceutical composition of the present invention, to suffer from a deficiency of the kidney in treatment and have loose bowels on type calf diarrhea, therapeutic effect is good, determined curative effect, and ensure that the normal growth of cattle.
Citing: vaccary, Liaocheng cowboying 1000, in JIUYUE, 2014,200 calves occur suffering from a deficiency of the kidney type calf diarrhea symptom of having loose bowels: disease sees that chronic diarrhea is not healed, excrement is rare such as water, rushes down weight night, and namely borborygmus rush down, after rushing down, pain subtracts, coldness of the body with chills, tetraparesis, waist hip is unable, anal incontinence, with hind leg edema under abdomen, mouth color is light, deep,thready and forceless pulse.Select 100 ill cattle to carry out isolation treatment, adopt the medicine composition injection agent of the embodiment of the present invention 3 to treat, intramuscular injection every day 5ml, normally feed conventional feed, carry out 2.What cure is 100, cure rate 100%.Body weight increases 1.93kg during treating.The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (3)

1. a treatment is suffered from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels, it is characterized in that, including following raw medicinal material: beans, Cortex Magnoliae Officinalis, Pericarpium Zanthoxyli, Semen Canavaliae, Herba Trigonotidis peduncularis, Radix Rhodiolae Dumulosae, Herba Cynomorii, Cortex Lycii, Galla Turcica (Galla Helepensis), Fructus Kaki, DIGEN, Fructus Alpiniae Oxyphyllae, Semen castanopsis sclerophyllae, Radix et rhizoma smilacinae japonicae, Pericarpium Arecae, Radix Rubiae, Aster auriculatus Franch., Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Tupistrae pachynemae, Lentinus Edodes, Ganoderma and Herba malachii aquatici.
null2. treatment according to claim 1 is suffered from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels，It is characterized in that，The raw medicinal material having following mass fraction prepares: beans 4-9 weight portion、Cortex Magnoliae Officinalis 10-15 weight portion、Pericarpium Zanthoxyli 3-5 weight portion、Semen Canavaliae 10-15 weight portion、Herba Trigonotidis peduncularis 6-13 weight portion、Radix Rhodiolae Dumulosae 10-20 weight portion、Herba Cynomorii 3-5 weight portion、Cortex Lycii 10-15 weight portion、Galla Turcica (Galla Helepensis) 7-12 weight portion、Fructus Kaki 8-15 weight portion、DIGEN 10-15 weight portion、Fructus Alpiniae Oxyphyllae 10-20 weight portion、Semen castanopsis sclerophyllae 8-13 weight portion、Radix et rhizoma smilacinae japonicae 7-13 weight portion、Pericarpium Arecae 10-20 weight portion、Radix Rubiae 15-20 weight portion、Aster auriculatus Franch. 10-15 weight portion、Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 12-20 weight portion、Rhizoma Tupistrae pachynemae 2-3 weight portion、Lentinus Edodes 6-12 weight portion、Ganoderma 5-9 weight portion and Herba malachii aquatici 10-15 weight portion.
3. treatment according to claim 1 and 2 is suffered from a deficiency of the kidney the pharmaceutical composition of type calf diarrhea of having loose bowels, it is characterized in that, the raw medicinal material having following mass fraction prepares: beans 6 weight portion, Cortex Magnoliae Officinalis 12 weight portion, Pericarpium Zanthoxyli 4 weight portion, Semen Canavaliae 12 weight portion, Herba Trigonotidis peduncularis 12 weight portion, Radix Rhodiolae Dumulosae 15 weight portion, Herba Cynomorii 4 weight portion, Cortex Lycii 12 weight portion, Galla Turcica (Galla Helepensis) 9 weight portion, Fructus Kaki 12 weight portion, DIGEN 12 weight portion, Fructus Alpiniae Oxyphyllae 15 weight portion, Semen castanopsis sclerophyllae 12 weight portion, Radix et rhizoma smilacinae japonicae 9 weight portion, Pericarpium Arecae 16 weight portion, Radix Rubiae 18 weight portion, Aster auriculatus Franch. 12 weight portion, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 17 weight portion, Rhizoma Tupistrae pachynemae 2 weight portion, Lentinus Edodes 8 weight portion, Ganoderma 7 weight portion and Herba malachii aquatici 12 weight portion.
CN201610307023.6A 2016-05-11 2016-05-11 Pharmaceutical composition for treating kidney-deficiency diarrhea type calf diarrhea Withdrawn CN105727124A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
罗超应: "《牛病中西医结合治疗》", 31 January 2008, 金盾出版社 *

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