CN105727246A - Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof - Google Patents

Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof Download PDF

Info

Publication number
CN105727246A
CN105727246A CN201610307032.5A CN201610307032A CN105727246A CN 105727246 A CN105727246 A CN 105727246A CN 201610307032 A CN201610307032 A CN 201610307032A CN 105727246 A CN105727246 A CN 105727246A
Authority
CN
China
Prior art keywords
weight portion
mixed powder
diarrhea
herba
fructus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610307032.5A
Other languages
Chinese (zh)
Inventor
滕旭光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yantai Minwang Electromechanical Technology Co Ltd
Original Assignee
Yantai Minwang Electromechanical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yantai Minwang Electromechanical Technology Co Ltd filed Critical Yantai Minwang Electromechanical Technology Co Ltd
Priority to CN201610307032.5A priority Critical patent/CN105727246A/en
Publication of CN105727246A publication Critical patent/CN105727246A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732—Chaenomeles, e.g. flowering quince
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Dermatology (AREA)

Abstract

The invention discloses a pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and a preparation method thereof. The pharmaceutical composition comprises the following raw medicinal materials: mangnolia officinalis, fructus evodiae, rhizoma zingiberis, pepper, fructus psoraleae, mulberry, jasmine flowers, Indian adenosma herb, grapes, white hyacinth beans, pawpaws, herba eupatorii, herb of hairystalk loosestrife, arthraxon hispidus, lysimachia congestiflorahemsl, rubus hirsutus, alpinia katsumadai, aleuritopteris argentea fee, saxifraga stolonifera, adina pilulifera and caulis polygoni multiflori. The beneficial effects of the invention are as follows: the pharmaceutical composition disclosed by the invention is used for treating cold-dampness diarrhea type calf diarrhea and has the functions of warming the middle and stopping diarrhea, relieving exterior and resolving dampness and dispelling cold and removing dampness; and through scientific conditioning of the base body, the pharmaceutical composition realizes a good effect, takes effect quickly, rarely causes replase, avoids toxic and side effects and greatly promotes the growth of calves.

Description

A kind of cold-damp for the treatment of is had loose bowels the pharmaceutical composition and preparation method thereof of type calf diarrhea
Technical field
The present invention relates to herbal medicine pharmaceutical technology field, have loose bowels the pharmaceutical composition and preparation method thereof of type calf diarrhea particularly to a kind of cold-damp for the treatment of.
Background technology
Calf diarrhea is had loose bowels also known as calf, all can occur throughout the year, is a kind of gastrointestinal disease of often sending out of calf.Calf often after birth 2～3d start morbidity, to the growth of calf, grow, survive etc. and to have a significant impact.When jumpbogroup is raised, calf diarrhea incidence rate often reaches 90%～100%, and mortality rate reaches as high as more than 50%, threatens very big to the development of milk industry.
The generation of calf diarrhea, the impact with the condition of fetal development phase and external environment is relevant.Because of the difference in area and season etc., the situation that calf suffers from diarrhoea is also different.It is summed up, mainly has the reason of following several respects to cause.
The cause of disease: 1. antibacterial causes product enterotoxin angstrom Xi Shi escherichia coli (ETEC), Campylobacter, Salmonella, bacillus aerogenes capsulatus etc. all can cause calf diarrhea.And ETEC is the main bacteria causing the calf diarrhea in 1 week old, it invades and discharges one or both enterotoxins after in calf body and cause calf diarrhea.Clostridium perfringens bacterium is the pathogen that calf suffers from enterotoxemia.2. virus causes rotavirus, coronavirus, star virus, viral, the micro-virus of small cup shape etc. all can cause calf diarrhea, and rotavirus and coronavirus play important nosetiology effect.3. feeding and management is improper causes (1) if daily ration is uneven during cow miscarriage 1. cow gestation, not full price, lack motion, the nutritional metabolic process then making cow gets muddled, result makes fetus normal development in parent be affected, cause new-born calve dysplasia, have bad physiques, lower for the resistance, postnatal initial several days, nearly all it is susceptible to suffer from diarrhoea.2. the breast of cow and nipple are clean, or with suffering from milk hello the calf of mastitis cow, it is also possible to cause the another kind of approach of calf diarrhea.3. underfed biestings is of poor quality, secretion is few, and immunoglobulin content is low, and new-born calve failed to have colostrum within several hours puerperal, very easily caused lienteric diarrhea.4. just tire Niu Yinqi diarrhea disease percentage is high.Owing to first tire mother's beestings is few, milk is poor, and contained immunoglobulin concentrations is low;First tire cow takes care of the ability of calf, and calf Chang Buneng has enough colostrums;Difficult labour rate is high, and the stress of calf is big, mostly needs again midwifery during childbirth, and artificial pollution chance is many.(2), to moist and cold adaptation ability is very weak, the most easily there is lienteric diarrhea in the raising of calf, management and nurse that bad 1. calf house is excessively moist or body catches cold: the thermoregulation of nascent calf is unsound.2. sanitary condition is bad, has important impact.The milk feeding calf is unclean, and feed trough, to raise tool contaminated, and cowshed unclean (cattle pen, cattle bed do not clean for a long time, do not sterilize, and pad grass is changed without causing fecaluria for a long time and gathers and dirty etc.), thus adding morbidity chance.3. artificial suckling variable interval, non-quantitative, indefinite Lac Bovis seu Bubali temperature, can interfere with the normal activity of digestive function and cause a disease.4. feeding method is different.According to investigations, during as breast-feeded with the nursing-bottle with nipple or well-bucket, because of diarrhoea, the calf of death to reach 95 or 9.4%, and using instead when suckling bucket is breast-feeded is then 6.9%.5. the feed supplement of calf age of sucking is improper.When being fed transition by breast milk changed course feedstuff, wean too urgent, or supply feedstuff or is modulated inappropriate in quality, then easily make the gastrointestinal tract irriate of calf that lienteric diarrhea occurs.6. animal house improper ventilation, sultry crowded, lacks sunlight darkness moist etc., all can promote the generation of disease.7. time of nursing is too late, and calf licks dirt because of hungry, causes the blunt system of active receiving grandson of lactic acid bacteria in intestinal, and lactic acid lacks, enteral corruption mattress amount reproduction, thus destroying the normal stool effect to milk.(3) raising scale is more big, and the calf mortality rate that diarrhoea causes is more high.The research report of Cornell Univ USA confirms this point.Such as raising scale mortality rate average out to 6.8% of diarrhoea in 44 cows of 50,3 monthly ages;And at 15 cows of 150, average out to 11.0%;When 200～350 then up to 21.3%.(4) during calf group feeding, prevalence and mortality rate are all fed high than individually, and when its reason is group feeding, calf suffers from fecal pollution, suffers from anthelmintic, and the sickness rate of calf diarrhea may be up to 60%, and change into when individually feeding only 9%;Calf is as to give up interior group feeding for, time main, often eating by hair because mutually sucking umbilicus or ear, formed ball top by hair in cud, caused dyspepsia and cause diarrhoea.4. stress cause owing to the Alimentary 26S Proteasome Structure and Function of new-born calve is grown perfect not, the bad adaptability of environment to external world, thus at some undesirable elements, as disorderly in often resulted in calf digestive system under the effect of hot and cold, noise etc., there is malnutrition.Such as, when bottle-feeding, spirit and environment aspect also can cause stress to calf and affect its absorption to first calf immunoglobulin, thus reducing the premunition of calf, causes diarrhoea.And for example, when calf is subject to harsh weather and takes the photograph the various stresses such as people's full milk in a large number, digestive function weakens, and in intestinal, generation sharply changes, intestinal poison type escherichia coli or Clostridium perfringens bacterium are then easily invaded in human body and breed in a large number, thus causing the generation of dysentery or enterotoxemia.5. Cryptosporidium causes Cryptosporidium to be a kind of protozoacide (coccidiosis), may result in new-born calve and breaks out diarrhoea.Cryptosporidium often colonizes in calf jejunum and ileum and is adsorbed on enterocyte microvillus, only infects the calf within 4 ages in days, and multiple with the calf of 6～17 ages in days, by digestive tract infection, mortality rate is up to 30%.
Chinese medical discrimination is divided into, and cold-damp is had loose bowels type: disease sees that feces is thin in water, and stomachache, borborygmus, mouth color is light white or bluish white；Diarrhea due to damp-heat type: disease sees that calf spirit is depressed, appetite is useless absolutely, languishment, enophthalmos,enophthalmus, mouth red complexion is red, yellowish fur, morbidity is very fast, suffers from diarrhoea lasting, violent, and feces is thin in water, yellow skin, sometimes band blood, borborygmus are suffered from abdominal pain, slack anus, faecal incontinence, heart sound is muddy, palpitating speed, extremity tip is ice-cold sometimes, goes into a coma drowsiness；Dyspepsia due to improper feeding is had loose bowels type: disease sees that calf spirit is depressed, is reluctant to walk about, and mouth, nose are sent out cool, and the rotten acid of prolixity is smelly, and anorexia, slight distension gas, the rare thickness of excrement, color are yellowish, have unpleasant foul odour；Diarrhea due to hypofunction of the spleen type: disease sees that with the passing of time diarrhoea do not heal, and feces is thin, is mixed with bubble, or accompanies indigested feedstuff or milk block, sucks the breast seldom, becomes thin gradually, spiritlessness and weakness is reluctant to stand, and mouth color is light white, deep-slow pulse；Suffering from a deficiency of the kidney the type of having loose bowels: disease sees that chronic diarrhea is not healed, excrement is rare such as water, rushes down weight night, and namely borborygmus rush down, and after rushing down, pain subtracts, coldness of the body with chills, tetraparesis, and waist hip is unable, anal incontinence, and under abdomen and hind leg edema, mouth color is light, deep,thready and forceless pulse；Incoordination between the liver and spleen type: disease sees that borborygmus are suffered from abdominal pain, loose stool and diarrhea, rushes down and must suffer from abdominal pain, thin white fur of tongue, and arteries and veins revolves and delays.
Western medical treatment is generally only cured the symptoms, not the disease, and calf itself is caused certain injury by Western medicine, is unfavorable for the growth of cattle, and therefore, Chinese medicine has certain advantage.
Summary of the invention
In order to solve the problems referred to above, the invention provides a kind of cold-damp for the treatment of and have loose bowels the pharmaceutical composition and preparation method thereof of type calf diarrhea.
nullIn order to realize foregoing invention purpose，The invention provides a kind of cold-damp for the treatment of to have loose bowels the pharmaceutical composition of type calf diarrhea，Wherein，Prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 10-20 weight portion、Fructus Evodiae 2-4 weight portion、Rhizoma Zingiberis 15-20 weight portion、Pericarpium Zanthoxyli 6-12 weight portion、Fructus Psoraleae 8-13 weight portion、Fructus Mori 10-20 weight portion、Flos Jasmini Sambac 10-20 weight portion、Herba Adenosmae 8-15 weight portion、Fructus Vitis viniferae 10-20 weight portion、Semen Lablab Album 10-15 weight portion、Fructus Chaenomelis 8-13 weight portion、Herba Eupatorii 6-12 weight portion、Herba lysimachiae capillipedis 10-20 weight portion、Herba Arthraxonis Hispidi 8-15 weight portion、Wind and cold grass 10-15 weight portion、Fluffy 6-12 weight portion、Semen Alpiniae Katsumadai 10-20 weight portion、Aleuritopteris argentea (Gmel.) Fee 8-12 weight portion、Herba Saxifragae 2-4 weight portion、Ramulus et Folium Adinae Piluliferae 1-3 weight portion and rattan crow 2-4 weight portion.
Wherein, the raw medicinal material of following mass fraction prepare: Cortex Magnoliae Officinalis 14 weight portion, Fructus Evodiae 3 weight portion, Rhizoma Zingiberis 18 weight portion, Pericarpium Zanthoxyli 8 weight portion, Fructus Psoraleae 10 weight portion, Fructus Mori 16 weight portion, Flos Jasmini Sambac 16 weight portion, Herba Adenosmae 12 weight portion, Fructus Vitis viniferae 16 weight portion, Semen Lablab Album 12 weight portion, Fructus Chaenomelis 10 weight portion, Herba Eupatorii 8 weight portion, Herba lysimachiae capillipedis 15 weight portion, Herba Arthraxonis Hispidi 12 weight portion, wind and cold grass 12 weight portions, fluffy 8 weight portions, Semen Alpiniae Katsumadai 15 weight portion, Aleuritopteris argentea (Gmel.) Fee 10 weight portion, Herba Saxifragae 3 weight portion, Ramulus et Folium Adinae Piluliferae 2 weight portion and rattan crow 3 weight portions.
In order to achieve the above object, present invention also offers the have loose bowels preparation method of pharmaceutical composition of type calf diarrhea of described treatment cold-damp to comprise the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 80%～90% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 50～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%；
3rd step, takes mixed powder 1～3g that second step obtains, and adds sodium chloride 60～90g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.22～0.24 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention, treatment cold-damp is had loose bowels type calf diarrhea, there is warming middle-JIAO to stop diarrhea, effect of induce sweat removing dampness and damp eliminating of dispeling cold, by the science of matrix is nursed one's health, effective, curative effect is fast, not easily recurs, and have no side effect, the growth of calf is had very big facilitation.
Detailed description of the invention
The present invention provides a kind of cold-damp for the treatment of to have loose bowels the pharmaceutical composition of type calf diarrhea, wherein, including following raw medicinal material: Cortex Magnoliae Officinalis, Fructus Evodiae, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Fructus Psoraleae, Fructus Mori, Flos Jasmini Sambac, Herba Adenosmae, Fructus Vitis viniferae, Semen Lablab Album, Fructus Chaenomelis, Herba Eupatorii, Herba lysimachiae capillipedis, Herba Arthraxonis Hispidi, wind and cold are careless, fluffy, Semen Alpiniae Katsumadai, Aleuritopteris argentea (Gmel.) Fee, Herba Saxifragae, Ramulus et Folium Adinae Piluliferae and rattan crow.Ingredients scientific matching, reaches treatment cold-damp and has loose bowels the purpose of type calf diarrhea, have good effect.
The pharmacology of various raw medicinal materials is as follows:
Cortex Magnoliae Officinalis: [nature and flavor] are bitter, pungent, temperature.[return through] returns spleen, stomach, lung, large intestine channel.[function cures mainly] dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Fructus Evodiae: [nature and flavor] are pungent, bitter, heat.[return through] returns liver, spleen, stomach, kidney channel.[function cures mainly] dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomits acid regurgitation, Diarrhoea, external treatment aphtha；Hypertension.
Rhizoma Zingiberis: [nature and flavor] are pungent, hot.[return through] returns spleen, stomach, kidney, the heart, lung meridian.[function cures mainly] Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.
Pericarpium Zanthoxyli: [nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, kidney channel.[function cures mainly] warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis；External treatment eczema pruritus.
Fructus Psoraleae: [nature and flavor] are pungent, bitter, temperature.[return through] returns kidney, spleen channel.[function cures mainly] warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, alopecia areata.
Fructus Mori: [nature and flavor] are sweet, cold.1. Tang Materia Medica: " sweet in the mouth, cold, nontoxic." 2. amplification on Canon of Materia Medica: " is micro-cool." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sweet acid." [return through] enters liver, kidney channel.1. " Bencao Congxin ": " enter kidney." 2. " book on Chinese herbal medicine brief points ": " enters sufficient faint the moon, shaoyin channel." [function cures mainly] tonifying liver, kidney tonifying, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Controlling hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.1. Tang Materia Medica: " single food, master quenches one's thirst." 2. supplement to the Herbal: " profit the five internal organs joint, logical vim and vigour, smash end, honey and be ball.It is thirsty that " 3. amplification on Canon of Materia Medica: " controls heat, spermatogenesis god, and small intestinal heat." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " kidney tonifying is dirty and controlling nocturnal emission with astringent drugs, takes hair color improving eyesight for a long time." 5. " detailed outline ": " smashes juice drink, solves alcohol intoxication, wine brewing clothes, diuretic gas, detumescence." 6. " beautiful Chinese catalpa medicine solution ": " controls infirmity pouring, scrofula, tinea alba." 7. " book on Chinese herbal medicine is looked for the truth ": " heat extraction, yin nourishing, antidiarrheal." 8. " occupying diet spectrum with breath ": " liver nourishing kidney, congested liquid, wind-damp dispelling, walk with vigorous strides to carry out, cease wind syndrome caused by deficiency, clear asthenic fire." 9. " modern Practical Chinese medicinal ": " refrigerant cough-relieving." 10. " Chinese medicine shape sex experience differential method ": " is antiabortive."
Flos Jasmini Sambac: [nature and flavor] acrid, sweet, cool.[function cures mainly] flower, leaf: clearing away heat and expelling pathogen in the exterior, dampness removing.
Herba Adenosmae: [nature and flavor] hardship pungent, micro-, tepor.[function cures mainly] dispelling wind to relieve the exterior syndrome, removing dampness disappears stagnant.For catching a cold, fever and headache, dyspepsia, enteritis, stomachache.
Fructus Vitis viniferae: [nature and flavor] really: sweet, flat.[function cures mainly] really: rash of inducing sweat, and diuresis is antiabortive.For measles without adequate eruption, dysuria, frequent fetal movement.Root, rattan: wind-damp dispelling, diuresis.For rheumatic ostalgia, edema；Fracture is controlled in external.
Semen Lablab Album: [nature and flavor] are sweet, tepor.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen for eliminating dampness, and in relieve summer heat.For weakness of the spleen and stomach, inappetence, diarrhea, leukorrhagia, heat-damp in summer is vomited and diarrhoea, abdominal distention uncomfortable in chest.
Fructus Chaenomelis: [nature and flavor] acid, temperature.[return through] returns liver, spleen channel.[function cures mainly] suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, waist knee joint acid weight pain, convulsion of vomiting and diarrhoea, beriberi edema.
Herba Eupatorii: [nature and flavor] are pungent, flat.[return through] returns spleen, stomach, lung meridian.[function cures mainly] removing dampness by means of aromatics, appetizing of being amusing, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.
Herba lysimachiae capillipedis: [nature and flavor] " Traditional Chinese Medicine in Sichuan will ": " sweet in the mouth, property is put down, nontoxic." [function cures mainly] cures cold, cough with asthma, rheumatalgia, menoxenia.1. " will planted by middle traditional Chinese medicines ": " control weakness." 2. " Traditional Chinese Medicine in Sichuan will ": " wind-damp dispelling, regulates the flow of vital energy, and only pain due to disorder of QI, refreshment relieving restlessness, put freckle on the skin." 3. " GUIHAIA register ": " QI invigorating qi-restoratives, expelling wind and activating blood circulation.Control weakness, tracheitis, asthma, menoxenia, cold cough."
Herba Arthraxonis Hispidi: [nature and flavor] are bitter is flat.[function cures mainly] heat clearing away, sending down the abnormal ascending QI, relieving cough and asthma, removing toxic substances, rheumatism.Curing mainly hepatitis, chronic cough is panted, pharyngolaryngitis, stomatitis, rhinitis, lymphadenitis, mastitis.Scabies, skin pruritus, carbuncle furuncle are controlled in external.
Wind and cold grass: [nature and flavor] are pungent；Micro-hardship；Slightly warm in nature.[function cures mainly] expelling wind and cold；Preventing phlegm from forming and stopping coughing；Detoxification and promoting urination；Removing food stagnancy calculus.Main headche due to wind-cold；Cough with copious phlegm；Laryngopharynx swelling and pain；Jaundice；Biliary Calculi；Lithangiuria；Children's mansion is amassed；Carbuncle furuncle；Venom.
Fluffy: [nature and flavor] sweet acid, temperature.1. " herbal classic ": " acid, flat." 2. " not Lu ": " be salty, nontoxic." 3. " feeding habits book on Chinese herbal medicine ": " sweet acid, slight fever." [function cures mainly] invigorating the liver and kidney, urine reducing.Zhiduo County urinates, the vertigo.
Semen Alpiniae Katsumadai: [nature and flavor] are pungent, temperature.1. " not Lu ": " acrid in the mouth, temperature, nontoxic." 2. " a thousand pieces of gold dietetic therapy ": " acrid in the mouth, temperature, puckery, nontoxic." 3. " medicine origin ": " gas heat, taste great Xin." [return through] enters spleen, stomach warp.1. Materia Medica of Decoction: " enter lunar, the Yangming Channel of foot." 2. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, lung three warp." [function cures mainly] warming middle-JIAO, cold relieving, circulation of qi promoting, dampness.Controlling trusted subordinate's cold type of pain, feeling of fullness dyspepsia, dysphagia and regurgitation, cold-damp is vomited and diarrhoea, and phlegm retention is gathered.
Aleuritopteris argentea (Gmel.) Fee: [nature and flavor] " Henan Chinese herbal medicine handbook ": " property is put down, lightly seasoned；Leaf: bitter in the mouth." [function cures mainly] cough-relieving, regulating menstruation, damp eliminating.Control cough, menoxenia, leucorrhea with red and white discharge.1. " Shanxi Chinese medicinal herbal ": " promoting blood circulation to restore menstrual flow." 2. " Zhejiang natural resources of Chinese medicinal materials register ": " is controlled the frightened contraction of children's and is twitched." 3. " register planted by Guangxi medicine ": " cough-relieving, controls gynaecological disease, " 4. " Henan Chinese herbal medicine handbook ": " promoting blood flow to regulate menstruation, damp eliminating, cold expelling, pain relieving."
Herba Saxifragae: [nature and flavor] 1. " carry out rock book on Chinese herbal medicine ": " cool in nature." 2. " detailed outline ": " micro-toil, cold, slightly poisonous." [function cures mainly] dispels the wind, heat clearing away, removing pathogenic heat from blood and toxic substance from the body.Control rubella；Eczema, otitis media, erysipelas, cough is spitted blood, lung abscess, metrorrhagia, haemorrhoids.
Ramulus et Folium Adinae Piluliferae: [nature and flavor] are bitter is flat.1. " Fujian traditional herbal medicine ": " bitter, flat." 2. " Luchuan book on Chinese herbal medicine ": " is sweet light, is slightly cold." 3. " Nanning City's medicine will ": " is puckery." [function cures mainly] clearing away heat-damp and promoting diuresis, repercussive analgesic therapy, hemostasia and promoting granulation.Control dysentery, enteritis, damp and hot edema, carbuncle sore tumefacting virus, eczema, rotten foot, ulcer being unable to heal, wound hemorrhage.
Rattan crow: [nature and flavor] are pungent, hot greatly.[function cures mainly] invigorating blood circulation analgesia, searches wind damp eliminating.For rheumatalgia, traumatic injury.
Currently preferred only above raw medicinal material prepares.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1
Proportioning: Cortex Magnoliae Officinalis 10g, Fructus Evodiae 2g, Rhizoma Zingiberis 15g, Pericarpium Zanthoxyli 6g, Fructus Psoraleae 8g, Fructus Mori 10g, Flos Jasmini Sambac 10g, Herba Adenosmae 8g, Fructus Vitis viniferae 10g, Semen Lablab Album 10g, Fructus Chaenomelis 8g, Herba Eupatorii 6g, Herba lysimachiae capillipedis 10g, Herba Arthraxonis Hispidi 8g, wind and cold grass 10g, fluffy 6g, Semen Alpiniae Katsumadai 10g, Aleuritopteris argentea (Gmel.) Fee 8g, Herba Saxifragae 2g, Ramulus et Folium Adinae Piluliferae 1g and rattan crow 2g.
Its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85% relative to 5 times of mixture, heat to boiling reflux 4 hours, filter, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.08Mpa is the mastic of 1.08, spray drying, the inlet temperature of spray dryer 170 DEG C, leaving air temp 85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, make granule, dries in 45 DEG C, it is thus achieved that granule.
Embodiment 2
Proportioning: Cortex Magnoliae Officinalis 20g, Fructus Evodiae 4g, Rhizoma Zingiberis 20g, Pericarpium Zanthoxyli 12g, Fructus Psoraleae 13g, Fructus Mori 20g, Flos Jasmini Sambac 20g, Herba Adenosmae 15g, Fructus Vitis viniferae 20g, Semen Lablab Album 15g, Fructus Chaenomelis 13g, Herba Eupatorii 12g, Herba lysimachiae capillipedis 20g, Herba Arthraxonis Hispidi 15g, wind and cold grass 15g, fluffy 12g, Semen Alpiniae Katsumadai 20g, Aleuritopteris argentea (Gmel.) Fee 12g, Herba Saxifragae 4g, Ramulus et Folium Adinae Piluliferae 3g and rattan crow 4g.
Its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 2 times, be heated to reflux 3 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 350 orders；
3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
Embodiment 3
Proportioning: Cortex Magnoliae Officinalis 14g, Fructus Evodiae 3g, Rhizoma Zingiberis 18g, Pericarpium Zanthoxyli 8g, Fructus Psoraleae 10g, Fructus Mori 16g, Flos Jasmini Sambac 16g, Herba Adenosmae 12g, Fructus Vitis viniferae 16g, Semen Lablab Album 12g, Fructus Chaenomelis 10g, Herba Eupatorii 8g, Herba lysimachiae capillipedis 15g, Herba Arthraxonis Hispidi 12g, wind and cold grass 12g, fluffy 8g, Semen Alpiniae Katsumadai 15g, Aleuritopteris argentea (Gmel.) Fee 10g, Herba Saxifragae 3g, Ramulus et Folium Adinae Piluliferae 2g and rattan crow 3g.
Its preparation method is:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 1 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is 97%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24 hours when 5 DEG C, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, concentrate and dry, and pulverizing 55 minutes in super micron mill are put at this, the mixed powder that the micron particles of 2 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is 97%；
3rd step, takes the mixed powder 2g that second step obtains, and adds sodium chloride 80g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.23 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
The toxicity test of medicine
1. acute toxicity test: with the pharmaceutical composition of the embodiment of the present invention 1 for object, 150 times of clinical consumption per day give white mouse big enteral dispensing, observe 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not have toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: mice is pressed 15,30 and 45g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight by the pharmaceutical composition of the embodiment of the present invention 2, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Contrast test
Vaccary, Shandong cultivation cattle about 1000, cold-damp is had loose bowels the symptom of type calf diarrhea to have 200 calves to occur: disease sees that feces is thin in water, suffers from abdominal pain, and borborygmus, mouth color is light white or bluish white.
Select 200 ill cattle, isolation cultivation, and be randomly divided into four groups, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often group 50.
Embodiment 1 group adopts the medicament composition granule agent of the embodiment of the present invention 1 to treat, and is mixed in conventional feed by granule according to the ratio of 4:100, normally feeds, carries out 2.
Embodiment 2 groups adopts the medicinal composition powders of the embodiment of the present invention 2 to treat, and is mixed in conventional feed by powder according to the ratio of 4:100, normally feeds, carries out 2.
Embodiment 3 groups adopts the medicine composition injection agent of the embodiment of the present invention 3 to treat, and will inject liquor intramuscular injection every day 10ml, and conventional feed normally feeds, and carries out 2.
Matched group: adopt the every kg body weight 0.1～0.3g of sulfamethoxyplridazine, take orally once a day.Conventional feed normally feeds, and carries out 2.
The treatment situation of record experimentation.Referring to table 1.
The average weight of the calf before and after record experiment, calculates average weight growth pattern.Referring to table 2.
Table 1 is treatment situation contrast (often organizing 50 altogether) of each group
Group Cure number Invalid number Cure rate Inefficiency
Embodiment 1 group 50 0 100% 0%
Embodiment 2 groups 50 0 100% 0%
Embodiment 3 groups 50 0 100% 0%
Matched group 40 10 80% 20%
Can be seen that referring to table 1, the healing number of the treatment calf of embodiment 1 group, embodiment 2 groups and embodiment 3 groups and cure rate will be higher than healing number and the cure rate of the calf of matched group, it is appreciated that, the pharmaceutical composition of the present invention, treatment cold-damp is had loose bowels on type calf diarrhea, and therapeutic effect is good, determined curative effect, instant effect, well improves the state of an illness.
Table 2 is the balanced growth body weight contrast of the calf of each group
Group Sum Average weight before experiment Average weight after test Average daily gain
Embodiment group 1 50 45.0kg 46.9kg 0.95kg/d
Embodiment group 2 50 45.2kg 47.05kg 0.94kg/d
Embodiment group 2 50 45.1kg 46.96kg 0.93kg/d
Matched group 50 45.1kg 46.56kg 0.73kg/d
Referring to table 2 it can be seen that the treatment cold-damp of embodiment 1 group, embodiment 2 groups and embodiment 3 groups is had loose bowels while type calf diarrhea, growth rate faster than matched group, will maintain the normal growth of calf.
In sum, pharmaceutical composition of the present invention, to have loose bowels on type calf diarrhea in treatment cold-damp, therapeutic effect is good, determined curative effect, instant effect, and ensure that the normal growth of calf.
Citing: vaccary, Liaocheng cowboying 1000, in October, 2014,200 calves occur that cold-damp is had loose bowels type calf diarrhea symptom: disease sees that feces is thin in water, suffers from abdominal pain, and borborygmus, mouth color is light white or bluish white.200 ill calves are treated, adopts the medicinal composition powders of the embodiment of the present invention 2 to treat, powder is mixed in conventional feed according to the ratio of 4:100, normally feeds, carry out 2.What cure is 200, cure rate 100%.Body weight increases 1.9kg during treating.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (4)

  1. null1. treat cold-damp and have loose bowels the pharmaceutical composition of type calf diarrhea for one kind，It is characterized in that，Prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 10-20 weight portion、Fructus Evodiae 2-4 weight portion、Rhizoma Zingiberis 15-20 weight portion、Pericarpium Zanthoxyli 6-12 weight portion、Fructus Psoraleae 8-13 weight portion、Fructus Mori 10-20 weight portion、Flos Jasmini Sambac 10-20 weight portion、Herba Adenosmae 8-15 weight portion、Fructus Vitis viniferae 10-20 weight portion、Semen Lablab Album 10-15 weight portion、Fructus Chaenomelis 8-13 weight portion、Herba Eupatorii 6-12 weight portion、Herba lysimachiae capillipedis 10-20 weight portion、Herba Arthraxonis Hispidi 8-15 weight portion、Wind and cold grass 10-15 weight portion、Fluffy 6-12 weight portion、Semen Alpiniae Katsumadai 10-20 weight portion、Aleuritopteris argentea (Gmel.) Fee 8-12 weight portion、Herba Saxifragae 2-4 weight portion、Ramulus et Folium Adinae Piluliferae 1-3 weight portion and rattan crow 2-4 weight portion.
  2. 2. treatment cold-damp according to claim 1 is had loose bowels the pharmaceutical composition of type calf diarrhea, it is characterized in that, prepared by the raw medicinal material of following mass fraction: Cortex Magnoliae Officinalis 14 weight portion, Fructus Evodiae 3 weight portion, Rhizoma Zingiberis 18 weight portion, Pericarpium Zanthoxyli 8 weight portion, Fructus Psoraleae 10 weight portion, Fructus Mori 16 weight portion, Flos Jasmini Sambac 16 weight portion, Herba Adenosmae 12 weight portion, Fructus Vitis viniferae 16 weight portion, Semen Lablab Album 12 weight portion, Fructus Chaenomelis 10 weight portion, Herba Eupatorii 8 weight portion, Herba lysimachiae capillipedis 15 weight portion, Herba Arthraxonis Hispidi 12 weight portion, wind and cold grass 12 weight portions, fluffy 8 weight portions, Semen Alpiniae Katsumadai 15 weight portion, Aleuritopteris argentea (Gmel.) Fee 10 weight portion, Herba Saxifragae 3 weight portion, Ramulus et Folium Adinae Piluliferae 2 weight portion and rattan crow 3 weight portions.
  3. 3. treatment cold-damp according to claim 1 and 2 is had loose bowels the pharmaceutical composition of type calf diarrhea, it is characterised in that its preparation method comprises the following steps:
    The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%；
    Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 80%～90% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 50～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%；
    3rd step, takes mixed powder 1～3g that second step obtains, and adds sodium chloride 60～90g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.22～0.24 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
  4. 4. the treatment cold-damp described in an any one of claims 1 to 3 is had loose bowels the preparation method of pharmaceutical composition of type calf diarrhea, it is characterised in that comprise the following steps:
    The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%；
    Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 80%～90% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 50～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 96%；
    3rd step, takes mixed powder 1～3g that second step obtains, and adds sodium chloride 60～90g, adds 1000ml water for injection, and stirring makes it dissolve；Inject water to 10000ml；With 0.22～0.24 μm of filtering with microporous membrane；Subpackage embedding, every bottle of 250ml, sterilizing can obtain injection liquor.
CN201610307032.5A 2016-05-11 2016-05-11 Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof Withdrawn CN105727246A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610307032.5A CN105727246A (en) 2016-05-11 2016-05-11 Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610307032.5A CN105727246A (en) 2016-05-11 2016-05-11 Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105727246A true CN105727246A (en) 2016-07-06

Family

ID=56288864

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610307032.5A Withdrawn CN105727246A (en) 2016-05-11 2016-05-11 Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105727246A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104940778A (en) * 2015-07-15 2015-09-30 王丽丽 Medicine for treating organ dysfunction type pelvic inflammation and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104940778A (en) * 2015-07-15 2015-09-30 王丽丽 Medicine for treating organ dysfunction type pelvic inflammation and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
罗超应: "《牛病中西医结合治疗》", 31 January 2008, 金盾出版社 *

Similar Documents

Publication Publication Date Title
CN102048933B (en) Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN103355553B (en) Mixed feed for broiler at age of 1 to 7 d in brooding period and preparation method thereof
CN103251873B (en) Traditional Chinese veterinary medicine capable of helping to digest and remove retention
CN102198262B (en) Chinese medicine preparation for treating infant rotavirus enteritis and preparation method thereof
CN104187172B (en) Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed
CN103690919B (en) Medicine being used for the treatment of piglet iron-deficiency anemia and preparation method thereof
CN104351573A (en) Mixed feed for treating cow hypogalactia and preparation method thereof
CN105166544A (en) Pig mixed feed and preparation method thereof
CN101537145B (en) Traditional Chinese medicinal composition for treating ruminant fore-stomach stony indigestion, preparation method and applications thereof
CN104606663B (en) A kind of Chinese medicine for promoting Recovery and preparation method thereof
CN103239667B (en) Chinese traditional medicine for treating foot-and-mouth disease of domestic animals
CN105325714A (en) Compound feed for cows and preparation method thereof
CN104189413A (en) Medicine composition for treating enterogastritis diseases of turtles and preparation method of medicine composition
CN105166543A (en) Cow compound feed and preparation method thereof
CN105902741A (en) Pharmaceutical composition for treating damp-heat diarrhea type calf diarrhea and preparation method thereof
CN104435962A (en) Pharmaceutical composition for treating dyspeptic diarrhea of piglets and preparation method thereof
CN105727246A (en) Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof
CN103251840B (en) Veterinary traditional Chinese medicine for tonifying qi and strengthening exterior
CN103211988B (en) Pharmaceutical composition for treating porcine infectious gastrointestinal inflammations
CN103007145A (en) Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition
CN105727124A (en) Pharmaceutical composition for treating kidney-deficiency diarrhea type calf diarrhea
CN105920527A (en) Medicine for treating stomach-yin deficiency type peptic ulcer and preparation method thereof
CN104800687A (en) Traditional Chinese medicine preparation for treating infantile malnutrition and preparation method thereof
CN105617121A (en) Medicine for treating children stomatitis and preparation method of medicine
CN105106757A (en) Fat cow syndrome treatment medicine and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20160706

WW01 Invention patent application withdrawn after publication