CN101535305B - 5-羟基甲基-噁唑烷-2-酮衍生物 - Google Patents

5-羟基甲基-噁唑烷-2-酮衍生物 Download PDF

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Publication number
CN101535305B
CN101535305B CN2007800418985A CN200780041898A CN101535305B CN 101535305 B CN101535305 B CN 101535305B CN 2007800418985 A CN2007800418985 A CN 2007800418985A CN 200780041898 A CN200780041898 A CN 200780041898A CN 101535305 B CN101535305 B CN 101535305B
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fluoro
oxo
formula
compound
dihydro
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Expired - Fee Related
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CN2007800418985A
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English (en)
Chinese (zh)
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CN101535305A (zh
Inventor
克里斯蒂安·哈伯舒兰
菲利普·潘彻德
吉恩-卢克·斯拜克林
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN2007800418985A 2006-11-10 2007-11-09 5-羟基甲基-噁唑烷-2-酮衍生物 Expired - Fee Related CN101535305B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/IB2006/054189 2006-11-10
IBPCT/IB2006/054189 2006-11-10
IB2006054189 2006-11-10
PCT/IB2007/054557 WO2008056335A1 (en) 2006-11-10 2007-11-09 5-hydroxymethyl-oxazolidin-2-one derivatives

Publications (2)

Publication Number Publication Date
CN101535305A CN101535305A (zh) 2009-09-16
CN101535305B true CN101535305B (zh) 2013-09-18

Family

ID=39170372

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800418985A Expired - Fee Related CN101535305B (zh) 2006-11-10 2007-11-09 5-羟基甲基-噁唑烷-2-酮衍生物

Country Status (27)

Country Link
EP (1) EP2086968B1 (cg-RX-API-DMAC10.html)
JP (2) JP4484965B2 (cg-RX-API-DMAC10.html)
KR (1) KR101118402B1 (cg-RX-API-DMAC10.html)
CN (1) CN101535305B (cg-RX-API-DMAC10.html)
AR (1) AR063788A1 (cg-RX-API-DMAC10.html)
AT (1) ATE544764T1 (cg-RX-API-DMAC10.html)
AU (1) AU2007318901B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0718862B8 (cg-RX-API-DMAC10.html)
CA (1) CA2668280C (cg-RX-API-DMAC10.html)
CL (1) CL2007003232A1 (cg-RX-API-DMAC10.html)
CY (1) CY1112696T1 (cg-RX-API-DMAC10.html)
DK (1) DK2086968T3 (cg-RX-API-DMAC10.html)
ES (1) ES2380388T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20120385T1 (cg-RX-API-DMAC10.html)
IL (1) IL198645A (cg-RX-API-DMAC10.html)
MA (1) MA30960B1 (cg-RX-API-DMAC10.html)
MX (1) MX2009004764A (cg-RX-API-DMAC10.html)
MY (1) MY148847A (cg-RX-API-DMAC10.html)
NO (1) NO344727B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ577538A (cg-RX-API-DMAC10.html)
PL (1) PL2086968T3 (cg-RX-API-DMAC10.html)
PT (1) PT2086968E (cg-RX-API-DMAC10.html)
RU (1) RU2453546C2 (cg-RX-API-DMAC10.html)
SI (1) SI2086968T1 (cg-RX-API-DMAC10.html)
TW (1) TWI374138B (cg-RX-API-DMAC10.html)
WO (1) WO2008056335A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200904028B (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
MXPA05011654A (es) 2003-04-30 2005-12-15 Morphochem Ag Komb Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
ES2310299T5 (es) † 2003-12-18 2014-02-10 Morphochem Aktiengesellschaft für kombinatorische Chemie Antibióticos híbridos a base de oxazolidinona-quinolona
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
PL2296651T3 (pl) * 2008-05-09 2012-12-31 Actelion Pharmaceuticals Ltd Pochodne 5-hydroksymetylooksazolidyn-2-onu do leczenia bakteryjnych chorób jelitowych
IN2014CN04126A (cg-RX-API-DMAC10.html) * 2011-11-08 2015-07-10 Actelion Pharmaceuticals Ltd
RU2675847C2 (ru) 2013-05-28 2018-12-25 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Комбинированные терапевтические средства, содержащие оксазолидинон-хинолоны, предназначенные для лечения бактериальных инфекций
EP3003289B1 (en) 2013-05-28 2019-02-20 Morphochem Aktiengesellschaft für kombinatorische Chemie Administration of oxazolidinone-quinolone hybrid antibacterials
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
US10851079B2 (en) 2016-02-26 2020-12-01 Otsuka Pharmaceutical Co., Ltd. Piperidine derivative
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058886A1 (en) * 2003-12-18 2005-06-30 Dong-A Pharm.Co.,Ltd. Novel oxazolidinone derivatives
CN1832746A (zh) * 2003-04-30 2006-09-13 莫弗凯姆联合化学股份公司 噁唑烷酮－喹啉杂化物抗生素用于治疗炭疽和其它感染的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1156597A3 (ru) * 1982-04-28 1985-05-15 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных 3-( @ -алкилсульфонилфенил)оксазолидинона или их фармацевтически приемлемых кислотно-аддитивных солей
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
EP1349853B1 (en) * 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
EP1358185A2 (en) * 2001-02-07 2003-11-05 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
MXPA05011654A (es) * 2003-04-30 2005-12-15 Morphochem Ag Komb Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
ES2310299T5 (es) * 2003-12-18 2014-02-10 Morphochem Aktiengesellschaft für kombinatorische Chemie Antibióticos híbridos a base de oxazolidinona-quinolona

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1832746A (zh) * 2003-04-30 2006-09-13 莫弗凯姆联合化学股份公司 噁唑烷酮－喹啉杂化物抗生素用于治疗炭疽和其它感染的用途
WO2005058886A1 (en) * 2003-12-18 2005-06-30 Dong-A Pharm.Co.,Ltd. Novel oxazolidinone derivatives

Also Published As

Publication number Publication date
WO2008056335A1 (en) 2008-05-15
ES2380388T3 (es) 2012-05-11
JP5490553B2 (ja) 2014-05-14
PL2086968T3 (pl) 2012-07-31
TW200829580A (en) 2008-07-16
CA2668280C (en) 2015-02-10
KR101118402B1 (ko) 2012-03-07
CA2668280A1 (en) 2008-05-15
DK2086968T3 (da) 2012-03-19
CY1112696T1 (el) 2016-02-10
AU2007318901A1 (en) 2008-05-15
ZA200904028B (en) 2010-08-25
RU2453546C2 (ru) 2012-06-20
CL2007003232A1 (es) 2008-06-27
IL198645A (en) 2014-05-28
NO344727B1 (no) 2020-03-23
BRPI0718862B1 (pt) 2020-10-13
BRPI0718862A2 (pt) 2013-12-17
RU2009121812A (ru) 2010-12-20
AR063788A1 (es) 2009-02-18
HK1136276A1 (en) 2010-06-25
JP2010132677A (ja) 2010-06-17
NO20092209L (no) 2009-06-09
EP2086968B1 (en) 2012-02-08
HRP20120385T1 (hr) 2012-06-30
SI2086968T1 (sl) 2012-06-29
PT2086968E (pt) 2012-04-13
KR20090075875A (ko) 2009-07-09
MX2009004764A (es) 2009-05-21
MY148847A (en) 2013-06-14
NZ577538A (en) 2011-11-25
CN101535305A (zh) 2009-09-16
JP2010509314A (ja) 2010-03-25
EP2086968A1 (en) 2009-08-12
ATE544764T1 (de) 2012-02-15
TWI374138B (en) 2012-10-11
IL198645A0 (en) 2010-02-17
AU2007318901B2 (en) 2013-03-14
MA30960B1 (fr) 2009-12-01
JP4484965B2 (ja) 2010-06-16
BRPI0718862B8 (pt) 2021-05-25

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