CN101534803A - 给予含有药物的薄膜产品的方法 - Google Patents

给予含有药物的薄膜产品的方法 Download PDF

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Publication number
CN101534803A
CN101534803A CNA2007800409505A CN200780040950A CN101534803A CN 101534803 A CN101534803 A CN 101534803A CN A2007800409505 A CNA2007800409505 A CN A2007800409505A CN 200780040950 A CN200780040950 A CN 200780040950A CN 101534803 A CN101534803 A CN 101534803A
Authority
CN
China
Prior art keywords
film
thin film
poly
combination
ethylene oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800409505A
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English (en)
Chinese (zh)
Inventor
G·L·迈尔斯
R·C·福兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aquestive Therapeutics Inc
Original Assignee
MonoSol Rx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MonoSol Rx LLC filed Critical MonoSol Rx LLC
Publication of CN101534803A publication Critical patent/CN101534803A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2007800409505A 2006-09-26 2007-09-25 给予含有药物的薄膜产品的方法 Pending CN101534803A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/526,996 US20080050422A1 (en) 2001-10-12 2006-09-26 Method of administering a film product containing a drug
US11/526,996 2006-09-26

Publications (1)

Publication Number Publication Date
CN101534803A true CN101534803A (zh) 2009-09-16

Family

ID=39166452

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800409505A Pending CN101534803A (zh) 2006-09-26 2007-09-25 给予含有药物的薄膜产品的方法

Country Status (7)

Country Link
US (1) US20080050422A1 (https=)
EP (1) EP2079457A2 (https=)
JP (1) JP2010504993A (https=)
CN (1) CN101534803A (https=)
AU (1) AU2007300197A1 (https=)
CA (1) CA2664669A1 (https=)
WO (1) WO2008039737A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102440979A (zh) * 2010-09-30 2012-05-09 迪特克(济源)绿色生物科技有限公司 一种纤维素衍生物复合膜及其制备方法
CN102048711B (zh) * 2009-11-11 2013-06-05 河北奥星集团药业有限公司 一种格拉司琼膜制剂及其制备方法
CN111655242A (zh) * 2018-01-26 2020-09-11 Lts勒曼治疗系统股份公司 多层口服薄膜

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100753959B1 (ko) * 2006-01-12 2007-08-31 에이펫(주) 기판 건조장치를 이용한 기판 건조방법
JP4916894B2 (ja) * 2007-01-11 2012-04-18 株式会社ツキオカ フィルム状製剤及びフィルム状製剤の製造方法
US8323695B2 (en) 2007-08-13 2012-12-04 Mcneil-Ppc, Inc. Method for stabilizing phenylephrine
US8623401B2 (en) * 2008-03-27 2014-01-07 Fenwafe Inc. Wafer formulation
WO2010023874A1 (ja) * 2008-08-25 2010-03-04 救急薬品工業株式会社 ロペラミド塩酸塩含有フィルム製剤
ES2699077T3 (es) 2009-06-12 2019-02-07 Sunovion Pharmaceuticals Inc Apomorfina sublingual
CN102665666A (zh) * 2009-06-30 2012-09-12 陶氏环球技术有限责任公司 含防晒剂的可溶解膜
US12186426B2 (en) 2009-10-30 2025-01-07 Ix Biopharma Ltd. Solid dosage form
DK2493457T3 (en) * 2009-10-30 2017-10-02 Ix Biopharma Ltd QUICK-SOLVING SOLID DOSAGE FORM
CN102892405A (zh) 2009-12-28 2013-01-23 莫诺索尔克斯有限公司 包含昂丹司琼的可经口施用的膜剂型
WO2011081625A1 (en) * 2009-12-30 2011-07-07 Novartis Ag Melt extruded thin strips containing coated pharmaceutical actives
JP6050564B2 (ja) * 2010-03-11 2016-12-21 テイカ製薬株式会社 フィルム状製剤
PT2651357T (pt) 2010-12-16 2020-06-17 Sunovion Pharmaceuticals Inc Películas sublinguais
US11129799B2 (en) 2011-04-12 2021-09-28 Aquestive Therapeutics, Inc. Dual lane coating
US9993422B2 (en) * 2012-04-18 2018-06-12 SpecGx LLC Immediate release, abuse deterrent pharmaceutical compositions
WO2016004170A1 (en) 2014-07-03 2016-01-07 Mallinckrodt Llc Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides
US20160220480A1 (en) * 2015-02-03 2016-08-04 Intelgenx Corp. Oral dosage film exhibiting enhanced mucosal penetration
EP4578461A3 (en) 2015-04-21 2025-09-03 Sumitomo Pharma America, Inc. Methods of treating parkinsons disease by administration of apomorphine to an oral mucosa
JP2018197216A (ja) * 2017-05-24 2018-12-13 株式会社プラスアルファー フィルムシート状栄養剤
JP6842998B2 (ja) * 2017-05-30 2021-03-17 日清ファルマ株式会社 コエンザイムｑ１０フィルム製剤
JP7365409B2 (ja) * 2018-06-28 2023-10-19 エイアールエックス エルエルシー 溶解性単位用量膜構造物を製造するための分配方法
WO2020014776A1 (en) * 2018-07-15 2020-01-23 Rapid Dose Therapeutics Corp. Cannabinoid oral dispersible film strip
EP3856160A4 (en) 2018-09-25 2022-07-06 SpecGx LLC ABUSE-PROOF IMMEDIATE RELEASE CAPSULE DOSAGE FORMS
EP3895692A1 (en) * 2020-04-15 2021-10-20 LTS Lohmann Therapie-Systeme AG Oral thin film with smooth fused film
EP3895691A1 (en) * 2020-04-15 2021-10-20 LTS Lohmann Therapie-Systeme AG Ulipristal acetate otf

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
AU679937B2 (en) * 1992-11-18 1997-07-17 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US7666337B2 (en) * 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
CA2411889A1 (en) * 2001-11-16 2003-05-16 National Starch And Chemical Investment Holding Corporation Films containing starch
AU2002343734A1 (en) * 2001-11-16 2003-06-10 Givaudan Sa Edible film
KR20110004921A (ko) * 2002-05-16 2011-01-14 규큐 야쿠힝 고교 가부시키가이샤 속용성 필름형상 제제
GB0217382D0 (en) * 2002-07-26 2002-09-04 Pfizer Ltd Process for making orally consumable dosage forms
EP2716284A3 (en) * 2003-05-28 2014-11-05 MonoSol RX LLC Polyethylene oxide-based films and drug delivery systems made herefrom
CA2581851C (en) * 2004-09-30 2016-11-01 Monosolrx Llc Multi-layer films having uniform content

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048711B (zh) * 2009-11-11 2013-06-05 河北奥星集团药业有限公司 一种格拉司琼膜制剂及其制备方法
CN102440979A (zh) * 2010-09-30 2012-05-09 迪特克(济源)绿色生物科技有限公司 一种纤维素衍生物复合膜及其制备方法
CN111655242A (zh) * 2018-01-26 2020-09-11 Lts勒曼治疗系统股份公司 多层口服薄膜

Also Published As

Publication number Publication date
CA2664669A1 (en) 2008-04-03
JP2010504993A (ja) 2010-02-18
US20080050422A1 (en) 2008-02-28
AU2007300197A1 (en) 2008-04-03
EP2079457A2 (en) 2009-07-22
WO2008039737A2 (en) 2008-04-03
WO2008039737A3 (en) 2008-05-22

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20090916