CN101522219A - 改变抗体溶液中离子强度以减少乳光/聚集物 - Google Patents

改变抗体溶液中离子强度以减少乳光/聚集物 Download PDF

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Publication number
CN101522219A
CN101522219A CNA2007800368948A CN200780036894A CN101522219A CN 101522219 A CN101522219 A CN 101522219A CN A2007800368948 A CNA2007800368948 A CN A2007800368948A CN 200780036894 A CN200780036894 A CN 200780036894A CN 101522219 A CN101522219 A CN 101522219A
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China
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antibody
preparation
protein
opalescence
salt
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CNA2007800368948A
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English (en)
Chinese (zh)
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P·E·尼科尔斯
D·L·路易西
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Wyeth LLC
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Wyeth LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNA2007800368948A 2006-10-12 2007-10-12 改变抗体溶液中离子强度以减少乳光/聚集物 Pending CN101522219A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85165106P 2006-10-12 2006-10-12
US60/851,651 2006-10-12

Publications (1)

Publication Number Publication Date
CN101522219A true CN101522219A (zh) 2009-09-02

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ID=39205011

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800368948A Pending CN101522219A (zh) 2006-10-12 2007-10-12 改变抗体溶液中离子强度以减少乳光/聚集物

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Country Link
US (1) US7744890B2 (ko)
EP (1) EP2076287A2 (ko)
JP (1) JP2010506839A (ko)
KR (1) KR20090069330A (ko)
CN (1) CN101522219A (ko)
AU (1) AU2007308145A1 (ko)
BR (1) BRPI0719250A2 (ko)
CA (1) CA2665423A1 (ko)
IL (1) IL197778A0 (ko)
MX (1) MX2009003542A (ko)
RU (1) RU2009111138A (ko)
WO (1) WO2008045563A2 (ko)

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CN107236038A (zh) * 2017-06-20 2017-10-10 华兰生物工程股份有限公司 微晶纤维素提高蛋白质澄清度的方法及其产品和应用
CN109661577A (zh) * 2016-08-18 2019-04-19 瑞泽恩制药公司 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定

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JP2010209068A (ja) * 2009-03-11 2010-09-24 Wyeth Llc 小モジュラー免疫薬タンパク質を精製する方法
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JP6027744B2 (ja) * 2009-12-25 2016-11-16 積水メディカル株式会社 ヒトインスリン測定方法及び測定試薬
CN107693791B (zh) * 2010-02-26 2022-06-07 诺沃—诺迪斯克有限公司 包含稳定抗体的组合物
KR101807894B1 (ko) 2010-03-01 2017-12-12 바이엘 헬스케어 엘엘씨 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
AU2011257219B2 (en) 2010-05-28 2014-12-04 Novo Nordisk A/S Stable multi-dose compositions comprising an antibody and a preservative
US9221904B2 (en) 2012-07-19 2015-12-29 National Cheng Kung University Treatment of osteoarthritis using IL-20 antagonists
US8603470B1 (en) 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
US8852588B2 (en) 2012-08-07 2014-10-07 National Cheng Kung University Treating allergic airway disorders using anti-IL-20 receptor antibodies
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
CN108472276B (zh) * 2016-05-19 2021-07-23 长弘生物科技股份有限公司 用于延缓肺纤维化的发病及／或治疗肺纤维化的药剂
JP7233980B2 (ja) * 2019-03-08 2023-03-07 キオクシア株式会社 粒子計測方法及び検出液

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109661577A (zh) * 2016-08-18 2019-04-19 瑞泽恩制药公司 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定
US11428695B2 (en) 2016-08-18 2022-08-30 Regeneron Pharmaceuticals, Inc. Concentration-dependent self-interaction assay
CN109661577B (zh) * 2016-08-18 2022-09-27 瑞泽恩制药公司 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定
US11988668B2 (en) 2016-08-18 2024-05-21 Regeneron Pharmaceuticals, Inc. Concentration-dependent self-interaction assay
CN107236038A (zh) * 2017-06-20 2017-10-10 华兰生物工程股份有限公司 微晶纤维素提高蛋白质澄清度的方法及其产品和应用

Also Published As

Publication number Publication date
BRPI0719250A2 (pt) 2015-06-16
WO2008045563A2 (en) 2008-04-17
EP2076287A2 (en) 2009-07-08
JP2010506839A (ja) 2010-03-04
US7744890B2 (en) 2010-06-29
US20080154023A1 (en) 2008-06-26
CA2665423A1 (en) 2008-04-17
WO2008045563A3 (en) 2008-06-19
IL197778A0 (en) 2011-08-01
RU2009111138A (ru) 2010-11-20
AU2007308145A1 (en) 2008-04-17
MX2009003542A (es) 2009-04-15
KR20090069330A (ko) 2009-06-30
WO2008045563A9 (en) 2008-08-14

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