CN101501024A - 用于治疗疼痛、阿尔茨海默病和精神分裂症的毒蕈碱性受体激动剂 - Google Patents

用于治疗疼痛、阿尔茨海默病和精神分裂症的毒蕈碱性受体激动剂 Download PDF

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Publication number
CN101501024A
CN101501024A CNA2007800294554A CN200780029455A CN101501024A CN 101501024 A CN101501024 A CN 101501024A CN A2007800294554 A CNA2007800294554 A CN A2007800294554A CN 200780029455 A CN200780029455 A CN 200780029455A CN 101501024 A CN101501024 A CN 101501024A
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alkyl
alkoxyl group
heteroaryl
heterocyclylalkyl
cycloalkyl
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Chinese (zh)
Inventor
程云兴
金淑娟
梅尔纳兹·波拉施雷夫
米洛斯劳·托马斯泽夫斯基
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101501024A publication Critical patent/CN101501024A/zh
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D471/08—Bridged systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800294554A 2006-06-09 2007-06-08 用于治疗疼痛、阿尔茨海默病和精神分裂症的毒蕈碱性受体激动剂 Pending CN101501024A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81220806P 2006-06-09 2006-06-09
US60/812,208 2006-06-09

Publications (1)

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CN101501024A true CN101501024A (zh) 2009-08-05

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ID=38801729

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CNA2007800294554A Pending CN101501024A (zh) 2006-06-09 2007-06-08 用于治疗疼痛、阿尔茨海默病和精神分裂症的毒蕈碱性受体激动剂

Country Status (18)

Country Link
US (1) US20100173935A1 (https=)
EP (1) EP2035412A4 (https=)
JP (1) JP2009539833A (https=)
KR (1) KR20090016636A (https=)
CN (1) CN101501024A (https=)
AR (1) AR061306A1 (https=)
AU (1) AU2007256014B2 (https=)
BR (1) BRPI0712415A2 (https=)
CA (1) CA2654147A1 (https=)
EC (1) ECSP088967A (https=)
IL (1) IL195427A0 (https=)
MX (1) MX2008015155A (https=)
NO (1) NO20085271L (https=)
RU (1) RU2008147543A (https=)
TW (1) TW200815405A (https=)
UY (1) UY30393A1 (https=)
WO (1) WO2007142585A1 (https=)
ZA (1) ZA200809976B (https=)

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CN104640851A (zh) * 2012-09-18 2015-05-20 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物

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TW200813018A (en) * 2006-06-09 2008-03-16 Astrazeneca Ab Novel compounds
TW201322983A (zh) * 2007-08-31 2013-06-16 Purdue Pharma Lp 經取代之喹□啉型哌啶化合物及其用途
UY31672A1 (es) * 2008-02-28 2009-09-30 "agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación"
US20090221642A1 (en) * 2008-03-03 2009-09-03 Astrazeneca Ab Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof-176
CN102105465B (zh) 2008-07-21 2015-03-11 普渡制药公司 取代的喹喔啉型桥连哌啶化合物及其用途
GB0817982D0 (en) * 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
WO2012020813A1 (ja) * 2010-08-10 2012-02-16 大日本住友製薬株式会社 縮環ピロリジン誘導体
CN103764641B (zh) 2011-05-06 2016-10-26 扎夫根股份有限公司 部分饱和的三环化合物及其制备和使用方法
JP2015083543A (ja) * 2012-02-14 2015-04-30 大日本住友製薬株式会社 新規縮環ピロリジン誘導体
US20140171466A1 (en) * 2012-08-14 2014-06-19 Regents Of The University Of Minnesota Pain management in sickle cell anemia
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UY31672A1 (es) * 2008-02-28 2009-09-30 "agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación"
US20090221642A1 (en) * 2008-03-03 2009-09-03 Astrazeneca Ab Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof-176
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Cited By (5)

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Publication number Priority date Publication date Assignee Title
CN104640851A (zh) * 2012-09-18 2015-05-20 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物
CN104640851B (zh) * 2012-09-18 2017-05-31 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物
CN107098899A (zh) * 2012-09-18 2017-08-29 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物
US10259802B2 (en) 2012-09-18 2019-04-16 Heptares Therapeutics Limited Bicyclic aza compounds as muscarinic M1 receptor antagonists
CN107098899B (zh) * 2012-09-18 2019-09-06 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物

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EP2035412A1 (en) 2009-03-18
KR20090016636A (ko) 2009-02-16
RU2008147543A (ru) 2010-07-20
WO2007142585A1 (en) 2007-12-13
NO20085271L (no) 2009-01-06
AR061306A1 (es) 2008-08-20
CA2654147A1 (en) 2007-12-13
AU2007256014A1 (en) 2007-12-13
ZA200809976B (en) 2011-04-28
UY30393A1 (es) 2009-04-30
MX2008015155A (es) 2008-12-12
US20100173935A1 (en) 2010-07-08
AU2007256014B2 (en) 2011-06-30
JP2009539833A (ja) 2009-11-19
IL195427A0 (en) 2009-08-03
ECSP088967A (es) 2009-01-30
TW200815405A (en) 2008-04-01
BRPI0712415A2 (pt) 2012-09-04
EP2035412A4 (en) 2011-02-16

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