CN101479250B - 四唑取代的芳基酰胺类 - Google Patents
四唑取代的芳基酰胺类 Download PDFInfo
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- CN101479250B CN101479250B CN2007800241415A CN200780024141A CN101479250B CN 101479250 B CN101479250 B CN 101479250B CN 2007800241415 A CN2007800241415 A CN 2007800241415A CN 200780024141 A CN200780024141 A CN 200780024141A CN 101479250 B CN101479250 B CN 101479250B
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- methyl
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- tetrazol
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- biphenyl
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- 0 C[C@](*)NC(c1cc(-[n]2nnnc2*)cc(C2=CC=C(C)C=*=C2)c1)=O Chemical compound C[C@](*)NC(c1cc(-[n]2nnnc2*)cc(C2=CC=C(C)C=*=C2)c1)=O 0.000 description 4
- VJWXJLPFRFVDKA-UHFFFAOYSA-N CC(C)C(Nc1cc(-c(nc2)ccc2Cl)cc(C(OC)=O)c1)=O Chemical compound CC(C)C(Nc1cc(-c(nc2)ccc2Cl)cc(C(OC)=O)c1)=O VJWXJLPFRFVDKA-UHFFFAOYSA-N 0.000 description 1
- JIOVBBWGOIGBJI-UHFFFAOYSA-N CC(C)c1nnn[n]1-c1cc(-c(nc2)ccc2Cl)cc(C(OC)=O)c1 Chemical compound CC(C)c1nnn[n]1-c1cc(-c(nc2)ccc2Cl)cc(C(OC)=O)c1 JIOVBBWGOIGBJI-UHFFFAOYSA-N 0.000 description 1
- IPYYWXRGBBYBNO-UHFFFAOYSA-N CC(C)c1nnn[n]1-c1cc(C(NCc2cnc(C)cn2)=O)cc(-c(nc2)ccc2Cl)c1 Chemical compound CC(C)c1nnn[n]1-c1cc(C(NCc2cnc(C)cn2)=O)cc(-c(nc2)ccc2Cl)c1 IPYYWXRGBBYBNO-UHFFFAOYSA-N 0.000 description 1
- DKUHRMQFVUOLMW-UHFFFAOYSA-N CC(C)c1nnn[n]1-c1cc(C(O)=O)cc(-c(nc2)ccc2Cl)c1 Chemical compound CC(C)c1nnn[n]1-c1cc(C(O)=O)cc(-c(nc2)ccc2Cl)c1 DKUHRMQFVUOLMW-UHFFFAOYSA-N 0.000 description 1
- LMCNHPBNHZCIII-UHFFFAOYSA-N COC(c1cc(N)cc(-c(nc2)ccc2Cl)c1)=O Chemical compound COC(c1cc(N)cc(-c(nc2)ccc2Cl)c1)=O LMCNHPBNHZCIII-UHFFFAOYSA-N 0.000 description 1
- MPBCUCGKHDEUDD-UHFFFAOYSA-N Cc1ncc(CN)nc1 Chemical compound Cc1ncc(CN)nc1 MPBCUCGKHDEUDD-UHFFFAOYSA-N 0.000 description 1
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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| CN108137566A (zh) * | 2015-10-06 | 2018-06-08 | 豪夫迈·罗氏有限公司 | 三唑衍生物 |
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| AU2013273626B2 (en) * | 2007-12-17 | 2016-04-28 | F.Hoffmann-La Roche Ag | Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists |
| EP2570407B1 (en) * | 2007-12-17 | 2014-08-13 | F. Hoffmann-La Roche AG | Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists |
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| CA2755680A1 (en) | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
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| WO2010149634A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel indole, indazole and benzimidazole arylamides as p2x3 and/or p2x2/3 antagonists |
| SG177308A1 (en) * | 2009-06-22 | 2012-02-28 | Hoffmann La Roche | Novel biphenyl and phenyl-pyridine amides |
| ES2593405T3 (es) | 2009-06-22 | 2016-12-09 | F. Hoffmann-La Roche Ag | Nuevas arilamidas sustituidas por benzoxazolona |
| US9045445B2 (en) * | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| EP3381917B1 (en) * | 2013-01-31 | 2021-09-08 | Bellus Health Cough Inc. | Imidazopyridine compounds and uses thereof |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| HRP20211002T1 (hr) | 2014-12-09 | 2021-09-17 | Bayer Aktiengesellschaft | 1,3-tiazol-2-il supstituirani benzamidi |
| JP6518789B2 (ja) * | 2015-04-23 | 2019-05-22 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 精神障害の処置において使用するためのテトラゾール誘導体 |
| JP6877359B2 (ja) * | 2015-06-04 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | イミダゾール誘導体 |
| EP3411365B1 (en) | 2016-02-02 | 2019-11-20 | H. Hoffnabb-La Roche Ag | Pyrazol-pyridine derivatives as eaat3 inhibitors |
| TWI696615B (zh) * | 2016-05-05 | 2020-06-21 | 瑞士商伊蘭科動物健康公司 | 雜芳基-1,2,4-三唑及雜芳基-三唑化合物 |
| WO2017202896A1 (en) | 2016-05-27 | 2017-11-30 | F. Hoffmann-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
| WO2018069362A1 (en) | 2016-10-14 | 2018-04-19 | F. Hoffmann-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
| TWI741040B (zh) * | 2016-10-20 | 2021-10-01 | 德商拜耳作物科學公司 | 製備3-烷基硫基-2-氯-n-(1-烷基-1h-四唑-5-基)-4-三氟甲基苯甲醯胺之方法 |
| RU2650780C1 (ru) | 2016-12-06 | 2018-04-17 | Общество с ограниченной ответственностью "Анальгетики будущего" | Пептидный модулятор пуринергических рецепторов |
| EP3976609A1 (en) | 2019-05-31 | 2022-04-06 | Chiesi Farmaceutici S.p.A. | Pyridopyrimidines derivatives as p2x3 inhibitors |
| AU2020285336A1 (en) | 2019-05-31 | 2022-01-06 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as P2X3 inhibitors |
| ES3026309T3 (en) | 2020-11-27 | 2025-06-11 | Chiesi Farm Spa | Amino quinazoline derivatives as p2x3 inhibitors |
| KR20230113536A (ko) | 2020-11-27 | 2023-07-31 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 (아자)퀴놀린 4-아민 유도체 |
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| US20070037974A1 (en) * | 2005-08-15 | 2007-02-15 | Roche Palo Alto Llc | Inhibitors of P2X3 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108137566A (zh) * | 2015-10-06 | 2018-06-08 | 豪夫迈·罗氏有限公司 | 三唑衍生物 |
| CN108137566B (zh) * | 2015-10-06 | 2021-05-25 | 豪夫迈·罗氏有限公司 | 三唑衍生物 |
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