CN101426815A - 具有表皮生长因子受体和/或血管内皮生长因子结合特异性的配体及其使用方法 - Google Patents
具有表皮生长因子受体和/或血管内皮生长因子结合特异性的配体及其使用方法 Download PDFInfo
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- CN101426815A CN101426815A CNA200680052392XA CN200680052392A CN101426815A CN 101426815 A CN101426815 A CN 101426815A CN A200680052392X A CNA200680052392X A CN A200680052392XA CN 200680052392 A CN200680052392 A CN 200680052392A CN 101426815 A CN101426815 A CN 101426815A
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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| CN101426815A true CN101426815A (zh) | 2009-05-06 |
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| CNA200680052392XA Pending CN101426815A (zh) | 2005-12-06 | 2006-12-05 | 具有表皮生长因子受体和/或血管内皮生长因子结合特异性的配体及其使用方法 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105175546A (zh) * | 2015-05-27 | 2015-12-23 | 连祺周 | 人血管内皮生长因子与表皮生长因子样结构域7的融合蛋白 |
| CN105814082A (zh) * | 2013-09-26 | 2016-07-27 | 埃博灵克斯股份有限公司 | 双特异性纳米抗体 |
| CN109134611A (zh) * | 2018-08-14 | 2019-01-04 | 江苏大学 | 特异性结合egfr抑制egf促肿瘤细胞增殖的多肽 |
| CN111732662A (zh) * | 2020-06-11 | 2020-10-02 | 军事科学院军事医学研究院军事兽医研究所 | 抗H5N1病毒入胞抗体PTD-7B-mFc及其应用 |
| CN112566932A (zh) * | 2018-06-05 | 2021-03-26 | 诺沃班德畜牧业治疗公司 | 抗水产养殖病原体的抗体及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| NZ540196A (en) | 2002-11-08 | 2008-09-26 | Ablynx Nv | Camelidae antibodies against imminoglobulin E and use thereof for the treatment of allergic disorders |
| US20100003253A1 (en) * | 2002-11-08 | 2010-01-07 | Ablynx N.V. | Single domain antibodies directed against epidermal growth factor receptor and uses therefor |
| AR069979A1 (es) * | 2007-12-26 | 2010-03-03 | Biotest Ag | Metodo para disminuir los efectos secundarios citotoxicos y mejorar la eficacia de los inmunoconjugados |
| WO2009080829A1 (en) | 2007-12-26 | 2009-07-02 | Biotest Ag | Agents targeting cd138 and uses thereof |
| MX2010007102A (es) * | 2007-12-26 | 2011-07-01 | Biotest Ag | Inmunoconjugados dirigidos contra cd138 y sus usos. |
| US9446146B2 (en) * | 2007-12-26 | 2016-09-20 | Biotest Ag | Methods and agents for improving targeting of CD138 expressing tumor cells |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| WO2009088805A2 (en) | 2008-01-03 | 2009-07-16 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US9198952B2 (en) | 2008-09-22 | 2015-12-01 | The Brigham And Women's Hospital, Inc. | Compositions of and methods of using ligand dimers |
| US20110257373A1 (en) * | 2008-10-21 | 2011-10-20 | Rudolf Maria De Wildt | Ligands that have binding specificity for dc-sign |
| EP3330287B1 (en) * | 2009-02-19 | 2019-12-18 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| CA2761120A1 (en) * | 2009-05-06 | 2010-11-11 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
| AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| EP2555788B1 (en) | 2010-03-24 | 2017-10-11 | Massachusetts Institute of Technology | NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY. |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| ES2704038T3 (es) | 2011-05-24 | 2019-03-13 | Zyngenia Inc | Complejos multiespecíficos multivalentes y monovalentes y sus usos |
| KR20140100571A (ko) | 2011-12-08 | 2014-08-14 | 바이오테스트 아게 | Cd138을 타겟팅하는 면역접합체의 용도 |
| JP6154895B2 (ja) * | 2012-06-07 | 2017-06-28 | デューク ユニバーシティー | ヒト二重特異性EGFRvIII抗体結合分子 |
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| US10150800B2 (en) | 2013-03-15 | 2018-12-11 | Zyngenia, Inc. | EGFR-binding modular recognition domains |
| WO2017081211A2 (en) * | 2015-11-10 | 2017-05-18 | University Medical Center Hamburg - Eppendorf | Antigen-binding polypeptides directed against cd38 |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| WO2017223111A1 (en) | 2016-06-21 | 2017-12-28 | Teneobio, Inc. | Cd3 binding antibodies |
| MY200988A (en) | 2016-09-14 | 2024-01-27 | Teneobio Inc | CD3 Binding Antibodies |
| EP3515494A4 (en) | 2016-09-26 | 2020-10-07 | The Brigham and Women's Hospital, Inc. | REGULATORS OF B-LYMPHOCYTES MEDIA IMMUNOSUPPRESSION |
| CN109789183A (zh) * | 2016-09-29 | 2019-05-21 | Aebi有限公司 | 治疗性多靶向构建体及其用途 |
| EP3559035A1 (en) | 2016-12-21 | 2019-10-30 | TeneoBio, Inc. | Anti-bcma heavy chain-only antibodies |
| CN118146370A (zh) | 2017-06-20 | 2024-06-07 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
| CA3067584A1 (en) | 2017-06-20 | 2018-12-27 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
| WO2019035938A1 (en) * | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| RU2020112490A (ru) * | 2017-09-13 | 2021-10-13 | Тенеобио, Инк. | Антитела из тяжелых цепей, связывающиеся с эктоферментами |
| EP3870611A1 (en) * | 2018-10-26 | 2021-09-01 | TeneoBio, Inc. | Heavy chain antibodies binding to cd38 |
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| EA202192736A1 (ru) | 2019-04-05 | 2022-01-27 | Тенеобио, Инк. | Антитела, содержащие только тяжелые цепи, которые связываются с псма |
| PH12021553145A1 (en) | 2019-06-14 | 2022-07-25 | Teneobio Inc | Multispecific heavy chain antibodies binding to cd22 and cd3 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2135879A3 (en) * | 2002-06-28 | 2010-06-23 | Domantis Limited | Ligand |
| CA2501818C (en) * | 2002-10-10 | 2012-03-27 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Pharmaceutical compositions directed to erb-b1 receptors |
| US20060228355A1 (en) * | 2003-11-07 | 2006-10-12 | Toon Laeremans | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
| GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| MX2007011064A (es) * | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
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- 2006-12-05 CN CNA2006800523775A patent/CN101379088A/zh active Pending
- 2006-12-05 AU AU2006323415A patent/AU2006323415A1/en not_active Abandoned
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- 2006-12-05 US US12/086,115 patent/US20100021473A1/en not_active Abandoned
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- 2008-06-02 MA MA30989A patent/MA30020B1/fr unknown
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105814082A (zh) * | 2013-09-26 | 2016-07-27 | 埃博灵克斯股份有限公司 | 双特异性纳米抗体 |
| CN105175546A (zh) * | 2015-05-27 | 2015-12-23 | 连祺周 | 人血管内皮生长因子与表皮生长因子样结构域7的融合蛋白 |
| CN112566932A (zh) * | 2018-06-05 | 2021-03-26 | 诺沃班德畜牧业治疗公司 | 抗水产养殖病原体的抗体及其用途 |
| CN109134611A (zh) * | 2018-08-14 | 2019-01-04 | 江苏大学 | 特异性结合egfr抑制egf促肿瘤细胞增殖的多肽 |
| CN111732662A (zh) * | 2020-06-11 | 2020-10-02 | 军事科学院军事医学研究院军事兽医研究所 | 抗H5N1病毒入胞抗体PTD-7B-mFc及其应用 |
| CN111732662B (zh) * | 2020-06-11 | 2023-09-15 | 军事科学院军事医学研究院军事兽医研究所 | 抗H5N1病毒入胞抗体PTD-7B-mFc及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EA200801171A1 (ru) | 2008-12-30 |
| WO2007066109A8 (en) | 2008-07-17 |
| CA2632424A1 (en) | 2007-06-14 |
| CN101379088A (zh) | 2009-03-04 |
| AU2006323415A1 (en) | 2007-06-14 |
| US20100021473A1 (en) | 2010-01-28 |
| ZA200804307B (en) | 2009-09-30 |
| CR10100A (es) | 2008-08-21 |
| TW200738750A (en) | 2007-10-16 |
| KR20080090414A (ko) | 2008-10-08 |
| EP1963370A1 (en) | 2008-09-03 |
| BRPI0619460A2 (pt) | 2011-11-08 |
| MA30020B1 (fr) | 2008-12-01 |
| WO2007066109A1 (en) | 2007-06-14 |
| JP2009518025A (ja) | 2009-05-07 |
| NO20082381L (no) | 2008-08-26 |
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