EA200801171A1 - Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения - Google Patents

Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения

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Publication number
EA200801171A1
EA200801171A1 EA200801171A EA200801171A EA200801171A1 EA 200801171 A1 EA200801171 A1 EA 200801171A1 EA 200801171 A EA200801171 A EA 200801171A EA 200801171 A EA200801171 A EA 200801171A EA 200801171 A1 EA200801171 A1 EA 200801171A1
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EA
Eurasian Patent Office
Prior art keywords
binding
methods
ligands
surface cell
cell targets
Prior art date
Application number
EA200801171A
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English (en)
Inventor
Елена Де Анджелис
Стив Холмс
Айан М. Томлинсон
Эрик Йи-чун Хуанг
Люси Дж. Холт
Клэр И. Эверетт
Original Assignee
Домантис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Домантис Лимитед filed Critical Домантис Лимитед
Publication of EA200801171A1 publication Critical patent/EA200801171A1/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

Раскрыты лиганды, содержащие первый полипептидный домен, имеющий связывающий участок со специфичностью связывания с первой поверхностной клеточной мишенью, и второй полипептидный домен, имеющий связывающий участок со специфичностью связывания со второй поверхностной клеточной мишенью, где каждая мишень отличается от другой, и они находятся на одной и той же клетке. В некоторых воплощениях указанные лиганды далее содержат токсин. В других воплощениях указанные лиганды дополнительно содержат группировки, удлиняющие период полувыведения. Также раскрыты способы применения указанных лигандов. В частности, описано применение указанных лигандов для лечения рака.
EA200801171A 2005-12-06 2006-12-05 Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения EA200801171A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74299205P 2005-12-06 2005-12-06
PCT/GB2006/004565 WO2007066109A1 (en) 2005-12-06 2006-12-05 Bispecific ligands with binding specificity to cell surface targets and methods of use therefor

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EA200801171A1 true EA200801171A1 (ru) 2008-12-30

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EA200801171A EA200801171A1 (ru) 2005-12-06 2006-12-05 Биспецифичные лиганды, обладающие специфичностью связывания с поверхностными клеточными мишенями, и способы их применения

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Country Link
US (1) US20100021473A1 (ru)
EP (1) EP1963370A1 (ru)
JP (1) JP2009518025A (ru)
KR (1) KR20080090414A (ru)
CN (2) CN101426815A (ru)
AU (1) AU2006323415A1 (ru)
BR (1) BRPI0619460A2 (ru)
CA (1) CA2632424A1 (ru)
CR (1) CR10100A (ru)
EA (1) EA200801171A1 (ru)
MA (1) MA30020B1 (ru)
NO (1) NO20082381L (ru)
TW (1) TW200738750A (ru)
WO (1) WO2007066109A1 (ru)
ZA (1) ZA200804307B (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519763A (ja) 2002-11-08 2006-08-31 アブリンクス エン．ヴェー． 治療用ポリペプチドの投与法およびそのためのポリペプチド
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
US20060034845A1 (en) 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
JP5817034B2 (ja) 2007-12-26 2015-11-18 バイオテスト・アクチエンゲゼルシヤフト Ｃｄ１３８を標的とする免疫複合体及びその使用
JP2011507933A (ja) * 2007-12-26 2011-03-10 バイオテスト・アクチエンゲゼルシヤフト 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法
AR069978A1 (es) * 2007-12-26 2010-03-03 Dana Farber Cancer Inst Inc Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd 138
EP2238168B8 (en) * 2007-12-26 2014-07-23 Biotest AG Agents targeting cd138 and uses thereof
CA2711256C (en) 2008-01-03 2019-01-15 The Scripps Research Institute Antibody targeting through a modular recognition domain
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US9198952B2 (en) 2008-09-22 2015-12-01 The Brigham And Women's Hospital, Inc. Compositions of and methods of using ligand dimers
MX2011004244A (es) * 2008-10-21 2011-05-25 Domantis Ltd Ligandos que tienen especificidad de enlace para dc-sign.
CA3079184A1 (en) * 2009-02-19 2010-08-26 Glaxo Group Limited Improved anti-serum albumin binding variants
AU2013201618B2 (en) * 2009-05-06 2016-06-02 Biotest Ag Uses of immunoconjugates targeting CD138
BRPI1013990A2 (pt) 2009-05-06 2019-04-30 Biotest Ag método para tratar uma doença , e, combinação anticâncer
EP2555788B1 (en) 2010-03-24 2017-10-11 Massachusetts Institute of Technology NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY.
WO2012009705A1 (en) 2010-07-15 2012-01-19 Zyngenia, Inc. Ang-2 binding complexes and uses thereof
WO2012162561A2 (en) 2011-05-24 2012-11-29 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
KR20140100571A (ko) 2011-12-08 2014-08-14 바이오테스트 아게 Ｃｄ１３８을 타겟팅하는 면역접합체의 용도
WO2013185010A1 (en) * 2012-06-07 2013-12-12 Duke University HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES
TWI660972B (zh) * 2012-09-10 2019-06-01 愛爾蘭商尼歐托普生物科學公司 抗ｍｃａｍ抗體及相關使用方法
ITFI20120257A1 (it) * 2012-11-26 2014-05-27 Maria Barbara Carnemolla Anticorpo ricombinante umano e suo uso per l¿identificazione di syndecano-1 (cd-138) per scopi diagnostici e terapeutici.
CA2907181C (en) 2013-03-15 2023-10-17 Viktor Roschke Multivalent and monovalent multispecific complexes and their uses
EP3049439B1 (en) 2013-09-26 2019-12-25 Ablynx N.V. Bispecific nanobodies
CN105175546A (zh) * 2015-05-27 2015-12-23 连祺周 人血管内皮生长因子与表皮生长因子样结构域7的融合蛋白
CA3004792A1 (en) * 2015-11-10 2017-05-18 University Medical Center Hamburg - Eppendorf Antigen-binding polypeptides directed against cd38
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
EP3471773A4 (en) 2016-06-21 2020-07-08 Teneobio, Inc. ANTIBODIES BINDING CD3
JP7030109B2 (ja) 2016-09-14 2022-03-04 テネオバイオ， インコーポレイテッド Ｃｄ３結合抗体
US11739163B2 (en) 2016-09-29 2023-08-29 Aebi Ltd. Therapeutic multi-targeting constructs and uses thereof
WO2018119215A1 (en) 2016-12-21 2018-06-28 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
EP3642236A1 (en) 2017-06-20 2020-04-29 TeneoOne, Inc. Anti-bcma heavy chain-only antibodies
EP3642237A2 (en) 2017-06-20 2020-04-29 Teneobio, Inc. Anti-bcma heavy chain-only antibodies
WO2019035938A1 (en) * 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
SG11202002093TA (en) * 2017-09-13 2020-04-29 Teneobio Inc Heavy chain antibodies binding to ectoenzymes
CA3102039A1 (en) * 2018-06-05 2020-01-09 Novobind Livestock Therapeutics Inc. Antibodies against aquaculture disease-causing agents and uses thereof
CN109134611B (zh) * 2018-08-14 2021-08-03 江苏大学 特异性结合egfr抑制egf促肿瘤细胞增殖的多肽
US20210388106A1 (en) * 2018-10-26 2021-12-16 Teneobio, Inc. Heavy chain antibodies binding to cd38
AU2019376632A1 (en) * 2018-11-05 2021-06-17 Xyphos Biosciences Inc. Non-natural NKG2D receptors that do not directly signal the cells to which they are attached
AR119746A1 (es) 2019-06-14 2022-01-05 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
CN111732662B (zh) * 2020-06-11 2023-09-15 军事科学院军事医学研究院军事兽医研究所 抗H5N1病毒入胞抗体PTD-7B-mFc及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366718A3 (en) * 2002-06-28 2012-05-02 Domantis Limited Ligand
EP1549345A1 (en) * 2002-10-10 2005-07-06 MERCK PATENT GmbH Bispecific anti-erb-b antibodies and their use in tumor therapy
GB0230203D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
ATE485307T1 (de) * 2003-11-07 2010-11-15 Ablynx Nv Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung
EP2535355B1 (en) * 2005-03-23 2019-01-02 Genmab A/S Antibodies against CD38 for treatment of multiple myeloma

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