ZA200804307B - Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor - Google Patents
Ligands that have binding specificity for EGFR and/or VEGF and methods of use thereforInfo
- Publication number
- ZA200804307B ZA200804307B ZA200804307A ZA200804307A ZA200804307B ZA 200804307 B ZA200804307 B ZA 200804307B ZA 200804307 A ZA200804307 A ZA 200804307A ZA 200804307 A ZA200804307 A ZA 200804307A ZA 200804307 B ZA200804307 B ZA 200804307B
- Authority
- ZA
- South Africa
- Prior art keywords
- egfr
- vegf
- ligands
- methods
- binding specificity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74299205P | 2005-12-06 | 2005-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200804307B true ZA200804307B (en) | 2009-09-30 |
Family
ID=37820651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200804307A ZA200804307B (en) | 2005-12-06 | 2008-05-19 | Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100021473A1 (ru) |
EP (1) | EP1963370A1 (ru) |
JP (1) | JP2009518025A (ru) |
KR (1) | KR20080090414A (ru) |
CN (2) | CN101426815A (ru) |
AU (1) | AU2006323415A1 (ru) |
BR (1) | BRPI0619460A2 (ru) |
CA (1) | CA2632424A1 (ru) |
CR (1) | CR10100A (ru) |
EA (1) | EA200801171A1 (ru) |
MA (1) | MA30020B1 (ru) |
NO (1) | NO20082381L (ru) |
TW (1) | TW200738750A (ru) |
WO (1) | WO2007066109A1 (ru) |
ZA (1) | ZA200804307B (ru) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
WO2004041865A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Stabilized single domain antibodies |
US20100003253A1 (en) * | 2002-11-08 | 2010-01-07 | Ablynx N.V. | Single domain antibodies directed against epidermal growth factor receptor and uses therefor |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
JP5990365B2 (ja) * | 2007-12-26 | 2016-09-14 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする剤及びその使用 |
MX2010007101A (es) * | 2007-12-26 | 2011-07-01 | Biotest Ag | Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd138. |
JP5817034B2 (ja) | 2007-12-26 | 2015-11-18 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする免疫複合体及びその使用 |
WO2009080831A1 (en) * | 2007-12-26 | 2009-07-02 | Biotest Ag | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
NZ586701A (en) | 2008-01-03 | 2013-07-26 | Scripps Research Inst | Antibody targeting through a modular recognition domain (MRD) wherein the MRD targets angiopoietin-2 (ANG-2) |
US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
WO2010033249A2 (en) * | 2008-09-22 | 2010-03-25 | Massachusetts Institute Of Technology | Compositions of and methods using ligand dimers |
CN102257009A (zh) * | 2008-10-21 | 2011-11-23 | 杜门蒂斯有限公司 | 具有针对dc-sign的结合特异性的配体 |
MX2011008749A (es) * | 2009-02-19 | 2011-09-06 | Glaxo Group Ltd | Variantes de union a anti-albumina de suero mejoradas. |
AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
NZ596807A (en) * | 2009-05-06 | 2013-09-27 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
WO2011119836A1 (en) | 2010-03-24 | 2011-09-29 | Massachusetts Institute Of Technology | Methods and compositions for cardioprotection and cardioregeneration |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
CN106432506A (zh) | 2011-05-24 | 2017-02-22 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
MX358680B (es) | 2011-12-08 | 2018-08-31 | Biotest Ag | Usos de inmunoconjugados dirigidos a cd138. |
AU2013271428B2 (en) * | 2012-06-07 | 2016-08-04 | Duke University | Human bispecific EGFRvIII antibody engaging molecules |
TWI595007B (zh) * | 2012-09-10 | 2017-08-11 | Neotope Biosciences Ltd | 抗mcam抗體及相關使用方法 |
ITFI20120257A1 (it) * | 2012-11-26 | 2014-05-27 | Maria Barbara Carnemolla | Anticorpo ricombinante umano e suo uso per l¿identificazione di syndecano-1 (cd-138) per scopi diagnostici e terapeutici. |
EA201890895A1 (ru) | 2013-03-15 | 2019-02-28 | Зинджения, Инк. | Мультивалентные и моновалентные мультиспецифические комплексы и их применение |
EP3049439B1 (en) | 2013-09-26 | 2019-12-25 | Ablynx N.V. | Bispecific nanobodies |
CN105175546A (zh) * | 2015-05-27 | 2015-12-23 | 连祺周 | 人血管内皮生长因子与表皮生长因子样结构域7的融合蛋白 |
CA3004792A1 (en) | 2015-11-10 | 2017-05-18 | University Medical Center Hamburg - Eppendorf | Antigen-binding polypeptides directed against cd38 |
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JP7030109B2 (ja) | 2016-09-14 | 2022-03-04 | テネオバイオ, インコーポレイテッド | Cd3結合抗体 |
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EP4215548A1 (en) | 2016-12-21 | 2023-07-26 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
AU2018288803A1 (en) | 2017-06-20 | 2020-02-06 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
EP3642237A2 (en) | 2017-06-20 | 2020-04-29 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
WO2019035938A1 (en) * | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
SG11202002093TA (en) * | 2017-09-13 | 2020-04-29 | Teneobio Inc | Heavy chain antibodies binding to ectoenzymes |
CN112566932A (zh) * | 2018-06-05 | 2021-03-26 | 诺沃班德畜牧业治疗公司 | 抗水产养殖病原体的抗体及其用途 |
CN109134611B (zh) * | 2018-08-14 | 2021-08-03 | 江苏大学 | 特异性结合egfr抑制egf促肿瘤细胞增殖的多肽 |
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DE60305919T2 (de) * | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
HUE025086T2 (en) * | 2002-10-10 | 2016-02-29 | Merck Patent Gmbh | Pharmaceutical preparations for ERB-B1 receptor |
GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
EP2251357A1 (en) * | 2003-11-07 | 2010-11-17 | Ablynx N.V. | Camelidae single domain antibodies VHH directed against epidermal growth factor receptor and uses therefor |
CN112480257A (zh) * | 2005-03-23 | 2021-03-12 | 根马布股份公司 | 用于治疗多发性骨髓瘤的cd38抗体 |
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- 2006-12-05 BR BRPI0619460-5A patent/BRPI0619460A2/pt not_active IP Right Cessation
- 2006-12-05 CN CNA200680052392XA patent/CN101426815A/zh active Pending
- 2006-12-05 EP EP06808727A patent/EP1963370A1/en not_active Withdrawn
- 2006-12-05 AU AU2006323415A patent/AU2006323415A1/en not_active Abandoned
- 2006-12-05 CA CA002632424A patent/CA2632424A1/en not_active Abandoned
- 2006-12-05 EA EA200801171A patent/EA200801171A1/ru unknown
- 2006-12-05 CN CNA2006800523775A patent/CN101379088A/zh active Pending
- 2006-12-05 JP JP2008543894A patent/JP2009518025A/ja active Pending
- 2006-12-05 KR KR1020087016535A patent/KR20080090414A/ko not_active Application Discontinuation
- 2006-12-05 TW TW095145117A patent/TW200738750A/zh unknown
- 2006-12-05 US US12/086,115 patent/US20100021473A1/en not_active Abandoned
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- 2008-06-02 MA MA30989A patent/MA30020B1/fr unknown
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CR10100A (es) | 2008-08-21 |
JP2009518025A (ja) | 2009-05-07 |
KR20080090414A (ko) | 2008-10-08 |
CN101379088A (zh) | 2009-03-04 |
WO2007066109A8 (en) | 2008-07-17 |
TW200738750A (en) | 2007-10-16 |
US20100021473A1 (en) | 2010-01-28 |
WO2007066109A1 (en) | 2007-06-14 |
BRPI0619460A2 (pt) | 2011-11-08 |
CN101426815A (zh) | 2009-05-06 |
CA2632424A1 (en) | 2007-06-14 |
AU2006323415A1 (en) | 2007-06-14 |
EP1963370A1 (en) | 2008-09-03 |
NO20082381L (no) | 2008-08-26 |
EA200801171A1 (ru) | 2008-12-30 |
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