ATE530577T1 - Epha2 agonistische monoklonale antikörper und deren anwendungsverfahren - Google Patents
Epha2 agonistische monoklonale antikörper und deren anwendungsverfahrenInfo
- Publication number
- ATE530577T1 ATE530577T1 AT03784738T AT03784738T ATE530577T1 AT E530577 T1 ATE530577 T1 AT E530577T1 AT 03784738 T AT03784738 T AT 03784738T AT 03784738 T AT03784738 T AT 03784738T AT E530577 T1 ATE530577 T1 AT E530577T1
- Authority
- AT
- Austria
- Prior art keywords
- epha2
- methods
- cancer
- antibodies
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37936802P | 2002-05-10 | 2002-05-10 | |
US41820402P | 2002-10-14 | 2002-10-14 | |
US46035803P | 2003-04-03 | 2003-04-03 | |
PCT/US2003/015046 WO2004014292A2 (en) | 2002-05-10 | 2003-05-12 | EphA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE530577T1 true ATE530577T1 (de) | 2011-11-15 |
Family
ID=31721472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03784738T ATE530577T1 (de) | 2002-05-10 | 2003-05-12 | Epha2 agonistische monoklonale antikörper und deren anwendungsverfahren |
Country Status (8)
Country | Link |
---|---|
US (3) | US20040091486A1 (de) |
EP (1) | EP1575509B1 (de) |
JP (1) | JP4585968B2 (de) |
AT (1) | ATE530577T1 (de) |
AU (2) | AU2003276832A1 (de) |
CA (1) | CA2485548A1 (de) |
ES (1) | ES2377720T3 (de) |
WO (1) | WO2004014292A2 (de) |
Families Citing this family (57)
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US6864227B1 (en) | 1998-04-13 | 2005-03-08 | California Institute Of Technology | Artery-and vein-specific proteins and uses therefor |
US7192698B1 (en) * | 1999-08-17 | 2007-03-20 | Purdue Research Foundation | EphA2 as a diagnostic target for metastatic cancer |
US6927203B1 (en) | 1999-08-17 | 2005-08-09 | Purdue Research Foundation | Treatment of metastatic disease |
US7101976B1 (en) | 2000-09-12 | 2006-09-05 | Purdue Research Foundation | EphA2 monoclonal antibodies and methods of making and using same |
US20050152899A1 (en) * | 2002-05-10 | 2005-07-14 | Kinch Michael S. | EphA2 agonistic monoclonal antibodies and methods of use thereof |
WO2004014292A2 (en) * | 2002-05-10 | 2004-02-19 | Purdue Research Foundation | EphA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF |
JP4557714B2 (ja) * | 2002-05-10 | 2010-10-06 | メディミューン,エルエルシー | EphA2モノクローナル抗体およびその使用法 |
AU2004293034B2 (en) * | 2002-05-10 | 2012-02-02 | Medimmune, Llc | EphA2 agonistic monoclonal antibodies and methods of use thereof |
JP2006501153A (ja) * | 2002-05-23 | 2006-01-12 | パーデュー・リサーチ・ファウンデーション | 診断及び治療用標的としての低分子量タンパク質チロシンホスファターゼ(lmw−ptp) |
AU2004220459B2 (en) | 2003-03-12 | 2010-08-05 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
US7381410B2 (en) | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
WO2004091375A2 (en) * | 2003-04-11 | 2004-10-28 | Medimmune, Inc. | Epha2 and non-neoplastic hyperproliferative cell disorders |
KR101224235B1 (ko) * | 2003-04-11 | 2013-01-25 | 메디뮨 엘엘씨 | 재조합 il9 항체 및 그의 용도 |
EP1628992A4 (de) | 2003-05-13 | 2008-04-16 | Novartis Vaccines & Diagnostic | Verfahren zur modulation der metastasierung sowie von metastasen herrührender verwandter ereignisse im skelett |
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US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
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-
2003
- 2003-05-12 WO PCT/US2003/015046 patent/WO2004014292A2/en active Application Filing
- 2003-05-12 EP EP03784738A patent/EP1575509B1/de not_active Expired - Lifetime
- 2003-05-12 US US10/436,783 patent/US20040091486A1/en not_active Abandoned
- 2003-05-12 AU AU2003276832A patent/AU2003276832A1/en not_active Abandoned
- 2003-05-12 CA CA002485548A patent/CA2485548A1/en not_active Abandoned
- 2003-05-12 ES ES03784738T patent/ES2377720T3/es not_active Expired - Lifetime
- 2003-05-12 AT AT03784738T patent/ATE530577T1/de not_active IP Right Cessation
- 2003-05-12 JP JP2005506130A patent/JP4585968B2/ja not_active Expired - Fee Related
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2006
- 2006-10-06 US US11/544,332 patent/US20070086943A1/en not_active Abandoned
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2009
- 2009-11-24 AU AU2009239780A patent/AU2009239780B2/en not_active Ceased
- 2009-11-25 US US12/626,016 patent/US20100298545A1/en not_active Abandoned
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AU2009239780B2 (en) | 2011-03-17 |
ES2377720T3 (es) | 2012-03-30 |
WO2004014292A2 (en) | 2004-02-19 |
EP1575509A4 (de) | 2007-04-25 |
EP1575509A2 (de) | 2005-09-21 |
WO2004014292A3 (en) | 2006-02-16 |
US20100298545A1 (en) | 2010-11-25 |
AU2003276832A1 (en) | 2004-02-25 |
US20070086943A1 (en) | 2007-04-19 |
AU2009239780A1 (en) | 2009-12-10 |
US20040091486A1 (en) | 2004-05-13 |
CA2485548A1 (en) | 2004-02-19 |
EP1575509B1 (de) | 2011-10-26 |
JP2006507013A (ja) | 2006-03-02 |
JP4585968B2 (ja) | 2010-11-24 |
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