CN101381371B - 二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用 - Google Patents

二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用 Download PDF

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Publication number
CN101381371B
CN101381371B CN200710045600XA CN200710045600A CN101381371B CN 101381371 B CN101381371 B CN 101381371B CN 200710045600X A CN200710045600X A CN 200710045600XA CN 200710045600 A CN200710045600 A CN 200710045600A CN 101381371 B CN101381371 B CN 101381371B
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China
Prior art keywords
hydrogen
alkyl
dimethoxyphenyl
aryl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200710045600XA
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English (en)
Chinese (zh)
Other versions
CN101381371A (zh
Inventor
王国平
刘全海
孙海燕
吴渭
侯建
姚林
李春刚
刘珉宇
李飞
吴学军
赵帅
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Pharmaceutical Industry
Shanghai Shyndec Pharmaceutical Co Ltd
Original Assignee
Shanghai Institute of Pharmaceutical Industry
Shanghai Modern Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Shanghai Institute of Pharmaceutical Industry, Shanghai Modern Pharmaceutical Co Ltd filed Critical Shanghai Institute of Pharmaceutical Industry
Priority to CN200710045600XA priority Critical patent/CN101381371B/zh
Priority to PCT/CN2008/072207 priority patent/WO2009033396A1/zh
Priority to JP2010523259A priority patent/JP5186566B2/ja
Priority to EP08800719.0A priority patent/EP2192122B1/en
Priority to US12/676,470 priority patent/US8258176B2/en
Publication of CN101381371A publication Critical patent/CN101381371A/zh
Application granted granted Critical
Publication of CN101381371B publication Critical patent/CN101381371B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN200710045600XA 2007-09-05 2007-09-05 二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用 Expired - Fee Related CN101381371B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN200710045600XA CN101381371B (zh) 2007-09-05 2007-09-05 二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用
PCT/CN2008/072207 WO2009033396A1 (fr) 2007-09-05 2008-08-29 Composés dithiolopyrrolones, leur préparation et leur utilisation
JP2010523259A JP5186566B2 (ja) 2007-09-05 2008-08-29 ジチオロピロロン化合物類、それらの調製及び使用
EP08800719.0A EP2192122B1 (en) 2007-09-05 2008-08-29 Dithiolopyrrolone compounds, the preparation and the use thereof
US12/676,470 US8258176B2 (en) 2007-09-05 2008-08-29 Dithiolopyrrolone compounds, the preparation and the use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200710045600XA CN101381371B (zh) 2007-09-05 2007-09-05 二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用

Publications (2)

Publication Number Publication Date
CN101381371A CN101381371A (zh) 2009-03-11
CN101381371B true CN101381371B (zh) 2011-05-18

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Family Applications (1)

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CN200710045600XA Expired - Fee Related CN101381371B (zh) 2007-09-05 2007-09-05 二硫杂环戊烯并吡咯酮类化合物及其制备方法和应用

Country Status (5)

Country Link
US (1) US8258176B2 (enExample)
EP (1) EP2192122B1 (enExample)
JP (1) JP5186566B2 (enExample)
CN (1) CN101381371B (enExample)
WO (1) WO2009033396A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102219724B (zh) * 2010-05-17 2014-10-01 上海现代制药股份有限公司 吡咯酮类化合物及其制备方法和应用
CN106310264B (zh) * 2015-06-29 2019-05-10 上海医药工业研究院 包含二硫杂环戊烯并吡咯酮衍生物的组合物
CN109535174B (zh) * 2018-12-20 2020-06-12 桂林医学院 一种n-芳基二硫吡咯酮-吡喃酮杂合衍生物及其制备方法和应用
CN110981888B (zh) * 2019-11-28 2020-07-28 桂林医学院 N-芳基二硫吡咯酮脲类和氨基酯类衍生物及其制备和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020360A (en) * 1996-09-18 2000-02-01 Webster; John M. Anticancer property of dithiolopyrrolones
CN1276723A (zh) * 1997-09-05 2000-12-13 约翰·麦尔康姆·韦伯斯特 用作抗肿瘤剂的二硫杂环戊烯并吡咯酮及其相应的一氧化物和二氧化物
CN1642959A (zh) * 2002-03-26 2005-07-20 维理生物技术公司 具有治疗作用的新型二硫杂环戊烯并吡咯酮类化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2170498A (en) 1985-02-04 1986-08-06 Ici Plc Processes for making fungicidal dithiolopyrrolones
JPS63284181A (ja) 1987-05-14 1988-11-21 Nippon Kayaku Co Ltd ジチオロピロ−ル系化合物およびそれを有効成分とする農園芸用殺菌剤
JPH11279179A (ja) 1998-03-25 1999-10-12 Nippon Kayaku Co Ltd ジチオロピロール系化合物およびこれを有効成分とする農園芸用病害虫防除剤
MXPA03002045A (es) 2000-09-08 2003-07-24 Amgen Inc Composiciones analogas de factor estimulador de colonias de granulocitos y metodos para su elaboracion.
JP5189595B2 (ja) * 2006-09-29 2013-04-24 セレスティアル ファーマシューティカルズ （シェンチェン） リミテッド 新規なジチオロピロロンおよびそれらの治療的応用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020360A (en) * 1996-09-18 2000-02-01 Webster; John M. Anticancer property of dithiolopyrrolones
CN1276723A (zh) * 1997-09-05 2000-12-13 约翰·麦尔康姆·韦伯斯特 用作抗肿瘤剂的二硫杂环戊烯并吡咯酮及其相应的一氧化物和二氧化物
CN1642959A (zh) * 2002-03-26 2005-07-20 维理生物技术公司 具有治疗作用的新型二硫杂环戊烯并吡咯酮类化合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JP昭61-183290A 1986.08.15
JP昭63-112586A 1988.05.17
JP昭63-284181A 1988.11.21
JP特开平11-279179A 1999.10.12

Also Published As

Publication number Publication date
WO2009033396A1 (fr) 2009-03-19
US20100210856A1 (en) 2010-08-19
EP2192122B1 (en) 2014-01-01
JP2010538023A (ja) 2010-12-09
CN101381371A (zh) 2009-03-11
US8258176B2 (en) 2012-09-04
JP5186566B2 (ja) 2013-04-17
EP2192122A1 (en) 2010-06-02
EP2192122A4 (en) 2011-05-11

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Granted publication date: 20110518