CN101346133A - 掩盖粉末的味道 - Google Patents

掩盖粉末的味道 Download PDF

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Publication number
CN101346133A
CN101346133A CNA2006800490555A CN200680049055A CN101346133A CN 101346133 A CN101346133 A CN 101346133A CN A2006800490555 A CNA2006800490555 A CN A2006800490555A CN 200680049055 A CN200680049055 A CN 200680049055A CN 101346133 A CN101346133 A CN 101346133A
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CN
China
Prior art keywords
micron
solid
coated solid
coated
preferred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800490555A
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English (en)
Chinese (zh)
Inventor
R·贝林豪森
D·鲁德哈德特
F·里德
M·斯泰因贝克
J·詹克
M·韦斯
O·贝伦德
U·范斯蒂普豪特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN101346133A publication Critical patent/CN101346133A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Seasonings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2006800490555A 2005-12-24 2006-12-20 掩盖粉末的味道 Pending CN101346133A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005062270.4 2005-12-24
DE102005062270A DE102005062270A1 (de) 2005-12-24 2005-12-24 Geschmacksmaskierung von Pulvern

Publications (1)

Publication Number Publication Date
CN101346133A true CN101346133A (zh) 2009-01-14

Family

ID=38042692

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800490555A Pending CN101346133A (zh) 2005-12-24 2006-12-20 掩盖粉末的味道

Country Status (24)

Country Link
US (1) US20090269411A1 (enExample)
EP (1) EP1968555A2 (enExample)
JP (2) JP5275039B2 (enExample)
KR (2) KR20080081021A (enExample)
CN (1) CN101346133A (enExample)
AU (1) AU2006331009B2 (enExample)
BR (1) BRPI0620618A2 (enExample)
CA (1) CA2634481A1 (enExample)
CR (1) CR10112A (enExample)
CU (1) CU23877B1 (enExample)
DE (1) DE102005062270A1 (enExample)
EC (1) ECSP088577A (enExample)
GT (1) GT200800126A (enExample)
HN (1) HN2008000964A (enExample)
IL (1) IL192085A0 (enExample)
MA (1) MA30072B1 (enExample)
MY (1) MY149601A (enExample)
NZ (1) NZ569279A (enExample)
RU (1) RU2440103C2 (enExample)
SV (1) SV2009002971A (enExample)
TN (1) TNSN08284A1 (enExample)
UA (1) UA93072C2 (enExample)
WO (1) WO2007073911A2 (enExample)
ZA (1) ZA200805498B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102612358A (zh) * 2009-08-12 2012-07-25 拜耳医药股份有限公司 包含5-甲基-(6s)-四氢叶酸盐的稳定化颗粒

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
EP2050437A1 (en) * 2007-10-15 2009-04-22 Laboratoires SMB Improved pharmaceutical dry powder compositions for inhalation.
EP2252261A2 (en) * 2008-02-13 2010-11-24 Bayer Schering Pharma Aktiengesellschaft Drug delivery system with stabilising effect
US20110097405A1 (en) * 2008-02-13 2011-04-28 Bayer Schering Pharma Aktiengesellschaft Estradiol-containing drug delivery system
CA2745456A1 (en) * 2008-12-05 2010-06-10 Bayer Animal Health Gmbh Extrudate having spicular active substances
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
US20120207836A1 (en) 2009-08-19 2012-08-16 Bayer Pharma Aktiengesellschaft Drug delivery systems (wafer) for pediatric use
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
WO2012031129A2 (en) 2010-09-03 2012-03-08 Bend Research, Inc. Spray-drying apparatus and methods of using the same
CN103619514B (zh) 2010-09-20 2016-09-28 Spi制药公司 微包囊方法和制品
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
HU231017B1 (hu) 2012-05-08 2019-11-28 LAVET Gyógyszeripari Kft. Praziquantel tartalmú ízfedett formulációk
US8993041B2 (en) * 2012-10-15 2015-03-31 New Jersey Institute Of Technology Taste masked active pharmaceutical powder compositions and processes for making them
JP6650933B2 (ja) 2014-10-31 2020-02-19 ベンド リサーチ， インコーポレイテッド マトリックス中に分散された活性薬剤ドメインを形成するためのプロセス
CN114993892B (zh) * 2019-05-13 2024-10-18 南京制药厂有限公司 吡喹酮粒度的光散射检测法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
NL193682C (nl) * 1987-05-14 2000-07-04 Glaxo Group Ltd Beklede cefuroximaxetilsamenstelling.
NZ507951A (en) * 1998-04-09 2002-12-20 Eurand Internat S Wettable microcapsules having hydrophobic polymer coated cores
FR2811913B1 (fr) * 2000-07-19 2003-09-19 Separex Sa Procede d'encapsulation sous forme de micro-capsules de fines particules solides
GB2405798A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler with primary and secondary piercing elements and a medicament pack for use with an inhalation device.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102612358A (zh) * 2009-08-12 2012-07-25 拜耳医药股份有限公司 包含5-甲基-(6s)-四氢叶酸盐的稳定化颗粒

Also Published As

Publication number Publication date
TNSN08284A1 (en) 2009-10-30
AU2006331009A1 (en) 2007-07-05
UA93072C2 (ru) 2011-01-10
IL192085A0 (en) 2008-12-29
AU2006331009B2 (en) 2012-10-04
BRPI0620618A2 (pt) 2011-11-16
ZA200805498B (en) 2009-11-25
WO2007073911A3 (de) 2007-08-23
GT200800126A (es) 2010-06-25
SV2009002971A (es) 2009-04-28
CA2634481A1 (en) 2007-07-05
KR101245627B1 (ko) 2013-03-20
CR10112A (es) 2009-01-07
US20090269411A1 (en) 2009-10-29
DE102005062270A1 (de) 2007-06-28
KR20080081021A (ko) 2008-09-05
CU20080124A7 (es) 2010-08-30
JP2013144695A (ja) 2013-07-25
RU2008130171A (ru) 2010-01-27
KR20120006085A (ko) 2012-01-17
JP5275039B2 (ja) 2013-08-28
MY149601A (en) 2013-09-13
MA30072B1 (fr) 2008-12-01
EP1968555A2 (de) 2008-09-17
NZ569279A (en) 2011-06-30
HN2008000964A (es) 2013-03-11
ECSP088577A (es) 2008-07-30
CU23877B1 (es) 2013-04-19
WO2007073911A2 (de) 2007-07-05
JP2009521419A (ja) 2009-06-04
RU2440103C2 (ru) 2012-01-20

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