CN101321528B - 治疗增殖性疾病或炎症的3,11b-顺式-二氢丁苯那嗪 - Google Patents

治疗增殖性疾病或炎症的3,11b-顺式-二氢丁苯那嗪 Download PDF

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Publication number
CN101321528B
CN101321528B CN2006800366007A CN200680036600A CN101321528B CN 101321528 B CN101321528 B CN 101321528B CN 2006800366007 A CN2006800366007 A CN 2006800366007A CN 200680036600 A CN200680036600 A CN 200680036600A CN 101321528 B CN101321528 B CN 101321528B
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CN
China
Prior art keywords
dihydrotetrabenazine
isomer
cis
isomers
cells
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Expired - Fee Related
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CN2006800366007A
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English (en)
Chinese (zh)
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CN101321528A (zh
Inventor
A·J·杜菲尔德
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Valeant Laboratories International Bermuda SRL
Original Assignee
Biowell Laboratory International Barbados Co ltd
Cambridge Laboratories Ireland Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2006800366007A 2005-08-05 2006-08-04 治疗增殖性疾病或炎症的3,11b-顺式-二氢丁苯那嗪 Expired - Fee Related CN101321528B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0516168.2 2005-08-05
GBGB0516168.2A GB0516168D0 (en) 2005-08-05 2005-08-05 Pharmaceutical compounds
PCT/GB2006/002909 WO2007017643A1 (en) 2005-08-05 2006-08-04 3 , llB-CIS-DIHYDROTETRABENAZINE FOR THE TREATMENT OF A PROLIFERATIVE DISEASE OR AN INFLAMMATION

Publications (2)

Publication Number Publication Date
CN101321528A CN101321528A (zh) 2008-12-10
CN101321528B true CN101321528B (zh) 2011-05-25

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CN2006800366007A Expired - Fee Related CN101321528B (zh) 2005-08-05 2006-08-04 治疗增殖性疾病或炎症的3,11b-顺式-二氢丁苯那嗪

Country Status (23)

Country Link
US (1) US20090275605A1 (cg-RX-API-DMAC10.html)
EP (2) EP1964565A1 (cg-RX-API-DMAC10.html)
JP (1) JP2009503045A (cg-RX-API-DMAC10.html)
KR (1) KR20080033501A (cg-RX-API-DMAC10.html)
CN (1) CN101321528B (cg-RX-API-DMAC10.html)
AT (1) ATE412414T1 (cg-RX-API-DMAC10.html)
AU (1) AU2006277836B8 (cg-RX-API-DMAC10.html)
CA (1) CA2620952A1 (cg-RX-API-DMAC10.html)
CY (1) CY1108729T1 (cg-RX-API-DMAC10.html)
DE (1) DE602006003415D1 (cg-RX-API-DMAC10.html)
DK (1) DK1861100T3 (cg-RX-API-DMAC10.html)
ES (1) ES2317564T3 (cg-RX-API-DMAC10.html)
GB (1) GB0516168D0 (cg-RX-API-DMAC10.html)
HR (1) HRP20090017T3 (cg-RX-API-DMAC10.html)
MX (1) MX2008001546A (cg-RX-API-DMAC10.html)
NZ (1) NZ566010A (cg-RX-API-DMAC10.html)
PL (1) PL1861100T3 (cg-RX-API-DMAC10.html)
PT (1) PT1861100E (cg-RX-API-DMAC10.html)
RS (1) RS50720B (cg-RX-API-DMAC10.html)
RU (1) RU2409364C2 (cg-RX-API-DMAC10.html)
SI (1) SI1861100T1 (cg-RX-API-DMAC10.html)
WO (1) WO2007017643A1 (cg-RX-API-DMAC10.html)
ZA (2) ZA200801170B (cg-RX-API-DMAC10.html)

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GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
GB0514501D0 (en) * 2005-07-14 2005-08-24 Cambridge Lab Ireland Ltd Pharmaceutical compounds
DK2081929T3 (da) 2006-11-08 2013-04-15 Neurocrine Biosciences Inc Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse
GB0721669D0 (en) * 2007-11-02 2007-12-12 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
GB2463451A (en) 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
US20120003330A1 (en) 2010-06-01 2012-01-05 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
CN102285984B (zh) * 2010-11-25 2012-10-10 江苏威凯尔医药科技有限公司 (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法
KR20160111999A (ko) 2014-01-27 2016-09-27 오스펙스 파마슈티칼스, 인코포레이티드 소포성 모노아민 수송체 2의 벤조퀴놀린 억제제
MA41177A (fr) * 2014-12-15 2017-10-24 Esteve Labor Dr Utilisation de ligands des récepteurs sigma dans l'arthrose
US10550120B2 (en) 2016-03-25 2020-02-04 Tohoku University Indole alkaloid compound having immune checkpoint inhibitory action
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法
CN109283263B (zh) * 2017-07-21 2019-06-25 南京正大天晴制药有限公司 用于雷替曲塞合成质量控制的检测分析方法

Citations (1)

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WO2005077946A1 (en) * 2004-02-11 2005-08-25 Cambridge Laboratories (Ireland) Limited Dihydrotetrabenazines and pharmaceutical compositions containing them

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GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
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Also Published As

Publication number Publication date
CY1108729T1 (el) 2014-04-09
DE602006003415D1 (de) 2008-12-11
DK1861100T3 (da) 2008-12-15
AU2006277836A1 (en) 2007-02-15
ZA200801171B (en) 2009-08-26
HK1111084A1 (en) 2008-08-01
ES2317564T3 (es) 2009-04-16
NZ566010A (en) 2010-05-28
GB0516168D0 (en) 2005-09-14
PL1861100T3 (pl) 2009-06-30
SI1861100T1 (sl) 2009-04-30
HRP20090017T3 (hr) 2009-03-31
EP1861100B1 (en) 2008-10-29
RS50720B (sr) 2010-08-31
ZA200801170B (en) 2009-12-30
RU2008108516A (ru) 2009-09-10
MX2008001546A (es) 2008-04-04
AU2006277836B2 (en) 2011-11-10
ATE412414T1 (de) 2008-11-15
WO2007017643A1 (en) 2007-02-15
CA2620952A1 (en) 2007-02-15
RU2409364C2 (ru) 2011-01-20
CN101321528A (zh) 2008-12-10
PT1861100E (pt) 2008-12-26
EP1964565A1 (en) 2008-09-03
KR20080033501A (ko) 2008-04-16
AU2006277836B8 (en) 2011-12-08
EP1861100A1 (en) 2007-12-05
JP2009503045A (ja) 2009-01-29
US20090275605A1 (en) 2009-11-05

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