CN101307107A - tau蛋白 - Google Patents
tau蛋白 Download PDFInfo
- Publication number
- CN101307107A CN101307107A CNA2008101081547A CN200810108154A CN101307107A CN 101307107 A CN101307107 A CN 101307107A CN A2008101081547 A CNA2008101081547 A CN A2008101081547A CN 200810108154 A CN200810108154 A CN 200810108154A CN 101307107 A CN101307107 A CN 101307107A
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- CN
- China
- Prior art keywords
- gly
- ser
- lys
- pro
- tau
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| AU2003246664B2 (en) * | 2002-07-12 | 2007-06-14 | Axon Neuroscience Se | Transgenic animal expressing Alzheimer's tau protein |
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| CN117903302A (zh) | 2005-11-30 | 2024-04-19 | Abbvie 公司 | 抗-Aβ球聚体抗体，其相关产品，生产所述抗体的方法，所述抗体的应用以及使用方法 |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| ES2321996B1 (es) * | 2006-01-26 | 2010-03-05 | Consejo Superior Investig. Cientificas | Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias. |
| US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
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| AU2010286501B2 (en) * | 2009-08-28 | 2015-06-11 | The Board Of Regents Of The University Of Texas System | Antibodies that bind Tau oligomers |
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| EA031698B1 (ru) | 2010-10-11 | 2019-02-28 | Байоджен Интернэшнл Нейросайенз Гмбх | Человеческие анти-тау антитела |
| WO2012051498A2 (en) | 2010-10-15 | 2012-04-19 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
| CA2826286C (en) | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| EP2709728B1 (en) * | 2011-05-20 | 2019-01-23 | Oligomerix, Inc. | Tau protease methods of use |
| SMT201800109T1 (it) | 2011-09-19 | 2018-05-02 | Axon Neuroscience Se | Terapia a base di proteine e diagnosi di una patologia mediata da tau nella malattia di alzheimer |
| BR112014008202B1 (pt) * | 2011-10-07 | 2022-01-04 | Ac Immune S.A. | Anticorpo, polinucleotídeo, composição farmacêutica, usos de um anticorpo, método in vitro, método de detecção da formação de um complexo imunológico, método de detecção postmortem de multimêros do fosfo-tau, kits de teste, linhagem celular isolada e método de detecção de multimêros de fosfo-tau |
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| US9200068B2 (en) * | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
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| NZ630610A (en) | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
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| GEP20217222B (en) * | 2016-07-12 | 2021-02-10 | Lundbeck A/S H | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
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| US5733734A (en) * | 1991-08-14 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments |
| JPH06239899A (ja) | 1993-02-12 | 1994-08-30 | Teijin Ltd | ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法 |
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| US20020164657A1 (en) * | 2001-02-23 | 2002-11-07 | Sharma Satish K. | Assays for assessing A beta-Tau aggregation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105143258A (zh) * | 2013-03-15 | 2015-12-09 | Ac免疫有限公司 | 抗Tau抗体和使用方法 |
| CN105143258B (zh) * | 2013-03-15 | 2020-06-23 | Ac免疫有限公司 | 抗Tau抗体和使用方法 |
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| WO2002062851A8 (en) | 2002-09-12 |
| CN100503638C (zh) | 2009-06-24 |
| RU2299889C2 (ru) | 2007-05-27 |
| AT500379A3 (de) | 2009-02-15 |
| ES2339427T3 (es) | 2010-05-20 |
| US20040082763A1 (en) | 2004-04-29 |
| RU2003126594A (ru) | 2005-03-10 |
| CA2437453C (en) | 2013-06-11 |
| AU2002237296A1 (en) | 2002-08-19 |
| EP1355949B1 (en) | 2010-03-24 |
| DE60235746D1 (de) | 2010-05-06 |
| CN1492879A (zh) | 2004-04-28 |
| WO2002062851A1 (en) | 2002-08-15 |
| AT500379A2 (de) | 2005-12-15 |
| ATE461941T1 (de) | 2010-04-15 |
| CA2437453A1 (en) | 2002-08-15 |
| US20090123936A1 (en) | 2009-05-14 |
| AT500379B8 (de) | 2009-08-15 |
| AT500379B1 (de) | 2009-07-15 |
| JP4163955B2 (ja) | 2008-10-08 |
| DK1355949T3 (da) | 2010-05-25 |
| US7446180B2 (en) | 2008-11-04 |
| EP1355949A1 (en) | 2003-10-29 |
| JP2004532817A (ja) | 2004-10-28 |
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