CA2437453C - Conformationally abnormal forms of tau proteins and specific antibodies thereto - Google Patents
Conformationally abnormal forms of tau proteins and specific antibodies thereto Download PDFInfo
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- CA2437453C CA2437453C CA2437453A CA2437453A CA2437453C CA 2437453 C CA2437453 C CA 2437453C CA 2437453 A CA2437453 A CA 2437453A CA 2437453 A CA2437453 A CA 2437453A CA 2437453 C CA2437453 C CA 2437453C
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- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| AT0017501A AT500379B8 (de) | 2001-02-02 | 2001-02-02 | Tau-proteine |
| ATA175/2001 | 2001-02-02 | ||
| PCT/EP2002/000897 WO2002062851A1 (en) | 2001-02-02 | 2002-01-29 | Conformationally abnormal forms of tau proteins and specific antibodies thereto |
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| CA2437453A1 CA2437453A1 (en) | 2002-08-15 |
| CA2437453C true CA2437453C (en) | 2013-06-11 |
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| CA2437453A Expired - Lifetime CA2437453C (en) | 2001-02-02 | 2002-01-29 | Conformationally abnormal forms of tau proteins and specific antibodies thereto |
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| EP (1) | EP1355949B1 (enExample) |
| JP (1) | JP4163955B2 (enExample) |
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| AT (2) | AT500379B8 (enExample) |
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| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| DE60320258T2 (de) * | 2002-07-12 | 2009-06-25 | Axon Neuroscience Forschungs- Und Entwicklungs Gmbh | Transgenes tier welches das trunkierte alzheimer tau protein exprimiert |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| CA2628703C (en) | 2005-11-30 | 2019-10-29 | Abbott Laboratories | Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
| ES2321996B1 (es) * | 2006-01-26 | 2010-03-05 | Consejo Superior Investig. Cientificas | Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias. |
| US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| WO2009143556A1 (en) * | 2008-05-30 | 2009-12-03 | The University Of Sydney | TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION |
| EP2440234A4 (en) * | 2009-06-10 | 2013-11-06 | Univ New York | IMMUNOLOGICAL AIMING OF PATHOLOGICAL TAU PROTEINS |
| US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| AU2010286501B2 (en) | 2009-08-28 | 2015-06-11 | The Board Of Regents Of The University Of Texas System | Antibodies that bind Tau oligomers |
| US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
| ITRM20100320A1 (it) * | 2010-06-11 | 2011-12-11 | Consiglio Nazionale Ricerche | Metodo per la diagnostica e il trattamento delle taupatie |
| WO2012024187A1 (en) | 2010-08-14 | 2012-02-23 | Abbott Laboratories | Amyloid-beta binding proteins |
| CN103339146B (zh) | 2010-10-11 | 2017-09-01 | 比奥根国际神经科学公司 | 人抗tau抗体 |
| WO2012051498A2 (en) | 2010-10-15 | 2012-04-19 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
| US8703137B2 (en) | 2011-01-31 | 2014-04-22 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| JP6457263B2 (ja) * | 2011-05-20 | 2019-01-23 | オリゴメリックス インコーポレイテッド | タウプロテアーゼ組成物および使用方法 |
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| US5733734A (en) * | 1991-08-14 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments |
| JPH06239899A (ja) | 1993-02-12 | 1994-08-30 | Teijin Ltd | ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法 |
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| US20020164657A1 (en) * | 2001-02-23 | 2002-11-07 | Sharma Satish K. | Assays for assessing A beta-Tau aggregation |
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| JP4163955B2 (ja) | 2008-10-08 |
| WO2002062851A1 (en) | 2002-08-15 |
| DK1355949T3 (da) | 2010-05-25 |
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| CN100503638C (zh) | 2009-06-24 |
| AT500379A2 (de) | 2005-12-15 |
| ATE461941T1 (de) | 2010-04-15 |
| RU2003126594A (ru) | 2005-03-10 |
| US7446180B2 (en) | 2008-11-04 |
| CN1492879A (zh) | 2004-04-28 |
| AT500379A3 (de) | 2009-02-15 |
| US20090123936A1 (en) | 2009-05-14 |
| US20040082763A1 (en) | 2004-04-29 |
| AU2002237296A1 (en) | 2002-08-19 |
| EP1355949B1 (en) | 2010-03-24 |
| CA2437453A1 (en) | 2002-08-15 |
| EP1355949A1 (en) | 2003-10-29 |
| CN101307107A (zh) | 2008-11-19 |
| RU2299889C2 (ru) | 2007-05-27 |
| AT500379B1 (de) | 2009-07-15 |
| JP2004532817A (ja) | 2004-10-28 |
| DE60235746D1 (de) | 2010-05-06 |
| WO2002062851A8 (en) | 2002-09-12 |
| ES2339427T3 (es) | 2010-05-20 |
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