CN101291599A - 对骨骼肌供给能量和保护心血管的膳食补充剂 - Google Patents
对骨骼肌供给能量和保护心血管的膳食补充剂 Download PDFInfo
- Publication number
- CN101291599A CN101291599A CNA2006800388186A CN200680038818A CN101291599A CN 101291599 A CN101291599 A CN 101291599A CN A2006800388186 A CNA2006800388186 A CN A2006800388186A CN 200680038818 A CN200680038818 A CN 200680038818A CN 101291599 A CN101291599 A CN 101291599A
- Authority
- CN
- China
- Prior art keywords
- carnitine
- acid
- milligrams
- dietary supplements
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 31
- 210000002027 skeletal muscle Anatomy 0.000 title claims abstract description 14
- 230000002526 effect on cardiovascular system Effects 0.000 title description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims abstract description 28
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims abstract description 15
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000019161 pantothenic acid Nutrition 0.000 claims abstract description 14
- 229940055726 pantothenic acid Drugs 0.000 claims abstract description 14
- 239000011713 pantothenic acid Substances 0.000 claims abstract description 14
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019192 riboflavin Nutrition 0.000 claims abstract description 13
- 229960002477 riboflavin Drugs 0.000 claims abstract description 13
- 239000002151 riboflavin Substances 0.000 claims abstract description 13
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000017471 coenzyme Q10 Nutrition 0.000 claims abstract description 10
- 150000001413 amino acids Chemical class 0.000 claims abstract description 9
- 230000037081 physical activity Effects 0.000 claims abstract description 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 56
- 239000002253 acid Substances 0.000 claims description 31
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 22
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 17
- 229960003624 creatine Drugs 0.000 claims description 11
- 239000006046 creatine Substances 0.000 claims description 11
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 9
- 229950007002 phosphocreatine Drugs 0.000 claims description 9
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims description 9
- 229940035936 ubiquinone Drugs 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 8
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 229940024606 amino acid Drugs 0.000 claims description 8
- 229940009098 aspartate Drugs 0.000 claims description 8
- 229960004203 carnitine Drugs 0.000 claims description 8
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 8
- 239000010452 phosphate Substances 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical class OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims description 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 4
- VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims description 4
- 229960000310 isoleucine Drugs 0.000 claims description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
- IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims description 4
- 150000003891 oxalate salts Chemical class 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 229940095064 tartrate Drugs 0.000 claims description 4
- 229940066528 trichloroacetate Drugs 0.000 claims description 4
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 4
- 239000004474 valine Substances 0.000 claims description 4
- 230000002787 reinforcement Effects 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 2
- 239000007937 lozenge Substances 0.000 claims 3
- 235000002639 sodium chloride Nutrition 0.000 abstract description 14
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 abstract 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- 229940110767 coenzyme Q10 Drugs 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 39
- 210000003205 muscle Anatomy 0.000 description 28
- 238000004904 shortening Methods 0.000 description 25
- 230000000694 effects Effects 0.000 description 20
- 241001465754 Metazoa Species 0.000 description 11
- 230000036586 afterload Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 210000004165 myocardium Anatomy 0.000 description 6
- 230000000747 cardiac effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 210000003540 papillary muscle Anatomy 0.000 description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- -1 alkanoyl L-carnitine Chemical compound 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 210000000107 myocyte Anatomy 0.000 description 3
- 238000005424 photoluminescence Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000003505 Myosin Human genes 0.000 description 2
- 108030001204 Myosin ATPases Proteins 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 210000000748 cardiovascular system Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 125000002743 phosphorus functional group Chemical group 0.000 description 2
- 230000026731 phosphorylation Effects 0.000 description 2
- 238000006366 phosphorylation reaction Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 230000009090 positive inotropic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000002407 ATP formation Effects 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010015548 Euthanasia Diseases 0.000 description 1
- DSLZVSRJTYRBFB-UHFFFAOYSA-N Galactaric acid Natural products OC(=O)C(O)C(O)C(O)C(O)C(O)=O DSLZVSRJTYRBFB-UHFFFAOYSA-N 0.000 description 1
- 208000000501 Lipidoses Diseases 0.000 description 1
- 206010024585 Lipidosis Diseases 0.000 description 1
- 229920005479 Lucite® Polymers 0.000 description 1
- 102000008934 Muscle Proteins Human genes 0.000 description 1
- 108010074084 Muscle Proteins Proteins 0.000 description 1
- 229920005439 Perspex® Polymers 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 229910001080 W alloy Inorganic materials 0.000 description 1
- HNSUOMBUJRUZHJ-REVJHSINSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;(z)-4-hydroxy-4-oxobut-2-enoate Chemical compound OC(=O)\C=C/C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O HNSUOMBUJRUZHJ-REVJHSINSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000489 anti-atherogenic effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000030609 dephosphorylation Effects 0.000 description 1
- 238000006209 dephosphorylation reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019262 disodium citrate Nutrition 0.000 description 1
- 239000002526 disodium citrate Substances 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- YZURQOBSFRVSEB-UHFFFAOYSA-L magnesium;2-aminoethanesulfonate Chemical compound [Mg+2].NCCS([O-])(=O)=O.NCCS([O-])(=O)=O YZURQOBSFRVSEB-UHFFFAOYSA-L 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000008811 mitochondrial respiratory chain Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000017802 other dietary supplement Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 125000001655 ubiquinone group Chemical group 0.000 description 1
- 230000006439 vascular pathology Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/253,806 | 2005-10-20 | ||
| US11/253,806 US8252309B2 (en) | 2000-04-04 | 2005-10-20 | Dietary supplement energy-providing to skeletal muscles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101291599A true CN101291599A (zh) | 2008-10-22 |
Family
ID=37479888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800388186A Pending CN101291599A (zh) | 2005-10-20 | 2006-09-20 | 对骨骼肌供给能量和保护心血管的膳食补充剂 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8252309B2 (enExample) |
| EP (1) | EP1940251B1 (enExample) |
| JP (1) | JP2009512430A (enExample) |
| CN (1) | CN101291599A (enExample) |
| AR (1) | AR056129A1 (enExample) |
| AT (1) | ATE535159T1 (enExample) |
| AU (1) | AU2006303417A1 (enExample) |
| BR (1) | BRPI0617487A2 (enExample) |
| CA (1) | CA2622555A1 (enExample) |
| CY (1) | CY1112660T1 (enExample) |
| DK (1) | DK1940251T3 (enExample) |
| ES (1) | ES2378655T3 (enExample) |
| HR (1) | HRP20120138T1 (enExample) |
| PL (1) | PL1940251T3 (enExample) |
| PT (1) | PT1940251E (enExample) |
| RS (1) | RS52129B (enExample) |
| SI (1) | SI1940251T1 (enExample) |
| TW (1) | TW200803761A (enExample) |
| WO (1) | WO2007045533A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112535294A (zh) * | 2020-11-24 | 2021-03-23 | 苏州麦轮生物科技有限公司 | 牛磺酸镁在制备改善心血管健康的营养补充剂中的应用 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003070091A1 (en) * | 2002-02-22 | 2003-08-28 | Hans Gregersen | Method and apparatus for investigating force-deformation properties in muscles in walls of bodily hollow systems |
| IN2013MN01582A (enExample) | 2011-01-20 | 2015-06-12 | Oneday Biotech And Pharma Ltd | |
| JP2014131961A (ja) * | 2011-04-08 | 2014-07-17 | Mitsubishi Gas Chemical Co Inc | 動物用栄養組成物 |
| CN104717970A (zh) | 2012-07-23 | 2015-06-17 | 万德-生物技术及制药有限公司 | 提高谷胱甘肽的组合物及其用途 |
| EP2877194A4 (en) | 2012-07-25 | 2016-03-16 | Oneday Biotech And Pharma Ltd | Compositions and methods for increasing carnitine concentration in muscle tissue |
| US9327005B1 (en) | 2012-11-15 | 2016-05-03 | Vdf Futureceuticals, Inc. | Compositions and methods for improved energy metabolism |
| KR101636946B1 (ko) * | 2013-07-29 | 2016-07-06 | 한국생명공학연구원 | 오로트산을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물 |
| US10674746B2 (en) | 2015-10-27 | 2020-06-09 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
| CN108473384A (zh) | 2015-10-27 | 2018-08-31 | 细胞酶动物营养品公司 | 动物营养成分及相关方法 |
| AU2019261476B2 (en) * | 2018-04-25 | 2021-11-18 | Oncocross Co.,Ltd. | Composition for preventing and treating muscular disease |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3219454A (en) | 1961-06-15 | 1965-11-23 | Borden Co | Low calorie diet |
| US3689641A (en) | 1970-08-20 | 1972-09-05 | Merck & Co Inc | Concentrated water suspension of nutrients |
| US4237118A (en) | 1972-03-06 | 1980-12-02 | Howard Alan N | Dietary supplement and dietary methods employing said supplement for the treatment of obesity |
| US5466469A (en) * | 1988-06-28 | 1995-11-14 | Cibus Pharmaceutical, Inc. | Granular drug delivery system |
| DE4410238A1 (de) | 1994-03-25 | 1995-09-28 | Beiersdorf Ag | Hautpflegemittel |
| IT1275434B (it) | 1995-05-19 | 1997-08-07 | Farmila Farma Milano | Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante |
| IT1277953B1 (it) | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per |
| IL127266A (en) * | 1996-05-31 | 2002-09-12 | Sigma Tau Ind Farmaceuti | Stable, non-hygroscopic mucate salts of l(-) carnitine and alkanoyl l(-) carnitines, a process for their preparation and solid, orally administrable compositions containing such salts |
| US5976568A (en) | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
| IT1291127B1 (it) | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
| IT1299161B1 (it) | 1998-04-17 | 2000-02-29 | Sigma Tau Healthscience Spa | Composizione comprendente l-carnitina o un'alcanoil l-carnitina e nadh e/o nadph |
| US6479069B1 (en) * | 1999-09-23 | 2002-11-12 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
| US6562869B1 (en) | 1999-09-23 | 2003-05-13 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
| IT1317008B1 (it) * | 2000-04-04 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore alimentare energizzante sulla muscolatura scheletrica eprotettivo sull'apparato cardiovascolare. |
| WO2002047493A2 (en) * | 2000-12-16 | 2002-06-20 | Aventis Pharma Deutschland Gmbh | Health promoting compositions |
| JP2004081010A (ja) * | 2002-08-22 | 2004-03-18 | Fancl Corp | 食品組成物 |
| JP2005097161A (ja) * | 2003-09-24 | 2005-04-14 | Nisshin Pharma Inc | 抗疲労用組成物およびこれを含有する食品 |
| US7169385B2 (en) * | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
| WO2005060952A1 (en) * | 2003-12-24 | 2005-07-07 | N.V. Nutricia | Compositions comprising pantothenic acid or derivatives thereof and their use for stimulating appetite |
-
2005
- 2005-10-20 US US11/253,806 patent/US8252309B2/en not_active Expired - Fee Related
-
2006
- 2006-08-21 TW TW095130679A patent/TW200803761A/zh unknown
- 2006-09-20 CA CA002622555A patent/CA2622555A1/en not_active Abandoned
- 2006-09-20 WO PCT/EP2006/066538 patent/WO2007045533A1/en not_active Ceased
- 2006-09-20 SI SI200631270T patent/SI1940251T1/sl unknown
- 2006-09-20 EP EP06793668A patent/EP1940251B1/en active Active
- 2006-09-20 JP JP2008536001A patent/JP2009512430A/ja active Pending
- 2006-09-20 PT PT06793668T patent/PT1940251E/pt unknown
- 2006-09-20 CN CNA2006800388186A patent/CN101291599A/zh active Pending
- 2006-09-20 DK DK06793668.2T patent/DK1940251T3/da active
- 2006-09-20 HR HRP20120138TT patent/HRP20120138T1/hr unknown
- 2006-09-20 US US12/066,625 patent/US20090257996A1/en not_active Abandoned
- 2006-09-20 BR BRPI0617487-6A patent/BRPI0617487A2/pt not_active IP Right Cessation
- 2006-09-20 AU AU2006303417A patent/AU2006303417A1/en not_active Abandoned
- 2006-09-20 ES ES06793668T patent/ES2378655T3/es active Active
- 2006-09-20 PL PL06793668T patent/PL1940251T3/pl unknown
- 2006-09-20 AT AT06793668T patent/ATE535159T1/de active
- 2006-09-20 RS RS20120068A patent/RS52129B/sr unknown
- 2006-10-17 AR ARP060104514A patent/AR056129A1/es unknown
-
2012
- 2012-02-28 CY CY20121100205T patent/CY1112660T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112535294A (zh) * | 2020-11-24 | 2021-03-23 | 苏州麦轮生物科技有限公司 | 牛磺酸镁在制备改善心血管健康的营养补充剂中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200803761A (en) | 2008-01-16 |
| EP1940251A1 (en) | 2008-07-09 |
| ATE535159T1 (de) | 2011-12-15 |
| WO2007045533A1 (en) | 2007-04-26 |
| CA2622555A1 (en) | 2007-04-26 |
| HRP20120138T1 (hr) | 2012-05-31 |
| US20060057188A1 (en) | 2006-03-16 |
| EP1940251B1 (en) | 2011-11-30 |
| ES2378655T3 (es) | 2012-04-16 |
| SI1940251T1 (sl) | 2012-03-30 |
| AU2006303417A1 (en) | 2007-04-26 |
| US20090257996A1 (en) | 2009-10-15 |
| RS52129B (sr) | 2012-08-31 |
| JP2009512430A (ja) | 2009-03-26 |
| BRPI0617487A2 (pt) | 2011-07-26 |
| CY1112660T1 (el) | 2016-02-10 |
| PL1940251T3 (pl) | 2012-05-31 |
| US8252309B2 (en) | 2012-08-28 |
| DK1940251T3 (da) | 2012-03-19 |
| AR056129A1 (es) | 2007-09-19 |
| PT1940251E (pt) | 2012-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101291599A (zh) | 对骨骼肌供给能量和保护心血管的膳食补充剂 | |
| JPH07509230A (ja) | クレアチン供給デポーの増加法 | |
| JP7738384B2 (ja) | 持久運動能力を向上させるためおよび脂質代謝を刺激するためのコラーゲン加水分解物の使用 | |
| Paul et al. | Amino acid and protein metabolism during exercise and recovery | |
| HUP0202298A2 (en) | Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise | |
| CA2374333C (en) | Dietary supplement energy-providing to skeletal muscles and protecting the cardiovascular tract | |
| AU782367B2 (en) | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose | |
| CN101331950B (zh) | 一种提高运动爆发力的营养补剂 | |
| CN112384215A (zh) | 通过d-核糖和维生素b3提高哺乳动物中nad含量的方法及成分 | |
| Figueiredo et al. | Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi | |
| HK1125268A (en) | Dietary supplemant energy-providing to skeletal muscles and protecting the cardio vascular tract | |
| Ööpik et al. | Effect of creatine administration on blood urea level and postexercise glycogen repletion in liver and skeletal muscle in rats | |
| Semanchik et al. | Influence of Mechanistic Target of Rapamycin (mTOR)-Regulated Anabolic Pathways on Equine Skeletal Muscle Health | |
| Hoffman | Creatine and β-alanine supplementation in strength/power athletes. | |
| Kostadinova et al. | Creatine lysinate–part I: investigation of the toxicity and the influence on some biochemical parameters in mice | |
| Kostadinova et al. | Creatine lysinate–part I: investigation of the toxicity and the influence on some biochemical parameters in mice. Pharmacia 70 (4): 895–899 | |
| Smith | Metabolism of muscle at rest and during exercise | |
| TRAPPE | 18 METABOLIC DEMANDS FOR SWIMMING | |
| Vargiu et al. | 1Department of Science Applied to Biosystems, Section of Physiology and Human Nutrition, University of Cagliari, Italy 2Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, Ancona, Italy 3Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy | |
| CZ347999A3 (cs) | Doplňková výživa pro snazší adaptaci kosterního svalstva vyčerpaného zatěžujícími výkony a paralyzování únavy asthenických jedinců |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1125268 Country of ref document: HK |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20081022 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1125268 Country of ref document: HK |