CN101272781A - 新的1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 - Google Patents
新的1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 Download PDFInfo
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- CN101272781A CN101272781A CNA2006800354264A CN200680035426A CN101272781A CN 101272781 A CN101272781 A CN 101272781A CN A2006800354264 A CNA2006800354264 A CN A2006800354264A CN 200680035426 A CN200680035426 A CN 200680035426A CN 101272781 A CN101272781 A CN 101272781A
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- hexane
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- Chemical & Material Sciences (AREA)
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- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410309301.2A CN104059013B8 (zh) | 2005-07-27 | 2006-07-25 | 1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70336405P | 2005-07-27 | 2005-07-27 | |
| US60/703,364 | 2005-07-27 | ||
| US11/493,431 US20070082940A1 (en) | 2005-07-27 | 2006-07-25 | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| US11/493,431 | 2006-07-25 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410309301.2A Division CN104059013B8 (zh) | 2005-07-27 | 2006-07-25 | 1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101272781A true CN101272781A (zh) | 2008-09-24 |
Family
ID=37709141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410309301.2A Active CN104059013B8 (zh) | 2005-07-27 | 2006-07-25 | 1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 |
| CNA2006800354264A Pending CN101272781A (zh) | 2005-07-27 | 2006-07-25 | 新的1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410309301.2A Active CN104059013B8 (zh) | 2005-07-27 | 2006-07-25 | 1-芳基-3-氮杂二环[3.1.0]己烷:其制备方法和用于治疗神经精神障碍的用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (9) | US20070082940A1 (enExample) |
| EP (2) | EP1915146A4 (enExample) |
| JP (3) | JP5184354B2 (enExample) |
| KR (3) | KR101733180B1 (enExample) |
| CN (2) | CN104059013B8 (enExample) |
| AU (1) | AU2006275870B2 (enExample) |
| BR (1) | BRPI0613943B1 (enExample) |
| CA (1) | CA2659215C (enExample) |
| CY (1) | CY1122238T1 (enExample) |
| IL (2) | IL189008A (enExample) |
| NO (1) | NO343037B1 (enExample) |
| NZ (1) | NZ592836A (enExample) |
| PL (1) | PL2719384T3 (enExample) |
| RU (1) | RU2008107336A (enExample) |
| WO (1) | WO2007016155A2 (enExample) |
| ZA (1) | ZA200801825B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106029637A (zh) * | 2013-12-09 | 2016-10-12 | 纽罗万斯公司 | 新的组合物 |
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| US20070082940A1 (en) | 2005-07-27 | 2007-04-12 | Phil Skolnick | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| US20080045725A1 (en) * | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| EP2016053B1 (en) * | 2006-04-28 | 2010-11-10 | Merck Sharp & Dohme Corp. | Process for the synthesis of (+) and (-)-1-aryl-3-azabicyclo[3.1.0]hexanes |
| US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| GB0716632D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Compounds |
| GB0716633D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Compounds |
| GB0804326D0 (en) * | 2008-03-07 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
| ES2421171T3 (es) * | 2008-12-16 | 2013-08-29 | Sunovion Pharmaceuticals Inc. | Inhibidores de reabsorción triples y su uso en métodos |
| CN102803224A (zh) | 2009-06-26 | 2012-11-28 | 万能药生物有限公司 | 新的氮杂双环己烷类化合物 |
| WO2012033956A1 (en) * | 2010-09-08 | 2012-03-15 | Mithridion, Inc. | Cognition enhancing compounds and compositions, methods of making, and methods of treating |
| US9133116B2 (en) | 2010-09-28 | 2015-09-15 | Panacea Biotec Ltd. | Bicyclic compounds |
| LT2819516T (lt) * | 2011-07-30 | 2020-05-25 | Otsuka America Pharmaceutical, Inc. | (1r,5s)-(+)-1-(naftalen-2-il)-3-azabiciklo{3.1.0} heksano naudojimas monoamino neurotransmiterių paveiktoms ligoms gydyti |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| JP6284140B2 (ja) * | 2013-06-17 | 2018-02-28 | 株式会社タムラ製作所 | Ga2O3系半導体素子 |
| HUE059348T2 (hu) | 2015-06-17 | 2022-11-28 | Otsuka America Pharmaceutical Inc | Kristályos vegyületek |
| WO2018119291A1 (en) * | 2016-12-21 | 2018-06-28 | Otsuka America Pharmaceutical, Inc. | Synthetic methods |
| WO2019208807A1 (ja) | 2018-04-26 | 2019-10-31 | 株式会社エーピーアイ コーポレーション | 芳香族ニトリル化合物の製造方法 |
| US12421246B2 (en) * | 2019-01-09 | 2025-09-23 | Eisai R&D Management Co., Ltd. | Method for synthesis of diazabicyclo[6.2.0]decane related compounds |
| KR20220083740A (ko) | 2019-10-16 | 2022-06-20 | 오츠카 세이야쿠 가부시키가이샤 | 센타나파딘의 제조 방법 |
| CN120842114A (zh) | 2019-10-29 | 2025-10-28 | 株式会社Api | 高纯度2-萘乙腈及其生产方法 |
| WO2022181625A1 (en) | 2021-02-23 | 2022-09-01 | Otsuka Pharmaceutical Co., Ltd. | Centanafadine pharmaceutical formulations, and methods of making and using same |
| US20240246914A1 (en) | 2021-05-31 | 2024-07-25 | Teva Pharmaceuticals International Gmbh | Solid state form of centanafadine hcl and process for preparation thereof |
| CN117480153A (zh) * | 2021-06-15 | 2024-01-30 | 大塚制药株式会社 | 氮杂双环[3.1.0]己烷化合物 |
| US20250375418A1 (en) | 2022-09-02 | 2025-12-11 | Otsuka Pharmaceutical Co., Ltd. | 1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane for treating major depressive disorder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106029637A (zh) * | 2013-12-09 | 2016-10-12 | 纽罗万斯公司 | 新的组合物 |
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