KR101733180B1 - 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 - Google Patents
신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 Download PDFInfo
- Publication number
- KR101733180B1 KR101733180B1 KR1020147018408A KR20147018408A KR101733180B1 KR 101733180 B1 KR101733180 B1 KR 101733180B1 KR 1020147018408 A KR1020147018408 A KR 1020147018408A KR 20147018408 A KR20147018408 A KR 20147018408A KR 101733180 B1 KR101733180 B1 KR 101733180B1
- Authority
- KR
- South Korea
- Prior art keywords
- hexane
- azabicyclo
- bicyclo
- aza
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *N(CC1(C2C1)[Al])C2=O Chemical compound *N(CC1(C2C1)[Al])C2=O 0.000 description 5
- UHETVIUTDGSMBO-UHFFFAOYSA-N NCC1(C(CO)C1)[AlH2] Chemical compound NCC1(C(CO)C1)[AlH2] UHETVIUTDGSMBO-UHFFFAOYSA-N 0.000 description 2
- FKCRPEOKQIXVBI-UHFFFAOYSA-N CC(C)(C)N(C(C(C1)C11c(cc2Cl)ccc2Cl)=O)C1=O Chemical compound CC(C)(C)N(C(C(C1)C11c(cc2Cl)ccc2Cl)=O)C1=O FKCRPEOKQIXVBI-UHFFFAOYSA-N 0.000 description 1
- AGQQLHNNAQMNEQ-UHFFFAOYSA-N CC(C)(C)OC(NCC1(C(CO)C1)[AlH2])=O Chemical compound CC(C)(C)OC(NCC1(C(CO)C1)[AlH2])=O AGQQLHNNAQMNEQ-UHFFFAOYSA-N 0.000 description 1
- WRQHJJODLHDMQW-UHFFFAOYSA-N CC(C)(C)OC(NCC1(C(CO)C1)[Ar])=O Chemical compound CC(C)(C)OC(NCC1(C(CO)C1)[Ar])=O WRQHJJODLHDMQW-UHFFFAOYSA-N 0.000 description 1
- FRPFCQJWJJXTED-BZNIZROVSA-N CC(C)(C)OC(N[C@](C1)([C@H]1C(C)=O)c(cc1)cc(Cl)c1Cl)=O Chemical compound CC(C)(C)OC(N[C@](C1)([C@H]1C(C)=O)c(cc1)cc(Cl)c1Cl)=O FRPFCQJWJJXTED-BZNIZROVSA-N 0.000 description 1
- GNMMVIVNCUDTJB-UHFFFAOYSA-N CC1(CNCCC1)c1ccc(cc(cc2)OC)c2c1 Chemical compound CC1(CNCCC1)c1ccc(cc(cc2)OC)c2c1 GNMMVIVNCUDTJB-UHFFFAOYSA-N 0.000 description 1
- UQCOLLNFWRQEBE-ACGXKRRESA-N CC1=NCC(C2)[C@]12c(cc1Cl)ccc1Cl Chemical compound CC1=NCC(C2)[C@]12c(cc1Cl)ccc1Cl UQCOLLNFWRQEBE-ACGXKRRESA-N 0.000 description 1
- KCRITGUPBTXIOU-UHFFFAOYSA-N CCN(CC1C2)CC12c(ccc(F)c1)c1F Chemical compound CCN(CC1C2)CC12c(ccc(F)c1)c1F KCRITGUPBTXIOU-UHFFFAOYSA-N 0.000 description 1
- YCEPPWZMXQMHRV-GXFFZTMASA-N CCN(C[C@@H]1C2)C[C@]12c(cc1Cl)ccc1Cl Chemical compound CCN(C[C@@H]1C2)C[C@]12c(cc1Cl)ccc1Cl YCEPPWZMXQMHRV-GXFFZTMASA-N 0.000 description 1
- PZSAUCRKLIVWSM-UHFFFAOYSA-N CCOc(cc1)cc2c1cc(C1(C3)C3CNC1)cc2 Chemical compound CCOc(cc1)cc2c1cc(C1(C3)C3CNC1)cc2 PZSAUCRKLIVWSM-UHFFFAOYSA-N 0.000 description 1
- PKGMEUPETHRWEF-UHFFFAOYSA-N CN(C(C(C1)C11c(ccc(Cl)c2)c2Cl)=O)C1=O Chemical compound CN(C(C(C1)C11c(ccc(Cl)c2)c2Cl)=O)C1=O PKGMEUPETHRWEF-UHFFFAOYSA-N 0.000 description 1
- XRJYSWDRCDIBTN-UHFFFAOYSA-N CN(C(C(C1)C11c(ccc(F)c2)c2F)=O)C1=O Chemical compound CN(C(C(C1)C11c(ccc(F)c2)c2F)=O)C1=O XRJYSWDRCDIBTN-UHFFFAOYSA-N 0.000 description 1
- IRTCVHAWULHIPH-UHFFFAOYSA-N CN(C(C=C1c(c(F)c2)ccc2F)=O)C1=O Chemical compound CN(C(C=C1c(c(F)c2)ccc2F)=O)C1=O IRTCVHAWULHIPH-UHFFFAOYSA-N 0.000 description 1
- JYAIYICHKDGVMX-KHFHPKRRSA-N C[C@@H]1C(CC[C@]2(C)[C@H](C)N(C)CC2)=[IH]2[IH]CC=C=[I]C2C1 Chemical compound C[C@@H]1C(CC[C@]2(C)[C@H](C)N(C)CC2)=[IH]2[IH]CC=C=[I]C2C1 JYAIYICHKDGVMX-KHFHPKRRSA-N 0.000 description 1
- CHQOAFAYKZYODU-MMODKWEGSA-N C[C@H](C1(C(CNC(OC(C)(C)C)=O)C1)c(cc1Cl)ccc1Cl)O Chemical compound C[C@H](C1(C(CNC(OC(C)(C)C)=O)C1)c(cc1Cl)ccc1Cl)O CHQOAFAYKZYODU-MMODKWEGSA-N 0.000 description 1
- PULZERPRRHYDRO-UHFFFAOYSA-N Cc(ccc(C12C3N(C)CC1C23)c1)c1F Chemical compound Cc(ccc(C12C3N(C)CC1C23)c1)c1F PULZERPRRHYDRO-UHFFFAOYSA-N 0.000 description 1
- AFKUTJAEGSFAJE-KFJBMODSSA-N Cc1ccc([C@@]2(C3)C3CNC2)cc1F Chemical compound Cc1ccc([C@@]2(C3)C3CNC2)cc1F AFKUTJAEGSFAJE-KFJBMODSSA-N 0.000 description 1
- KKNFDVOWVMDKSH-UHFFFAOYSA-N N#CC1(C(CO)C1)[AlH2] Chemical compound N#CC1(C(CO)C1)[AlH2] KKNFDVOWVMDKSH-UHFFFAOYSA-N 0.000 description 1
- FRCFDYKFAZQENI-UHFFFAOYSA-N NCC1(CC1)c(cc1Cl)ccc1F Chemical compound NCC1(CC1)c(cc1Cl)ccc1F FRCFDYKFAZQENI-UHFFFAOYSA-N 0.000 description 1
- WIRJRUVPAOFWLK-WJXVXWFNSA-N [AlH2][C@]1(C2)[C@@H]2CNC1 Chemical compound [AlH2][C@]1(C2)[C@@H]2CNC1 WIRJRUVPAOFWLK-WJXVXWFNSA-N 0.000 description 1
- OMMSKEYOUWXFMC-BRJRFNKRSA-N [Ar][C@@]1(C2)C2CNC1 Chemical compound [Ar][C@@]1(C2)C2CNC1 OMMSKEYOUWXFMC-BRJRFNKRSA-N 0.000 description 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
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- Biomedical Technology (AREA)
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- Addiction (AREA)
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- Psychology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
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- Hematology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70336405P | 2005-07-27 | 2005-07-27 | |
| US60/703,364 | 2005-07-27 | ||
| US11/493,431 US20070082940A1 (en) | 2005-07-27 | 2006-07-25 | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| PCT/US2006/029006 WO2007016155A2 (en) | 2005-07-27 | 2006-07-25 | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| US11/493,431 | 2006-07-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087004765A Division KR101465178B1 (ko) | 2005-07-27 | 2008-02-27 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177000085A Division KR20170005888A (ko) | 2005-07-27 | 2006-07-25 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140093750A KR20140093750A (ko) | 2014-07-28 |
| KR101733180B1 true KR101733180B1 (ko) | 2017-05-08 |
Family
ID=37709141
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147018408A Expired - Fee Related KR101733180B1 (ko) | 2005-07-27 | 2006-07-25 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
| KR1020177000085A Ceased KR20170005888A (ko) | 2005-07-27 | 2006-07-25 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
| KR1020087004765A Active KR101465178B1 (ko) | 2005-07-27 | 2008-02-27 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177000085A Ceased KR20170005888A (ko) | 2005-07-27 | 2006-07-25 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
| KR1020087004765A Active KR101465178B1 (ko) | 2005-07-27 | 2008-02-27 | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
Country Status (16)
| Country | Link |
|---|---|
| US (9) | US20070082940A1 (enExample) |
| EP (2) | EP1915146A4 (enExample) |
| JP (3) | JP5184354B2 (enExample) |
| KR (3) | KR101733180B1 (enExample) |
| CN (2) | CN104059013B8 (enExample) |
| AU (1) | AU2006275870B2 (enExample) |
| BR (1) | BRPI0613943B1 (enExample) |
| CA (1) | CA2659215C (enExample) |
| CY (1) | CY1122238T1 (enExample) |
| IL (2) | IL189008A (enExample) |
| NO (1) | NO343037B1 (enExample) |
| NZ (1) | NZ592836A (enExample) |
| PL (1) | PL2719384T3 (enExample) |
| RU (1) | RU2008107336A (enExample) |
| WO (1) | WO2007016155A2 (enExample) |
| ZA (1) | ZA200801825B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| US20070082940A1 (en) | 2005-07-27 | 2007-04-12 | Phil Skolnick | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| US20080045725A1 (en) * | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| EP2016053B1 (en) * | 2006-04-28 | 2010-11-10 | Merck Sharp & Dohme Corp. | Process for the synthesis of (+) and (-)-1-aryl-3-azabicyclo[3.1.0]hexanes |
| US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| GB0716632D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Compounds |
| GB0716633D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Compounds |
| GB0804326D0 (en) * | 2008-03-07 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
| ES2421171T3 (es) * | 2008-12-16 | 2013-08-29 | Sunovion Pharmaceuticals Inc. | Inhibidores de reabsorción triples y su uso en métodos |
| CN102803224A (zh) | 2009-06-26 | 2012-11-28 | 万能药生物有限公司 | 新的氮杂双环己烷类化合物 |
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