CN101264282A - Chinese medicinal composition for treating chronic atrophic gastritis and preparation thereof - Google Patents

Abstract

The invention relates to a Chinese herbal medicine composition for curing chronic atrophic gastritis, comprising combined spicebush, danshen root, Sichuan coptis root, radish seed, bitter orange, tangerine peel, lanceolata, bupleurum, angelica sinensis, kingpam, semen alpinaekatsumadai, dried green orange peel, lily, hungry root, radix glycyrrhizae and/or medically acceptable carrier. The Chinese herbal medicine composition has the functions of invigorating qi, warming the interior, activating blood circulation, eliminating blood stasis, removing stagnation, producing skin, relieving liver and regulating qi, and is used for curing symptoms such as epigastria distension, eructation and poor appetite caused by chronic atrophic gastritis.

Description

A kind of Chinese medicine composition for the treatment of chronic atrophic gastritis and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, specifically, relate to a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis and preparation method thereof.

Background technology

Chronic atrophic gastritis is a type of chronic gastritis, be the intrinsic gland atrophy of gastric mucosa (the quantity minimizing of limitation or popularity, function lowers), often with intestinal epithelial metaplasia and inflammatory reaction, the main pathology finding that relies on gastroscope to find stomach function regulating biopsy of mucous membrane of its diagnosis.With advancing age, the incidence rate of primary disease also increases thereupon, and lesion degree is also heavy more, so there is the people to think that chronic atrophic gastritis is the degeneration of person in middle and old age's gastric mucosa, is a kind of " reason in half a lifetime " phenomenon.The sickness rate of gastric cancer district occurred frequently chronic atrophic gastritis is than the low district's height of sending out.

Check distribution with the gastric pathological changes according to the atrophic gastritis seroimmunity, it is divided into independently type of two of A type and Type Bs.A type atrophic gastritis pathological changes is mainly seen in body of stomach, and many diffusivities distribute, and antrum is generally normal, the serum parietal cell antibody positive, serum gastrin increases, and gastric acid and intrinsic factor secretion reduce or lack, pernicious anemia easily takes place, and is called autoimmunity gastritis again.Type B atrophic gastritis pathological changes is more common in gastric antrum portion, is the distribution of many kitchen ranges property, serum parietal cell antibody feminine gender, and how normal serum gastrin is, and gastric acid secretion is normal or slight to be lowered, no pernicious anemia, easier concurrent gastric cancer, this is a kind of simple atrophy gastritis.

The clinical manifestation of chronic atrophic gastritis not only lacks specificity, and also not quite identical with lesion degree.Clinically, but some chronic atrophic gastritis patient non-evident sympton.But Most patients can have epigastrium causalgia, distending pain, dull pain or distension, painful abdominal mass vexed, especially eating the back for very, and symptoms such as inappetence, nauseating, belch, constipation or diarrhoea.Severe patient can be become thin, anemia, onychorrhexis, glossitis or atrophy of tongue papillae, and minority gastric mucosal erosion person can be with upper gastrointestinal hemorrhage.Wherein the concurrent pernicious anemia of A type atrophic gastritis is rare in China.Primary disease does not have special sign, and epigastrium can have mild tenderness.

Because primary disease sickness rate height, and Chang Fanfu outbreak clinically are difficult for curing, close with being related of gastric cancer again, thereby chronic atrophic gastritis more and more is subject to people's attention.

The prevention of chronic atrophic gastritis should accomplish following some:

Food want fresh and nutritious, guarantee to have enough protein, vitamin and irony to take in.Feed on time, eating and drinking too much at one meal is not eaten supercool or superheated food, uses no or little zest flavoring agent such as fresh peppery powder etc.

2. be moderate in drinking, non-smoking is to avoid the infringement of nicotine to gastric mucosa; Avoid taking for a long time anti-inflammation analgesic, as aspirin and corticosteroids medicine etc., to reduce the gastric mucosa infringement.

3. make regular check on, do gastroscopy in case of necessity.

4. meet sx, become thin, should in time arrive examination in hospital during situation such as anorexia, melena.

The traditional Chinese medical science thinks that chronic atrophic gastritis belongs to categories such as " gastric abscess ", " feeling of fullness ".Huangdi's Internal Classics has records such as " epigastralgia right below the heart ", " painful abdominal mass ", " painful abdominal mass plug "; Also comprised primary disease in the Tang Dynasty Sun Simiao Thousand Golden Prescriptions " nine types of precordial pain ".The traditional Chinese medical science thinks that the incongruous feelings will of diet freely is not topmost two causes of disease of this disease.In addition, innate deficiency, weather also have certain influence to primary disease.

Wet, stagnant, empty, four aspects of the stasis of blood that its pathogenesis has:

Wet: have a liking for because of patient's element drink, addiction to greasy and sweet foods and pungent ∫ help and wetly help heat so that retention of damp-heat in the interior hinders in middle Jiao.

Stagnate: often because of the emotion melancholy, psychentonia causes stagnation of QI due to depression of the liver, and perverse and unreasonable manner is violated stomach, or because of deficiency-weakness of spleen-QI, middle gas is not transported, the empty stagnation of QI in causing.

Empty: hungry full variable, eating cold and uncooked food excessively and roughage, or the tax of patient's spring is not enough, and injury due to diet causes weakness of the spleen and stomach in addition.If its people's innate deficiency of YANG in the body then shows as Pi insufficiency of stomach sympotoms caused by cold factors, if the plain body deficiency of YIN, or cold-evil's heat-transformation, or the medicine of life-time service warm-dryness syndrome, compel the stomach-Yin of burning, the downward consumption of kidney-YIN by excessive heart-fire, the disease of one-tenth deficiency of stomach-Yin.Both can influence each other again, become the disease of deficiency of both YIN and YANG.

The stasis of blood: functional activity of QI being not smooth, blood are followed the long-pending stasis of blood that forms that stagnates; Cloudy Tianjin is not applied, and the stomach film loses supports, and local organization is done withered not gentle, the withered one-tenth stasis of blood in Tianjin; Network is hindered in heat-transformation, and network decreases blood oozing from the body openings or subcuta neous tissue, and long-pending is blood stasis.

Primary disease can be divided into following four types:

1. deficiency of spleen-QI and stomach-QI (or YANG deficiency of the spleen and stomach): gastral cavilty has a dull ache, the patient's condition protracted course of disease, inappetence, anorexia abdominal distention, belch, fatigue and weakness, or see lustreless complexion or sallow, the hands and feet being not warm, big loose stool is thin, the time general clear water b pale tongue with white fur, thready and weak pulse or soft-weak pulse.

2. incoordination between the liver and stomach: the gastral cavilty distension, to attack support and have a pain, pain connects two sides of body, belch uncomfortable in chest, sighing frequently, susceptible to lose temper due to restlessness is whenever done because of worry is disgruntled, and how thin white or yellow tongue is, stringy pulse or stringy and thready pulse.

3. deficiency of stomach-Yin: the indistinct causalgia of gastral cavilty, even heartburn sense is arranged, and noisy polyphagia, hunger but having no desire to eat, pain is pain relieved by pressing then, dryness of the mouth and throat, excessive thirst is thought drink, constipation.Red tongue with a little fluid, the few or stripping of tongue, thready and rapid pulse.

4. the stasis of blood hinders the stomach network: stomachache is acute, or as bore spine, continues endlessly, and fix and do not move, tenderness, or see haematemesis, just black, even Na Gu falls sharply retch, emaciated physique, dim complexion.Purplish tongue or ecchymosis is arranged, hesitant pulse.

The traditional Chinese medical science adopts in the fill temperature, this disease of decoction for the treatment of promoting blood circulation to remove blood stasis, detumescence and promoting granulation, depressed liver-energy dispersing and QI regulating.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Linderae 5-10 part Radix Salviae Miltiorrhizae 15-25 part Rhizoma Coptidis 10-20 part Semen Raphani 10-15 part

Fructus Aurantii 5-15 part Pericarpium Citri Reticulatae 10-15 part Radix Codonopsis 10-20 part Radix Bupleuri 10-15 part

Bulky 10-20 part of Radix Angelicae Sinensis 10-15 part Semen Alpiniae Katsumadai 15-25 part Pericarpium Citri Reticulatae Viride 10-25 part

Bulbus Lilii 20-25 part Radix Et Rhizoma Nardostachyos 15-25 part Radix Glycyrrhizae 20-30 part

Effective ingredient is preferably made by weight by following raw materials according:

13 parts of 16 parts of Semen Raphanis of 21 parts of Rhizoma Coptidis of 8 parts of Radix Salviae Miltiorrhizaes of the Radix Linderae

13 parts of 16 parts of Radix Bupleuri of 13 parts of Radix Codonopsis of 11 parts of Pericarpium Citri Reticulataes of Fructus Aurantii

18 parts on 21 parts of Pericarpium Citri Reticulatae Virides of 13 parts bulky 16 parts of Semen Alpiniae Katsumadai of Radix Angelicae Sinensis

26 parts in 21 portions of Radix Glycyrrhizaes of 23 parts of Radix Et Rhizoma Nardostachyos of Bulbus Lilii

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) to be ground into impalpable powder standby for Radix Bupleuri;

(2) Fructus Aurantii, Radix Codonopsis, Pericarpium Citri Reticulatae Viride are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Linderae, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Semen Raphani, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, bulky, Semen Alpiniae Katsumadai, Bulbus Lilii, Radix Et Rhizoma Nardostachyos, Radix Glycyrrhizae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Effects such as Chinese medicine composition of the present invention has in the fill temperature, promoting blood circulation to remove blood stasis, detumescence and promoting granulation, depressed liver-energy dispersing and QI regulating are used for that the upper abdomen that chronic atrophic gastritis causes is glutted, disease such as belch, stomach poor appetite move back.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) to be ground into impalpable powder standby for Radix Bupleuri 130g;

(2) Fructus Aurantii 110g, Radix Codonopsis 160g, Pericarpium Citri Reticulatae Viride 180g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Linderae 80g, Radix Salviae Miltiorrhizae 210g, Rhizoma Coptidis 160g, Semen Raphani 130g, Pericarpium Citri Reticulatae 130g, Radix Angelicae Sinensis 130g, bulky 160g, Semen Alpiniae Katsumadai 210g, Bulbus Lilii 230g, Radix Et Rhizoma Nardostachyos 210g, Radix Glycyrrhizae 260g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, add dextrin 800g, lactose 200g, mixing, with 70% ethanol wet granulation promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) to be ground into impalpable powder standby for Radix Bupleuri 130g;

(2) Fructus Aurantii 110g, Radix Codonopsis 160g, Pericarpium Citri Reticulatae Viride 180g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Linderae 80g, Radix Salviae Miltiorrhizae 210g, Rhizoma Coptidis 160g, Semen Raphani 130g, Pericarpium Citri Reticulatae 130g, Radix Angelicae Sinensis 130g, bulky 160g, Semen Alpiniae Katsumadai 210g, Bulbus Lilii 230g, Radix Et Rhizoma Nardostachyos 210g, Radix Glycyrrhizae 260g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) to be ground into impalpable powder standby for Radix Bupleuri 150g;

(2) Fructus Aurantii 110g, Radix Codonopsis 160g, Pericarpium Citri Reticulatae Viride 180g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Linderae 80g, Radix Salviae Miltiorrhizae 210g, Rhizoma Coptidis 160g, Semen Raphani 130g, Pericarpium Citri Reticulatae 130g, Radix Angelicae Sinensis 130g, bulky 160g, Semen Alpiniae Katsumadai 210g, Bulbus Lilii 230g, Radix Et Rhizoma Nardostachyos 210g, Radix Glycyrrhizae 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add starch 300g, microcrystalline Cellulose 200g, mixing, with 70% ethanol wet granulation, tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of chronic atrophic gastritis is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Radix Linderae 5-10 part Radix Salviae Miltiorrhizae 15-25 part Rhizoma Coptidis 10-20 part Semen Raphani 10-15 part

Fructus Aurantii 5-15 part Pericarpium Citri Reticulatae 10-15 part Radix Codonopsis 10-20 part Radix Bupleuri 10-15 part

Bulky 10-20 part of Radix Angelicae Sinensis 10-15 part Semen Alpiniae Katsumadai 15-25 part Pericarpium Citri Reticulatae Viride 10-25 part

Bulbus Lilii 20-25 part Radix Et Rhizoma Nardostachyos 15-25 part Radix Glycyrrhizae 20-30 part

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

13 parts of 16 parts of Semen Raphanis of 21 parts of Rhizoma Coptidis of 8 parts of Radix Salviae Miltiorrhizaes of the Radix Linderae

13 parts of 16 parts of Radix Bupleuri of 13 parts of Radix Codonopsis of 11 parts of Pericarpium Citri Reticulataes of Fructus Aurantii

18 parts on 21 parts of Pericarpium Citri Reticulatae Virides of 13 parts bulky 16 parts of Semen Alpiniae Katsumadai of Radix Angelicae Sinensis

26 parts in 21 portions of Radix Glycyrrhizaes of 23 parts of Radix Et Rhizoma Nardostachyos of Bulbus Lilii

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) to be ground into impalpable powder standby for Radix Bupleuri;

(2) Fructus Aurantii, Radix Codonopsis, Pericarpium Citri Reticulatae Viride are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Linderae, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Semen Raphani, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, bulky, Semen Alpiniae Katsumadai, Bulbus Lilii, Radix Et Rhizoma Nardostachyos, Radix Glycyrrhizae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.