CN102973835B - Traditional Chinese medicine composition for treating damp-heat type cholecystitis - Google Patents
Traditional Chinese medicine composition for treating damp-heat type cholecystitis Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines for treating cholecystitis. For solving the problem that the existing traditional Chinese medicines for treating cholecystitis are not applicable to the crowd with weak constitutions, the invention provides a traditional Chinese medicine composition for treating damp-heat type cholecystitis, which is prepared from corn silk, stringy stonecrop, tuckahoe, dandelion, lophatherum, abrus herb, phellodendron bark, semen dolichoris album, bighead atractylodes rhizome, Chinese atractylodes, astragalus root, wolfberry fruit, common rue herb, sanchi flower, vladimiria root, liquorice and fresh fruits of elm according to a special proportion. The traditional Chinese medicine composition for treating damp-heat type cholecystitis mainly aims at weak patients with chronic cholecystitis, mainly takes effects on soothing the liver, strengthening the spleen and normalizing the gallbladder, simultaneously contains medicines for clearing away heat and toxic material and medicines for alleviating pain, can address symptoms by removing heat, eliminating dampness, promoting subsidence of swelling and alleviating pain, and also can effect a permanent cure by strengthening the spleen, nourishing the stomach and nourishing the liver and gall, thereby achieving the aim of eliminating root causes of disease. Therefore, the traditional Chinese medicine composition provided by the invention has the advantages of addressing both the symptoms and root causes and having small side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of cholecystitis, relate in particular to a kind of Chinese medicine composition for the treatment of damp-heat cholecystitis.
Background technology
The traditional Chinese medical science is by categories such as cholecystitis ownership " hypochondriac pain ", " blocked-up chest ", " yellow cellulitis ".Think that eating and drinking without temperance, disorder of emotion are the Etiologicals that causes primary disease.As long-term excessive drinking, have a liking for food delicious food savoury person, damp and hot interior life, pents up taste, hot and suffocating liver and gall, causing soil, to stop up wood strongly fragrant, or the hot and suffocating stone that decocts into; Or have a liking for food Pickles rareripe, and make parasitic ovum people in gastrointestinal, with the passing of time malnutrition due to parasitic infestation retardance liver and gall mechanism of qi, causes bile catharsis unfavorable.The easy impairing the liver of anxiety and rage, the gallbladder being attached to the liver, both are the exterior and the interior each other, and liver hinders gallbladder must get involved, and liver and gall are lost and are dredged, and gallbladder internal organs is logical falls mistake department, and bile excretion is not smooth.
For the crowd who has a delicate constitution, it is insufficiency of the spleen and can not removing dampness that its cause of disease of suffering from cholecystitis mostly is, hot and suffocating liver and gall, and liver network is become estranged, and not catharsis of gallbladder, therefore have persistence upper right abdominal distention and pain or angor; Gallbladder meridian is capable of the side of health, therefore pain is drawn the shoulder back of the body; Damp and hot interior knot, pathogenic heat are flourishing, therefore there is heating fear of cold; Damp and hot middle resistance, taste are stranded, therefore see indigestion and loss of appetite, nausea vomiting uncomfortable in chest, bitter taste in the mouth and dry throat; Yellowish fur, stringy and tense pulse are resembling for dampness-heat in the liver and gallbladder.And the Chinese medicine of existing treatment cholecystitis is main mainly with heat clearing away, the property of medicine is stronger; The weak crowd of body constitution tends to occur comparatively serious side effect while using.
Summary of the invention
In order to solve the weak inapplicable problem of crowd of the existing body constitution of Chinese medicine of existing treatment cholecystitis, the invention provides a kind of Chinese medicine composition for the treatment of damp-heat cholecystitis.Chinese medicine composition of the present invention, mainly for the chronic cholecystitis patient who has a delicate constitution, take soothing liver and strengthening spleen function of gallbladder promoting as main, thereby can reach the object of eradicating the cause of disease.
Technical scheme of the present invention:
Treat a Chinese medicine composition for damp-heat cholecystitis, by the medicinal raw material of following weight parts, formed: Stigma Maydis 30-40 part, Herba Sedi 25-30 part, Poria 10-15 part, Herba Taraxaci 15-20 part, Herba Lophatheri 6-12 part, Herba Abri 15-20 part, Cortex Phellodendri 3-9 part, Semen Lablab Album 10-15 part, Rhizoma Atractylodis Macrocephalae 6-15 part, Rhizoma Atractylodis 5-9 part, Radix Astragali 15-25 part, Fructus Lycii 6-15 part, Herba rutae 5-15 part, flower of Radix Notoginseng 9-15 part, Radix Vladimiriae 1.5-9 part, Radix Glycyrrhizae 15-25 part, fresh Ulmus pumila L. 0-60g; Except fresh Ulmus pumila L., described raw material is dry product.
The Chinese medicine composition of above-mentioned treatment damp-heat cholecystitis, preferably, the medicinal raw material by following weight parts forms: 40 parts of Stigma Maydis, 30 parts of Herba Sedis, 15 parts, Poria, 20 parts of Herba Taraxacis, 6 parts of Herba Lophatheris, 15 parts of Herba Abris, 6 parts of Cortex Phellodendris, 12 parts of Semen Lablab Albums, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Rhizoma Atractylodis, 15 parts of the Radixs Astragali, 12 parts of Fructus Lycii, 6 parts of Herba rutaes, 12 parts of flower of Radix Notoginseng, 6 parts of Radix Vladimiriaes, 25 parts, Radix Glycyrrhizae, fresh Ulmus pumila L. 40-60g; Except fresh Ulmus pumila L., described raw material is dry product.
Stigma Maydis; Property is put down, sweet in the mouth, light; Return bladder, liver, gallbladder meridian; Be mainly used in: inducing diuresis to remove edema, dampness removing jaundice eliminating.Cure mainly edema, dribbling urination, jaundice, cholecystitis, cholelithiasis.
Poria; Property is put down, sweet in the mouth, light; GUIXIN, lung, spleen, kidney channel; Be mainly used in: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, insufficiency of the spleen lack of appetite.
Herba Sedi; Cool in nature, sweet in the mouth, light; Return liver, gallbladder, small intestine meridian; Be mainly used in: heat clearing away, detumescence, removing toxic substances.
Herba Taraxaci; Cold in nature, sweet in the mouth, hardship; Return liver, stomach warp; Be mainly used in: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
Herba Lophatheri; Cold in nature, sweet in the mouth, light; GUIXIN, stomach, small intestine meridian; Be mainly used in: clearing heat and relieving fidgetness, diuresis.
Herba Abri; Cool in nature, sweet in the mouth, micro-hardship; Return liver, stomach warp; Be mainly used in: heat-clearing and toxic substances removing, Shugan Zhitong, depression of liver-QI.Taboo: this product seed is poisonous, the used time must be extractd soybean pod, in order to avoid poisoning.
Cortex Phellodendri; Cold in nature, bitter in the mouth; Return kidney, urinary bladder channel; Be mainly used in: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.
Semen Lablab Album; Slightly warm in nature, sweet in the mouth; Return spleen, stomach warp; Be mainly used in: invigorating the spleen for eliminating dampness, weakness of the spleen and stomach, inappetence.
The Rhizoma Atractylodis Macrocephalae; Warm in nature, bitter in the mouth, sweet; Return spleen, stomach warp; Be mainly used in: air making-up and spleen enlivening, dampness diuretic, insufficiency of the spleen lack of appetite.
Rhizoma Atractylodis; Warm in nature, bitter in the mouth, pungent; Return spleen, stomach warp; Be mainly used in: drying damp and strengthening spleen, expelling wind and cold.
The Radix Astragali; Slightly warm in nature, sweet in the mouth; Return spleen, lung meridian; Be mainly used in: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the deficiency of vital energy is weak.
Fructus Lycii; Property is put down, sweet in the mouth; Return liver, kidney channel; Be mainly used in: nourishing the liver and kidney, interior-heat is quenched one's thirst.
Herba rutae; Cold in nature, bitter in the mouth, pungent; Be mainly used in: dispel the wind, bring down a fever, diuresis, invigorates blood circulation removing toxic substances, detumescence.
Flower of Radix Notoginseng; Cool in nature, sweet in the mouth; Return Liver Channel; Be mainly used in: heat clearing away, suppressing the hyperactive liver.
Radix Vladimiriae; Warm in nature; Acrid in the mouth, hardship; Return spleen, stomach, large intestine, gallbladder meridian; Be mainly used in: promoting the circulation of QI to relieve pain, liver and gall pain.
Radix Glycyrrhizae; Property is put down, sweet in the mouth; GUIXIN, lung, spleen, stomach warp; Be mainly used in: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, weakness of the spleen and stomach, cushion toxicity, strong, coordinating the actions of various ingredients in a prescription.
Ulmus pumila L., property is flat, sweet in the mouth, micro-pungent; Return lung, spleen, heart channel; Be mainly used in: spleen-benefiting mind-tranquilizing, clearing heart fire, detumescence is reduced phlegm, clearing away heat and promoting diuresis.
Stigma Maydis in the present invention, Herba Sedi and Poria promoting diuresis to clear away damp pathogen; Herba Taraxaci, Herba Lophatheri, Herba Abri, Herba rutae, flower of Radix Notoginseng and Cortex Phellodendri heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Their combineds effect are to eliminate the damp and hot symptom of chronic cholecystitis; And Radix Vladimiriae, Radix Glycyrrhizae are used for promoting the circulation of QI to relieve pain, thereby can alleviate patient's pain.And Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, the Radix Astragali, Fructus Lycii is wherein used for strengthening the spleen and nourishing the stomach, nourishing liver and gall; To strengthen patient's body constitution, elimination, produce damp and hot root; Thereby reach the object of effecting a permanent cure.The property of medicine of Herba Taraxaci, Herba Lophatheri, Herba Abri and Cortex Phellodendri is less, helps Semen Lablab Album, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, the Radix Astragali, Fructus Lycii with strengthening the spleen and nourishing the stomach simultaneously, therefore, there will not be the side effect such as diarrhoea, vomiting; Be applicable to suffer from patient chronic cholecystitis, weakness of the spleen and stomach.
The preparation method of Chinese medicine composition of the present invention: decoct with water, make water preparation, or further concentrated, make honeyed pill; Or directly grind and make tablet, capsule; And other conventional preparation methoies.
The using method of Chinese medicine composition of the present invention: take decoction as example, get crude drug 140-200g every day, decoct with water, concentrated decoction liquor is to 300-500ml; Take at twice, sooner or later respectively once, one after each meal; Period in a medicine, the food of greasy, meat or fish one class of edible oil, is not advisable with vegetarian diet.
Beneficial effect:
Chinese medicine composition of the present invention, take removing dampness spleen invigorating as main, has medicine and the analgesic drug product of heat-clearing and toxic substances removing concurrently simultaneously; Not only can reach the function of taking stopgap measures of heat extraction removing dampness, reducing swelling and alleviating pain; Can also play the function of effecting a permanent cure of strengthening the spleen and nourishing the stomach, nourishing liver and gall simultaneously.Therefore, Chinese medicine composition of the present invention possesses treating both the principal and secondary aspects of a disease, the little advantage of side effect.
The curative effect of Chinese medicine composition of the present invention is described below by clinical trial.
This test MethodsThe cases enrolled is totally 240 examples, all derives from the outpatient service of same institute of traditional Chinese medicine and inpatient, all, through being diagnosed as the damp and hot interior knot patient of chronic cholecystitis and the traditional Chinese medical science, is divided at random 4 groups, and test 1-3 group is 60 examples, matched group 60 examples.Wherein, test 1 group, male 18 examples, female's 42 examples, maximum 60 years old, minimum 25 years old, 45.6 ± 8.3 years old mean age, the course of disease was the shortest 3 months, the longest 36 months, average course of disease 12.5 ± 3.1 months; Test 2 groups, male 22 examples, female's 38 examples, maximum 61 years old, minimum 25 years old, 46.1 ± 7.9 years old mean age, the course of disease was the shortest 3 months, the longest 36 months, average course of disease 12.7 ± 2.9 months.Test 3 groups, male 21 examples, female's 39 examples, maximum 60 years old, minimum 26 years old, 45.9 ± 8.4 years old mean age, the course of disease was the shortest 3 months, the longest 36 months, average course of disease 12.8 ± 3.3 months.Matched group, male 20 examples, female's 40 examples, maximum 61 years old, minimum 26 years old, 47.1 ± 8.7 years old mean age, the course of disease was the shortest 3 months, the longest 36 months, average course of disease 12.1 ± 3.5 months.Epidemiological Analysis by statistics, four groups of cases are from sex, age, the course of disease, the comparison of state of an illness aspect, its difference there are no significant meaning (p>0.05).
Through patient, agree to, test 1 group of patient and adopt the Chinese medicine composition of embodiment 1 to treat; Adopt the Chinese medicine composition 150g of embodiment 1 every day, with being decocted in water for oral dose; Take at twice, sooner or later respectively once, one after each meal.Testing 2 groups of patients adopts the Chinese medicine composition of embodiment 2 to treat; Adopt the Chinese medicine composition 150g of embodiment 2 every day, with being decocted in water for oral dose; Take at twice, sooner or later respectively once, one after each meal.Testing 3 groups of patients adopts the Chinese medicine composition of embodiment 3 to treat; Adopt the Chinese medicine composition 150g of embodiment 3 every day, with being decocted in water for oral dose; Take at twice, sooner or later respectively once, one after each meal.Matched group patient adopts depressed liver-energy dispersing and function of gallbladder promoting soup to treat.During medication, all patients are the food of greasy, meat or fish one class of edible oil not all, with vegetarian diet, is advisable.
Curative effect determinate standard
1. recovery from illness: right flank dull pain transference cure; Feed greasy food postemphasis, xerostomia, abdominal distention, the transference cure such as weak; The wall thickness of gallbladder or gallbladder tube wall, three of crude, entrant sounds recover normal;
2. effective: right flank dull pain symptom is obviously improved; Feed greasy food postemphasis, xerostomia, abdominal distention, the symptom such as weak are obviously improved; The wall thickness of gallbladder or gallbladder tube wall, crude, two improvement of entrant sound;
3. effective: right flank dull pain symptom is improved; Feed greasy food postemphasis, xerostomia, abdominal distention, the symptom such as weak are improved; The wall thickness of gallbladder or gallbladder tube wall, crude, improvement of entrant sound;
4. invalid: right flank dull pain symptom is not improved; Feed greasy food postemphasis, xerostomia, abdominal distention, the symptom such as weak are not improved; Three of the wall thickness of gallbladder or gallbladder tube wall, crude, entrant sound are all without improving;
5. untoward reaction: have diarrhoea, vomiting, feel sick, the one symptom in bitter taste occurs;
6. relapse rate: reappear disease after drug withdrawal 10-30 days.
After medication 6 months; Statistical result is as following table
| ? | Test 1 group | Test 2 groups | Test 3 groups | Matched group |
| Recovery from illness | 15 | 14 | 13 | 9 |
| Effective | 25 | 24 | 25 | 20 |
| Effectively | 18 | 20 | 19 | 22 |
| Invalid | 2 | 2 | 3 | 9 |
| Total effective rate | 96.7％ | 96.7％ | 95％ | 85％ |
| Untoward reaction | 0 | 1 | 1 | 9 |
| Untoward reaction rate | 0 | 1.67％ | 1.67％ | 15％ |
| Recurrence | 1 | 0 | 0 | 3 |
| Relapse rate | 1.67％ | 0 | 0 | 5％ |
The total effective rate of test group is 96.1%, and average untoward reaction rate is 1.1%, and average relapse rate is 0.56%; And the effective percentage of matched group is 85%, untoward reaction rate is 15%, and relapse rate is 5%.
Above-mentioned clinical trial shows, Chinese medicine composition good effect of the present invention, cure rate is high, untoward reaction rate is low, relapse rate is low.
The specific embodiment
Embodiment 1
A kind of Chinese medicine composition for the treatment of damp-heat cholecystitis, in taking dose on the one, by Stigma Maydis 20g, Herba Sedi 15g, Poria 8g, Herba Taraxaci 10g, Herba Lophatheri 3g, Herba Abri 8g, Cortex Phellodendri 3g, Semen Lablab Album 6g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Atractylodis 8g, Radix Astragali 8g, Fructus Lycii 6g, Herba rutae 3g, flower of Radix Notoginseng 6g, Radix Vladimiriae 3g, Radix Glycyrrhizae 13g, fresh Ulmus pumila L. 30g, formed; Except fresh Ulmus pumila L., described raw material is dry product.
Embodiment 2
A kind of Chinese medicine composition for the treatment of damp-heat cholecystitis, in taking dose on the one, by Stigma Maydis 24g, Herba Sedi 18g, Poria 10g, Herba Taraxaci 12g, Herba Lophatheri 4g, Herba Abri 10g, Cortex Phellodendri 4g, Semen Lablab Album 8g, Rhizoma Atractylodis Macrocephalae 7g, Rhizoma Atractylodis 5g, Radix Astragali 10g, Fructus Lycii 7g, Herba rutae 4g, flower of Radix Notoginseng 7g, Radix Vladimiriae 4g, Radix Glycyrrhizae 16g, formed; Described raw material is dry product.
Embodiment 3
A kind of Chinese medicine composition for the treatment of damp-heat cholecystitis, in taking dose on the one, by Stigma Maydis 22g, Herba Sedi 16g, Poria 7g, Herba Taraxaci 12g, Herba Lophatheri 6g, Herba Abri 12g, Cortex Phellodendri 5g, Semen Lablab Album 7g, Rhizoma Atractylodis Macrocephalae 6g, Rhizoma Atractylodis 6g, Radix Astragali 9g, Fructus Lycii 8g, Herba rutae 5g, flower of Radix Notoginseng 8g, Radix Vladimiriae 4g, Radix Glycyrrhizae 15g, formed; Described raw material is dry product.
Claims (1)
1. a Chinese medicine composition for the treatment of damp-heat cholecystitis, it is characterized in that, by the medicinal raw material of following weight parts, formed: 40 parts of Stigma Maydis, 30 parts of Herba Sedis, 15 parts, Poria, 20 parts of Herba Taraxacis, 6 parts of Herba Lophatheris, 15 parts of Herba Abris, 6 parts of Cortex Phellodendris, 12 parts of Semen Lablab Albums, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Rhizoma Atractylodis, 15 parts of the Radixs Astragali, 12 parts of Fructus Lycii, 6 parts of Herba rutaes, 12 parts of flower of Radix Notoginseng, 6 parts of Radix Vladimiriaes, 25 parts, Radix Glycyrrhizae, fresh Ulmus pumila L. 40-60g; Except fresh Ulmus pumila L., described raw material is dry product.
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| CN104758620A (en) * | 2015-04-22 | 2015-07-08 | 王玉玲 | Liver-soothing and bladder-relieving agent for patients with cholecystitis and preparation method of liver-soothing and bladder-relieving agent |
| CN110946889A (en) * | 2019-12-27 | 2020-04-03 | 西南大学 | Application of radix aucklandiae or radix aucklandiae extract in preparation of anti-cholestasis drug |
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