CN101258154B - 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 - Google Patents
作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 Download PDFInfo
- Publication number
- CN101258154B CN101258154B CN2006800322776A CN200680032277A CN101258154B CN 101258154 B CN101258154 B CN 101258154B CN 2006800322776 A CN2006800322776 A CN 2006800322776A CN 200680032277 A CN200680032277 A CN 200680032277A CN 101258154 B CN101258154 B CN 101258154B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- azepine
- phenyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *[n]1nc(CCNCC2)c2c1 Chemical compound *[n]1nc(CCNCC2)c2c1 0.000 description 3
- IRXCERGGZYNFJI-UHFFFAOYSA-N C(C1)CC1N(CCc1c2)CCc1n[n]2-c(cc1)ccc1N1CCCCC1 Chemical compound C(C1)CC1N(CCc1c2)CCc1n[n]2-c(cc1)ccc1N1CCCCC1 IRXCERGGZYNFJI-UHFFFAOYSA-N 0.000 description 1
- QXNHMMUIMGMLEH-UHFFFAOYSA-M CNC(c(cc1)ccc1[N-]/C=C(/CCN(CC1)C2CCC2)\C1=N)=O Chemical compound CNC(c(cc1)ccc1[N-]/C=C(/CCN(CC1)C2CCC2)\C1=N)=O QXNHMMUIMGMLEH-UHFFFAOYSA-M 0.000 description 1
- PPKYYYZMDGNSDA-UHFFFAOYSA-N Cc1n[o]c(-c(cc2)ccc2-[n]2nc(CCN(CC3)C4CCC4)c3c2)n1 Chemical compound Cc1n[o]c(-c(cc2)ccc2-[n]2nc(CCN(CC3)C4CCC4)c3c2)n1 PPKYYYZMDGNSDA-UHFFFAOYSA-N 0.000 description 1
- ZZWYBGWBUVCGCI-UHFFFAOYSA-N Cc1n[o]c(-c(cc2)ccc2-[n]2nc(CCN(CC3)C4CCCC4)c3c2)n1 Chemical compound Cc1n[o]c(-c(cc2)ccc2-[n]2nc(CCN(CC3)C4CCCC4)c3c2)n1 ZZWYBGWBUVCGCI-UHFFFAOYSA-N 0.000 description 1
- JSPMYAZGTGJOAI-UHFFFAOYSA-N NC(c(cc1)ccc1-[n]1nc(CCN(CC2)C3CCC3)c2c1)=O Chemical compound NC(c(cc1)ccc1-[n]1nc(CCN(CC2)C3CCC3)c2c1)=O JSPMYAZGTGJOAI-UHFFFAOYSA-N 0.000 description 1
- TTWVEAVVWIPVRA-UHFFFAOYSA-N O=C(CCC1)CCN1c1ccccc1 Chemical compound O=C(CCC1)CCN1c1ccccc1 TTWVEAVVWIPVRA-UHFFFAOYSA-N 0.000 description 1
- PFKVVKZVZKQJIY-UHFFFAOYSA-N O=C(CCC1)N1c(cc1)ccc1-[n]1nc(CCN(CC2)C3CCCC3)c2c1 Chemical compound O=C(CCC1)N1c(cc1)ccc1-[n]1nc(CCN(CC2)C3CCCC3)c2c1 PFKVVKZVZKQJIY-UHFFFAOYSA-N 0.000 description 1
- GMHPWGYTSXHHPI-UHFFFAOYSA-N O=C1CCNCCC1 Chemical compound O=C1CCNCCC1 GMHPWGYTSXHHPI-UHFFFAOYSA-N 0.000 description 1
- PJVRZZUYFFUPHR-UHFFFAOYSA-N O=CC(CCN(CC1)P)=C1Cl Chemical compound O=CC(CCN(CC1)P)=C1Cl PJVRZZUYFFUPHR-UHFFFAOYSA-N 0.000 description 1
- TZYAOUOEZBDAKN-UHFFFAOYSA-N PN1CCc2n[nH]cc2CC1 Chemical compound PN1CCc2n[nH]cc2CC1 TZYAOUOEZBDAKN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0513886.2 | 2005-07-06 | ||
| GBGB0513886.2A GB0513886D0 (en) | 2005-07-06 | 2005-07-06 | Novel compounds |
| PCT/EP2006/006613 WO2007025596A1 (en) | 2005-07-06 | 2006-07-04 | Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101258154A CN101258154A (zh) | 2008-09-03 |
| CN101258154B true CN101258154B (zh) | 2011-01-19 |
Family
ID=34856781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800322776A Expired - Fee Related CN101258154B (zh) | 2005-07-06 | 2006-07-04 | 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 |
Country Status (27)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| JP5203360B2 (ja) | 2006-06-23 | 2013-06-05 | アボット・ラボラトリーズ | ヒスタミンｈ３受容体調節剤としてのシクロプロピルアミン誘導体 |
| MX2010002938A (es) | 2007-09-24 | 2010-04-01 | Comentis Inc | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN102952139B (zh) * | 2011-08-30 | 2016-08-10 | 上海药明康德新药开发有限公司 | 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9910887B2 (en) * | 2013-04-25 | 2018-03-06 | Facebook, Inc. | Variable search query vertical access |
| KR20190040140A (ko) * | 2016-05-25 | 2019-04-17 | 아카나 테라퓨틱스, 엘티디. | 질환의 치료를 위한 융합된 비시클릭 화합물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325267A (zh) * | 1998-09-09 | 2001-12-05 | 石原产业株式会社 | 用作除草剂的稠合的苯衍生物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1173438A1 (en) * | 1999-04-16 | 2002-01-23 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| JP2001220390A (ja) | 2000-02-09 | 2001-08-14 | Yamanouchi Pharmaceut Co Ltd | 縮合ピラゾール誘導体 |
| WO2003104235A1 (en) | 2002-06-06 | 2003-12-18 | Novo Nordisk A/S | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]pyrazines and decahydropyrazino[1,2-a]azepines |
| US6770597B2 (en) | 2002-07-17 | 2004-08-03 | Ishihara Sangyo Kaisha, Ltd. | Benzohydrazide derivatives as herbicides and desiccant compositions containing them |
| US20060135508A1 (en) | 2002-07-25 | 2006-06-22 | Manuela Villa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| AU2003256793A1 (en) * | 2002-08-20 | 2004-03-11 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| TWI323256B (en) | 2002-12-20 | 2010-04-11 | Glaxo Group Ltd | Novel benzazepine derivatives and pharmaceutical compositions comprising said compounds |
| EA010905B1 (ru) * | 2003-09-17 | 2008-12-30 | Янссен Фармацевтика Н.В. | Сопряжённые гетероциклические соединения |
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| GB0405628D0 (en) | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| PE20060302A1 (es) | 2004-06-18 | 2006-04-08 | Glaxo Group Ltd | Derivados de benzazepina como antagonistas del receptor h3 |
| GB0418267D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
| JP2008523006A (ja) | 2004-12-07 | 2008-07-03 | グラクソ グループ リミテッド | インデニル誘導体および神経学的障害の治療のためのそれらの使用 |
| AU2006224440A1 (en) | 2005-03-14 | 2006-09-21 | Glaxo Group Limited | Fused thiazole derivatives having affinity for the histamine H3 receptor |
-
2005
- 2005-07-06 GB GBGB0513886.2A patent/GB0513886D0/en not_active Ceased
-
2006
- 2006-07-04 MX MX2008000383A patent/MX2008000383A/es active IP Right Grant
- 2006-07-04 BR BRPI0612719-3A patent/BRPI0612719A2/pt not_active IP Right Cessation
- 2006-07-04 ES ES06818218T patent/ES2345841T3/es active Active
- 2006-07-04 EA EA200800264A patent/EA013600B1/ru not_active IP Right Cessation
- 2006-07-04 HR HR20100401T patent/HRP20100401T1/hr unknown
- 2006-07-04 DE DE602006014273T patent/DE602006014273D1/de active Active
- 2006-07-04 UA UAA200800190A patent/UA93047C2/ru unknown
- 2006-07-04 SI SI200630733T patent/SI1899350T1/sl unknown
- 2006-07-04 CN CN2006800322776A patent/CN101258154B/zh not_active Expired - Fee Related
- 2006-07-04 US US11/994,689 patent/US7888347B2/en not_active Expired - Fee Related
- 2006-07-04 AT AT06818218T patent/ATE467636T1/de active
- 2006-07-04 WO PCT/EP2006/006613 patent/WO2007025596A1/en not_active Ceased
- 2006-07-04 DK DK06818218.7T patent/DK1899350T3/da active
- 2006-07-04 PL PL06818218T patent/PL1899350T3/pl unknown
- 2006-07-04 CA CA002614232A patent/CA2614232A1/en not_active Abandoned
- 2006-07-04 AU AU2006286897A patent/AU2006286897A1/en not_active Abandoned
- 2006-07-04 JP JP2008519862A patent/JP5145218B2/ja not_active Expired - Fee Related
- 2006-07-04 EP EP06818218A patent/EP1899350B1/en active Active
- 2006-07-04 KR KR1020087000265A patent/KR20080037651A/ko not_active Ceased
- 2006-07-04 PT PT06818218T patent/PT1899350E/pt unknown
-
2007
- 2007-12-12 ZA ZA200710798A patent/ZA200710798B/xx unknown
- 2007-12-17 IL IL188184A patent/IL188184A0/en unknown
- 2007-12-20 CR CR9622A patent/CR9622A/es not_active Application Discontinuation
-
2008
- 2008-01-09 MA MA30562A patent/MA29623B1/fr unknown
- 2008-01-30 NO NO20080563A patent/NO20080563L/no not_active Application Discontinuation
-
2010
- 2010-07-29 CY CY20101100713T patent/CY1110711T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325267A (zh) * | 1998-09-09 | 2001-12-05 | 石原产业株式会社 | 用作除草剂的稠合的苯衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20080563L (no) | 2008-02-01 |
| CA2614232A1 (en) | 2007-03-08 |
| WO2007025596A1 (en) | 2007-03-08 |
| CN101258154A (zh) | 2008-09-03 |
| CR9622A (es) | 2008-04-10 |
| HRP20100401T1 (hr) | 2010-09-30 |
| JP2009500366A (ja) | 2009-01-08 |
| KR20080037651A (ko) | 2008-04-30 |
| EP1899350A1 (en) | 2008-03-19 |
| ATE467636T1 (de) | 2010-05-15 |
| US20080176832A1 (en) | 2008-07-24 |
| ES2345841T3 (es) | 2010-10-04 |
| PT1899350E (pt) | 2010-07-21 |
| DE602006014273D1 (de) | 2010-06-24 |
| AU2006286897A1 (en) | 2007-03-08 |
| EA200800264A1 (ru) | 2008-06-30 |
| DK1899350T3 (da) | 2010-09-06 |
| SI1899350T1 (sl) | 2010-09-30 |
| UA93047C2 (ru) | 2011-01-10 |
| BRPI0612719A2 (pt) | 2010-11-30 |
| JP5145218B2 (ja) | 2013-02-13 |
| PL1899350T3 (pl) | 2010-10-29 |
| CY1110711T1 (el) | 2015-06-10 |
| ZA200710798B (en) | 2008-11-26 |
| GB0513886D0 (en) | 2005-08-10 |
| EA013600B1 (ru) | 2010-06-30 |
| EP1899350B1 (en) | 2010-05-12 |
| MA29623B1 (fr) | 2008-07-01 |
| IL188184A0 (en) | 2008-03-20 |
| MX2008000383A (es) | 2008-03-07 |
| US7888347B2 (en) | 2011-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110119 Termination date: 20130704 |