CN101223133B - 双（硫代酰肼酰胺）盐的合成 - Google Patents

双（硫代酰肼酰胺）盐的合成 Download PDF

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Publication number
CN101223133B
CN101223133B CN2006800170928A CN200680017092A CN101223133B CN 101223133 B CN101223133 B CN 101223133B CN 2006800170928 A CN2006800170928 A CN 2006800170928A CN 200680017092 A CN200680017092 A CN 200680017092A CN 101223133 B CN101223133 B CN 101223133B
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China
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methyl
alkali
organic solvent
phenyl
compound
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Expired - Fee Related
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CN2006800170928A
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English (en)
Chinese (zh)
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CN101223133A (zh
Inventor
陈寿军
夏志强
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Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800170928A 2005-05-16 2006-05-11 双（硫代酰肼酰胺）盐的合成 Expired - Fee Related CN101223133B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16
US60/681,263 2005-05-16
PCT/US2006/018653 WO2006124736A2 (en) 2005-05-16 2006-05-11 Synthesis of bis(thio-hydrazide amide) salts

Publications (2)

Publication Number Publication Date
CN101223133A CN101223133A (zh) 2008-07-16
CN101223133B true CN101223133B (zh) 2012-02-29

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800170928A Expired - Fee Related CN101223133B (zh) 2005-05-16 2006-05-11 双（硫代酰肼酰胺）盐的合成

Country Status (16)

Country Link
US (1) US7709683B2 (OSRAM)
EP (1) EP1888520A2 (OSRAM)
JP (1) JP2008540658A (OSRAM)
KR (1) KR20080008399A (OSRAM)
CN (1) CN101223133B (OSRAM)
AU (1) AU2006247470B2 (OSRAM)
BR (1) BRPI0611262A2 (OSRAM)
CA (1) CA2607890A1 (OSRAM)
IL (1) IL187056A (OSRAM)
MX (1) MX2007014314A (OSRAM)
NO (1) NO20075707L (OSRAM)
NZ (1) NZ563124A (OSRAM)
RU (1) RU2407734C2 (OSRAM)
TW (1) TWI387579B (OSRAM)
WO (1) WO2006124736A2 (OSRAM)
ZA (1) ZA200709395B (OSRAM)

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TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
NZ552159A (en) 2004-06-23 2009-12-24 Synta Pharmaceuticals Corp Bis(thio-hydrazide amide) salts for treatment of cancers
US8148426B2 (en) * 2004-11-19 2012-04-03 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
EP1877048A1 (en) 2005-04-15 2008-01-16 Synta Pharmaceuticals Corporation Combination cancer therapy with bis(thiohydrazide) amide compounds
JP2008536870A (ja) * 2005-04-15 2008-09-11 シンタ ファーマシューティカルズ コーポレーション 治療のためのナチュラルキラー細胞活性増強法
MX2008002152A (es) 2005-08-16 2008-04-19 Synta Pharmaceuticals Corp Formulacion de bis(tio-hidrazida amida.
WO2008024299A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
WO2008024303A2 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
EP2061451A2 (en) * 2006-08-21 2009-05-27 Synta Pharmaceuticals Corporation Bis(thiohydrazide amides) for treating melanoma
JP2010501559A (ja) * 2006-08-21 2010-01-21 シンタ ファーマシューティカルズ コーポレーション 黒色腫の再発を予防するまたは遅らせるのに使用するためのビス（チオヒドラジドアミド）
AU2007290490B2 (en) * 2006-08-31 2011-09-08 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
US7645904B2 (en) * 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
US8618170B2 (en) 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8581004B2 (en) 2008-02-21 2013-11-12 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8633323B2 (en) * 2008-03-31 2014-01-21 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
CN102256937B (zh) 2008-10-22 2014-12-17 辛塔医药品有限公司 双[硫代酰肼酰胺]化合物的过渡金属络合物
KR20110081300A (ko) 2008-10-22 2011-07-13 신타 파마슈티칼스 코프. 비스[티오하이드라자이드 아미드] 화합물의 전이금속 복합물
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
EP2370402A2 (en) 2008-12-01 2011-10-05 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
EP2560627A1 (en) 2010-04-20 2013-02-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide]compounds such as elesclomol for treating cancers

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CN1553894A (zh) * 2001-07-10 2004-12-08 ����ҽҩƷ���޹�˾ 紫杉醇增强化合物

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TW479053B (en) 1998-10-19 2002-03-11 Agro Kanesho Co Ltd Hydrazineoxoacetamide derivatives and pesticides
ES2161594B1 (es) 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
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EP1164126A1 (de) 2000-06-16 2001-12-19 Basf Aktiengesellschaft Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen
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US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
NZ552159A (en) 2004-06-23 2009-12-24 Synta Pharmaceuticals Corp Bis(thio-hydrazide amide) salts for treatment of cancers
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
US8148426B2 (en) * 2004-11-19 2012-04-03 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
JP2008536870A (ja) 2005-04-15 2008-09-11 シンタ ファーマシューティカルズ コーポレーション 治療のためのナチュラルキラー細胞活性増強法
EP1877048A1 (en) 2005-04-15 2008-01-16 Synta Pharmaceuticals Corporation Combination cancer therapy with bis(thiohydrazide) amide compounds
MX2008002152A (es) * 2005-08-16 2008-04-19 Synta Pharmaceuticals Corp Formulacion de bis(tio-hidrazida amida.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1553894A (zh) * 2001-07-10 2004-12-08 ����ҽҩƷ���޹�˾ 紫杉醇增强化合物

Also Published As

Publication number Publication date
CA2607890A1 (en) 2006-11-23
KR20080008399A (ko) 2008-01-23
NO20075707L (no) 2007-12-11
US20060270873A1 (en) 2006-11-30
TWI387579B (zh) 2013-03-01
WO2006124736A3 (en) 2007-03-29
IL187056A0 (en) 2008-02-09
ZA200709395B (en) 2008-10-29
IL187056A (en) 2013-10-31
TW200722411A (en) 2007-06-16
JP2008540658A (ja) 2008-11-20
WO2006124736A2 (en) 2006-11-23
AU2006247470A1 (en) 2006-11-23
RU2407734C2 (ru) 2010-12-27
RU2007144216A (ru) 2009-06-27
US7709683B2 (en) 2010-05-04
AU2006247470B2 (en) 2010-04-01
BRPI0611262A2 (pt) 2010-08-24
NZ563124A (en) 2010-12-24
MX2007014314A (es) 2008-02-11
CN101223133A (zh) 2008-07-16
EP1888520A2 (en) 2008-02-20

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Granted publication date: 20120229

Termination date: 20130511