TWI387579B - 雙（硫代醯肼醯胺）鹽之合成 - Google Patents

雙（硫代醯肼醯胺）鹽之合成 Download PDF

Info

Publication number
TWI387579B
TWI387579B TW095116857A TW95116857A TWI387579B TW I387579 B TWI387579 B TW I387579B TW 095116857 A TW095116857 A TW 095116857A TW 95116857 A TW95116857 A TW 95116857A TW I387579 B TWI387579 B TW I387579B
Authority
TW
Taiwan
Prior art keywords
thioguanamine
bis
group
organic solvent
base
Prior art date
Application number
TW095116857A
Other languages
English (en)
Chinese (zh)
Other versions
TW200722411A (en
Inventor
Shoujun Chen
Zhi-Qiang Xia
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of TW200722411A publication Critical patent/TW200722411A/zh
Application granted granted Critical
Publication of TWI387579B publication Critical patent/TWI387579B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW095116857A 2005-05-16 2006-05-12 雙（硫代醯肼醯胺）鹽之合成 TWI387579B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16

Publications (2)

Publication Number Publication Date
TW200722411A TW200722411A (en) 2007-06-16
TWI387579B true TWI387579B (zh) 2013-03-01

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095116857A TWI387579B (zh) 2005-05-16 2006-05-12 雙（硫代醯肼醯胺）鹽之合成

Country Status (16)

Country Link
US (1) US7709683B2 (OSRAM)
EP (1) EP1888520A2 (OSRAM)
JP (1) JP2008540658A (OSRAM)
KR (1) KR20080008399A (OSRAM)
CN (1) CN101223133B (OSRAM)
AU (1) AU2006247470B2 (OSRAM)
BR (1) BRPI0611262A2 (OSRAM)
CA (1) CA2607890A1 (OSRAM)
IL (1) IL187056A (OSRAM)
MX (1) MX2007014314A (OSRAM)
NO (1) NO20075707L (OSRAM)
NZ (1) NZ563124A (OSRAM)
RU (1) RU2407734C2 (OSRAM)
TW (1) TWI387579B (OSRAM)
WO (1) WO2006124736A2 (OSRAM)
ZA (1) ZA200709395B (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
NZ552159A (en) 2004-06-23 2009-12-24 Synta Pharmaceuticals Corp Bis(thio-hydrazide amide) salts for treatment of cancers
US8148426B2 (en) * 2004-11-19 2012-04-03 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
EP1877048A1 (en) 2005-04-15 2008-01-16 Synta Pharmaceuticals Corporation Combination cancer therapy with bis(thiohydrazide) amide compounds
JP2008536870A (ja) * 2005-04-15 2008-09-11 シンタ ファーマシューティカルズ コーポレーション 治療のためのナチュラルキラー細胞活性増強法
MX2008002152A (es) 2005-08-16 2008-04-19 Synta Pharmaceuticals Corp Formulacion de bis(tio-hidrazida amida.
WO2008024299A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
WO2008024303A2 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
EP2061451A2 (en) * 2006-08-21 2009-05-27 Synta Pharmaceuticals Corporation Bis(thiohydrazide amides) for treating melanoma
JP2010501559A (ja) * 2006-08-21 2010-01-21 シンタ ファーマシューティカルズ コーポレーション 黒色腫の再発を予防するまたは遅らせるのに使用するためのビス（チオヒドラジドアミド）
AU2007290490B2 (en) * 2006-08-31 2011-09-08 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
US7645904B2 (en) * 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
US8618170B2 (en) 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8581004B2 (en) 2008-02-21 2013-11-12 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8633323B2 (en) * 2008-03-31 2014-01-21 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
CN102256937B (zh) 2008-10-22 2014-12-17 辛塔医药品有限公司 双[硫代酰肼酰胺]化合物的过渡金属络合物
KR20110081300A (ko) 2008-10-22 2011-07-13 신타 파마슈티칼스 코프. 비스[티오하이드라자이드 아미드] 화합물의 전이금속 복합물
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
EP2370402A2 (en) 2008-12-01 2011-10-05 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
EP2560627A1 (en) 2010-04-20 2013-02-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide]compounds such as elesclomol for treating cancers

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2097737A5 (en) 1970-07-14 1972-03-03 Berlin Chemie Veb Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-
DE2037257A1 (en) 1970-07-28 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn
US4012360A (en) 1973-12-03 1977-03-15 Ciba-Geigy Corporation Bis-salicyloyl-dicarboxylic acid dihydrazides as stabilizers for polyolefines
JPS5091056A (OSRAM) 1973-12-17 1975-07-21
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
WO1997011094A1 (en) 1995-09-22 1997-03-27 Novo Nordisk A/S Novel variants of green fluorescent protein, gfp
US6235787B1 (en) 1997-06-30 2001-05-22 Hoffmann-La Roche Inc. Hydrazine derivatives
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
TW479053B (en) 1998-10-19 2002-03-11 Agro Kanesho Co Ltd Hydrazineoxoacetamide derivatives and pesticides
ES2161594B1 (es) 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US6322303B1 (en) 2000-05-12 2001-11-27 David M. John Dunnage bag and method of making same
EP1164126A1 (de) 2000-06-16 2001-12-19 Basf Aktiengesellschaft Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
JP2004532187A (ja) 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド 三置換カルボサイクリックサイクロフィリン結合化合物とその用途
US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI297335B (en) * 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
NZ552159A (en) 2004-06-23 2009-12-24 Synta Pharmaceuticals Corp Bis(thio-hydrazide amide) salts for treatment of cancers
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
US8148426B2 (en) * 2004-11-19 2012-04-03 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
JP2008536870A (ja) 2005-04-15 2008-09-11 シンタ ファーマシューティカルズ コーポレーション 治療のためのナチュラルキラー細胞活性増強法
EP1877048A1 (en) 2005-04-15 2008-01-16 Synta Pharmaceuticals Corporation Combination cancer therapy with bis(thiohydrazide) amide compounds
MX2008002152A (es) * 2005-08-16 2008-04-19 Synta Pharmaceuticals Corp Formulacion de bis(tio-hidrazida amida.

Also Published As

Publication number Publication date
CA2607890A1 (en) 2006-11-23
KR20080008399A (ko) 2008-01-23
NO20075707L (no) 2007-12-11
US20060270873A1 (en) 2006-11-30
WO2006124736A3 (en) 2007-03-29
IL187056A0 (en) 2008-02-09
ZA200709395B (en) 2008-10-29
IL187056A (en) 2013-10-31
TW200722411A (en) 2007-06-16
JP2008540658A (ja) 2008-11-20
WO2006124736A2 (en) 2006-11-23
AU2006247470A1 (en) 2006-11-23
RU2407734C2 (ru) 2010-12-27
CN101223133B (zh) 2012-02-29
RU2007144216A (ru) 2009-06-27
US7709683B2 (en) 2010-05-04
AU2006247470B2 (en) 2010-04-01
BRPI0611262A2 (pt) 2010-08-24
NZ563124A (en) 2010-12-24
MX2007014314A (es) 2008-02-11
CN101223133A (zh) 2008-07-16
EP1888520A2 (en) 2008-02-20

Similar Documents

Publication Publication Date Title
TWI387579B (zh) 雙（硫代醯肼醯胺）鹽之合成
RU2007101898A (ru) Соли бис (тиогидразидамида) для лечения рака
JP2008504264A5 (OSRAM)
JP2021181463A (ja) 薬物内包微小球の形成が可能なｎ−末端で官能基化されたアミノ酸誘導体
US11771712B2 (en) Carborane compounds and methods of use thereof
JP2008540658A5 (OSRAM)
TW201726600A (zh) 陽離子性脂質
JP2011526250A (ja) ジグリシドエーテル誘導体治療剤およびその使用方法
US20150232434A1 (en) Stat3 inhibitors and their anticancer use
US9340501B2 (en) Marinopyrrole derivatives as anticancer agents
US9409868B2 (en) Inhibitors of rho associated protein kinases (ROCK) and methods of use
WO2009073147A2 (en) Process for preparing bis(thiohydrazide amides)
US10556928B2 (en) Stabilized peptoid-peptide hybrids and uses thereof
US20250188098A1 (en) Carborane compounds and methods of use thereof
HK1261921B (en) Carborane compounds and methods of use thereof
HK1261921A1 (en) Carborane compounds and methods of use thereof

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees