CN101199683A - 一种治疗皮肤病的中药及其制备方法 - Google Patents
一种治疗皮肤病的中药及其制备方法 Download PDFInfo
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Abstract
Description
组别 | 合计(例) | 男(人) | 女(人) | 18-30岁 | 31-40岁 | 41-50岁 | 51-65岁 |
治疗组 | 300 | 128 | 172 | 105 | 90 | 53 | 52 |
对照组 | 121 | 48 | 73 | 59 | 29 | 17 | 16 |
组别 | 男 | 女 | 18-29 | 30-41 | 42-53 | 54-65 |
治疗组 | 35 | 25 | 12 | 12 | 23 | 13 |
对照组 | 34 | 26 | 10 | 22 | 15 | 13 |
皮疹 | 皮色银屑 | 瘙痒 | 心烦 | 口渴 | 大便秘结 | 小便黄 | |
治疗前 | 泛发周身 | 皮色深红,银屑厚 | 瘙痒难忍,频繁抓搔,搔痕显著严重影响睡眠和工作 | 烦而不止,严重影响睡眠和工作 | 口渴喜冷饮而多 | 3日不便,排便困难 | 色如浓茶 |
治疗后 | 皮疹限于一、二处 | 皮色较红,银屑较薄 | 瘙痒较轻,可见抓痕 | 无 | 饮水正常 | 1日不便 | 色如淡茶 |
皮疹 | 皮色银屑 | 瘙痒 | 心烦 | 口渴 | 大便秘结 | 小便黄 | |
治疗前 | 泛发周身 | 皮色深红,银屑厚 | 瘙痒难忍,频繁抓搔,搔痕显著严重影响睡眠和工作 | 烦而不止,严重影响睡眠和工作 | 口渴喜冷饮而多 | 3日不便,排便困难 | 色如浓茶 |
治疗后 | 皮疹见于头皮、四肢关节等处 | 皮色较红,银屑较薄 | 瘙痒较轻,可见抓痕 | 偶尔心烦,症状较轻 | 饮水略多 | 1日不便 | 色如正常茶色 |
组别 | 男 | 女 | 18~29 | 30~41 | 42~53 | 54~65 |
治疗组 | 30 | 30 | 15 | 19 | 13 | 13 |
对照组 | 31 | 29 | 17 | 16 | 17 | 10 |
皮损红肿、灼热 | 糜烂流水 | 皮肤瘙痒 | 心烦 | 口渴 | 大便秘结 | 小便黄 | |
治疗前 | 皮损部色紫红,触之灼执 | 皮损部有流浓性渗出液 | 剧烈瘙痒,严重影响睡眠和工作 | 心烦不止,严重影响睡眠和工作 | 喜冷饮而多 | 3日不便,排便困难 | 色如浓茶 |
治疗后 | 恢复正常皮色,无发热 | 无 | 偶有轻度瘙痒 | 症状较轻 | 正常饮水量 | 1日不便 | 色如淡茶 |
皮损红肿、灼热 | 糜烂流水 | 皮肤瘙痒 | 心烦 | 口渴 | 大便秘结 | 小便黄 | |
治疗前 | 皮损部色紫红,触之灼执 | 皮损部有流浓性渗出液 | 剧烈瘙痒,严重影响睡眠和工作 | 心烦不止,严重影响睡眠和工作 | 喜冷饮而多 | 3日不便,排便困难 | 色如浓茶 |
治疗后 | 皮损部红色,局部发热 | 少量渗出液 | 偶有轻度瘙痒 | 症状较轻 | 饮水略多 | 1日不便 | 色如淡茶 |
分组 | 标本数(N) | 浓度 | 收缩幅度平均相对值X±SD(%) | 抑制率(%) |
溶媒对照 | 8 | - | 102.20±13.66 | |
皮敏消胶囊皮敏消胶囊皮敏消胶囊 | 888 | 10(g/l)20(g/l)40(g/l) | 84.20±13.6674.68±26.3261.74±32.63 | 17.5627.4539.55 |
扑尔敏扑尔敏 | 88 | 0.06(mg/L)0.03(mg/L) | 12.46±8.2424.74±21.66 | 87.7875.73 |
分组 | 动物数(N) | 剂量 | 蓝染斑直径(X±SDmm) | P |
生理盐水 | 10 | - | 26.32±9.45 | - |
皮敏消胶囊皮敏消胶囊皮敏消胶囊 | 101010 | 12.5(g/kg)25(g/kg)50(g/kg) | 24.72±8.3612.33±5.078.24±6.32 | >0.05<0.05<0.01 |
地塞米松地塞米松 | 1010 | 12.5(g/kg)25(g/kg) | 10.36±6.776.68±3.55 | <0.01<0.01 |
级别 | 皮肤反应 |
0 | 无反应 |
0.5 | 稍有皮肤改变或皮疹 |
1.0 | 颜色改变明显 |
2.0 | 有隆起或水肿 |
3.0 | 红肿稍有坏死 |
4.0 | 坏死结痴 |
分组 | 动物数(N) | 剂量 | 皮肤反应级(X±SD) | P |
生理盐水皮敏消胶囊皮敏消胶囊皮敏消胶囊 | 8888 | -10(g/kg)20(g/kg)40(g/kg) | 2.6±0.822.15±0.461.19±0.530.65±0.31 | ->0.05<0.05<0.01 |
地塞米松地塞米松 | 88 | 10(mg/kg)10(mg/kg) | 0.61±0.420.37±0.45 | <0.01<0.01 |
分组 | 动物数(N) | 剂量 | 释放率(5) | P |
生理盐水 | 8 | - | 92.65±6.82 | - |
皮敏消胶囊 | 8 | 5(g/kg) | 87.43±9.10 | >0.05 |
皮敏消胶囊 | 8 | 20(g/kg) | 75.68±7.02 | <0.05 |
皮敏消胶囊 | 8 | 40(g/kg) | 70.36±12.15 | <0.01 |
强地松 | 8 | 25(mg/kg) | 71.87±9.42 | <0.01 |
强地松 | 8 | 50(mg/kg) | 65.11±9.37 | <0.01 |
序号 | 试验项目 | 研究结果 |
1 | 对致敏豚鼠离体回肠平滑肌收缩的影响 | 皮敏消胶囊浸膏不同剂量对离体豚鼠回肠平滑肌收缩呈现剂量依赖性的抑制作用 |
2 | 对大白鼠被动皮肤过敏反应试验 | 皮敏消胶囊浸膏各剂量组不同程度抑制大鼠被动皮肤过敏反应 |
3 | 对DNCB诱导豚鼠迟发型皮肤过敏反应的影响 | 皮敏消胶囊浸膏可抑制DNCB诱导豚鼠皮肤迟发型过敏反应,并呈量效依赖关系 |
4 | 对大鼠腹腔肥大细胞释放组胺的影响 | 皮敏消胶囊浸膏能明显抑制大鼠腹腔肥大细胞释放组胺 |
5 | 对卡拉胶致大鼠肿胀的抑制作用 | 皮敏消对卡拉胶致大鼠炎性足肿胀有明显抑制作用,并呈一定量效关系 |
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