CN101175754A - 用作CB1受体配体的新四氢-1H-吡啶并[4,3-b]吲哚衍生物 - Google Patents

用作CB1受体配体的新四氢-1H-吡啶并[4,3-b]吲哚衍生物 Download PDF

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Publication number
CN101175754A
CN101175754A CNA2006800168097A CN200680016809A CN101175754A CN 101175754 A CN101175754 A CN 101175754A CN A2006800168097 A CNA2006800168097 A CN A2006800168097A CN 200680016809 A CN200680016809 A CN 200680016809A CN 101175754 A CN101175754 A CN 101175754A
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tetrahydro
pyrido
indole
carbonyl
alkyl
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Chinese (zh)
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程云星
麦罗斯劳·托马萨维斯基
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AstraZeneca AB
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AstraZeneca AB
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
CNA2006800168097A 2005-03-22 2006-03-17 用作CB1受体配体的新四氢-1H-吡啶并[4,3-b]吲哚衍生物 Pending CN101175754A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE05006549 2005-03-22
SE0500654 2005-03-22

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CN2010105223008A Pending CN102030750A (zh) 2005-03-22 2006-03-17 用作CB1受体配体的新四氢-1H-吡啶并[4,3-b]吲哚衍生物

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US (1) US20100113502A1 (enExample)
EP (1) EP1863810A4 (enExample)
JP (1) JP2008534496A (enExample)
CN (2) CN101175754A (enExample)
AR (1) AR053699A1 (enExample)
TW (1) TW200716628A (enExample)
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CN102153549A (zh) * 2010-12-14 2011-08-17 华东理工大学 γ咔啉化合物、制备方法和用途
CN105229004B (zh) * 2013-05-28 2017-05-03 阿斯利康(瑞典)有限公司 化合物
CN116425670A (zh) * 2022-07-15 2023-07-14 英矽智能科技(上海)有限公司 作为tead抑制剂的新型杂环化合物

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WO2008036022A1 (en) * 2006-09-20 2008-03-27 Astrazeneca Ab Tetrahydro-lh-pyrido[3,4-b] indole derivatives as cb1 receptor ligands
WO2008036021A1 (en) * 2006-09-20 2008-03-27 Astrazeneca Ab Tetrahydro-lh-pyrido [3,4 -b] indole derivatives as cbl receptor ligands
RU2329044C1 (ru) * 2006-11-16 2008-07-20 Андрей Александрович Иващенко Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство
US20090062251A1 (en) * 2007-08-17 2009-03-05 Astrazeneca Ab Novel Compounds 002
AU2008302751A1 (en) 2007-09-20 2009-03-26 D2E, Llc Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
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EP2231666B1 (en) 2007-12-12 2015-07-29 Rigel Pharmaceuticals, Inc. Carboxamide, sulfonamide and amine compounds for metabolic disorders
JP5666036B2 (ja) * 2008-01-25 2015-02-04 メディベイション テクノロジーズ， インコーポレイテッド 新規２，３，４，５−テトラヒドロ−１Ｈ−ピリド［４，３−ｂ］インドール化合物およびその使用方法
RU2544856C2 (ru) * 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
TWI498328B (zh) * 2008-01-25 2015-09-01 Medivation Technologies Inc 新穎之２，３，４，５－四氫－１ｈ－吡啶并〔４，３－ｂ〕吲哚化合物及其使用方法
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AR073923A1 (es) 2008-10-31 2010-12-09 Medivation Technologies Inc Pirido( 4,3-b) indoles que contienen restos rigidos
CN102316732B (zh) 2008-10-31 2015-04-01 梅迪维新技术公司 氮杂*并[4,5-b]吲哚以及使用方法
WO2011044134A1 (en) 2009-10-05 2011-04-14 Albany Molecular Research, Inc. Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof
AU2012207335A1 (en) 2011-01-19 2013-07-25 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
CA2829045A1 (en) 2011-02-18 2012-08-23 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
CN103864779B (zh) * 2012-12-07 2016-06-22 天津科技大学 一种1-(苯基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚衍生物的制备及其在抗肿瘤药物中的应用
CN103864781A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新型1，9-二取代四氢咔啉类衍生物的制备及其抗肿瘤药物中的应用
UA125824C2 (uk) 2016-10-24 2022-06-15 Астразенека Аб 6,7,8,9-ТЕТРАГІДРО-3H-ПІРАЗОЛО[4,3-f]ІЗОХІНОЛІНОВІ ПОХІДНІ, ЗАСТОСОВНІ В ЛІКУВАННІ РАКУ
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US20210330653A1 (en) 2020-04-24 2021-10-28 Astrazeneca Ab Dosage Regimen for the Treatment of Cancer
CN120917021A (zh) * 2023-03-15 2025-11-07 纽脑泰智有限公司 用于预防或治疗神经退行性疾病的包含新型吡啶并吲哚衍生物化合物作为活性成分的组合物

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JP2005162657A (ja) * 2003-12-02 2005-06-23 Takeda Chem Ind Ltd カンナビノイド受容体調節剤
WO2008036022A1 (en) * 2006-09-20 2008-03-27 Astrazeneca Ab Tetrahydro-lh-pyrido[3,4-b] indole derivatives as cb1 receptor ligands
WO2008036021A1 (en) * 2006-09-20 2008-03-27 Astrazeneca Ab Tetrahydro-lh-pyrido [3,4 -b] indole derivatives as cbl receptor ligands

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153549A (zh) * 2010-12-14 2011-08-17 华东理工大学 γ咔啉化合物、制备方法和用途
CN102153549B (zh) * 2010-12-14 2012-11-14 华东理工大学 γ咔啉化合物、制备方法和用途
CN105229004B (zh) * 2013-05-28 2017-05-03 阿斯利康(瑞典)有限公司 化合物
CN116425670A (zh) * 2022-07-15 2023-07-14 英矽智能科技(上海)有限公司 作为tead抑制剂的新型杂环化合物

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EP1863810A1 (en) 2007-12-12
AR053699A1 (es) 2007-05-16
TW200716628A (en) 2007-05-01
UY29427A1 (es) 2006-10-31
US20100113502A1 (en) 2010-05-06
JP2008534496A (ja) 2008-08-28
EP1863810A4 (en) 2010-03-31
CN102030750A (zh) 2011-04-27

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