CN101123996B - 用于增强成像对比度的组合物和方法 - Google Patents

用于增强成像对比度的组合物和方法 Download PDF

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Publication number
CN101123996B
CN101123996B CN200580020169.2A CN200580020169A CN101123996B CN 101123996 B CN101123996 B CN 101123996B CN 200580020169 A CN200580020169 A CN 200580020169A CN 101123996 B CN101123996 B CN 101123996B
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China
Prior art keywords
liposome
contrast
liposomes
phospholipid
compositions
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Expired - Fee Related
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CN200580020169.2A
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English (en)
Chinese (zh)
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CN101123996A (zh
Inventor
A·安纳普拉加达
R·V·贝拉姆康达
E·霍夫曼
C·维亚拉克什米
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Marvel Therapeutics
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Marvel Therapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200580020169.2A 2004-04-21 2005-01-12 用于增强成像对比度的组合物和方法 Expired - Fee Related CN101123996B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/830,190 US7713517B2 (en) 2004-04-21 2004-04-21 Compositions and methods for enhancing contrast in imaging
US10/830,190 2004-04-21
PCT/US2005/000876 WO2005107820A1 (en) 2004-04-21 2005-01-12 Compositions and methods for enhancing contrast in imaging

Publications (2)

Publication Number Publication Date
CN101123996A CN101123996A (zh) 2008-02-13
CN101123996B true CN101123996B (zh) 2014-07-16

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CN200580020169.2A Expired - Fee Related CN101123996B (zh) 2004-04-21 2005-01-12 用于增强成像对比度的组合物和方法

Country Status (7)

Country Link
US (4) US7713517B2 (https=)
EP (2) EP1742669B1 (https=)
JP (2) JP5210630B2 (https=)
CN (1) CN101123996B (https=)
AU (1) AU2005239980B2 (https=)
CA (1) CA2563692C (https=)
WO (1) WO2005107820A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713517B2 (en) * 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
CA2600220C (en) * 2006-09-07 2014-12-09 Canadian Blood Services Surface cross-linked lipidic particles, methods of production and uses therefor
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US20110177156A1 (en) * 2007-11-14 2011-07-21 Szoka Jr Francis C Sterol-Modified Amphiphilic Lipids
US8642013B2 (en) * 2007-12-05 2014-02-04 Ananth Annapragada Nano-scale contrast agents and methods of use
US8956591B2 (en) 2008-05-15 2015-02-17 Osaka Prefectural Hospital Organization Method for detecting cancer using ICG fluorescence method
AU2009257279A1 (en) * 2008-06-13 2009-12-17 Marval Biosciences, Inc. Imaging of atherosclerotic plaques using liposomal imaging agents
CN102438591A (zh) * 2009-03-19 2012-05-02 马维尔生物科学公司 用于增强成像对比度的组合物和方法
BR112012033776A2 (pt) * 2010-07-12 2016-11-01 Ge Healthcare As composição,e, método de exame de raios-x.
US8658614B2 (en) 2010-08-13 2014-02-25 The University of Texas Health Science Center Aptamer-containing compositions and methods for targeting E-selectin
WO2012139080A2 (en) * 2011-04-06 2012-10-11 Board Of Regents Of The University Of Texas System Lipid-based nanoparticles
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN107982550A (zh) * 2012-01-11 2018-05-04 通用电气医疗集团股份有限公司 具有低碘浓度的x-射线成像造影介质和x-射线成像方法
CA2848994A1 (en) 2012-01-20 2013-07-25 Ananth Annapragada Methods and compositions for objectively characterizing medical images
WO2014047116A1 (en) * 2012-09-18 2014-03-27 Comfort Care For Animals Llc Encapsulating liposomes
EP3047271B1 (en) * 2013-09-20 2022-05-11 California Institute Of Technology Methods for phenotyping of intact whole tissues
EP3204051B1 (en) 2014-10-08 2019-05-29 Texas Children's Hospital Mri imaging of amyloid plaque using liposomes
CN109513017B (zh) * 2018-12-27 2021-09-21 中国科学院高能物理研究所 一种脂质纳米囊及其制备方法和应用
EP3753549A1 (en) 2019-06-20 2020-12-23 InnoMedica Holding AG Liposomal doxorubicin formulation, method for producing a liposomal doxorubicin formulation and use of a liposomal doxorubicin formulation as a medicament
CN115279424A (zh) 2020-02-12 2022-11-01 德克萨斯儿童医院 用于α-突触核蛋白沉积MRI的靶向对比剂
CN115957351B (zh) * 2022-11-15 2023-06-27 中国人民解放军海军第九七一医院 一种碘海醇注射液及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312615A (en) * 1987-05-22 1994-05-17 Bracco - Industria Chimica S.P.A. Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations
CN1148812A (zh) * 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”
US6217849B1 (en) * 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US5204085A (en) * 1985-01-08 1993-04-20 Mallinckrodt Medical, Inc. Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents
DE68901733T2 (de) * 1988-03-04 1993-03-25 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
US4994213A (en) 1988-05-17 1991-02-19 Liposome Technology, Inc. Method of preparing lipid structures
ATE108651T1 (de) * 1988-05-20 1994-08-15 Liposome Co Inc Aktives mittel: lipid-komplex mit hohem verhältnis.
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
IN172208B (https=) * 1990-04-02 1993-05-01 Sint Sa
GB9314499D0 (en) * 1993-07-12 1993-08-25 Nycomed Imaging As Method
DE4341472A1 (de) * 1993-12-02 1995-06-08 Schering Ag Verfahren zur Erhöhung der Stabilität von hydrophile Wirkstoffe enthaltenden Liposomensuspensionen
JP3759765B2 (ja) * 1994-03-28 2006-03-29 第一製薬株式会社 リポソーム
US5811581A (en) * 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
NZ334365A (en) 1996-08-02 1999-10-28 Nycomed Imaging As Use of a contrast agent comprising microbubbles of biocompatible gas stabilised by opsonisable amphiphilic material for ultrasound imaging of the liver
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
AU7104598A (en) * 1997-04-09 1998-10-30 Philipp Lang New technique to monitor drug delivery noninvasively (in vivo)
WO1998046275A2 (en) * 1997-04-11 1998-10-22 The Board Of Regents Of The University Of Michigan Blood-pool carrier for lipophilic imaging agents
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
KR100679906B1 (ko) 1998-09-16 2007-02-07 알자 코포레이션 리포솜-엔트랩된 토포이소머라제 억제제
US6203778B1 (en) * 1998-12-08 2001-03-20 The Regents Of The University Of California Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization
US6425864B1 (en) 1999-04-15 2002-07-30 General Electric Company Method and apparatus for optimal imaging of the peripheral vasculature
JP2004510830A (ja) * 2000-10-11 2004-04-08 ターゲサム・インコーポレーテッド 標的化された治療用薬剤
JP2005518266A (ja) 2001-09-28 2005-06-23 エスペリオン セラピューティクス，インコーポレイテッド 高圧でベシクルを押し出す方法および装置
JP2005519129A (ja) * 2002-03-05 2005-06-30 クリーブランド ステート ユニバーシティー エアロゾル薬物送達のための凝集粒子
US20060235296A1 (en) 2003-02-13 2006-10-19 Bracco Imaging S.P.A. Contrast enhanced x-ray phase imaging
JP2005170923A (ja) 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
US7713517B2 (en) 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US8357351B2 (en) * 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
WO2006084382A1 (en) 2005-02-11 2006-08-17 University Health Network Compositions and methods for multimodal imaging
US20080213350A1 (en) 2007-02-20 2008-09-04 Texas Tech University System Encapsulation of nucleic acids in liposomes
US8642013B2 (en) * 2007-12-05 2014-02-04 Ananth Annapragada Nano-scale contrast agents and methods of use
AU2009257279A1 (en) * 2008-06-13 2009-12-17 Marval Biosciences, Inc. Imaging of atherosclerotic plaques using liposomal imaging agents
CN102438591A (zh) * 2009-03-19 2012-05-02 马维尔生物科学公司 用于增强成像对比度的组合物和方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312615A (en) * 1987-05-22 1994-05-17 Bracco - Industria Chimica S.P.A. Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations
US6217849B1 (en) * 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
CN1148812A (zh) * 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Kao C.Y. et al.Long-Residence-Time Nano-scale Liposomal Iohexol for X-ray-based Blood Pool Imaging.Academic Radiology10 5.2003,10(5),475-483.
Kao C.Y. et al.Long-Residence-Time Nano-scale Liposomal Iohexol for X-ray-based Blood Pool Imaging.Academic Radiology10 5.2003,10(5),475-483. *
同上.

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Publication number Publication date
JP2013049702A (ja) 2013-03-14
JP5210630B2 (ja) 2013-06-12
EP1742669B1 (en) 2015-07-08
CA2563692C (en) 2013-05-14
AU2005239980A1 (en) 2005-11-17
US20080131369A1 (en) 2008-06-05
USRE45195E1 (en) 2014-10-14
HK1117407A1 (en) 2009-01-16
US7713517B2 (en) 2010-05-11
US20070212303A1 (en) 2007-09-13
EP1742669A4 (en) 2010-06-23
US20050238584A1 (en) 2005-10-27
EP2578237A1 (en) 2013-04-10
CN101123996A (zh) 2008-02-13
EP1742669A1 (en) 2007-01-17
AU2005239980B2 (en) 2010-02-25
JP2007533737A (ja) 2007-11-22
CA2563692A1 (en) 2005-11-17
US7785568B2 (en) 2010-08-31
WO2005107820A1 (en) 2005-11-17

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