CA2563692C - Compositions and methods for enhancing contrast in imaging - Google Patents
Compositions and methods for enhancing contrast in imaging Download PDFInfo
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- CA2563692C CA2563692C CA2563692A CA2563692A CA2563692C CA 2563692 C CA2563692 C CA 2563692C CA 2563692 A CA2563692 A CA 2563692A CA 2563692 A CA2563692 A CA 2563692A CA 2563692 C CA2563692 C CA 2563692C
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- liposomes
- glycero
- phospholipid
- contrast
- composition
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- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
- A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
- A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
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- A—HUMAN NECESSITIES
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US10/830,190 US7713517B2 (en) | 2004-04-21 | 2004-04-21 | Compositions and methods for enhancing contrast in imaging |
| US10/830,190 | 2004-04-21 | ||
| PCT/US2005/000876 WO2005107820A1 (en) | 2004-04-21 | 2005-01-12 | Compositions and methods for enhancing contrast in imaging |
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| CA2563692A1 CA2563692A1 (en) | 2005-11-17 |
| CA2563692C true CA2563692C (en) | 2013-05-14 |
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| US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| JP5072275B2 (ja) * | 2006-07-03 | 2012-11-14 | テルモ株式会社 | 閉鎖小胞の分離方法、製剤の製造方法および評価方法 |
| CA2600220C (en) * | 2006-09-07 | 2014-12-09 | Canadian Blood Services | Surface cross-linked lipidic particles, methods of production and uses therefor |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20110177156A1 (en) * | 2007-11-14 | 2011-07-21 | Szoka Jr Francis C | Sterol-Modified Amphiphilic Lipids |
| US8642013B2 (en) * | 2007-12-05 | 2014-02-04 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| US8956591B2 (en) | 2008-05-15 | 2015-02-17 | Osaka Prefectural Hospital Organization | Method for detecting cancer using ICG fluorescence method |
| AU2009257279A1 (en) * | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
| CN102438591A (zh) * | 2009-03-19 | 2012-05-02 | 马维尔生物科学公司 | 用于增强成像对比度的组合物和方法 |
| BR112012033776A2 (pt) * | 2010-07-12 | 2016-11-01 | Ge Healthcare As | composição,e, método de exame de raios-x. |
| US8658614B2 (en) | 2010-08-13 | 2014-02-25 | The University of Texas Health Science Center | Aptamer-containing compositions and methods for targeting E-selectin |
| WO2012139080A2 (en) * | 2011-04-06 | 2012-10-11 | Board Of Regents Of The University Of Texas System | Lipid-based nanoparticles |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| CN107982550A (zh) * | 2012-01-11 | 2018-05-04 | 通用电气医疗集团股份有限公司 | 具有低碘浓度的x-射线成像造影介质和x-射线成像方法 |
| CA2848994A1 (en) | 2012-01-20 | 2013-07-25 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| WO2014047116A1 (en) * | 2012-09-18 | 2014-03-27 | Comfort Care For Animals Llc | Encapsulating liposomes |
| EP3047271B1 (en) * | 2013-09-20 | 2022-05-11 | California Institute Of Technology | Methods for phenotyping of intact whole tissues |
| EP3204051B1 (en) | 2014-10-08 | 2019-05-29 | Texas Children's Hospital | Mri imaging of amyloid plaque using liposomes |
| CN109513017B (zh) * | 2018-12-27 | 2021-09-21 | 中国科学院高能物理研究所 | 一种脂质纳米囊及其制备方法和应用 |
| EP3753549A1 (en) | 2019-06-20 | 2020-12-23 | InnoMedica Holding AG | Liposomal doxorubicin formulation, method for producing a liposomal doxorubicin formulation and use of a liposomal doxorubicin formulation as a medicament |
| CN115279424A (zh) | 2020-02-12 | 2022-11-01 | 德克萨斯儿童医院 | 用于α-突触核蛋白沉积MRI的靶向对比剂 |
| CN115957351B (zh) * | 2022-11-15 | 2023-06-27 | 中国人民解放军海军第九七一医院 | 一种碘海醇注射液及其制备方法 |
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| JP2013049702A (ja) | 2013-03-14 |
| JP5210630B2 (ja) | 2013-06-12 |
| EP1742669B1 (en) | 2015-07-08 |
| AU2005239980A1 (en) | 2005-11-17 |
| US20080131369A1 (en) | 2008-06-05 |
| USRE45195E1 (en) | 2014-10-14 |
| HK1117407A1 (en) | 2009-01-16 |
| US7713517B2 (en) | 2010-05-11 |
| US20070212303A1 (en) | 2007-09-13 |
| EP1742669A4 (en) | 2010-06-23 |
| US20050238584A1 (en) | 2005-10-27 |
| EP2578237A1 (en) | 2013-04-10 |
| CN101123996A (zh) | 2008-02-13 |
| EP1742669A1 (en) | 2007-01-17 |
| CN101123996B (zh) | 2014-07-16 |
| AU2005239980B2 (en) | 2010-02-25 |
| JP2007533737A (ja) | 2007-11-22 |
| CA2563692A1 (en) | 2005-11-17 |
| US7785568B2 (en) | 2010-08-31 |
| WO2005107820A1 (en) | 2005-11-17 |
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