CN101112555A - Chinese traditional medicine preparations for treating skin amyloidosis - Google Patents

Abstract

The present invention relates to a traditional Chinese medicine preparation for treating cutaneous amyloidosis, which takes more than 10 Chinese herbal medicines of glabrous greenbrier rhizome, raw coix seed, densefruit pittany root-bark, medicinal cyathula root etc. as the raw materials. The present invention has the effects of removing dampness, removing toxicity, promoting diuresis and stopping itch. Based on the differential treatment of the traditional Chinese medicine, the invention is developed by combining the latest scientific research results with the traditional Chinese medicine. The present invention aims at providing the traditional Chinese medicine preparation for treating cutaneous amyloidosis. The present invention is characterized by accurate efficacy, safety, convenience, no toxicity or side effects and low price.

Description

A kind of Chinese medicine preparation for the treatment of skin amyloidosis

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of skin amyloidosis, is that a kind of skin amyloidosis for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Skin amyloidosis claims lichen sample and macule shape amyloidosis again.Be a kind of specific response that is, even structureless amyloid beta deposition does not involve a kind of chronic dermatosis of other organ in skin histology.The psoriasis, the toadskin category that belong to the traditional Chinese medical science.The cause of disease is still indeterminate, may be relevant with immunity with heredity, and be due to the protein metabolism disorder.The traditional Chinese medical science thinks that primary disease is the natural endowment deficiency, and is qi-blood disharmony, the heresy of diseases caused by exogenous pathogenic factor rheumatism, and the visitor stays strongly fragrant not going in skin, due to the consumption impairment of YIN blood, failure of skin and muscle to be nourished.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation clinically, obtains very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of skin amyloidosis.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by following raw materials by weight proportions:

1.0～4 parts of 1.0～4 parts of Radix Salviae Miltiorrhizaes of 1.5～6 parts of Poria of Rhizoma Smilacis Glabrae

0.1～2 part of 1.0～4 parts of Radix Codonopsis of 1.5～6 portions of Rhizoma Alismatis of Semen Coicis

0.1～2 part of 1.0～4 parts of Rhizoma Atractylodis Macrocephalae of 1.0～4 parts of Rhizoma Atractylodis of Cortex Dictamni

0.1～2 part of 1.0～4 parts of Radix Sophorae Flavescentis of 1.0～4 portions of Cortex Phellodendris of Radix Cyathulae.

The weight proportion of each crude drug of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 parts of Radix Salviae Miltiorrhizaes of 2.5～3.5 parts of Poria of Rhizoma Smilacis Glabrae

0.5～1.5 part of 1.5～2.5 parts of Radix Codonopsis of 2.5～3.5 portions of Rhizoma Alismatis of Semen Coicis

0.5～1.5 part of 1.5～2.5 parts of Rhizoma Atractylodis Macrocephalae of 1.5～2.5 parts of Rhizoma Atractylodis of Cortex Dictamni

0.5～1.5 part of 1.5～2.5 parts of Radix Sophorae Flavescentis of 1.5～2.5 portions of Cortex Phellodendris of Radix Cyathulae.

The weight proportion of each crude drug of optimum formula of the present invention is:

2 parts of 2 parts of Radix Salviae Miltiorrhizaes of 3 parts of Poria of Rhizoma Smilacis Glabrae

1 part of 2 parts of Radix Codonopsis of 3 portions of Rhizoma Alismatis of Semen Coicis

1 part of 2 parts of Rhizoma Atractylodis Macrocephalae of 2 parts of Rhizoma Atractylodis of Cortex Dictamni

1 part of 2 parts of Radix Sophorae Flavescentis of 2 portions of Cortex Phellodendris of Radix Cyathulae.

Drug action mechanism among the present invention is as follows:

The Rhizoma Smilacis Glabrae property of medicine is sweet, light, and is flat.Return liver,kidney,spleen, stomach warp.Have removing damp-heat, let out turbid detoxifcation, the effect of easing joint movement.Can treat syphilis, stranguria with turbid discharge is had loose bowels, muscles and bones spasm and pain, beriberi, carbuncle, skin ulcer tinea, scrofula, goiter and mercurialism etc.(the 124th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Semen Coicis property of medicine is sweet, light, is slightly cold.Return spleen, stomach, lung meridian.Has the dampness removing spleen invigorating, arthralgia relieving by relaxing muscles and tendons, the effect of clearing away heat and discharging pus.Can treat edema, beriberi, dribbling urination, damp-warm diseases is had loose bowels, leukorrhagia, rheumatic arthralgia, the contracture of muscle arteries and veins, lung abscess, acute appendicitis, verruca plana etc.(the 3725th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Dictamni property of medicine hardship, salty, cold.Return spleen, stomach warp.Has heat clearing and damp drying, dispelling wind for relieving itching, antidotal effect.Can treat the rubella eczema due to the wind heat noxious dampness, scabies, jaundice, rheumatism pyretic arthralgia etc.(the 1019th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Sweet, the little hardship of the Radix Cyathulae property of medicine, flat.Return liver, kidney channel.Has blood circulation promoting and blood stasis dispelling, the effect of expelling wind and removing dampness.Can treat the blood stasis amenorrhea, difficult labour, retention of placenta, postnatal blood stasis stomachache, pyretic stranguria, stranguria caused by urinary stone, dysmenorrhea, rheumatism lumbocrural pain, traumatic injury etc.(the 301st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Poria property of medicine is sweet, light, and is flat.GUIXIN, spleen, lung, kidney channel.Has promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can treat dysuria, the edema distension, is had loose bowels at phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine etc.(the 2154th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Atractylodis property of medicine suffering, hardship, temperature.Return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, wind-damp dispelling, the effect that makes eye bright.Can treat the spleen and stomach being stranded by dampness, the asthenia drowsiness, feeling of stuffiness in chest abdominal distention, inappetence, vomiting is had loose bowels, phlegm retention, damp-edema, the exterior syndrome folder is wet, a heavy sensation of the body pain, arthromyodynia domination of damp pathogen, podomere are ached and are being weighed, and flaccidity is sprained, nyctalopia etc.(the 1485th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Phellodendri property of medicine hardship, cold.Return kidney, bladder, large intestine channel.Has heat clearing and damp drying, the effect of eliminating fire and detoxication.Can treat hygropyretic dysentery, have loose bowels, jaundice, nocturnal emission, stranguria with turbid discharge, leukorrhagia, hectic fever due to YIN-deficiency consumptive fever ， Wei Bi, and aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore, skin eczema etc.(the 2823rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Salviae Miltiorrhizae property of medicine hardship is slightly cold.GUIXIN, pericardium, Liver Channel.Have blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, the effect of removing heat from blood eliminating carbuncle.Can treat menoxenia, dysmenorrhea, amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, heat is gone into nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore etc.(the 647th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Codonopsis property of medicine is sweet, and is flat.Return spleen, lung meridian.Has strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid.Can treat weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, deficiency of both QI and blood etc.(the 2579th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Atractylodis Macrocephalae property of medicine hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Sophorae Flavescentis property of medicine hardship, cold.GUIXIN, lung, kidney, large intestine channel.Has heat clearing and damp drying, the effect of wind dispelling insecticide.Can treat damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.(the 1758th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Rhizoma Smilacis Glabrae, Semen Coicis and Cortex Phellodendri; With Cortex Dictamni, Radix Cyathulae, Poria, Rhizoma Alismatis, Rhizoma Atractylodis and Radix Salviae Miltiorrhizae is ministerial drug; With Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and Radix Sophorae Flavescentis is adjuvant.All medicines are harmonious, and are total to the tool removing dampness and detoxicating, dampness removing itching relieving effect.The treatment skin amyloidosis has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment skin amyloidosis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat skin amyloidosis, and the prevention of skin amyloidosis is also had good effect, and the treatment skin amyloidosis has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment skin amyloidosis; Treatment skin amyloidosis patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.8 examples of fully recovering account for 40%, and 9 examples that take a turn for the better account for 45%, and more 3 examples do not account for 15%, and total effective rate reaches 85%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction is pressed following weight weighting raw materials:

2 parts of 2 parts of Radix Salviae Miltiorrhizaes of 3 parts of Poria of Rhizoma Smilacis Glabrae

1 part of 2 parts of Radix Codonopsis of 3 portions of Rhizoma Alismatis of Semen Coicis

1 part of 2 parts of Rhizoma Atractylodis Macrocephalae of 2 parts of Rhizoma Atractylodis of Cortex Dictamni

1 part of 2 parts of Radix Sophorae Flavescentis of 2 portions of Cortex Phellodendris of Radix Cyathulae.

Preparation method is to get the above-mentioned raw materials medicine to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment skin amyloidosis that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1. Chinese medicine preparation for the treatment of skin amyloidosis is characterized in that it is made by following raw materials by weight proportions:

1.0～4 parts of 1.0～4 parts of Radix Salviae Miltiorrhizaes of 1.5～6 parts of Poria of Rhizoma Smilacis Glabrae

0.1～2 part of 1.0～4 parts of Radix Codonopsis of 1.5～6 portions of Rhizoma Alismatis of Semen Coicis

0.1～2 part of 1.0～4 parts of Rhizoma Atractylodis Macrocephalae of 1.0～4 parts of Rhizoma Atractylodis of Cortex Dictamni

0.1～2 part of 1.0～4 parts of Radix Sophorae Flavescentis of 1.0～4 portions of Cortex Phellodendris of Radix Cyathulae.

2. a kind of Chinese medicine preparation for the treatment of skin amyloidosis according to claim 1, wherein the weight proportion of each crude drug is:

1.5～2.5 parts of 1.5～2.5 parts of Radix Salviae Miltiorrhizaes of 2.5～3.5 parts of Poria of Rhizoma Smilacis Glabrae

0.5～1.5 part of 1.5～2.5 parts of Radix Codonopsis of 2.5～3.5 portions of Rhizoma Alismatis of Semen Coicis

0.5～1.5 part of 1.5～2.5 parts of Rhizoma Atractylodis Macrocephalae of 1.5～2.5 parts of Rhizoma Atractylodis of Cortex Dictamni

0.5～1.5 part of 1.5～2.5 parts of Radix Sophorae Flavescentis of 1.5～2.5 portions of Cortex Phellodendris of Radix Cyathulae.

3. a kind of Chinese medicine preparation for the treatment of skin amyloidosis according to claim 1, wherein the weight proportion of each crude drug is:

2 parts of 2 parts of Radix Salviae Miltiorrhizaes of 3 parts of Poria of Rhizoma Smilacis Glabrae

1 part of 2 parts of Radix Codonopsis of 3 portions of Rhizoma Alismatis of Semen Coicis

1 part of 2 parts of Rhizoma Atractylodis Macrocephalae of 2 parts of Rhizoma Atractylodis of Cortex Dictamni

1 part of 2 parts of Radix Sophorae Flavescentis of 2 portions of Cortex Phellodendris of Radix Cyathulae.