CN101106997A - Pde5抑制剂组合物及治疗心脏病征候的方法 - Google Patents

Pde5抑制剂组合物及治疗心脏病征候的方法 Download PDF

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Publication number
CN101106997A
CN101106997A CNA200580035426XA CN200580035426A CN101106997A CN 101106997 A CN101106997 A CN 101106997A CN A200580035426X A CNA200580035426X A CN A200580035426XA CN 200580035426 A CN200580035426 A CN 200580035426A CN 101106997 A CN101106997 A CN 101106997A
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CN
China
Prior art keywords
cardiac
pde5 inhibitor
heart
inhibitor
xiduofeng
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Pending
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CNA200580035426XA
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English (en)
Chinese (zh)
Inventor
D·卡斯
泷本英树
H·钱皮恩
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Johns Hopkins University
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA200580035426XA 2004-08-17 2005-08-17 Pde5抑制剂组合物及治疗心脏病征候的方法 Pending CN101106997A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60213404P 2004-08-17 2004-08-17
US60/602,134 2004-08-17

Publications (1)

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CN101106997A true CN101106997A (zh) 2008-01-16

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CNA200580035426XA Pending CN101106997A (zh) 2004-08-17 2005-08-17 Pde5抑制剂组合物及治疗心脏病征候的方法

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Country Link
US (1) US8299083B2 (https=)
EP (1) EP1786428B1 (https=)
JP (1) JP5070052B2 (https=)
CN (1) CN101106997A (https=)
AU (1) AU2005277384B2 (https=)
CA (1) CA2577442A1 (https=)
WO (1) WO2006023603A2 (https=)

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JP5070052B2 (ja) 2012-11-07
JP2008510705A (ja) 2008-04-10
AU2005277384A1 (en) 2006-03-02
AU2005277384B2 (en) 2011-11-17
EP1786428A4 (en) 2009-08-05
EP1786428A2 (en) 2007-05-23
CA2577442A1 (en) 2006-03-02
WO2006023603A2 (en) 2006-03-02
US8299083B2 (en) 2012-10-30
WO2006023603A3 (en) 2006-10-19
US20090062313A1 (en) 2009-03-05
EP1786428B1 (en) 2012-05-16

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Application publication date: 20080116