CA2577442A1 - Pde5 inhibitor compositions and methods for treating cardiac indications - Google Patents
Pde5 inhibitor compositions and methods for treating cardiac indications Download PDFInfo
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- CA2577442A1 CA2577442A1 CA002577442A CA2577442A CA2577442A1 CA 2577442 A1 CA2577442 A1 CA 2577442A1 CA 002577442 A CA002577442 A CA 002577442A CA 2577442 A CA2577442 A CA 2577442A CA 2577442 A1 CA2577442 A1 CA 2577442A1
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- cardiac
- pde5 inhibitor
- composition
- sildenafil
- inhibitor
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60213404P | 2004-08-17 | 2004-08-17 | |
| US60/602,134 | 2004-08-17 | ||
| PCT/US2005/029327 WO2006023603A2 (en) | 2004-08-17 | 2005-08-17 | Pde5 inhibitor compositions and methods for treating cardiac indications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2577442A1 true CA2577442A1 (en) | 2006-03-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002577442A Abandoned CA2577442A1 (en) | 2004-08-17 | 2005-08-17 | Pde5 inhibitor compositions and methods for treating cardiac indications |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8299083B2 (https=) |
| EP (1) | EP1786428B1 (https=) |
| JP (1) | JP5070052B2 (https=) |
| CN (1) | CN101106997A (https=) |
| AU (1) | AU2005277384B2 (https=) |
| CA (1) | CA2577442A1 (https=) |
| WO (1) | WO2006023603A2 (https=) |
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| US8841300B2 (en) * | 2006-10-02 | 2014-09-23 | Jerry M. Held | Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor |
| CA2676422C (en) | 2007-02-06 | 2018-10-16 | Lixte Biotechnology Holdings, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| CN101754756A (zh) * | 2007-05-18 | 2010-06-23 | 维瓦斯公司 | 包含磷酸二酯酶-5抑制剂的新组合和它们的用途 |
| EA018618B1 (ru) | 2007-10-01 | 2013-09-30 | Ликсте Байотекнолоджи, Инк. | Ингибиторы hdac |
| CA2730148C (en) | 2008-08-01 | 2018-04-03 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| US8227473B2 (en) | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| TW201249843A (en) * | 2011-06-14 | 2012-12-16 | Univ Kaohsiung Medical | Processes for preparing amine salts of KMUP-3 and use thereof |
| RU2631597C2 (ru) | 2011-07-15 | 2017-09-25 | Нусерт Сайенсиз, Инк. | Композиции и способы модулирования метаболических путей |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| SG10201709195TA (en) | 2012-11-13 | 2017-12-28 | Nusirt Sciences Inc | Compositions and methods for increasing energy metabolism |
| EP2922465A4 (en) | 2012-11-21 | 2016-07-06 | Cardiomems Inc | DEVICES, SYSTEMS AND METHODS FOR ASSESSING AND TREATING PULMONARY ARTERIAL HYPERTENSION (PAH) |
| US9198908B2 (en) * | 2013-03-15 | 2015-12-01 | St. Jude Medical Luxembourg Holdings Ii S.A.R.L. (“Sjm Lux Ii”) | Methods for the treatment of cardiovascular conditions |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| EP2983661B1 (en) | 2013-04-09 | 2024-05-29 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
| KR20160119863A (ko) | 2014-02-27 | 2016-10-14 | 뉴서트 사이언시스, 인크. | 간 지방증의 감소 또는 예방을 위한 조성물 및 방법 |
| KR20190049691A (ko) * | 2016-07-07 | 2019-05-09 | 카듀리온 파마슈티칼스, 엘엘씨 | 심부전의 치료 방법 |
| MX2019006694A (es) | 2016-12-08 | 2019-08-21 | Lixte Biotechnology Inc | Oxabicicloheptanos para la modulacion de la respuesta inmunitaria. |
| EP3569249A4 (en) * | 2016-12-27 | 2020-11-11 | Osaka University | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF REFRACTORY HEART DISEASE |
| US20210386743A1 (en) * | 2018-10-08 | 2021-12-16 | The Johns Hopkins University | Use of pde9 inhibitors for treatment |
| WO2025226615A1 (en) * | 2024-04-22 | 2025-10-30 | Huyabio International, Llc | Sodium salt and ethanolamine salt of 23-hydroxytormentic acid |
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-
2005
- 2005-08-17 CN CNA200580035426XA patent/CN101106997A/zh active Pending
- 2005-08-17 JP JP2007527993A patent/JP5070052B2/ja not_active Expired - Fee Related
- 2005-08-17 US US11/660,440 patent/US8299083B2/en not_active Expired - Fee Related
- 2005-08-17 AU AU2005277384A patent/AU2005277384B2/en not_active Ceased
- 2005-08-17 EP EP05808662A patent/EP1786428B1/en not_active Expired - Lifetime
- 2005-08-17 WO PCT/US2005/029327 patent/WO2006023603A2/en not_active Ceased
- 2005-08-17 CA CA002577442A patent/CA2577442A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008510705A (ja) | 2008-04-10 |
| WO2006023603A3 (en) | 2006-10-19 |
| EP1786428B1 (en) | 2012-05-16 |
| CN101106997A (zh) | 2008-01-16 |
| AU2005277384B2 (en) | 2011-11-17 |
| AU2005277384A1 (en) | 2006-03-02 |
| EP1786428A4 (en) | 2009-08-05 |
| US8299083B2 (en) | 2012-10-30 |
| WO2006023603A2 (en) | 2006-03-02 |
| EP1786428A2 (en) | 2007-05-23 |
| JP5070052B2 (ja) | 2012-11-07 |
| US20090062313A1 (en) | 2009-03-05 |
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