AU2005277384B2 - PDE5 inhibitor compositions and methods for treating cardiac indications - Google Patents
PDE5 inhibitor compositions and methods for treating cardiac indications Download PDFInfo
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- AU2005277384B2 AU2005277384B2 AU2005277384A AU2005277384A AU2005277384B2 AU 2005277384 B2 AU2005277384 B2 AU 2005277384B2 AU 2005277384 A AU2005277384 A AU 2005277384A AU 2005277384 A AU2005277384 A AU 2005277384A AU 2005277384 B2 AU2005277384 B2 AU 2005277384B2
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- pde5
- selective inhibitor
- cardiac
- sildenafil
- pde5a
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60213404P | 2004-08-17 | 2004-08-17 | |
| US60/602,134 | 2004-08-17 | ||
| PCT/US2005/029327 WO2006023603A2 (en) | 2004-08-17 | 2005-08-17 | Pde5 inhibitor compositions and methods for treating cardiac indications |
Publications (2)
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|---|---|
| AU2005277384A1 AU2005277384A1 (en) | 2006-03-02 |
| AU2005277384B2 true AU2005277384B2 (en) | 2011-11-17 |
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Family Applications (1)
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|---|---|---|---|
| AU2005277384A Ceased AU2005277384B2 (en) | 2004-08-17 | 2005-08-17 | PDE5 inhibitor compositions and methods for treating cardiac indications |
Country Status (7)
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|---|---|
| US (1) | US8299083B2 (https=) |
| EP (1) | EP1786428B1 (https=) |
| JP (1) | JP5070052B2 (https=) |
| CN (1) | CN101106997A (https=) |
| AU (1) | AU2005277384B2 (https=) |
| CA (1) | CA2577442A1 (https=) |
| WO (1) | WO2006023603A2 (https=) |
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| US8841300B2 (en) * | 2006-10-02 | 2014-09-23 | Jerry M. Held | Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor |
| BRPI0806365B8 (pt) | 2007-02-06 | 2021-05-25 | Lixte Biotechnology Holdings Inc | composto, uso do composto, composição farmacêutica e uso da composição farmacêutica |
| CA2687679A1 (en) * | 2007-05-18 | 2008-11-27 | Vivus, Inc. | Novel compositions comprising a phosphodiesterase-5 inhibitor and their use in methods of treatment |
| JP5730575B2 (ja) | 2007-10-01 | 2015-06-10 | リクスト・バイオテクノロジー，インコーポレイテッド | Ｈｄａｃ阻害剤 |
| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| US8227473B2 (en) | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| WO2010014220A1 (en) | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| TW201249843A (en) * | 2011-06-14 | 2012-12-16 | Univ Kaohsiung Medical | Processes for preparing amine salts of KMUP-3 and use thereof |
| US8623924B2 (en) | 2011-07-15 | 2014-01-07 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| MX2015006023A (es) * | 2012-11-13 | 2016-03-31 | Nusirt Sciences Inc | Composiciones y metodos para incrementar el metabolismo energetico. |
| WO2014081958A1 (en) | 2012-11-21 | 2014-05-30 | Cardiomems, Inc. | Devices, systems, and methods for pulmonary arterial hypertension (pah) assessment and treatment |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| US9198908B2 (en) * | 2013-03-15 | 2015-12-01 | St. Jude Medical Luxembourg Holdings Ii S.A.R.L. (“Sjm Lux Ii”) | Methods for the treatment of cardiovascular conditions |
| KR20160004299A (ko) | 2013-04-09 | 2016-01-12 | 릭스트 바이오테크놀로지, 인코포레이티드 | 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형 |
| EP3110507B1 (en) | 2014-02-27 | 2020-11-18 | NuSirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| KR20190049691A (ko) * | 2016-07-07 | 2019-05-09 | 카듀리온 파마슈티칼스, 엘엘씨 | 심부전의 치료 방법 |
| EP4324477A3 (en) | 2016-12-08 | 2024-05-22 | Lixte Biotechnology, Inc. | Oxabicycloheptanes for modulation of immune response |
| JPWO2018124236A1 (ja) * | 2016-12-27 | 2019-11-14 | 国立大学法人大阪大学 | 難治性心疾患治療用医薬組成物 |
| US20210386743A1 (en) * | 2018-10-08 | 2021-12-16 | The Johns Hopkins University | Use of pde9 inhibitors for treatment |
| WO2025226615A1 (en) * | 2024-04-22 | 2025-10-30 | Huyabio International, Llc | Sodium salt and ethanolamine salt of 23-hydroxytormentic acid |
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2005
- 2005-08-17 CA CA002577442A patent/CA2577442A1/en not_active Abandoned
- 2005-08-17 US US11/660,440 patent/US8299083B2/en not_active Expired - Fee Related
- 2005-08-17 JP JP2007527993A patent/JP5070052B2/ja not_active Expired - Fee Related
- 2005-08-17 WO PCT/US2005/029327 patent/WO2006023603A2/en not_active Ceased
- 2005-08-17 AU AU2005277384A patent/AU2005277384B2/en not_active Ceased
- 2005-08-17 EP EP05808662A patent/EP1786428B1/en not_active Expired - Lifetime
- 2005-08-17 CN CNA200580035426XA patent/CN101106997A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101106997A (zh) | 2008-01-16 |
| JP5070052B2 (ja) | 2012-11-07 |
| JP2008510705A (ja) | 2008-04-10 |
| AU2005277384A1 (en) | 2006-03-02 |
| EP1786428A4 (en) | 2009-08-05 |
| EP1786428A2 (en) | 2007-05-23 |
| CA2577442A1 (en) | 2006-03-02 |
| WO2006023603A2 (en) | 2006-03-02 |
| US8299083B2 (en) | 2012-10-30 |
| WO2006023603A3 (en) | 2006-10-19 |
| US20090062313A1 (en) | 2009-03-05 |
| EP1786428B1 (en) | 2012-05-16 |
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