CN101052706B - 发酵木糖的真核细胞的代谢工程 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
RPE1 | YJL121C | D-核酮糖-5-磷酸3-差向 异构酶 | 299±24 | 2551±385 | +8.5 |
RKI1 | YOR095C | D-核糖-5-磷酸酮醇-异构 酶 | 96±8 | 483±64 | +5.0 |
GRE3 | YHR104w | 醛糖还原酶 | 322±6 | 12±0 | -26.8 |
ACT1 | YFL039C | 肌动蛋白 | 408±32 | 366±56 | NCa |
PDA1 | YER178W | 丙酮酸脱氢酶复合物的 E1α亚基 | 2901±142 | 3217±182 | NC |
菌株 | 过表达 | 缺失 |
RWB 204 | TAL1 | |
RWB 206 | TAL1 | gre3 |
RWB 208 | TAL1,TKL1 | gre3 |
RWB 210 | TAL1,TKL1,RPE1 | gre3 |
RWB 212 | TAL1,TKL1,RPE1,RKI1 | gre3 |
pUG6 | loxP-KanMX-loxP casette | Guldener et al.[3] |
pUG6PTPI1 | 具有TPI1启动子的pUG6 | 本研究 |
pUG6PTPI1-RPE1 | 具有位于TPI1启动子之后的RPE1的pUG6 | 本研究 |
pUG6PTPI1-TKL1 | 具有位于TPI1启动子之后的TKL1的pUG6 | 本研究 |
pAG32 | loxP-hphMX-loxP盒 | Goldstein and McCusker[9] |
PAKX002 | 2μ,URA3,位于TPI1启动子之后的Piromyces XylA | Kuyper et al.[20] |
P415ADH | CEN,LEU2,ADH1启动子 | Mumberg et al.[21] |
p415ADHXKS1 | CEN,LEU2,PADH1-XKS1 | 本研究 |
PSH47 | CEN,URA3,位于PGAL1之后的Cre重组酶 | Guldener et al.[3] |
Claims (19)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58838104P | 2004-07-16 | 2004-07-16 | |
US60/588,381 | 2004-07-16 | ||
EP04077073 | 2004-07-16 | ||
EP04077073.7 | 2004-07-16 | ||
US58983304P | 2004-07-22 | 2004-07-22 | |
US60/589,833 | 2004-07-22 | ||
PCT/NL2005/000516 WO2006009434A1 (en) | 2004-07-16 | 2005-07-15 | Metabolic engineering of xylose fermenting eukaryotic cells |
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CN2010102431314A Division CN101914462B (zh) | 2004-07-16 | 2005-07-15 | 发酵木糖的真核细胞的代谢工程 |
Publications (2)
Publication Number | Publication Date |
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CN101052706A CN101052706A (zh) | 2007-10-10 |
CN101052706B true CN101052706B (zh) | 2015-02-18 |
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CN2010102431314A Expired - Fee Related CN101914462B (zh) | 2004-07-16 | 2005-07-15 | 发酵木糖的真核细胞的代谢工程 |
CN200580031103.3A Expired - Fee Related CN101052706B (zh) | 2004-07-16 | 2005-07-15 | 发酵木糖的真核细胞的代谢工程 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN2010102431314A Expired - Fee Related CN101914462B (zh) | 2004-07-16 | 2005-07-15 | 发酵木糖的真核细胞的代谢工程 |
Country Status (10)
Country | Link |
---|---|
US (3) | US8034591B2 (zh) |
EP (1) | EP1781772B1 (zh) |
JP (2) | JP5796925B2 (zh) |
CN (2) | CN101914462B (zh) |
BR (1) | BRPI0513437A (zh) |
CA (2) | CA2573483C (zh) |
DK (1) | DK1781772T3 (zh) |
ES (1) | ES2607891T3 (zh) |
PL (1) | PL1781772T3 (zh) |
WO (1) | WO2006009434A1 (zh) |
Families Citing this family (123)
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BRPI0306740B1 (pt) | 2002-01-23 | 2019-08-27 | C5 Yeast Company B V | célula hospedeira transformada com um construto de ácido nucléico e processo para a produção de etanol |
BRPI0513437A (pt) * | 2004-07-16 | 2008-05-06 | Univ Delft Tech | célula hospedeira eucariótica com a capacidade para isomerizar diretamente xilose em xilulose, e, processos para produzir etanol e um produto de fermentação |
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EP1781772A1 (en) | 2007-05-09 |
BRPI0513437A (pt) | 2008-05-06 |
CN101914462A (zh) | 2010-12-15 |
CA2573483A1 (en) | 2006-01-26 |
WO2006009434A1 (en) | 2006-01-26 |
US20120225451A1 (en) | 2012-09-06 |
PL1781772T3 (pl) | 2017-03-31 |
US20150010943A1 (en) | 2015-01-08 |
US8790903B2 (en) | 2014-07-29 |
JP2008506383A (ja) | 2008-03-06 |
EP1781772B1 (en) | 2016-09-28 |
ES2607891T3 (es) | 2017-04-04 |
CA2573483C (en) | 2014-10-28 |
JP2013055948A (ja) | 2013-03-28 |
DK1781772T3 (en) | 2017-01-09 |
CA2861834A1 (en) | 2006-01-26 |
JP5796925B2 (ja) | 2015-10-21 |
CN101052706A (zh) | 2007-10-10 |
US8034591B2 (en) | 2011-10-11 |
CN101914462B (zh) | 2013-04-24 |
US20080261287A1 (en) | 2008-10-23 |
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