CN101048396A - 制备西酞普兰和依他普仑的方法 - Google Patents

制备西酞普兰和依他普仑的方法 Download PDF

Info

Publication number
CN101048396A
CN101048396A CNA2005800335447A CN200580033544A CN101048396A CN 101048396 A CN101048396 A CN 101048396A CN A2005800335447 A CNA2005800335447 A CN A2005800335447A CN 200580033544 A CN200580033544 A CN 200580033544A CN 101048396 A CN101048396 A CN 101048396A
Authority
CN
China
Prior art keywords
formula
described method
azodiformate
cyclization
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800335447A
Other languages
English (en)
Chinese (zh)
Inventor
G·科蒂切利
R·萨尔维蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adorkem Technology SpA
Original Assignee
Adorkem Technology SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adorkem Technology SpA filed Critical Adorkem Technology SpA
Publication of CN101048396A publication Critical patent/CN101048396A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
CNA2005800335447A 2004-10-01 2005-09-14 制备西酞普兰和依他普仑的方法 Pending CN101048396A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2004A001872 2004-10-01
IT001872A ITMI20041872A1 (it) 2004-10-01 2004-10-01 Processo per la preparazione di citalopram e di scitalopram

Publications (1)

Publication Number Publication Date
CN101048396A true CN101048396A (zh) 2007-10-03

Family

ID=35975504

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800335447A Pending CN101048396A (zh) 2004-10-01 2005-09-14 制备西酞普兰和依他普仑的方法

Country Status (11)

Country Link
US (1) US7482477B2 (https=)
EP (1) EP1794140B1 (https=)
JP (1) JP2008514670A (https=)
CN (1) CN101048396A (https=)
AT (1) ATE427306T1 (https=)
BR (1) BRPI0516318A (https=)
CA (1) CA2581195A1 (https=)
DE (1) DE602005013681D1 (https=)
IT (1) ITMI20041872A1 (https=)
MX (1) MX2007003925A (https=)
WO (1) WO2006037714A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101607951B (zh) * 2008-06-20 2011-09-28 上海医药工业研究院 一种艾斯西酞普兰的制备方法
CN102336729A (zh) * 2011-07-29 2012-02-01 齐鲁天和惠世制药有限公司 一种草酸艾司西酞普兰制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012954A1 (en) * 2005-07-27 2007-02-01 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
WO2017009866A1 (en) * 2015-07-11 2017-01-19 Ipca Laboratories Limited Novel recovery and recycling process of racemic 4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(hydroxymethyl)-benzonitrile

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
JPS62151196A (ja) * 1985-09-26 1987-07-06 Nitto Electric Ind Co Ltd ｌ−プロプラノロ−ルの生化学的分離法
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
US7390913B2 (en) 2002-12-23 2008-06-24 H. Lundbeck A/S Process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
ITMI20040717A1 (it) * 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101607951B (zh) * 2008-06-20 2011-09-28 上海医药工业研究院 一种艾斯西酞普兰的制备方法
CN102336729A (zh) * 2011-07-29 2012-02-01 齐鲁天和惠世制药有限公司 一种草酸艾司西酞普兰制备方法
CN102336729B (zh) * 2011-07-29 2014-03-26 齐鲁天和惠世制药有限公司 一种草酸艾司西酞普兰制备方法

Also Published As

Publication number Publication date
CA2581195A1 (en) 2006-04-13
ITMI20041872A1 (it) 2005-01-01
JP2008514670A (ja) 2008-05-08
MX2007003925A (es) 2007-06-07
US7482477B2 (en) 2009-01-27
ATE427306T1 (de) 2009-04-15
DE602005013681D1 (de) 2009-05-14
WO2006037714A2 (en) 2006-04-13
EP1794140A2 (en) 2007-06-13
EP1794140B1 (en) 2009-04-01
US20070270599A1 (en) 2007-11-22
WO2006037714A3 (en) 2006-07-27
BRPI0516318A (pt) 2008-09-02

Similar Documents

Publication Publication Date Title
US7550605B2 (en) Process for preparation of an anitdepressant compound
CN101048396A (zh) 制备西酞普兰和依他普仑的方法
US7939680B2 (en) Process for the preparation of Escitalopram
CN1279178C (zh) 通过酶水解制备取代羧酸酯的方法
CN100339367C (zh) 2－氨基甲基吡啶衍生物的制备方法
KR100511534B1 (ko) 아미드 화합물의 새로운 제조방법
JP4228571B2 (ja) 芳香族アルデヒドの製造方法
CN1022920C (zh) 五元含氮杂环芳香物质的制备方法
CN101044130A (zh) 一种制备缩水甘油衍生物的方法
EP1736550A1 (en) Chemoenzymatic process for the synthesis of escitalopram
CN1525964A (zh) 比哌立登的制备方法
CN101027277A (zh) (2r,3r)－2－羟基－3－氨基－3－芳基－丙酰胺和(2r,3r)－2－羟基－3－氨基－3－芳基－丙酸烷基酯的制备方法
US7534908B2 (en) Method for the production of optically active 3-alkylcarboxylic acids and the intermediate products thereof
CN101048387A (zh) 苯基2－嘧啶酮及其新的中间体的制备方法
WO2008037433A1 (en) Process for making aminoalkylphenyl carbamates and intermediates therefor
US7482476B2 (en) Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
JP2003534807A (ja) 酵素を使用するラセミα−置換ヘテロ環式カルボン酸の光学分割方法
JPWO1998016495A1 (ja) ジカルボン酸モノエステルの製造方法
JP2009019004A (ja) 光学活性アリールオキシカルボン酸誘導体の製造方法
JPH0566940B2 (https=)
JPH08217749A (ja) 塩酸ニカルジピンの新規製造法及び新規合成中間体
EP0908522A1 (en) A method for producing an optically active 2-alkanol
WO2009096039A1 (ja) {2-(4-ヒドロキシフェノキシ)プロピオニル}チオカルバジン酸エステル及びその製造方法
JP2006502201A (ja) 改良されたシンセトン合成
HK1061846B (en) New process for the industrial synthesis of substituted thiophene-carboxylates, and application of such compounds

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20071003