MX2007003925A - Proceso para la preparacion de citalopram y escitalopram. - Google Patents
Proceso para la preparacion de citalopram y escitalopram.Info
- Publication number
- MX2007003925A MX2007003925A MX2007003925A MX2007003925A MX2007003925A MX 2007003925 A MX2007003925 A MX 2007003925A MX 2007003925 A MX2007003925 A MX 2007003925A MX 2007003925 A MX2007003925 A MX 2007003925A MX 2007003925 A MX2007003925 A MX 2007003925A
- Authority
- MX
- Mexico
- Prior art keywords
- escitalopram
- citalopram
- preparation
- azodicarboxylate
- phosphine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
Se describe un proceso para la preparacion de citalopram (1) y del enantiomero activo de este, escitalopram (11), cuyo proceso comprende la reaccion de ciclizacion del precursor que corresponde dio1 de la formula 111 o, respectivamente, IC en la presencia de un azodicarboxilato, una fosfina y una base fuerte.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001872A ITMI20041872A1 (it) | 2004-10-01 | 2004-10-01 | Processo per la preparazione di citalopram e di scitalopram |
PCT/EP2005/054566 WO2006037714A2 (en) | 2004-10-01 | 2005-09-14 | Process for the preparation of citalopram and escitalopram |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007003925A true MX2007003925A (es) | 2007-06-07 |
Family
ID=35975504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007003925A MX2007003925A (es) | 2004-10-01 | 2005-09-14 | Proceso para la preparacion de citalopram y escitalopram. |
Country Status (11)
Country | Link |
---|---|
US (1) | US7482477B2 (es) |
EP (1) | EP1794140B1 (es) |
JP (1) | JP2008514670A (es) |
CN (1) | CN101048396A (es) |
AT (1) | ATE427306T1 (es) |
BR (1) | BRPI0516318A (es) |
CA (1) | CA2581195A1 (es) |
DE (1) | DE602005013681D1 (es) |
IT (1) | ITMI20041872A1 (es) |
MX (1) | MX2007003925A (es) |
WO (1) | WO2006037714A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939680B2 (en) * | 2005-07-27 | 2011-05-10 | Aurobindo Pharma Ltd. | Process for the preparation of Escitalopram |
WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
CN101607951B (zh) * | 2008-06-20 | 2011-09-28 | 上海医药工业研究院 | 一种艾斯西酞普兰的制备方法 |
CN102336729B (zh) * | 2011-07-29 | 2014-03-26 | 齐鲁天和惠世制药有限公司 | 一种草酸艾司西酞普兰制备方法 |
WO2017009866A1 (en) * | 2015-07-11 | 2017-01-19 | Ipca Laboratories Limited | Novel recovery and recycling process of racemic 4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(hydroxymethyl)-benzonitrile |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
JPS62151196A (ja) * | 1985-09-26 | 1987-07-06 | Nitto Electric Ind Co Ltd | l−プロプラノロ−ルの生化学的分離法 |
GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
AR034759A1 (es) * | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | Metodo para la preparacion de escitalopram |
PE20040991A1 (es) * | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
AU2003291960B2 (en) * | 2002-12-23 | 2009-11-19 | H. Lundbeck A/S | A process for the preparation of racemic citalopram diol and/or S- or R- citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram |
ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
-
2004
- 2004-10-01 IT IT001872A patent/ITMI20041872A1/it unknown
-
2005
- 2005-09-14 BR BRPI0516318-8A patent/BRPI0516318A/pt not_active IP Right Cessation
- 2005-09-14 DE DE602005013681T patent/DE602005013681D1/de not_active Expired - Fee Related
- 2005-09-14 WO PCT/EP2005/054566 patent/WO2006037714A2/en active Application Filing
- 2005-09-14 AT AT05789627T patent/ATE427306T1/de not_active IP Right Cessation
- 2005-09-14 US US11/664,317 patent/US7482477B2/en not_active Expired - Fee Related
- 2005-09-14 EP EP05789627A patent/EP1794140B1/en active Active
- 2005-09-14 MX MX2007003925A patent/MX2007003925A/es not_active Application Discontinuation
- 2005-09-14 CA CA002581195A patent/CA2581195A1/en not_active Abandoned
- 2005-09-14 JP JP2007533998A patent/JP2008514670A/ja active Pending
- 2005-09-14 CN CNA2005800335447A patent/CN101048396A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
US20070270599A1 (en) | 2007-11-22 |
ATE427306T1 (de) | 2009-04-15 |
US7482477B2 (en) | 2009-01-27 |
WO2006037714A3 (en) | 2006-07-27 |
EP1794140A2 (en) | 2007-06-13 |
CN101048396A (zh) | 2007-10-03 |
CA2581195A1 (en) | 2006-04-13 |
EP1794140B1 (en) | 2009-04-01 |
JP2008514670A (ja) | 2008-05-08 |
WO2006037714A2 (en) | 2006-04-13 |
BRPI0516318A (pt) | 2008-09-02 |
ITMI20041872A1 (it) | 2005-01-01 |
DE602005013681D1 (de) | 2009-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |