CN101040194B - 生物医学模制件 - Google Patents
生物医学模制件 Download PDFInfo
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- CN101040194B CN101040194B CN2005800351844A CN200580035184A CN101040194B CN 101040194 B CN101040194 B CN 101040194B CN 2005800351844 A CN2005800351844 A CN 2005800351844A CN 200580035184 A CN200580035184 A CN 200580035184A CN 101040194 B CN101040194 B CN 101040194B
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- pva
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- polyvinyl alcohol
- contact lenses
- prepolymer
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- 238000000465 moulding Methods 0.000 title abstract description 8
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 154
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 58
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- 239000000243 solution Substances 0.000 claims description 49
- -1 polyethylene Polymers 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 34
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 229920001577 copolymer Polymers 0.000 claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 9
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- 229920000573 polyethylene Polymers 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 238000007334 copolymerization reaction Methods 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 230000000977 initiatory effect Effects 0.000 claims description 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 2
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- 239000000178 monomer Substances 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 11
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- 239000005977 Ethylene Substances 0.000 description 8
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- 238000004519 manufacturing process Methods 0.000 description 7
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- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 4
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
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- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- GNWBLLYJQXKPIP-ZOGIJGBBSA-N (1s,3as,3bs,5ar,9ar,9bs,11as)-n,n-diethyl-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1h-indeno[5,4-f]quinoline-1-carboxamide Chemical compound CN([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)N(CC)CC)[C@@]2(C)CC1 GNWBLLYJQXKPIP-ZOGIJGBBSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
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- FNIATMYXUPOJRW-UHFFFAOYSA-N cyclohexylidene Chemical group [C]1CCCCC1 FNIATMYXUPOJRW-UHFFFAOYSA-N 0.000 description 2
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- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 2
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- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 description 1
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- 229940119545 isobornyl methacrylate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- CMMYGCUEJWTBCG-UHFFFAOYSA-N n-(2,2-dimethoxyethyl)prop-2-enamide Chemical compound COC(OC)CNC(=O)C=C CMMYGCUEJWTBCG-UHFFFAOYSA-N 0.000 description 1
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 description 1
- KKFHAJHLJHVUDM-UHFFFAOYSA-N n-vinylcarbazole Chemical compound C1=CC=C2N(C=C)C3=CC=CC=C3C2=C1 KKFHAJHLJHVUDM-UHFFFAOYSA-N 0.000 description 1
- 125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229920001987 poloxamine Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
- LYBIZMNPXTXVMV-UHFFFAOYSA-N propan-2-yl prop-2-enoate Chemical compound CC(C)OC(=O)C=C LYBIZMNPXTXVMV-UHFFFAOYSA-N 0.000 description 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 description 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003440 styrenes Chemical class 0.000 description 1
- 125000005504 styryl group Chemical group 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000005987 sulfurization reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
- C08L29/02—Homopolymers or copolymers of unsaturated alcohols
- C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2029/00—Use of polyvinylalcohols, polyvinylethers, polyvinylaldehydes, polyvinylketones or polyvinylketals or derivatives thereof as moulding material
- B29K2029/04—PVOH, i.e. polyvinyl alcohol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Health & Medical Sciences (AREA)
- Eyeglasses (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Conductive Materials (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61815704P | 2004-10-13 | 2004-10-13 | |
US60/618,157 | 2004-10-13 | ||
PCT/EP2005/010933 WO2006040130A1 (en) | 2004-10-13 | 2005-10-11 | Biomedical moldings |
Publications (2)
Publication Number | Publication Date |
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CN101040194A CN101040194A (zh) | 2007-09-19 |
CN101040194B true CN101040194B (zh) | 2010-10-06 |
Family
ID=34956309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2005800351844A Active CN101040194B (zh) | 2004-10-13 | 2005-10-11 | 生物医学模制件 |
Country Status (16)
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US (1) | US8030369B2 (zh) |
EP (1) | EP1803002B1 (zh) |
JP (1) | JP4975628B2 (zh) |
CN (1) | CN101040194B (zh) |
AT (1) | ATE550683T1 (zh) |
AU (1) | AU2005293729B2 (zh) |
BR (1) | BRPI0518156B1 (zh) |
CA (1) | CA2580768C (zh) |
DK (1) | DK1803002T3 (zh) |
ES (1) | ES2381271T3 (zh) |
MX (1) | MX2007004363A (zh) |
NO (1) | NO337928B1 (zh) |
PL (1) | PL1803002T3 (zh) |
PT (1) | PT1803002E (zh) |
WO (1) | WO2006040130A1 (zh) |
ZA (1) | ZA200702207B (zh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7726809B2 (en) | 2005-02-09 | 2010-06-01 | Safilens S.R.L. | Contact lens, method for producing same, and pack for storage and maintenance of a contact lens |
EP3015119A1 (en) * | 2006-10-30 | 2016-05-04 | Novartis AG | Method for applying a coating onto a silicone hydrogel lens |
JP5721267B2 (ja) | 2008-07-21 | 2015-05-20 | ノバルティス アーゲー | シリコーンハイドロゲルコンタクトレンズを製造する方法 |
TWI506333B (zh) | 2008-12-05 | 2015-11-01 | Novartis Ag | 用以傳遞疏水性舒適劑之眼用裝置及其製造方法 |
HUE027812T2 (en) | 2011-06-09 | 2016-11-28 | Novartis Ag | Nano-textured silicone hydrogel lenses |
EP3058003B8 (en) * | 2013-10-17 | 2020-08-26 | Alcon Inc. | Crosslinkable polyacetal for contact lenses |
US9981435B2 (en) | 2014-12-17 | 2018-05-29 | Novartis Ag | Reusable lens molds and methods of use thereof |
US9981436B2 (en) | 2014-12-17 | 2018-05-29 | Novartis Ag | Reusable lens molds and methods of use thereof |
JP6616137B2 (ja) * | 2015-09-15 | 2019-12-04 | 株式会社メニコン | コンタクトレンズ用組成物 |
EP3390025B1 (en) | 2015-12-17 | 2023-09-06 | Alcon Inc. | Reusable lens molds and methods of use thereof |
CA3010331C (en) * | 2016-02-22 | 2021-06-22 | Novartis Ag | Uv-absorbing vinylic monomers and uses thereof |
CN117270235A (zh) * | 2018-01-30 | 2023-12-22 | 爱尔康公司 | 在其上具有润滑涂层的隐形眼镜 |
CN110950772A (zh) * | 2018-09-26 | 2020-04-03 | 天津大学 | N-(2,2-二甲氧基乙基)丙烯酰胺的制备方法及由其制备得到的醛基官能化共聚物 |
US20210132411A1 (en) | 2019-11-04 | 2021-05-06 | Alcon Inc. | Contact lenses with surfaces having different softness |
WO2022023966A1 (en) | 2020-07-28 | 2022-02-03 | Alcon Inc. | Contact lenses with softer lens surfaces |
WO2022224169A1 (en) | 2021-04-22 | 2022-10-27 | Alcon Inc. | Method for applying a coating onto a non-silicone hydrogel lens |
US20240092043A1 (en) | 2022-08-17 | 2024-03-21 | Alcon Inc. | Contact lens with a hydrogel coating thereon |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583163A (en) * | 1993-08-06 | 1996-12-10 | Ciba Geigy Corporation | Photocrosslinked polymers |
US6149842A (en) * | 1998-11-12 | 2000-11-21 | Novartis Ag | Methods and compositions for manufacturing tinted ophthalmic lenses |
CN1278924A (zh) * | 1997-11-14 | 2001-01-03 | 诺瓦提斯公司 | 制造着色眼用透镜的方法和组合物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3220960A (en) * | 1960-12-21 | 1965-11-30 | Wichterle Otto | Cross-linked hydrophilic polymers and articles made therefrom |
JP2544313B2 (ja) | 1986-11-13 | 1996-10-16 | 日本合成化学工業株式会社 | 硬化性樹脂組成物 |
US5336551A (en) | 1992-12-14 | 1994-08-09 | Mizu Systems, Inc. | Reinforced polyvinyl alcohol hydrogels containing uniformly dispersed crystalline fibrils and method for preparing same |
ES2108407T3 (es) * | 1993-07-29 | 1997-12-16 | Ciba Geigy Ag | Procedimiento y dispositivo para la obtencion de cuerpos moldeados, asi como cuerpos moldeados obtenidos segun el procedimiento. |
US6407145B1 (en) * | 1994-08-04 | 2002-06-18 | Novartis Ag | Photocrosslinkable materials and applications |
US6042756A (en) * | 1995-02-02 | 2000-03-28 | Novartis Ag | Process for the manufacture of moulded articles that are partly colored or have regions of different colors |
WO1996024075A1 (en) * | 1995-02-03 | 1996-08-08 | Novartis Ag | Crosslinked polymers containing ester or amide groups |
AR008108A1 (es) * | 1996-08-01 | 1999-12-09 | Novartis Ag | Un metodo para formar un articulo polimerico absorbente de radiacion, un articulo polimerico asi formado, y un metodo para formar un tintepolimerico |
US6149692A (en) * | 1998-08-27 | 2000-11-21 | Novartis Ag | Method and composition for incorporating radiation-absorbing agents into polymers |
TWI261057B (en) * | 2001-03-07 | 2006-09-01 | Novartis Ag | Process for the manufacture of moldings |
US7049351B2 (en) * | 2002-11-01 | 2006-05-23 | Novartis Ag | Moldings and preparation and uses thereof |
-
2005
- 2005-10-05 US US11/243,930 patent/US8030369B2/en active Active
- 2005-10-11 PL PL05791892T patent/PL1803002T3/pl unknown
- 2005-10-11 AU AU2005293729A patent/AU2005293729B2/en active Active
- 2005-10-11 BR BRPI0518156-9A patent/BRPI0518156B1/pt active IP Right Grant
- 2005-10-11 JP JP2007536072A patent/JP4975628B2/ja active Active
- 2005-10-11 WO PCT/EP2005/010933 patent/WO2006040130A1/en active Application Filing
- 2005-10-11 AT AT05791892T patent/ATE550683T1/de active
- 2005-10-11 CN CN2005800351844A patent/CN101040194B/zh active Active
- 2005-10-11 DK DK05791892.2T patent/DK1803002T3/da active
- 2005-10-11 EP EP05791892A patent/EP1803002B1/en active Active
- 2005-10-11 PT PT05791892T patent/PT1803002E/pt unknown
- 2005-10-11 CA CA2580768A patent/CA2580768C/en active Active
- 2005-10-11 MX MX2007004363A patent/MX2007004363A/es active IP Right Grant
- 2005-10-11 ES ES05791892T patent/ES2381271T3/es active Active
-
2007
- 2007-03-16 ZA ZA200702207A patent/ZA200702207B/xx unknown
- 2007-04-24 NO NO20072125A patent/NO337928B1/no not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583163A (en) * | 1993-08-06 | 1996-12-10 | Ciba Geigy Corporation | Photocrosslinked polymers |
CN1278924A (zh) * | 1997-11-14 | 2001-01-03 | 诺瓦提斯公司 | 制造着色眼用透镜的方法和组合物 |
US6149842A (en) * | 1998-11-12 | 2000-11-21 | Novartis Ag | Methods and compositions for manufacturing tinted ophthalmic lenses |
Non-Patent Citations (1)
Title |
---|
CN 1278924 A,说明书第1页第23行至第15页第29行. |
Also Published As
Publication number | Publication date |
---|---|
WO2006040130A1 (en) | 2006-04-20 |
MX2007004363A (es) | 2007-05-04 |
AU2005293729A1 (en) | 2006-04-20 |
US20060079598A1 (en) | 2006-04-13 |
JP2008515576A (ja) | 2008-05-15 |
ATE550683T1 (de) | 2012-04-15 |
CN101040194A (zh) | 2007-09-19 |
BRPI0518156B1 (pt) | 2017-12-19 |
EP1803002A1 (en) | 2007-07-04 |
JP4975628B2 (ja) | 2012-07-11 |
AU2005293729B2 (en) | 2008-12-11 |
NO20072125L (no) | 2007-07-09 |
NO337928B1 (no) | 2016-07-11 |
CA2580768A1 (en) | 2006-04-20 |
ES2381271T3 (es) | 2012-05-24 |
ZA200702207B (en) | 2008-09-25 |
EP1803002B1 (en) | 2012-03-21 |
CA2580768C (en) | 2013-05-14 |
DK1803002T3 (da) | 2012-06-25 |
PT1803002E (pt) | 2012-05-15 |
BRPI0518156A (pt) | 2008-11-04 |
PL1803002T3 (pl) | 2012-08-31 |
US8030369B2 (en) | 2011-10-04 |
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