CN101010340B - 与GLP-1和肠促胰岛素类似物（exendin)有关的发明 - Google Patents

与GLP-1和肠促胰岛素类似物（exendin)有关的发明 Download PDF

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Publication number
CN101010340B
CN101010340B CN2005800297604A CN200580029760A CN101010340B CN 101010340 B CN101010340 B CN 101010340B CN 2005800297604 A CN2005800297604 A CN 2005800297604A CN 200580029760 A CN200580029760 A CN 200580029760A CN 101010340 B CN101010340 B CN 101010340B
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exendin
glp
peptide
receptor
ser
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Expired - Fee Related
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Chinese (zh)
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CN101010340A (zh
Inventor
马丁·戈特哈特
马丁·贝埃
托马斯·贝尔
布克哈德·J·戈克
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Philipps Universitaet Marburg
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
CN2005800297604A 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物（exendin)有关的发明 Expired - Fee Related CN101010340B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004043153A DE102004043153B4 (de) 2004-09-03 2004-09-03 Erfindung betreffend GLP-1 und Exendin
DE102004043153.1 2004-09-03
PCT/DE2005/001503 WO2006024275A2 (de) 2004-09-03 2005-08-26 Erfindung betreffend glp-1 und exendin

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2011101471272A Division CN102304179A (zh) 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物(exendin)有关的发明
CN201110114845.XA Division CN102358752B (zh) 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物(exendin)有关的发明

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CN101010340A CN101010340A (zh) 2007-08-01
CN101010340B true CN101010340B (zh) 2012-11-28

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CN2005800297604A Expired - Fee Related CN101010340B (zh) 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物（exendin)有关的发明
CN201110114845.XA Expired - Fee Related CN102358752B (zh) 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物(exendin)有关的发明
CN2011101471272A Pending CN102304179A (zh) 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物(exendin)有关的发明

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CN2011101471272A Pending CN102304179A (zh) 2004-09-03 2005-08-26 与GLP-1和肠促胰岛素类似物(exendin)有关的发明

Country Status (16)

Country Link
US (2) US8268781B2 (https=)
EP (3) EP2070946B1 (https=)
JP (1) JP5047795B2 (https=)
KR (1) KR101237152B1 (https=)
CN (3) CN101010340B (https=)
AT (1) ATE486090T1 (https=)
AU (1) AU2005279537C1 (https=)
BR (1) BRPI0515624A (https=)
CA (2) CA2578252A1 (https=)
DE (2) DE102004043153B4 (https=)
HR (1) HRP20110061T1 (https=)
MX (1) MX2007002455A (https=)
NO (1) NO20071592L (https=)
PL (2) PL2070946T3 (https=)
RU (3) RU2420536C2 (https=)
WO (1) WO2006024275A2 (https=)

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WO2011027584A1 (ja) * 2009-09-04 2011-03-10 国立大学法人京都大学 膵島イメージング用分子プローブ及びその使用
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HK1211232A1 (en) 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
CN103344764B (zh) * 2013-06-19 2014-11-26 天津美德太平洋科技有限公司 胰高血糖素样肽-1生物学活性检测试剂及检测方法和试剂盒
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
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ATE486090T1 (de) 2010-11-15
RU2010148447A (ru) 2012-06-10
US8268781B2 (en) 2012-09-18
HRP20110061T1 (hr) 2011-02-28
KR101237152B1 (ko) 2013-03-04
RU2007112115A (ru) 2008-10-10
JP2008511557A (ja) 2008-04-17
CN102358752B (zh) 2014-07-30
WO2006024275A2 (de) 2006-03-09
CA2797666A1 (en) 2006-03-09
AU2005279537A1 (en) 2006-03-09
DE102004043153B4 (de) 2013-11-21
EP2301962A2 (de) 2011-03-30
DE102004043153A1 (de) 2006-03-23
RU2010148446A (ru) 2012-06-10
EP2301962B1 (de) 2013-10-30
JP5047795B2 (ja) 2012-10-10
EP2070946A2 (de) 2009-06-17
AU2005279537C1 (en) 2012-07-05
WO2006024275A3 (de) 2006-11-30
US20090180953A1 (en) 2009-07-16
CN102358752A (zh) 2012-02-22
NO20071592L (no) 2007-05-29
BRPI0515624A (pt) 2008-07-29
EP2070946B1 (de) 2013-05-29
AU2005279537B2 (en) 2012-02-16
US20130095037A1 (en) 2013-04-18
RU2489443C2 (ru) 2013-08-10
RU2486197C2 (ru) 2013-06-27
EP1784422B1 (de) 2010-10-27
RU2420536C2 (ru) 2011-06-10
EP2070946A3 (de) 2009-09-09
PL2070946T3 (pl) 2013-09-30
KR20070093960A (ko) 2007-09-19
CA2578252A1 (en) 2006-03-09
EP1784422A2 (de) 2007-05-16
EP2301962A3 (de) 2011-11-02
MX2007002455A (es) 2007-10-10
CN101010340A (zh) 2007-08-01
CN102304179A (zh) 2012-01-04
PL2301962T3 (pl) 2014-05-30
DE502005010449D1 (de) 2010-12-09

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