AU2005279537C1 - GLP-1 and exendin related invention - Google Patents

GLP-1 and exendin related invention Download PDF

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Publication number
AU2005279537C1
AU2005279537C1 AU2005279537A AU2005279537A AU2005279537C1 AU 2005279537 C1 AU2005279537 C1 AU 2005279537C1 AU 2005279537 A AU2005279537 A AU 2005279537A AU 2005279537 A AU2005279537 A AU 2005279537A AU 2005279537 C1 AU2005279537 C1 AU 2005279537C1
Authority
AU
Australia
Prior art keywords
exendin
glp
peptide derivatives
therapy
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005279537A
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English (en)
Other versions
AU2005279537A1 (en
AU2005279537B2 (en
Inventor
Martin Behe
Thomas Behr
Burkhard J. Goke
Martin Gotthardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philipps Universitaet Marburg
Original Assignee
Philipps Universitaet Marburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philipps Universitaet Marburg filed Critical Philipps Universitaet Marburg
Publication of AU2005279537A1 publication Critical patent/AU2005279537A1/en
Application granted granted Critical
Publication of AU2005279537B2 publication Critical patent/AU2005279537B2/en
Priority to AU2012202855A priority Critical patent/AU2012202855B2/en
Publication of AU2005279537C1 publication Critical patent/AU2005279537C1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57563Vasoactive intestinal peptide [VIP]; Related peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
AU2005279537A 2004-09-03 2005-08-26 GLP-1 and exendin related invention Ceased AU2005279537C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012202855A AU2012202855B2 (en) 2004-09-03 2012-05-16 GLP-1 and exendin related invention

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004043153A DE102004043153B4 (de) 2004-09-03 2004-09-03 Erfindung betreffend GLP-1 und Exendin
DE102004043153.1 2004-09-03
PCT/DE2005/001503 WO2006024275A2 (de) 2004-09-03 2005-08-26 Erfindung betreffend glp-1 und exendin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012202855A Division AU2012202855B2 (en) 2004-09-03 2012-05-16 GLP-1 and exendin related invention

Publications (3)

Publication Number Publication Date
AU2005279537A1 AU2005279537A1 (en) 2006-03-09
AU2005279537B2 AU2005279537B2 (en) 2012-02-16
AU2005279537C1 true AU2005279537C1 (en) 2012-07-05

Family

ID=35970651

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005279537A Ceased AU2005279537C1 (en) 2004-09-03 2005-08-26 GLP-1 and exendin related invention

Country Status (16)

Country Link
US (2) US8268781B2 (https=)
EP (3) EP2070946B1 (https=)
JP (1) JP5047795B2 (https=)
KR (1) KR101237152B1 (https=)
CN (3) CN101010340B (https=)
AT (1) ATE486090T1 (https=)
AU (1) AU2005279537C1 (https=)
BR (1) BRPI0515624A (https=)
CA (2) CA2578252A1 (https=)
DE (2) DE102004043153B4 (https=)
HR (1) HRP20110061T1 (https=)
MX (1) MX2007002455A (https=)
NO (1) NO20071592L (https=)
PL (2) PL2070946T3 (https=)
RU (3) RU2420536C2 (https=)
WO (1) WO2006024275A2 (https=)

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BRPI0612471A2 (pt) * 2005-05-05 2016-09-06 Cadila Healthcare Ltd novos compostos como agonistas glp-1
SI3456340T1 (sl) 2007-01-08 2022-08-31 The Trustees Of The University Of Pennsylvania Antagonisti receptorja za GLP-1 za uporabo pri zdravljenju prirojenega hiperinsulinizma
WO2010032509A1 (ja) * 2008-09-20 2010-03-25 国立大学法人京都大学 膵島イメージング用分子プローブ前駆体及びその使用
CN102256618A (zh) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
WO2010118034A2 (en) * 2009-04-06 2010-10-14 Board Of Regents, The University Of Texas System Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells
EP2418216B1 (en) * 2009-08-10 2015-10-28 Kyoto University Molecular probe for imaging of pancreatic islet and precursor thereof, and use of the molecular probe or the precursor
WO2011027584A1 (ja) * 2009-09-04 2011-03-10 国立大学法人京都大学 膵島イメージング用分子プローブ及びその使用
CN102596259B (zh) 2009-09-30 2015-03-11 国立大学法人京都大学 胰岛成像用分子探针及其使用
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
CN102695527B (zh) 2009-12-10 2015-03-11 国立大学法人京都大学 胰岛成像用分子探针及其使用
CN101875700B (zh) * 2010-04-09 2012-09-26 无锡和邦生物科技有限公司 一种增加促胰岛素分泌肽融合蛋白生物活性的方法
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9278146B2 (en) 2010-10-08 2016-03-08 Kyoto University Peptide derivative and use of the same
US9289516B2 (en) * 2011-03-09 2016-03-22 The General Hospital Corporation Imaging beta cell mass
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2013004983A1 (en) 2011-07-04 2013-01-10 Imperial Innovations Limited Novel compounds and their effects on feeding behaviour
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
WO2013182217A1 (en) * 2012-04-27 2013-12-12 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
US8901484B2 (en) * 2012-04-27 2014-12-02 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
UA116217C2 (uk) * 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
TWI617574B (zh) * 2012-12-11 2018-03-11 梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑
HK1211232A1 (en) 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
CN103344764B (zh) * 2013-06-19 2014-11-26 天津美德太平洋科技有限公司 胰高血糖素样肽-1生物学活性检测试剂及检测方法和试剂盒
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/gip受體促效劑
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
DE102014112747A1 (de) 2014-09-04 2016-03-10 Eberhard Karls Universität Tübingen Medizinische Fakultät Verwendung eines Quinoxalinderivats in einem bildgebenden Verfahren
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患之治療
AU2016267052B2 (en) 2015-05-22 2022-01-20 The Bot Of The Leland Stanford Junior University Treatment of post-bariatric hypoglycemia with GLP-1 antagonists
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
PT3389697T (pt) 2015-12-14 2021-01-22 Antaros Medical Ab Agonistas seletivos do recetor de glucagão compreendendo uma fração quelante para propósitos de imagiologia
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WO1991001144A1 (en) * 1989-07-20 1991-02-07 Sandoz Ltd Labeled polypeptide derivatives
WO2000069900A2 (en) * 1999-05-17 2000-11-23 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
WO2001004156A1 (en) * 1999-07-12 2001-01-18 Zealand Pharmaceuticals A/S Peptides that lower blood glucose levels
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Also Published As

Publication number Publication date
ATE486090T1 (de) 2010-11-15
RU2010148447A (ru) 2012-06-10
US8268781B2 (en) 2012-09-18
CN101010340B (zh) 2012-11-28
HRP20110061T1 (hr) 2011-02-28
KR101237152B1 (ko) 2013-03-04
RU2007112115A (ru) 2008-10-10
JP2008511557A (ja) 2008-04-17
CN102358752B (zh) 2014-07-30
WO2006024275A2 (de) 2006-03-09
CA2797666A1 (en) 2006-03-09
AU2005279537A1 (en) 2006-03-09
DE102004043153B4 (de) 2013-11-21
EP2301962A2 (de) 2011-03-30
DE102004043153A1 (de) 2006-03-23
RU2010148446A (ru) 2012-06-10
EP2301962B1 (de) 2013-10-30
JP5047795B2 (ja) 2012-10-10
EP2070946A2 (de) 2009-06-17
WO2006024275A3 (de) 2006-11-30
US20090180953A1 (en) 2009-07-16
CN102358752A (zh) 2012-02-22
NO20071592L (no) 2007-05-29
BRPI0515624A (pt) 2008-07-29
EP2070946B1 (de) 2013-05-29
AU2005279537B2 (en) 2012-02-16
US20130095037A1 (en) 2013-04-18
RU2489443C2 (ru) 2013-08-10
RU2486197C2 (ru) 2013-06-27
EP1784422B1 (de) 2010-10-27
RU2420536C2 (ru) 2011-06-10
EP2070946A3 (de) 2009-09-09
PL2070946T3 (pl) 2013-09-30
KR20070093960A (ko) 2007-09-19
CA2578252A1 (en) 2006-03-09
EP1784422A2 (de) 2007-05-16
EP2301962A3 (de) 2011-11-02
MX2007002455A (es) 2007-10-10
CN101010340A (zh) 2007-08-01
CN102304179A (zh) 2012-01-04
PL2301962T3 (pl) 2014-05-30
DE502005010449D1 (de) 2010-12-09

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