CN101001646A - 稳定化的合成免疫原投递系统 - Google Patents

稳定化的合成免疫原投递系统 Download PDF

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Publication number
CN101001646A
CN101001646A CNA038040212A CN03804021A CN101001646A CN 101001646 A CN101001646 A CN 101001646A CN A038040212 A CNA038040212 A CN A038040212A CN 03804021 A CN03804021 A CN 03804021A CN 101001646 A CN101001646 A CN 101001646A
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China
Prior art keywords
peptide
immunostimulating complex
group
immunogen
water
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Granted
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CNA038040212A
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English (en)
Chinese (zh)
Inventor
肯尼士·K·沙寇
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United Biomedical Inc
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United Biomedical Inc
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Publication of CN101001646A publication Critical patent/CN101001646A/zh
Granted legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
CNA038040212A 2002-02-14 2003-02-14 稳定化的合成免疫原投递系统 Granted CN101001646A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/076,674 US8088388B2 (en) 2002-02-14 2002-02-14 Stabilized synthetic immunogen delivery system
US10/076,674 2002-02-14
US10/355,161 2003-01-31
US10/355,161 US8084015B2 (en) 2002-02-14 2003-05-21 Stabilized synthetic immunogen delivery system

Publications (1)

Publication Number Publication Date
CN101001646A true CN101001646A (zh) 2007-07-18

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN03804021.2A Expired - Lifetime CN101001646B (zh) 2002-02-14 2003-02-14 稳定化的合成免疫原投递系统
CNA038040212A Granted CN101001646A (zh) 2002-02-14 2003-02-14 稳定化的合成免疫原投递系统

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN03804021.2A Expired - Lifetime CN101001646B (zh) 2002-02-14 2003-02-14 稳定化的合成免疫原投递系统

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US (2) US8088388B2 (US08084015-20111227-C00002.png)
EP (1) EP1572074B1 (US08084015-20111227-C00002.png)
JP (2) JP5156170B2 (US08084015-20111227-C00002.png)
CN (2) CN101001646B (US08084015-20111227-C00002.png)
AT (1) ATE540697T1 (US08084015-20111227-C00002.png)
AU (1) AU2003213091C1 (US08084015-20111227-C00002.png)
BR (1) BRPI0307724B8 (US08084015-20111227-C00002.png)
CA (1) CA2475102C (US08084015-20111227-C00002.png)
DK (1) DK1572074T3 (US08084015-20111227-C00002.png)
ES (1) ES2383172T3 (US08084015-20111227-C00002.png)
HK (1) HK1085652A1 (US08084015-20111227-C00002.png)
MX (1) MXPA04007935A (US08084015-20111227-C00002.png)
TW (1) TWI359025B (US08084015-20111227-C00002.png)
WO (1) WO2003068169A2 (US08084015-20111227-C00002.png)

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CN101565458A (zh) * 2009-06-04 2009-10-28 中牧实业股份有限公司 一种动物用肽疫苗及其制备
CN102010461A (zh) * 2010-10-11 2011-04-13 华南理工大学 一种alpha螺旋状阳离子多肽分子及其制法和应用
CN103848902A (zh) * 2014-03-07 2014-06-11 中牧实业股份有限公司 一种合成肽疫苗及其制备方法
CN107073086A (zh) * 2014-07-25 2017-08-18 美国联合生物医学公司 免疫性lhrh组合物及其在猪只中的应用
CN107106674A (zh) * 2015-01-16 2017-08-29 硕腾服务有限责任公司 口蹄疫疫苗
CN107703294A (zh) * 2017-10-12 2018-02-16 华派生物工程集团有限公司 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法
CN109675025A (zh) * 2013-09-19 2019-04-26 硕腾服务有限责任公司 油基佐剂

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CN101565458A (zh) * 2009-06-04 2009-10-28 中牧实业股份有限公司 一种动物用肽疫苗及其制备
CN101565458B (zh) * 2009-06-04 2014-01-08 中牧实业股份有限公司 一种动物用肽疫苗及其制备
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CN102010461A (zh) * 2010-10-11 2011-04-13 华南理工大学 一种alpha螺旋状阳离子多肽分子及其制法和应用
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CN103848902A (zh) * 2014-03-07 2014-06-11 中牧实业股份有限公司 一种合成肽疫苗及其制备方法
CN107073086A (zh) * 2014-07-25 2017-08-18 美国联合生物医学公司 免疫性lhrh组合物及其在猪只中的应用
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CN107703294B (zh) * 2017-10-12 2019-06-04 华派生物工程集团有限公司 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法

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US8088388B2 (en) 2012-01-03
ATE540697T1 (de) 2012-01-15
US8084015B2 (en) 2011-12-27
US20040009897A1 (en) 2004-01-15
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