CN100582092C - 制备二苯基氮杂环丁烷酮衍生物的方法 - Google Patents

制备二苯基氮杂环丁烷酮衍生物的方法 Download PDF

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Publication number
CN100582092C
CN100582092C CN200580016190A CN200580016190A CN100582092C CN 100582092 C CN100582092 C CN 100582092C CN 200580016190 A CN200580016190 A CN 200580016190A CN 200580016190 A CN200580016190 A CN 200580016190A CN 100582092 C CN100582092 C CN 100582092C
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CN
China
Prior art keywords
alkyl
aryl
formula
och
solution
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200580016190A
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English (en)
Chinese (zh)
Other versions
CN1956951A (zh
Inventor
H·延德劳拉
G·比伦
W·弗里克
B·容克尔
T·A·沃尔曼
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN200580016190A 2004-05-21 2005-05-20 制备二苯基氮杂环丁烷酮衍生物的方法 Expired - Fee Related CN100582092C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004025072A DE102004025072A1 (de) 2004-05-21 2004-05-21 Verfahren zur Herstellung von Diphenyl-azetidinon-Derivaten
DE102004025072.3 2004-05-21

Publications (2)

Publication Number Publication Date
CN1956951A CN1956951A (zh) 2007-05-02
CN100582092C true CN100582092C (zh) 2010-01-20

Family

ID=34968088

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200580016190A Expired - Fee Related CN100582092C (zh) 2004-05-21 2005-05-20 制备二苯基氮杂环丁烷酮衍生物的方法

Country Status (13)

Country Link
US (1) US7563888B2 (fr)
EP (1) EP1753717A1 (fr)
JP (1) JP2007538041A (fr)
CN (1) CN100582092C (fr)
AR (1) AR049283A1 (fr)
AU (1) AU2005245123A1 (fr)
CA (1) CA2567481A1 (fr)
DE (1) DE102004025072A1 (fr)
IL (1) IL178993A0 (fr)
MX (1) MXPA06013258A (fr)
TW (1) TW200611895A (fr)
UY (1) UY28913A1 (fr)
WO (1) WO2005113495A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK7822003A3 (en) * 2000-12-21 2003-12-02 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
SA04250427A (ar) 2003-12-23 2005-12-03 استرازينيكا ايه بي مشتقات ثاني فينيل أزيتيدون
UY29607A1 (es) 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
MY148538A (en) 2005-06-22 2013-04-30 Astrazeneca Ab Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
JP5059355B2 (ja) * 2006-08-01 2012-10-24 壽製薬株式会社 オキサゾリジン誘導体の製造方法
CZ302395B6 (cs) * 2007-03-02 2011-04-27 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
EP2133347A4 (fr) 2007-03-06 2010-03-17 Teijin Pharma Ltd Dérivés de 1-biarylazétidinone
JP2010529148A (ja) * 2007-06-07 2010-08-26 テバ ファーマシューティカル インダストリーズ リミティド エゼチミブ製造のための還元方法
DE102007063671A1 (de) * 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP2414529A2 (fr) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Procédé enzymatique pour la préparation de la (s)-5-(4-fluorophényl)-5-hydroxy-1-morpholin-4-yl-pentan-1-one, un intermédiaire de l'ézétimibe et la conversion ultérieure en ézétimibe
WO2015039675A1 (fr) 2013-09-23 2015-03-26 Pharmathen S.A. Nouveau procédé de préparation d'intermédiaires d'ézétimibe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2107548T3 (es) * 1991-07-23 1997-12-01 Schering Corp Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.

Also Published As

Publication number Publication date
US20070149501A1 (en) 2007-06-28
AR049283A1 (es) 2006-07-12
TW200611895A (en) 2006-04-16
CA2567481A1 (fr) 2005-12-01
IL178993A0 (en) 2007-03-08
US7563888B2 (en) 2009-07-21
UY28913A1 (es) 2005-12-30
DE102004025072A1 (de) 2005-12-15
AU2005245123A1 (en) 2005-12-01
EP1753717A1 (fr) 2007-02-21
JP2007538041A (ja) 2007-12-27
CN1956951A (zh) 2007-05-02
WO2005113495A1 (fr) 2005-12-01
MXPA06013258A (es) 2007-02-28

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