UY28913A1 - Procedimiento para la preparación de derivados de difenil-azetidinona - Google Patents

Procedimiento para la preparación de derivados de difenil-azetidinona

Info

Publication number
UY28913A1
UY28913A1 UY28913A UY28913A UY28913A1 UY 28913 A1 UY28913 A1 UY 28913A1 UY 28913 A UY28913 A UY 28913A UY 28913 A UY28913 A UY 28913A UY 28913 A1 UY28913 A1 UY 28913A1
Authority
UY
Uruguay
Prior art keywords
general formula
preparation
difenil
procedure
substituents
Prior art date
Application number
UY28913A
Other languages
English (en)
Inventor
Dr Wendelin Frick
Dr Heiner Jendralla
Dr Guenter Billen
Dr Bernd Junker
Dr Theodor Andreas Wollmann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of UY28913A1 publication Critical patent/UY28913A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para la preparación de derivados de difenil-azetidinona de la fórmula general (I) o en las formas protegidas en los sustituyentes X, R1 y/o R2, en la que los símbolos, sustituyentes e índices tienen los significados que se especifican en la Memoria Descriptiva del invento, compuestos de la fórmula general (II), que son nuevos,en donde los sustituyentes e índices tienen los significados que se especifica en la Memoria Descriptiva que se hacen reaccionar con iminas de la fórmula general (III) apareciendo como productos intermedios nuevas aminoamidas de la fórmula general (IV).
UY28913A 2004-05-21 2005-05-20 Procedimiento para la preparación de derivados de difenil-azetidinona UY28913A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004025072A DE102004025072A1 (de) 2004-05-21 2004-05-21 Verfahren zur Herstellung von Diphenyl-azetidinon-Derivaten

Publications (1)

Publication Number Publication Date
UY28913A1 true UY28913A1 (es) 2005-12-30

Family

ID=34968088

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28913A UY28913A1 (es) 2004-05-21 2005-05-20 Procedimiento para la preparación de derivados de difenil-azetidinona

Country Status (13)

Country Link
US (1) US7563888B2 (es)
EP (1) EP1753717A1 (es)
JP (1) JP2007538041A (es)
CN (1) CN100582092C (es)
AR (1) AR049283A1 (es)
AU (1) AU2005245123A1 (es)
CA (1) CA2567481A1 (es)
DE (1) DE102004025072A1 (es)
IL (1) IL178993A0 (es)
MX (1) MXPA06013258A (es)
TW (1) TW200611895A (es)
UY (1) UY28913A1 (es)
WO (1) WO2005113495A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002216097B2 (en) * 2000-12-21 2006-09-07 Sanofi-Aventis Deutschland Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
BRPI0418004A (pt) 2003-12-23 2007-04-17 Astrazeneca Ab composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis
UY29607A1 (es) 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR057072A1 (es) 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
JP5059355B2 (ja) * 2006-08-01 2012-10-24 壽製薬株式会社 オキサゾリジン誘導体の製造方法
CZ302395B6 (cs) * 2007-03-02 2011-04-27 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
WO2008108486A1 (ja) 2007-03-06 2008-09-12 Teijin Pharma Limited １－ビアリールアゼチジノン誘導体
US20090047716A1 (en) * 2007-06-07 2009-02-19 Nurit Perlman Reduction processes for the preparation of ezetimibe
DE102007063671A1 (de) * 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
WO2015039675A1 (en) 2013-09-23 2015-03-26 Pharmathen S.A. Novel process for the preparation of ezetimibe intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67341A (en) * 1991-07-23 1995-03-28 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof

Also Published As

Publication number Publication date
IL178993A0 (en) 2007-03-08
EP1753717A1 (de) 2007-02-21
WO2005113495A1 (de) 2005-12-01
JP2007538041A (ja) 2007-12-27
CN100582092C (zh) 2010-01-20
CN1956951A (zh) 2007-05-02
TW200611895A (en) 2006-04-16
US20070149501A1 (en) 2007-06-28
CA2567481A1 (en) 2005-12-01
MXPA06013258A (es) 2007-02-28
US7563888B2 (en) 2009-07-21
DE102004025072A1 (de) 2005-12-15
AU2005245123A1 (en) 2005-12-01
AR049283A1 (es) 2006-07-12

Similar Documents

Publication Publication Date Title
UY28913A1 (es) Procedimiento para la preparación de derivados de difenil-azetidinona
CY1118231T1 (el) Συνθεση λιποσωματος
UY30498A1 (es) Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones
CY1112653T1 (el) Κρυσταλλικες τροποποιησεις της πυρακλοστροβινης
MA32811B1 (fr) Nouveaux composés
ES2338590T3 (es) Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos.
CO6511251A2 (es) Compuestos quimicos
ECSP109987A (es) Métodos y compuestos útiles para preparar inhibidores del co-transportador 2 sodio glucosa
CR9113A (es) Compuestos acetamida como fungicidas
UY29549A1 (es) Nuevos derivados del fluoreno, composiciones que los contienen y su utilización
UY30500A1 (es) Compuestos de azabencimidazolilo
UY28800A1 (es) 5,6-dialquil-7-amino-triazolopirimidinas, procedimientos para su preparación y el uso de las mismas para combatir hongos nocivos
UY28186A1 (es) N-arilheterociclos sustituidos, procedimientos para su preparación, y su empleo como medicamentos.
CY1115919T1 (el) Ενωσεις ενεργοποιησης τελομερασης και μεθοδοι χρησης αυτων
AR047526A1 (es) Halogenoalquilcarboxamidas
AR053334A1 (es) Pirazolilcarboxanilidas
UY30600A1 (es) Compuestos novedosos
SV2010003617A (es) Fungicidas
ECSP088221A (es) Agonistas adrenoreceptores alfa2c
EA200900397A1 (ru) Новые соединения диосметина, способ их получения и фармацевтические композиции, которые их содержат
ATE536354T1 (de) Neuartige 1-aza-bizykloalkyl-derivate für die behandlung psychotischer und neurodegenerativer störungen
MA32505B1 (fr) 5-alcynyl-pyrimidines
ECSP088677A (es) Piperazinas y piperidinas como potenciadores 157 del mglur5
ECSP11011485A (es) Espiro-epóxidos como productos intermedios.
DOP2011000134A (es) Lactamas como inhibidores de beta secretasa