CN100522954C - 含有2-苯基苯并噻唑啉衍生物的к-阿片样物质受体激动剂 - Google Patents
含有2-苯基苯并噻唑啉衍生物的к-阿片样物质受体激动剂 Download PDFInfo
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- CN100522954C CN100522954C CNB2006101392068A CN200610139206A CN100522954C CN 100522954 C CN100522954 C CN 100522954C CN B2006101392068 A CNB2006101392068 A CN B2006101392068A CN 200610139206 A CN200610139206 A CN 200610139206A CN 100522954 C CN100522954 C CN 100522954C
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- Prior art keywords
- phenyl
- compound
- methoxy
- ethanoyl
- propoxy
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- 239000002632 kappa opiate receptor agonist Substances 0.000 title claims abstract description 25
- 229940126470 kappa opioid receptor agonist Drugs 0.000 title claims abstract description 25
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 29
- BZGWZLIKWOCPLN-UHFFFAOYSA-N 1,3-benzothiazole;quinoline Chemical compound C1=CC=C2SC=NC2=C1.N1=CC=CC2=CC=CC=C21 BZGWZLIKWOCPLN-UHFFFAOYSA-N 0.000 claims description 133
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 46
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 45
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- 229910052801 chlorine Inorganic materials 0.000 description 15
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- 241001597008 Nomeidae Species 0.000 description 13
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Applications Claiming Priority (2)
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|---|---|---|---|
| JP097500/2002 | 2002-03-29 | ||
| JP2002097500 | 2002-03-29 |
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| CN038072750A Division CN1642929B (zh) | 2002-03-29 | 2003-03-28 | 含有2-苯基苯并噻唑啉衍生物的κ-阿片样物质受体激动剂 |
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| CN1911918A CN1911918A (zh) | 2007-02-14 |
| CN100522954C true CN100522954C (zh) | 2009-08-05 |
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| CNB2006101392068A Expired - Fee Related CN100522954C (zh) | 2002-03-29 | 2003-03-28 | 含有2-苯基苯并噻唑啉衍生物的к-阿片样物质受体激动剂 |
| CN038072750A Expired - Fee Related CN1642929B (zh) | 2002-03-29 | 2003-03-28 | 含有2-苯基苯并噻唑啉衍生物的κ-阿片样物质受体激动剂 |
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| CN038072750A Expired - Fee Related CN1642929B (zh) | 2002-03-29 | 2003-03-28 | 含有2-苯基苯并噻唑啉衍生物的κ-阿片样物质受体激动剂 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1642590A4 (en) * | 2003-07-04 | 2009-05-13 | Santen Pharmaceutical Co Ltd | MEANS TO INHIBIT THE DEGRADATION OF THE PAIN LIMIT |
| US7642274B2 (en) | 2004-07-02 | 2010-01-05 | Santen Pharmaceutical Co., Ltd. | Inhibitor of pain threshold decrease |
| EP1849465A4 (en) * | 2005-02-18 | 2008-12-24 | Takeda Pharmaceutical | AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR |
| US9303027B2 (en) | 2010-07-19 | 2016-04-05 | Dr. Reddy's Laboratories Ltd. | Kappa opioid receptor agonists |
| CN104271552B (zh) | 2012-03-05 | 2017-08-08 | 雷迪博士实验室有限公司 | 作为kappa阿片样物质受体(kor)激动剂的取代的杂环乙酰胺 |
| JP6275517B2 (ja) | 2013-03-22 | 2018-02-07 | あゆみ製薬株式会社 | Ｉｌ−２産生抑制 |
| WO2015093567A1 (ja) | 2013-12-18 | 2015-06-25 | 国立大学法人京都大学 | 疼痛に関する化合物及び医薬組成物 |
| WO2018230711A1 (ja) | 2017-06-16 | 2018-12-20 | 学校法人同志社 | ｍＴＯＲインヒビターを含む、眼の症状、障害または疾患を治療または予防するための医薬およびその応用 |
| US20200121652A1 (en) | 2017-06-16 | 2020-04-23 | The Doshisha | Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4479949A (en) * | 1981-09-12 | 1984-10-30 | Santen Pharmaceutical Co., Ltd. | Benzothiazoline compounds |
| US4547513A (en) * | 1983-12-27 | 1985-10-15 | Santen Pharmaceutical Co., Ltd. | 2-Arylbenzothiazoline derivatives and their use in treating angina cordis |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US547513A (en) * | 1895-10-08 | Chell | ||
| JPS4994667A (US20060205796A1-20060914-C00073.png) * | 1973-01-23 | 1974-09-09 | ||
| JPS5967276A (ja) | 1982-09-01 | 1984-04-16 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
| JPS6183175A (ja) * | 1984-09-06 | 1986-04-26 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤 |
| JPS62221679A (ja) | 1986-03-19 | 1987-09-29 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
| JPH066581B2 (ja) * | 1986-03-19 | 1994-01-26 | 参天製薬株式会社 | フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体 |
| JPH08231399A (ja) * | 1995-02-23 | 1996-09-10 | Shionogi & Co Ltd | モルヒネ禁断抑制作用剤 |
| US6174891B1 (en) * | 1996-11-25 | 2001-01-16 | Toray Industries, Inc. | Antipruritic agent |
| JP2000344821A (ja) | 1999-06-01 | 2000-12-12 | Toagosei Co Ltd | オレフィン重合用触媒 |
-
2003
- 2003-03-28 US US10/509,549 patent/US7112598B2/en not_active Expired - Fee Related
- 2003-03-28 AU AU2003220894A patent/AU2003220894B8/en not_active Ceased
- 2003-03-28 CN CNB2006101392068A patent/CN100522954C/zh not_active Expired - Fee Related
- 2003-03-28 EP EP03715569A patent/EP1496053B1/en not_active Expired - Lifetime
- 2003-03-28 CN CN038072750A patent/CN1642929B/zh not_active Expired - Fee Related
- 2003-03-28 KR KR1020047015318A patent/KR101035931B1/ko not_active IP Right Cessation
- 2003-03-28 EP EP09000611A patent/EP2042173A3/en not_active Withdrawn
- 2003-03-28 NZ NZ535987A patent/NZ535987A/en not_active IP Right Cessation
- 2003-03-28 CA CA2480560A patent/CA2480560C/en not_active Expired - Fee Related
- 2003-03-28 WO PCT/JP2003/003928 patent/WO2003082840A1/ja active Application Filing
- 2003-03-28 ES ES03715569T patent/ES2390052T3/es not_active Expired - Lifetime
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2006
- 2006-05-15 US US11/434,028 patent/US7410987B2/en not_active Expired - Fee Related
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2009
- 2009-02-02 JP JP2009021413A patent/JP5061134B2/ja not_active Expired - Fee Related
- 2009-03-30 AU AU2009201233A patent/AU2009201233B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4479949A (en) * | 1981-09-12 | 1984-10-30 | Santen Pharmaceutical Co., Ltd. | Benzothiazoline compounds |
| US4547513A (en) * | 1983-12-27 | 1985-10-15 | Santen Pharmaceutical Co., Ltd. | 2-Arylbenzothiazoline derivatives and their use in treating angina cordis |
Non-Patent Citations (3)
| Title |
|---|
| novel calcium antagonists. synthesis and structure-activityrelationship studies of benzothiazoline derivatives. Yamamoto, K.Journal of medicinal chemistry,Vol.31 No.5. 1988 |
| novel calcium antagonists. synthesis and structure-activityrelationship studies of benzothiazoline derivatives. Yamamoto, K.Journal of medicinal chemistry,Vol.31 No.5. 1988 * |
| synthesis and calcium antagonistic activity of (+)-R-and(-)-(s)-3-acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5-trimethoxyphene-thyl)amino]butoxy]phenyl]benzothiazolinehydrochloride. Fujita,M.chemical & pharmaceutical bulletin,Vol.38 No.4. 1990 |
Also Published As
| Publication number | Publication date |
|---|---|
| US7410987B2 (en) | 2008-08-12 |
| CN1642929A (zh) | 2005-07-20 |
| JP5061134B2 (ja) | 2012-10-31 |
| WO2003082840A1 (en) | 2003-10-09 |
| US20050113430A1 (en) | 2005-05-26 |
| EP1496053A1 (en) | 2005-01-12 |
| EP2042173A2 (en) | 2009-04-01 |
| ES2390052T3 (es) | 2012-11-06 |
| CN1911918A (zh) | 2007-02-14 |
| CN1642929B (zh) | 2010-05-12 |
| KR20040095329A (ko) | 2004-11-12 |
| NZ535987A (en) | 2006-08-31 |
| US7112598B2 (en) | 2006-09-26 |
| EP1496053B1 (en) | 2012-06-20 |
| AU2009201233B2 (en) | 2012-07-05 |
| CA2480560C (en) | 2011-02-15 |
| JP2009143940A (ja) | 2009-07-02 |
| AU2003220894B2 (en) | 2009-02-05 |
| EP2042173A3 (en) | 2010-02-24 |
| AU2003220894B8 (en) | 2009-02-19 |
| US20060205796A1 (en) | 2006-09-14 |
| CA2480560A1 (en) | 2003-10-09 |
| AU2009201233A1 (en) | 2009-04-23 |
| AU2003220894A1 (en) | 2003-10-13 |
| KR101035931B1 (ko) | 2011-05-23 |
| EP1496053A4 (en) | 2008-01-16 |
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