CN100522163C - 长春西汀小容量注射剂及其制备工艺 - Google Patents
长春西汀小容量注射剂及其制备工艺 Download PDFInfo
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- CN100522163C CN100522163C CNB2006101525144A CN200610152514A CN100522163C CN 100522163 C CN100522163 C CN 100522163C CN B2006101525144 A CNB2006101525144 A CN B2006101525144A CN 200610152514 A CN200610152514 A CN 200610152514A CN 100522163 C CN100522163 C CN 100522163C
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- 238000002347 injection Methods 0.000 title claims abstract description 17
- 239000007924 injection Substances 0.000 title claims abstract description 17
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 229960002726 vincamine Drugs 0.000 title claims abstract description 15
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- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical group C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 claims description 25
- 229960000744 vinpocetine Drugs 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 16
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
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- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
实施例1 | 实施例2 | 实施例3 | 实施例4 | |
主药 | 长春西汀10g | 长春西汀10g | 长春西汀10g | 长春西汀10g |
助溶剂 | 醋酸1g | 抗坏血酸1g | 抗坏血酸1g | 抗坏血酸1g |
抗氧剂 | 亚硫酸氢钠2g | 亚硫酸氢钠2g | 焦亚硫酸钠2g | 焦亚硫酸钠2g |
物理稳定剂 | 甘露醇100g | 山梨醇100g | 甘露醇100g | 山梨醇100g |
血管刺激调节剂 | 苯甲醇20g | 桂油醇20g | 桂油醇20g | 苯甲醇20g |
pH值调节剂 | 醋酸钠适量 | 醋酸钠适量 | 醋酸钠适量 | 酒石酸适量 |
药用炭 | 适量 | 适量 | 适量 | 适量 |
注射用水 | 2000ml | 2000ml | 2000ml | 2000ml |
Claims (2)
Priority Applications (1)
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CNB2006101525144A CN100522163C (zh) | 2006-09-28 | 2006-09-28 | 长春西汀小容量注射剂及其制备工艺 |
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CNB2006101525144A CN100522163C (zh) | 2006-09-28 | 2006-09-28 | 长春西汀小容量注射剂及其制备工艺 |
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Publication Number | Publication Date |
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CN101066244A CN101066244A (zh) | 2007-11-07 |
CN100522163C true CN100522163C (zh) | 2009-08-05 |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101264064B (zh) * | 2008-04-17 | 2011-04-20 | 孙向阳 | 一种长春西汀冻干粉针剂及其制备方法 |
CN101874776B (zh) * | 2009-04-28 | 2012-06-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 长春西汀的干乳剂及其制备方法 |
CN101889978B (zh) * | 2010-04-29 | 2012-01-04 | 袁璐 | 含有长春西汀的药用组合物及其制备方法和应用 |
CN102160853A (zh) * | 2011-02-11 | 2011-08-24 | 方宝林 | 一种长春西汀注射液及其制备方法 |
CN102423295B (zh) * | 2011-06-30 | 2013-03-13 | 武汉同源药业有限公司 | 一种含有长春西汀的小容量注射液组合物及其制备方法 |
CN102228428B (zh) * | 2011-06-30 | 2012-10-03 | 武汉同源药业有限公司 | 一种含有长春西汀的大容量注射液组合物及其制备方法 |
TWI619716B (zh) * | 2011-07-13 | 2018-04-01 | 江蘇恆瑞醫藥股份有限公司 | 含維生素c或其衍生物的替莫唑胺醫藥組成物及其製備方法 |
CN102327210B (zh) * | 2011-07-14 | 2012-11-21 | 海南灵康制药有限公司 | 长春西汀混悬注射剂 |
CN102716067B (zh) * | 2011-11-14 | 2014-12-10 | 河南润弘制药股份有限公司 | 长春西汀注射液及其生产方法 |
CN102716066B (zh) * | 2011-11-14 | 2014-04-16 | 河南润弘制药股份有限公司 | 长春西汀注射液及其制备方法 |
CN102716125B (zh) * | 2011-11-14 | 2013-07-31 | 河南润弘制药股份有限公司 | 长春西汀组合物及其制备方法 |
CN102716064B (zh) * | 2011-11-14 | 2014-04-09 | 河南润弘制药股份有限公司 | 一种长春西汀注射液及其生产方法 |
CN105878178A (zh) * | 2014-10-16 | 2016-08-24 | 山西国润制药有限公司 | 一种长春西汀注射液及其制造方法 |
CN110179745B (zh) * | 2018-07-16 | 2021-09-10 | 北京海浈医药科技有限公司 | 一种长春西汀注射液及其制备方法 |
-
2006
- 2006-09-28 CN CNB2006101525144A patent/CN100522163C/zh active Active
Non-Patent Citations (6)
Title |
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润坦注射液对大鼠局灶性脑缺血再灌注后神经元凋亡的影响. 曹贵方,杨期东,袁存国等.卒中与神经疾病,第12卷第1期. 2005 |
润坦注射液对大鼠局灶性脑缺血再灌注后神经元凋亡的影响. 曹贵方,杨期东,袁存国等.卒中与神经疾病,第12卷第1期. 2005 * |
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药剂学. 毕殿洲主编,241,人民卫生出版社. 2001 * |
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Address after: The new red road Xinzheng city Henan province 451100 Patentee after: HENAN RUNHONG PHARMACEUTICAL Co.,Ltd. Address before: Xinzheng City, Henan province 451100 new Lingrui Avenue Patentee before: HENAN RUNHONG PHARMACEUTICAL Co.,Ltd. |
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Denomination of invention: Vinpocetine small volume injection and its preparation process Effective date of registration: 20230222 Granted publication date: 20090805 Pledgee: CITIC Bank Limited by Share Ltd. Zhengzhou branch Pledgor: HENAN RUNHONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980033250 |
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Denomination of invention: Changchun Xiting Small Volume Injection and Its Preparation Process Granted publication date: 20090805 Pledgee: CITIC Bank Limited by Share Ltd. Zhengzhou branch Pledgor: HENAN RUNHONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980003580 |